scholarly journals Drug-Repositioning Approaches Based on Medical and Life Science Databases

2021 ◽  
Vol 12 ◽  
Author(s):  
Yoshito Zamami ◽  
Hirofumi Hamano ◽  
Takahiro Niimura ◽  
Fuka Aizawa ◽  
Kenta Yagi ◽  
...  
Keyword(s):  
Therapeutic Agent ◽  
Life Science ◽  
Medical Information ◽  
Drug Repositioning ◽  
Basic Research ◽  
Conventional Drug ◽  
Target Molecules ◽  
Diseased State ◽  
Time Required ◽  
The Cost

Drug repositioning is a drug discovery strategy in which an existing drug is utilized as a therapeutic agent for a different disease. As information regarding the safety, pharmacokinetics, and formulation of existing drugs is already available, the cost and time required for drug development is reduced. Conventional drug repositioning has been dominated by a method involving the search for candidate drugs that act on the target molecules of an organism in a diseased state through basic research. However, recently, information hosted on medical information and life science databases have been used in translational research to bridge the gap between basic research in drug repositioning and clinical application. Here, we review an example of drug repositioning wherein candidate drugs were found and their mechanisms of action against a novel therapeutic target were identified via a basic research method that combines the findings retrieved from various medical and life science databases.

Use of cold tolerant eucalyptus species as a partial replacement for southern mixed hardwoods

TAPPI Journal ◽  
2012 ◽  
Vol 11 (7) ◽  
pp. 29-35 ◽  
Author(s):  
PETER W. HART ◽  
DALE E. NUTTER
Keyword(s):  
Potential Method ◽  
The United States ◽  
Partial Replacement ◽  
Growth Time ◽  
Eucalyptus Species ◽  
Cold Tolerant ◽  
Hardwood Pulp ◽  
Time Required ◽  
The Cost ◽  
Operational Data

During the last several years, the increasing cost and decreasing availability of mixed southern hardwoods have resulted in financial and production difficulties for southern U.S. mills that use a significant percentage of hardwood kraft pulp. Traditionally, in the United States, hardwoods are not plantation grown because of the growth time required to produce a quality tree suitable for pulping. One potential method of mitigating the cost and supply issues associated with the use of native hardwoods is to grow eucalyptus in plantations for the sole purpose of producing hardwood pulp. However, most of the eucalyptus species used in pulping elsewhere in the world are not capable of surviving in the southern U.S. climate. This study examines the potential of seven different cold-tolerant eucalyptus species to be used as replacements for, or supplements to, mixed southern hardwoods. The laboratory pulping and bleaching aspects of these seven species are discussed, along with pertinent mill operational data. Selected mill trial data also are reviewed.

BGMSDDA: A bipartite graph diffusion algorithm with multiple similarity integration for drug-disease association prediction

2021 ◽  
Author(s):  
Guobo Xie ◽  
Jianming Li ◽  
Guosheng Gu ◽  
Yuping Sun ◽  
Zhiyi Lin ◽  
...  
Keyword(s):  
Bipartite Graph ◽  
Drug Repositioning ◽  
Disease Association ◽  
The Cost ◽  
Association Matrix

Drug repositioning, a method that relies on the information from the original drug-disease association matrix, aims to identify new indications for existing drugs and will greatly reduce the cost and...

Sample sizes for point, double sampling

1992 ◽  
Vol 22 (7) ◽  
pp. 980-983 ◽  
Author(s):  
Richard G. Oderwald ◽  
Elizabeth Jones
Keyword(s):  
Basal Area ◽  
Double Sampling ◽  
Sample Sizes ◽  
Measuring Volume ◽  
Sample Points ◽  
Time Required ◽  
The Cost ◽  
Minimum Ratio

Formulas are derived for determining the total number of sample points and the number of volume points for a point, double sample with a ratio of means estimator to replace a point sample and achieve the same variance. A minimum ratio of the cost of measuring volume to the cost of measuring basal area at a point is determined for which the point, double sample will be less costly, in terms of time required to measure points, than the point sample.

scholarly journals A Short Path Quantum Algorithm for Exact Optimization

Quantum ◽  
2018 ◽  
Vol 2 ◽  
pp. 78 ◽  
Author(s):  
M. B. Hastings
Keyword(s):  
Hybrid Algorithm ◽  
Optimal Solution ◽  
Quantum Algorithm ◽  
Low Energy ◽  
Weighted Sum ◽  
Natural Hybrid ◽  
Sum Of Products ◽  
Time Required ◽  
The Cost ◽  
Exact Optimization

We give a quantum algorithm to exactly solve certain problems in combinatorial optimization, including weighted MAX-2-SAT as well as problems where the objective function is a weighted sum of products of Ising variables, all terms of the same degree D; this problem is called weighted MAX-ED-LIN2. We require that the optimal solution be unique for odd D and doubly degenerate for even D; however, we expect that the algorithm still works without this condition and we show how to reduce to the case without this assumption at the cost of an additional overhead. While the time required is still exponential, the algorithm provably outperforms Grover's algorithm assuming a mild condition on the number of low energy states of the target Hamiltonian. The detailed analysis of the runtime dependence on a tradeoff between the number of such states and algorithm speed: fewer such states allows a greater speedup. This leads to a natural hybrid algorithm that finds either an exact or approximate solution.

