scholarly journals Oxidative Stress Biomarkers as a Predictor of Stage Illness and Clinical Course of Schizophrenia

2021 ◽  
Vol 12 ◽  
Author(s):  
Dariusz Juchnowicz ◽  
Michał Dzikowski ◽  
Joanna Rog ◽  
Napoleon Waszkiewicz ◽  
Anna Zalewska ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Regression Model ◽  
Antioxidant Status ◽  
Serum Levels ◽  
Stress Index ◽  
First Episode ◽  
Control Group ◽  
Healthy Individuals ◽  
Related Factors ◽  
Reducing Ability

Pro/antioxidant imbalance has been reported in schizophrenia (SZ). However, the results of studies are inconsistent and usually do not include other factors that are highly affected by oxidative stress (OS).This cross-sectional study aimed to determine the serum levels of OS markers and their potential connection with schizophrenia. The total sample comprised 147: 98 individuals with SZ −47 first-episode (FS) and 49 chronic patients (CS)—and 49 healthy individuals (HC) as a control group. The examination included clinical variables and serum levels of antioxidants and oxidative damage products. The significant changes were observed in concentrations of all examined markers, without any specific direction of the pro/antioxidant balance shift between SZ and HC. In the regression model adjusted for cofounders, catalase: OR = 0.81 (95%CI: 0.74–0.88); glutathione peroxidase: OR = 1.06 (95%CI: 1.02–1.10); total antioxidant capacity: OR = 0.85 (95%CI: 0.75–0.98); oxidative stress index: OR = 1.25 (95%CI: 1.03–1.52); ferric reducing ability of plasma: OR = 0.79 (95%CI: 0.69–0.89); advanced glycation end products: OR = 1.03 (95%CI: 1.01–1.04); and advanced oxidation protein products (AOPP): OR = 1.05 (95%CI: 1.03–1.07) turned out to be significant predictors of schizophrenia. In the multiple stepwise regression model, pro/antioxidant status and their interaction with the duration of illness-related factors affected schizophrenia symptoms: positive symptoms (FRAPxKYN), negative (DITYR, FRAP, CAT), general (KYN), and over-all psychopathology (KYNxNFK). The results confirm differences in serum levels of oxidative biomarkers between SZ patients and healthy individuals. The pro/antioxidant status could be considered a predictor of schizophrenia and the factor affects patients' symptom severity.

scholarly journals Relationship between diet, oxidative stress, and inflammation in ankylosing spondylitis

2021 ◽  
Author(s):  
Kübra Tel Adıgüzel ◽  
Fatma Gül Yurdakul ◽  
Nilgün Seremet Kürklü ◽  
Evren Yaşar ◽  
Hatice Bodur
Keyword(s):  
Oxidative Stress ◽  
Fatty Acid ◽  
Ankylosing Spondylitis ◽  
Vitamin C ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Control Group ◽  
Dietary Record ◽  
Significant Difference

Objectives: This study aims to investigate the relationship between disease activity, dietary phytochemical index (DPI), and serum total oxidant status (TOS) and total antioxidant status (TAS) in patients with ankylosing spondylitis (AS). Patients and methods: Between August 2020 and January 2021, a total of 37 patients (23 males, 14 females; mean age: 39.3±9.4 years; range, 21 to 61 years) with AS and 36 age-, sex-, and body mass index-matched healthy individuals (24 males, 12 females; mean age: 37.9±8.9 years; range, 20 to 60 years) were included. Serum TAS (μmoLTroloxEq/L) and TOS (μmoL H2O2Eq/L) measurements were performed and the oxidative stress index (OSI) was calculated. Dietary evaluation was made from a one-day dietary record and DPI was calculated. Results: Serum TAS level in AS patients was significantly lower than the healthy group (p=0.003). Serum TOS level was similar in both groups. The OSI of patients was significantly higher than the controls (p=0.035). The mean DPI, polyunsaturated fatty acid, n-3 fatty acid, and vitamin C intake of patients were significantly lower than controls (p=0.042, p=0.033, and p=0.022, respectively). A moderate positive correlation was found between the TAS level and DPI of the control group (r=0.352, p=0.035). According to medications, no significant difference was seen between the groups in terms of patients’ characteristics, DPI, and laboratory tests and there was no correlation between DPI, TAS, TOS, and OSI. Conclusion: Lower DPI and lower n-3 fatty acid and vitamin C intake in patient group demonstrated that patients with AS should pay more attention to their diet to increase serum antioxidant status.

