Effectiveness of Probiotic, Prebiotic, and Synbiotic Supplementation to Improve Perinatal Mental Health in Mothers: A Systematic Review and Meta-Analysis

Introduction: There is an emerging interest in modulating the gut microbiota to target the gut-brain axis and improve maternal mental health in the perinatal period. This systematic review evaluated the effectiveness of prebiotics, probiotics, and synbiotics supplementation during pregnancy to reduce the risk of maternal mental health problems in the perinatal period.Methods: Electronic biomedical databases and clinical trial registries were searched from database inception through August 2020 to identify randomized controlled clinical trials (RCTs) evaluating the effect of probiotic, prebiotic, or synbiotic supplements administered to women during pregnancy on measures of perinatal depression, anxiety, and other mental health outcomes. Study selection, risk of bias appraisal, and data extraction were independently performed by two reviewers. Pooled mean differences (MD) and odds ratios (pOR) with 95% confidence intervals (CI) were calculated in random-effects meta-analyses for the outcomes of interest in the review.Results: From 3,868 studies identified through the search strategy, three RCTs of low risk of bias involving 713 participants were included, all three testing probiotics. There were no differences between probiotics and control groups in the mean depression scores (MD −0.46; 95% CI −2.16, 1.25) at end of follow-up. Although statistical significance was not achieved, probiotics showed an advantage in the proportion of participants scoring below an established cut-off for depression (pOR 0.68; 95% CI 0.43, 1.07). Compared to placebo, probiotics in pregnancy reduced anxiety symptoms (MD −0.99; 95% CI −1.80, −0.18); however, this advantage was not translated in a reduction in the proportion of participants scoring above an established cut-off for anxiety (pOR 0.65; 95% CI 0.23, 1.85). There were no differences between probiotics and control groups in global mental health scores at end of follow-up (MD 1.09; 95% CI −2.04, 4.22).Conclusion: There is limited but promising evidence about the effectiveness of probiotics during pregnancy to reduce anxiety symptoms and reduce the proportion of women scoring ABOVE a cut-off depression score. There is a lack of RCT evidence supporting prebiotics and synbiotics supplementation for similar purposes in the perinatal period. More research is needed before prebiotics, probiotics, and synbiotics are recommended to support maternal mental health and well-being in the perinatal period.Systematic Review Registration: PROSPERO, CRD42019137158.

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When the Bough Breaks: A Systematic Review and Meta-Analysis of Mental Health Symptoms in Mothers of Young Children during the COVID-19 Pandemic

10.31234/osf.io/u8pnh ◽

2021 ◽

Author(s):

Nicole Racine ◽

Rachel Eirich ◽

Jessica Cookee ◽

Jenney Zhu ◽

Paolo Pador ◽

...

Keyword(s):

Mental Health ◽

Young Children ◽

Maternal Mental Health ◽

Meta Analysis ◽

Random Effect ◽

Well Being ◽

Anxiety Symptoms ◽

Study Quality ◽

Depression And Anxiety ◽

Meta Analyses

Parents have experienced considerable challenges and stress during the COVID-19 pandemic, which may impact their well-being. This meta-analysis sought to identify: 1) the prevalence of depression and anxiety in parents of young children (< age 5) during the COVID-19 pandemic, and 2) sociodemographic (e.g., parent age, minority status) and methodological moderators (e.g., study quality) that explain heterogeneity among studies. A systematic search was conducted across four databases from January 1st, 2020 to March 3st, 2021. A total of 18 non-overlapping studies (9,101 participants), all focused on maternal mental health, met inclusion criteria. Random-effect meta-analyses were conducted. Pooled prevalence estimates for clinically significant depression and anxiety symptoms for mothers of young children during the COVID-19 pandemic were 27.4% (95% CI: 21.5-34.3) and 43.5% (95% CI:27.5-60.9), respectively. Prevalence of clinically elevated depression and anxiety symptoms were higher in Europe and North America and among older mothers. Clinically elevated depressive symptoms were lower in studies with a higher percentage of racial and ethnic minority individuals. In comparison, clinically elevated anxiety symptoms were higher among studies of low study quality and in samples with highly educated mothers. Policies and resources targeting improvements in maternal mental health are essential.