scholarly journals SPECIFIC FEATURES OF FILLERS FROM SAND-GRAVEL MIXTURE ON THE EXAMPLE OF THE VEDENSKOE DEPOSIT

2020 ◽  
pp. 65-74
Author(s):  
Т. С-А. Муртазаева ◽  
М. С. Сайдумов ◽  
А. Х. Аласханов ◽  
А. З. Абуханов
Keyword(s):  
Basic Research ◽  
Cement Stone ◽  
North Caucasus ◽  
Concrete Technology ◽  
Large Aggregate ◽  
The North ◽  
Aggregate Fractions ◽  
Scientific Project ◽  
Sand And Gravel ◽  
The Cost

Представлены основные результаты исследований особенностей заполнителей из песчано-гравийной смеси (ПГС) Веденского месторождения Чеченской Республики. Приведены минералогический и петрографический составы известных месторождений ПГС Северного Кавказа. Изучены физико-механические и другие свойства как самих ПГС, так и отдельных их мелких и крупных фракций заполнителей. Получена зависимость стоимости бетонов на основе ПГС от класса бетона по прочности на сжатие. Представлены сравнительные данные бетонов на основе ПГС с бетонами на искусственном заполнителе - щебне. Доказана эффективность применения ПГС в технологии бетона после их обогащения и фракционирования, способствующих улучшению контактной зоны такого заполнителя и цементного камня и, как следствие, повышению прочности бетона. Работа выполнена при поддержке Российского фонда фундаментальных исследований» (РФФИ) в рамках научного проекта № 18-48-200001. The main results of studies of the features of aggregates from a sand and gravel mixture (SGM) of the Vedensky deposit in the Chechen Republic are presented. The mineralogical and petrographic compositions of the known deposits of SGM in the North Caucasus are presented. The physicomechanical and other properties of both the SGM themselves and their individual small and large aggregate fractions have been studied. The dependence of the cost of concrete based on SGM on the class of concrete in terms of compressive strength is obtained. Comparative data of concretes based on SGM with concretes based on artificial aggregate - crushed stone are presented. The effectiveness of the use of SGM in concrete technology after their enrichment and fractionation has been proven, which helps to improve the contact zone of such a filler and cement stone and, as a result, to increase the strength of concrete.This work is supported by the Russian Foundation for Basic Research (RFBR) in the framework of the scientific project No. 18-48-200001.

Comparison of two fluoroscopic images to ensure efficient scope insertion for biliary intervention in patients with Roux-en-Y hepaticojejunostomy

Endoscopy ◽  
2017 ◽  
Vol 49 (12) ◽  
pp. 1256-1261 ◽  
Author(s):  
Koichiro Tsutsumi ◽  
Hironari Kato ◽  
Ken Hirao ◽  
Sho Mizukawa ◽  
Shinichiro Muro ◽  
...  
Keyword(s):  
Medical Information ◽  
Standard Procedure ◽  
University Hospital ◽  
Information Network ◽  
Imaging Method ◽  
Anastomotic Site ◽  
Biliary Disease ◽  
Endoscopic Retrograde ◽  
Time Required ◽  
Clinical Trials Registry

Abstract Background and study aims No standard procedure for endoscopic retrograde cholangiopancreatography is available for patients with Roux-en-Y hepaticojejunostomy (RYHJ) with side-to-end hepaticojejunostomy. We therefore explored methods of efficient scope insertion at a hepaticojejunostomy site. Patients and methods Patients with suspected biliary disease were prospectively enrolled. Based on two fluoroscopic images obtained on scope insertion into each lumen of a two-pronged Roux-en-Y anastomosis, we selected the lumen in which the distal end of the scope progressed toward the patient’s liver or head. The accuracy of this method for selecting the correct lumen leading to the hepaticojejunostomy site was investigated. Results Of the 33 included patients, successful insertion to the hepaticojejunostomy site was achieved in 32 (97 %), 26 (81 %) of whom had undergone the imaging method. The accuracy of the method was 88 % (23/26). The time required for insertion between the anastomotic site and the hepaticojejunostomy site was shorter when the lumen selection had been correct (13 minutes [7 – 30] (n = 23) vs. 18 minutes [8 – 28] (n = 9); P = 0.95). Conclusion This method based on two fluoroscopic images was useful for achieving efficient scope insertion in patients with RYHJ.Trial registered at University Hospital Medical Information Network Clinical Trials Registry (UMIN000014183).