Evaluation of oxidant and antioxidant status in infants with hyperbilirubinemia and kernicterus

2011 ◽  
Vol 30 (11) ◽  
pp. 1751-1760 ◽  
Author(s):  
Murat Doğan ◽  
Erdal Peker ◽  
Ercan Kirimi ◽  
Ertan Sal ◽  
Sinan Akbayram ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Sulfhydryl Group ◽  
Stress Index ◽  
Control Group ◽  
Significant Difference ◽  
Group 2 ◽  
And Control ◽  
And Oxidative Stress ◽  
Group 1

Objective: The objective of the present study was to determine oxidant and antioxidant status in infants with hyperbilirubinemia and/or kernicterus and to find whether there is a relationship between bilirubin level and oxidant/antioxidant status. Patients: The study includes 69 full-term newborns (neonates with hyperbilirubinemia needing phototherapy [Group 1, n = 36] and neonates with kernicterus [Group 2, n = 33]) and 25 age-matched healthy newborn. Results: Plasma total antioxidant capacity (TAC) and serum total oxidant status (TOS) were significantly higher in Groups 1 and 2 than the control group. There was a significant difference between Group 1 and control cases for malondialdehyde (MDA; p < 0.001). Total free sulfhydryl group (TTHI) values were significantly elevated in Group 1 compared to Group 2 and control cases. Correlation analysis showed that the correlation between total bilirubin (TB) and TAC, TOS, MDA and oxidative stress index may be expressed by a quadratic curve. After phototherapy, a statistically significant increase in nitrite level was observed. Conclusion: We demonstrated that the relationship between serum TB and antioxidants and oxidative stress could be expressed by a quadratic correlation curve.

scholarly journals Impaired oxidative-antioxidative balance during migraine attack

2019 ◽  
Vol 6 (2) ◽  
pp. 2996-3002 ◽  
Author(s):  
Alireza Khosravi ◽  
Alireza Nakhaee ◽  
Abdoreza Ghoreishi ◽  
Zahra Arefpoor ◽  
Masoud Sadeghi
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Serum Levels ◽  
Protein Carbonyl ◽  
Stress Index ◽  
Healthy Controls ◽  
Antioxidative Status ◽  
Total Antioxidant ◽  
Migraine Group

Background: Recent evidence has suggested that oxidative stress may play a role in the pathophysiology of migraine. In this study, we aimed to evaluate the oxidative-antioxidative status in sera of migraine patients from an Iranian population during migraine attacks. Methods: This study recruited 46 migraine patients with or without aura and 45 sex- and age-matched healthy controls. The levels of protein carbonyl (PC), malondialdehyde (MDA) and total oxidants status (TOS) were measured as the indicators of oxidative stress. The levels of total thiols (T-SH), reduced glutathione (GSH) and total antioxidant capacity (TAC) were determined as markers of antioxidant status. Oxidative stress index (OSI) was calculated by dividing TOS to TAC. Results: The serum levels of MDA (4.10 +/- 0.70 vs. 3.20 +/- 0.62, P = 0.003), TOS (18.46 +/- 4.06 vs. 16.21 +/- 3.67, P = 0.007) and OSI (1.54 +/- 0.60 vs. 1.22 +/- 0.46, P = 0.006) were significantly higher in migraine group compared to controls, however, no statistically significant differences of PC levels were found between migraine patients and controls (0.615 +/- 0.161 vs. 0.517 +/- 0.126, P = 0.1). In contrast, the levels of T-SH (273 +/- 51.71 vs. 310.88 +/- 53.32, P = 0.001), GSH (28.08 +/- 6.20 vs. 32.13 +/- 5.8, P = 0.002) and TAC (1.27 +/- 0.226 vs. 1.41 +/- 0.26, P = 0.01) were significantly lower in migraine patients compared to healthy controls. Conclusion: Our study showed higher levels of oxidative stress and lower levels of antioxidant status in migraine group compared to controls, which indicates the possible role of oxidative stress in triggering migraine attacks.  