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Behaviour Problems in Pre-School Children: Family and Social Factors

The British Journal of Psychiatry ◽

10.1192/bjp.131.5.523 ◽

1977 ◽

Vol 131 (5) ◽

pp. 523-527 ◽

Cited By ~ 82

Author(s):

Naomi Richman

Keyword(s):

Mental Health ◽

Young Child ◽

Social Factors ◽

Maternal Mental Health ◽

Epidemiological Survey ◽

High Rate ◽

Behaviour Problems ◽

Behaviour Problem ◽

Control Groups ◽

And Control

In a group of 99 three-year-old children with behaviour problems identified in an epidemiological survey, family and social factors were compared with those in a group of controls. Behaviour problems were significantly associated with a strained marital relationship between parents, with social stresses and with type of housing. There was a high rate of maternal depression in both problem and control groups. The interaction between a behaviour problem in a young child, maternal mental health and social factors is discussed.

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Mental Health Literacy Intervention on Help-Seeking in Athletes: A Systematic Review

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17197263 ◽

2020 ◽

Vol 17 (19) ◽

pp. 7263

Author(s):

Danran Bu ◽

Pak-Kwong Chung ◽

Chun-Qing Zhang ◽

Jingdong Liu ◽

Xiang Wang

Keyword(s):

Mental Health ◽

Systematic Review ◽

Help Seeking ◽

Mental Health Literacy ◽

Health Knowledge ◽

Risk Of Bias ◽

Stigma Reduction ◽

Help Seeking Attitudes ◽

Mental Health Knowledge

Mental health literacy (MHL) is recognised as a major factor in whether athletes seek help when they experience mental health difficulties. Therefore, the current study aimed to provide a systematic review of the effectiveness of MHL training programmes in improving mental health knowledge and help-seeking and reducing stigma among athletes. To identify intervention studies of MHL programmes, five electronic databases were systematically searched for articles published before May 2020. The selection procedure was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All kinds of study designs were included. Effect sizes were calculated for mental health knowledge, stigma reduction and help-seeking attitudes, intentions and behaviours. Risk of bias was assessed for each study using the Cochrane tool and the Newcastle–Ottawa quality assessment scale. Five studies (1239 participants in total) were selected for review. Overall, either small or medium effects were found for mental health knowledge, stigma reduction, help-seeking attitudes, and intentions for post- and follow-up interventions, whereas a null effect was found in help-seeking behaviours for both post- and follow-up interventions. Furthermore, three studies had a low risk of bias, and two had a high risk of bias. MHL interventions can enhance help-seeking attitudes and intentions and mental health knowledge and reduce stigma but do not increase help-seeking behaviours for now. Further studies should evaluate interventions to enhance help-seeking behaviours. Furthermore, the methodological quality of studies, including randomized controlled trials and other designs, should be improved in future research.

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Mobile Apps that Promote Emotion Regulation, Positive Mental Health and Well-being in the General Population: Systematic Review and Meta-analysis (Preprint)

10.2196/preprints.31170 ◽

2021 ◽

Author(s):

Amelia Eisenstadt ◽

Shaun Liverpool ◽

Elisa Infanti ◽

Roberta Maria Ciuvat ◽

Courtney Carlsson

Keyword(s):