Telemedicine and Electronic Health

2018 ◽  
pp. 1-19
Author(s):  
Kijpokin Kasemsap
Keyword(s):  
Health Care ◽  
Developing Countries ◽  
Medical Information ◽  
Electronic Communications ◽  
Cost Of Health Care ◽  
Share Data ◽  
Strategic Goals ◽  
Hospital Stays ◽  
Electronic Health ◽  
The Cost

This chapter reveals the overview of telemedicine; telemedicine in developing countries; Electronic Health Record (EHR); and mobile health technologies. Telemedicine and Electronic Health (e-health) are modern technologies toward improving quality of care and increasing patient safety in developing countries. Telemedicine and e-health are the utilization of medical information exchanged from one site to another site via electronic communications. Telemedicine and e-health help health care organizations share data contained in the largely proprietary EHR systems in developing countries. Telemedicine and e-health help reduce the cost of health care and increases the efficiency through better management of chronic diseases, shared health professional staffing, reduced travel times, and shorter hospital stays. The chapter argues that utilizing telemedicine and e-health has the potential to enhance health care performance and reach strategic goals in developing countries.

Rich-Media Interactive Simulations

2016 ◽  
pp. 261-283
Author(s):  
Suzanne Tsacoumis
Keyword(s):  
Real World ◽  
High Fidelity ◽  
Rich Media ◽  
Job Candidates ◽  
Real World Applications ◽  
Fidelity Measures ◽  
Time Required ◽  
The Cost ◽  
Interactive Simulations

High fidelity measures have proven to be powerful tools for measuring a broad range of competencies and their validity is well documented. However, their high-touch nature is often a deterrent to their use due to the cost and time required to develop and implement them. In addition, given the increased reliance on technology to screen and evaluate job candidates, organizations are continuing to search for more efficient ways to gather the information they need about one's capabilities. This chapter describes how innovative, interactive rich-media simulations that incorporate branching technology have been used in several real-world applications. The main focus is on describing the nature of these assessments and highlighting potential solutions to the unique measurement challenges associated with these types of assessments.

scholarly journals Run-Time and Compiler Support for Programming in Adaptive Parallel Environments

1997 ◽  
Vol 6 (2) ◽  
pp. 215-227 ◽  
Author(s):  
Guy Edjlali ◽  
Gagan Guyagrawal ◽  
Alan Sussman ◽  
Jim Humphries ◽  
Joel Saltz
Keyword(s):  
Parallel Programming ◽  
High Performance ◽  
Navier Stokes ◽  
Programming Environments ◽  
Data Parallel ◽  
Adaptive Environment ◽  
Run Time ◽  
Time Required ◽  
The Cost ◽  
Performance Results

For better utilization of computing resources, it is important to consider parallel programming environments in which the number of available processors varies at run-time. In this article, we discuss run-time support for data-parallel programming in such an adaptive environment. Executing programs in an adaptive environment requires redistributing data when the number of processors changes, and also requires determining new loop bounds and communication patterns for the new set of processors. We have developed a run-time library to provide this support. We discuss how the run-time library can be used by compilers of high-performance Fortran (HPF)-like languages to generate code for an adaptive environment. We present performance results for a Navier-Stokes solver and a multigrid template run on a network of workstations and an IBM SP-2. Our experiments show that if the number of processors is not varied frequently, the cost of data redistribution is not significant compared to the time required for the actual computation. Overall, our work establishes the feasibility of compiling HPF for a network of nondedicated workstations, which are likely to be an important resource for parallel programming in the future.

Hiding time of the hermit crab Calcinus californiensis: observations from different shell types

2015 ◽  
Vol 93 (7) ◽  
pp. 559-565 ◽  
Author(s):  
Carlos Enrique Chávez-Solís ◽  
Guillermina Alcaraz
Keyword(s):  
Water Column ◽  
Potential Risk ◽  
Hermit Crab ◽  
Hermit Crabs ◽  
Resource Value ◽  
Risk Of Predation ◽  
Potential Risks ◽  
Time Required ◽  
The Cost ◽  
Return To Activity

Hermit crabs respond to predators by hiding in their shells. However, retraction may cause the crab to lose hold of the rock and fall through the water column, and the crab may land with the shell aperture in a different orientation. When the shell is aperture down, hermit crabs return to activity by moving their bodies forward and placing their legs on the ground. In contrast, when the shell is aperture up, crabs need to perform a righting maneuver by extending part of their bodies out of the shell, which makes them more vulnerable to predation. The main goal of this study was to examine the hiding time of the hermit crab Calcinus californiensis Bouvier, 1898 in different shell species under these two different situations to better understand the conflict between the cost of staying in hiding and the risk of predation. The study was conducted in rocky tide pools using seven different shell types that reflect different predator protection and resource value to the crab (based on previous studies). We measured the time required to perform the righting maneuver as a measure of the potential risk incurred when returning to activity. The hiding time with the shell aperture down was not affected by shell species. The requirement to carry out a righting maneuver lengthened the hiding time, which varied in the different shell species according to the time required to recover the natural position. The potential risks associated with the righting time, the protection offered by the shells, and the resource value played an important role in the hiding time of the crabs using different shells. This study shows that hermit crabs are aware of the attributes of the shell and use this information to make decisions about how long to stay hidden after being threatened.

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