scholarly journals Assessment of Lipid Peroxidation Levels and Total Antioxidant Status in Chronic and Aggressive Periodontitis Patients: An in vivo Study

2018 ◽  
Vol 19 (3) ◽  
pp. 287-291 ◽  
Author(s):  
Ashish Verma ◽  
Vivek Tripathi ◽  
Sahib T Singh ◽  
Chetan D Singh ◽  
Jaspreet S Gill
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Study Groups ◽  
Aggressive Periodontitis ◽  
Stress Index ◽  
Control Group ◽  
Total Antioxidant

ABSTRACT Introduction Periodontitis is a common problem affecting a significant population of the world. For the assessment of oxidative stress of an individual, total oxidation status (TOS) and total antioxidant capacity (TAOC) are the significant biomarkers. Hence, we planned the present study to assess malondialdehyde (MDA), TOS, TAOC levels, and oxidative stress index (OSI) in generalized aggressive periodontitis (GP) and chronic periodontitis (CP) patients. Materials and methods The present study included assessment of 40 CP patients, 40 GP patients, and 40 healthy controls. Clinical assessment of all the subjects was done by measuring the probing depth (PD), clinical attachment (CL), gingival index (GI), gingival bleeding index (GBI), and plaque index (PI). Salivary and serum samples were taken and assessed by standard procedures as described previously in the literature. All the values were assessed and compared. Results Significant results were obtained while comparing all the periodontal parameters in between various study groups. Mean serum MDA levels in the CP, GP, and control group were found to be 0.68, 0.65, and 0.61 µM respectively. Statistically nonsignificant results were obtained while comparing the serum MDA levels in between the three study groups. Significant results were obtained while comparing the mean serum and salivary TOS values, TAOC values, and OSI in between various study groups. Conclusion In periodontitis patients, oxidative stress was significantly higher in comparison with healthy subjects. Clinical significance Oxidative parameters do play a significant role in the pathologic profile of periodontitis. How to cite this article Tripathi V, Singh ST, Sharma V, Verma A, Singh CD, Gill JS. Assessment of Lipid Peroxidation Levels and Total Antioxidant Status in Chronic and Aggressive Periodontitis Patients: An in vivo Study. J Contemp Dent Pract 2018;19(3):287-291.

scholarly journals Oxidative Stress and Antioxidant Status in Patients with Bell’s Palsy

2017 ◽  
Vol 36 (1) ◽  
pp. 18-22 ◽  
Author(s):  
Suat Terzi ◽  
Engin Dursun ◽  
Adnan Yılmaz ◽  
Zerrin Özergin Coşkun ◽  
Abdulkadir Özgür ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Bell’S Palsy ◽  
Stress Index ◽  
Control Group ◽  
Bell's Palsy ◽  
Significant Difference ◽  
Total Antioxidant ◽  
High Oxidative Stress

SummaryBackground:Bell’s palsy (BP) is the most common acute mononeuropathy of unilateral facial paralysis. Immune, infective and ischaemic mechanisms are potential contributors to the development of BP, but the precise cause remains unclear. Recently, oxidative stress has been proposed as a risk factor of various idiopathic diseases. The aim of this study was to investigate the possible role of oxidative stress in patients with BP.Methods:Thirty-two patients with BP and 30 healthy controls were included in this study. Serum total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were measured by the Erel method.Results:Serum TOS activities and OSI values were significantly higher in patients with BP compared with the control group (P<0.003 for all comparisons), whereas there was no significant difference between the groups in terms of TAS levels (P>0.05).Conclusions:The data suggest that oxidative stress is increased in BP. These results of high oxidative stress in patients with BP may be helpful to clarify the etiopathogenesis of BP and contribute to improvement in the management or prevention of the disease.

scholarly journals Immunodepressant and oxidant potential of standard leukaemia drug regimen