Mental Health ◽

Systematic Review ◽

Emotion Regulation ◽

General Population ◽

Mobile Apps ◽

Meta Analysis ◽

Well Being ◽

Positive Mental Health ◽

Risk Of Bias ◽

Health And Well Being

BACKGROUND Among the general public there appears to be a growing need and interest in receiving digital mental health and well-being support. In response to this, a number of mental health apps (MHapps) are becoming available for monitoring, managing and promoting positive mental health and well-being. Thus far, the evidence supports positive outcomes when users engage with digital interventions. However, there is high variability in the theoretical base informing MHapps and the features incorporated. Such differences can have implications for the efficacy of the apps and the level of engagement among specific target population groups. Moreover, such heterogeneity may influence the extent to which the data from various MHapps can be pooled to assess the strength of the evidence. OBJECTIVE We aimed to systematically review the available research on MHapps that promote emotion regulation, positive mental health, and well-being in the general population aged 18-45. More specifically, the review aimed at providing a systematic description of the theoretical background and features of MHapps while evaluating any potential effectiveness. METHODS A comprehensive literature search of key databases; MEDLINE (via Ovid), EMBASE (via Ovid), PsycINFO (via Ovid), Web of Science, and the Cochrane Register of Controlled Trials (CENTRAL) was conducted until January 2021. Studies were included if they described standalone mental health and well-being apps for adults without a formal mental health diagnosis. All studies were quality assessed against the Mixed Methods Appraisal Tool. In addition, the Cochrane risk-of-bias tool (ROB-2) was used to assess randomized control trials (RCTs). Data were extracted using a modified extraction form the Cochrane Handbook of Systematic Reviews. A narrative synthesis and meta-analysis was then undertaken to address the review aims. RESULTS In total, 3156 abstracts were identified. Of these, 52 publications describing 48 MHapps met the inclusion criteria. Together the studies evaluated interventions across 15 countries. Thirty-nine RCTs were identified that suggested there is some support for the role of individual MHapps in improving and promoting mental health and well-being. Regarding pooled effect, MHapps, when compared to controls, showed a small effect for reducing mental health symptoms (k = 19, g = -0.24, 95% CI [-0.34, -0.14], p < .05) and improving well-being (k = 13, g = 0.17, 95% CI [0.05, 0.29], p < .05), and a medium effect for emotion regulation (k = 6, g = 0.49, 95% CI [0.23,0.74], p<.05). There is also a wide knowledge base of creative and innovative ways to engage users in techniques, such as mood monitoring and guided exercises. Mindfulness and Cognitive Behavioural approaches appear to be the most common among MHapp developers. Studies were generally assessed to contribute unclear or high risk of bias, or be of medium to low methodological quality. CONCLUSIONS The emerging evidence for MHapps that promote positive mental health and well-being continue to show some evidence of promise. Despite a wide range of MHapps, there are not many that specifically promote emotion regulation. However, our findings may position emotion regulation as an important mechanism for inclusion in future positive mental health and well-being MHapps. A fair proportion of the included studies were pilot or feasibility trials (k = 17, 33%), and full scale RCTs reported high attrition rates and non-diverse samples. Given the number and pace at which MHapps are being released, further robust research is warranted to inform the development and testing of evidence-based programs. CLINICALTRIAL Mia Eisenstadt, Elisa Infanti, Shaun Liverpool. Characteristics and effectiveness of mobile apps that promote emotion regulation and well-being in the general population: a systematic review protocol. PROSPERO 2020 CRD42020213051 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020213051

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Anxiety and depressive symptomatology among children and adolescents exposed to the COVID-19 pandemic - meta-analysis

Vojnosanitetski pregled ◽

10.2298/vsp210521092d ◽

2021 ◽

pp. 92-92

Author(s):

Sanja Djurdjevic ◽

Ghigliazza Conde ◽

Vesna Dukanac ◽

Ana Djurdjevic

Keyword(s):

Mental Health ◽

Systematic Review ◽

Depressive Symptoms ◽

Children And Adolescents ◽

Depressive Symptomatology ◽

Well Being ◽

Anxiety Symptoms ◽

Strong Impact ◽

Positive Correlations ◽

The Impact

Background/Aim: Children and adolescents are the sensitive groups for the development of mental disorders during the crisis. The aim of this systematic review is to assess the impact of the COVID-19 pandemic regarding anxiety and depressive symptomatology in this population. Method: Investigation is based on a Systematic Review followed by PRISMA protocol including Ovid MEDLINE, Embase, Global Health and APA Psyc Info data bases to identify relevant studies reporting anxiety and depressive symptoms among children and adolescents during the COVID-19 pandemic. 27 articles were included. Results: Anxiety symptoms increased from 28.3% before the pandemic to 49.5% during confinement (GAD-7 ? 11) (McNemar test p <0.0001). More depression symptomatology was found as well; weight and sleep changes are disturbances in children and adolescents? mental health. Additionally, female teenagers were experiencing grater declines in mood disorders than male teenagers during the COVID-19 crisis. On one hand, different positive correlations between anxiety and other variables, were found, such as clinical depressive symptoms and anxiety (3/14), smartphone and internet addiction (2/14), lower levels of family income (2/14), perceived threats (2/14), higher grades at school (2/14), loneliness (1/14). On the other hand, positive correlations were reported between depression and children and adolescents that were socially disconnected (3/17). Finally, mothers with higher levels of education and income were associated with more happiness (2/17). Conclusions: COVID-19 has a strong impact in children?s and adolescents? mental health regarding depression and anxiety symptoms. Prevention programs focused on coping strategies should also be considered to be delivered in elementary schools, middle schools and high schools. Mental health should become a priority matter for governments and the current pandemic could be an opportunity to highlight the importance of mental well-being and to invest in the betterment of clinical trainings, treatments and mental health research.

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The effectiveness of listening to the Holy Quran to improve mental disorders and psychological well-being: Systematic review and meta-analysis

10.21203/rs.3.rs-44376/v1 ◽

2020 ◽

Author(s):

Alaa Abd-alrazaq ◽

Ashraf A Malkawi ◽

Ahmed H Maabreh ◽

Tanvir Alam ◽

Bridgette M Bewick ◽

...

Keyword(s):

Mental Health ◽

Systematic Review ◽

Mental Disorders ◽

Meta Analysis ◽

Well Being ◽

Complementary Therapy ◽

Risk Of Bias ◽

Bibliographic Databases ◽

Reference List ◽

Psychological Well Being

Abstract Background: Listening to the Quran is one of spiritual therapies that have been used for treating mental disorders. Many studies have been conducted to assess the effect of listening to the Quran on mental health and psychological wellbeing. Several reviews were conducted to summarise results of such evidence. However, they either focused on studies published in a certain country (Iran), focused on certain setting (intensive care unit), or were written by Persian language. Moreover, none of them synthesised results of studies statistically.Objective: The study aimed to assess the effectiveness of listening to the Quran to improve mental disorders and psychological well-being by summarizing and pooling the findings of previous literature.Methods: A systematic review was conducted to accomplish this objective. The search sources included 6 bibliographic databases (e.g., MEDLINE, PsycINFO, CINHAL), the search engine “Google Scholar”, and backward and forward reference list checking of the included studies and relevant reviews. Two reviewers independently carried out the study selection, data extraction, risk of bias assessment, and quality of evidence evaluation. Results of the included studies were synthesized narratively and statistically, as appropriate.Results: Of 1724 citations retrieved, 11 studies met the eligibility criteria. Of these studies, 7 were included in meta-analysis. The evidence showed that listening to the Quran is significantly effective in improving state anxiety, trait anxiety, general anxiety, depression, stress and mental health. However, the evidence quality ranged from very low to low due to the high risk of bias, heterogeneity, and impression.Conclusion: Listening to the Quran has the potential to improve mental disorders and psychological well-being. Until high-quality studies approve its effect, health professionals and individuals should consider listening to the Quran as a complementary therapy to already available interventions. Researchers should conduct further studies to compare the effectiveness of reciting and listening to the Quran and Al-Ruqya Al-Shariya with active interventions on mental disorders and psychological well-being among Muslims and non-Muslims from different countries.

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Effects of mobile mindfulness meditation on mental health of university students: Systematic review and meta-analysis (Preprint)

10.2196/preprints.33882 ◽

2021 ◽

Author(s):

Hong Chen ◽

Bin Chen ◽

Ting Yang

Keyword(s):

Mental Health ◽

Systematic Review ◽

University Students ◽

Mindfulness Meditation ◽

Meta Analysis ◽

Well Being ◽

Cochrane Library ◽

Control Groups ◽

Registration Number ◽

Anxiety Depression

BACKGROUND Mobile mindfulness meditation (MMM) is mindfulness meditation intervention implemented by mobile devices like smart phones and apps. MMM has been used to help managing mental health of university students. OBJECTIVE The purpose of this study was to evaluate the effectiveness of MMM on mental health of university students in the areas of stress, anxiety, depression, mindfulness, well-being, and resilience. METHODS We conducted a systematic review and meta-analysis of the effectiveness of MMM on mental health of university students. An electronic literature search using the PubMed, Web of Science, EBSCO, Cochrane Library, and EMBASE from inception to July 16, 2021 was conducted to identify studies that reported the effects of MMM on stress, anxiety, depression, mindfulness, well-being, and resilience. Two reviewers retrieved articles, evaluated quality and extracted data independently. The methodological quality of the selected studies was determined using the Cochrane criteria for risk-of-bias assessment. The RevMan Version 5.3 was used to perform meta-analysis. RESULTS A total of 10 studies, including 958 university students, were selected for meta-analysis. Results showed that MMM was more effective than the control groups in decreasing stress (SMD=-0.41, 95% CI [-0.59, -0.23], P<0.0001), alleviating anxiety (SMD=-0.29, 95% CI [-0.50, -0.09], P=0.004), enhancing well-being (SMD=0.30, 95% CI [0.11, 0.50], P=0.003), and improving mindfulness (SMD=2.66, 95% CI [0.77, 4.55], P=0.006). However, there was no difference between MMM and the control groups in depression (SMD=-0.14, 95% CI [-0.30, 0.03], P=0.11), and resilience (SMD=-0.06, 95% CI [-0.26, 0.15], P=0.59). CONCLUSIONS MMM was an effective method to reduce stress, anxiety, and to increase well-being, mindfulness of university students, further studies are needed to confirm our findings. CLINICALTRIAL review article, no trail registration number.

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A systematic review of systematic reviews of interventions to improve maternal mental health and well-being

Midwifery ◽

10.1016/j.midw.2012.05.010 ◽

2013 ◽

Vol 29 (4) ◽

pp. 389-399 ◽

Cited By ~ 50

Author(s):

Fiona Alderdice ◽

Jenny McNeill ◽

Fiona Lynn

Keyword(s):

Mental Health ◽

Systematic Review ◽

Systematic Reviews ◽

Maternal Mental Health ◽

Well Being ◽

Health And Well Being

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Disrespect and abuse as a predictor of postnatal care utilisation and maternal-newborn well-being: a mixed-methods systematic review

BMJ Global Health ◽

10.1136/bmjgh-2020-004698 ◽

2021 ◽

Vol 6 (4) ◽

pp. e004698

Author(s):

Nicole Minckas ◽

Lu Gram ◽

Colette Smith ◽

Jenevieve Mannell

Keyword(s):

Mental Health ◽

Systematic Review ◽

Mixed Methods ◽

Postnatal Care ◽

Maternal Mental Health ◽

Meta Analysis ◽

Well Being ◽

Disrespect And Abuse ◽

Health Providers ◽

Negative Experience

IntroductionGlobally, a substantial number of women experience abusive and disrespectful care from health providers during childbirth. As evidence mounts on the nature and frequency of disrespect and abuse (D&A), little is known about the consequences of a negative experience of care on health and well-being of women and newborns. This review summarises available evidence on the associations of D&A of mother and newborns during childbirth and the immediate postnatal period (understood as the first 24 hours from birth) with maternal and neonatal postnatal care (PNC) utilisation, newborn feeding practices, newborn weight gain and maternal mental health.MethodsWe conducted a systematic review of all published qualitative, quantitative and mixed-methods studies on D&A and its postnatal consequences across all countries. Pubmed, Embase, Web of Science, LILACS and Scopus were searched using predetermined search terms. Quantitative and qualitative data were analysed and presented separately. Thematic analysis was used to synthesise the qualitative evidence.ResultsA total of 4 quantitative, 1 mixed-methods and 16 qualitative studies were included. Quantitative studies suggested associations between several domains of D&A and use of PNC as well as maternal mental health. Different definitions of exposure meant formal meta-analysis was not possible. Three main themes emerged from the qualitative findings associated with PNC utilisation: (1) women’s direct experiences; (2) women’s expectations and (3) women’s agency.ConclusionThis review is the first to examine the postnatal effect of D&A of women and newborns during childbirth. We highlight gaps in research that could help improve health outcomes and protect women and newborns during childbirth. Understanding the health and access consequences of a negative birth experience can help progress the respectful care agenda.

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Women’s Mental Health as a Factor Associated with Exclusive Breastfeeding and Breastfeeding Duration: Data from a Longitudinal Study in Greece

Children ◽

10.3390/children8020150 ◽

2021 ◽

Vol 8 (2) ◽

pp. 150

Author(s):

Maria Dagla ◽

Irina Mrvoljak-Theodoropoulou ◽

Despoina Karagianni ◽

Calliope Dagla ◽

Dimitra Sotiropoulou ◽

...

Keyword(s):

Mental Health ◽

Longitudinal Study ◽

Exclusive Breastfeeding ◽

Maternal Mental Health ◽

Negative Relationship ◽

Depression Scale ◽

Well Being ◽

Perinatal Period ◽

Breastfeeding Duration ◽

Patient Health

Background: This study investigated the relationship between exclusive breastfeeding and breastfeeding duration, and maternal psychological well-being in the perinatal period. Methods: A longitudinal study involving a retrospective follow-up of a group of 1080 women from pregnancy to the 1st year postpartum, who gave birth during the 5-year period between January 2014 and January 2019 in Athens, Greece, was designed. Women’s history and two psychometric tools—the Edinburg Postpartum Depression Scale (EPDS) and the Patient Health Questionnaire-9 (PHQ-9) administered at 5-time points—were used for data collection. Logistic regression analysis and a series of multiple analysis of variance (MANOVA) tests were performed. Results: The chance for exclusive breastfeeding (giving only breast milk) appeared to decrease (a) with an increase of the scores for psychometric tools antenatally (PHQ-9, p = 0.030) or at the 6th week postpartum (EPDS, p < 0.001 and PHQ-9, p < 0.001), (b) with an increase in the number of psychotherapeutic sessions needed antenatally (p = 0.030), and (c) when the initiation of psychotherapy was necessary postpartum (p = 0.002). Additionally, a shorter duration of any breastfeeding (with or without formula or other types of food/drink) seems to be associated with (a) the occurrence of pathological mental health symptoms (p = 0.029), (b) increased PHQ-9 scores antenatally (p = 0.018), (c) increased EPDS scores at the 6th week (p = 0.004) and the 12th month postpartum (p = 0.031), (d) the initiation of psychotherapy postpartum (p = 0.040), and e) the need for more than 13 psychotherapeutic sessions (p = 0.020). Conclusions: This study demonstrates a negative relationship between exclusive breastfeeding and breastfeeding duration, and poor maternal mental health in the perinatal period.

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