2020 ◽  
Vol 11 (4) ◽  
pp. 5608-5614
Author(s):  
Marwan M. Merkhan ◽  
Ibrahim M. Faisal ◽  
Dema Z. Alsaleem ◽  
Omer M. Shindala ◽  
Hani M. Almukhtar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Serum Levels ◽  
Drug Regimen ◽  
Significant Rise ◽  
Laboratory Method ◽  
Cytotoxic Drugs ◽  
Control Group ◽  
Healthy Individuals ◽  
Leukaemia Therapy ◽  
Immunoglobulin Levels

Chemotherapy improves cancer status but also could carry a risk of harmful side effects. In leukaemia patients, oxidative status and immune system are crucial parameters for patient improvement. The present study is aimed to assess the oxidative stress and the levels of immunoglobulin, including; IgG, IgA, and IgM in acute myelocytic leukaemias (AML) patients. A total of twenty-one patients with AML were enrolled in this study, alongside 24 healthy individuals as a control group. Initially, in both groups, the serum MDA, IgA, IgG, and IgM levels were measured. Then after a month of treatment with standard leukaemia therapy; the measurement of levels of these parameters were repeated for both the patients’ group and the control group for measuring immunoglobulin levels while analysis of MDA was done by the laboratory method. A highly significant rise in the serum MDA level was detected (P&lt;0.001) in patients with AML after treatment with specific cytotoxic drugs was observed in comparison with the control. Moreover, there was a significant modulation in the serum concentration of Ig after starting cytotoxic drugs in comparison with the controls. The study revealed that AML was associated with elevated oxidative stress parameters following treatment with cytotoxic drugs as reflected by the rise in the serum levels of MDA. The decreased serum Ig levels indicate a reduction in immune response in patients with AML due to cytotoxic drugs.

Serum Thiol-Disulphide Levels in Epileptic Pediatric Patients

2019 ◽  
Vol 22 (1) ◽  
pp. 65-68
Author(s):  
Halit Halil ◽  
Nilden Tuygun ◽  
Erhan Aksoy ◽  
Ozcan Erel ◽  
Can Demir Karacan
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Pediatric Patients ◽  
Serum Levels ◽  
The Body ◽  
Control Group ◽  
Study Group ◽  
Total Thiol ◽  
Stress Markers ◽  
Meaningful Relationship

Background: Epilepsy is a serious clinical condition characterized by recurrent seizures. Oxidative stress plays an important role in the etio-pathogenesis of epilepsy. Measurements of serum thiol and disulfide levels were used to evaluate the antioxidant status of the body. Objective: The aim of this study was to determine serum levels of thiol and disulfide in epileptic pediatric patients. Methods: Ninety patients, 54 epilepsy and 36 controls were included in the study. Serum levels of native thiol total thiol and disulfide were measured and disulfide/native, disulfide / total thiol and native thiol/ total thiol ratios were calculated. Hence, the ratios of disulfide/ native thiol, disulfide / total thiol and native thiol/ total thiol were calculated. Results: Serum levels of native thiol, total thiol and disulfide were significantly lower in the epilepsy group than the control group. The ratio of disulfide/native thiol and disulfide / total thiol were significantly higher in the study group than the control group. As well as, the native thiol / total thiol ratio was lower in the epilepsy group than the control group. Native thiol, total thiol and disulfide were significantly lower in the epilepsy group who were taking anti-epileptic drugs than those who were not taking anti-epileptic drugs. Conclusion: We demonstrated a meaningful relationship between oxidative stress markers and epilepsy in pediatric patients.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

The Effect of Immunosuppression on Selected Antioxidant Parameters in Patients with Graves’ Disease with Active Thyroid-Associated Orbitopathy

2020 ◽  
Author(s):  
Magdalena Londzin-Olesik ◽  
Beata Kos-Kudla ◽  
Jacek Karpe ◽  
Aleksandra Nowak ◽  
Mariusz Nowak
Keyword(s):  
Oxidative Stress ◽  
Clinical Symptoms ◽  
Immunosuppressive Treatment ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Paraoxonase 1 ◽  
Control Group ◽  
Graves Disease ◽  
Methylprednisolone Treatment ◽  
Antioxidant Parameters

Abstract Background and Study Aims Thyroid-associated orbitopathy, the most common extrathyroidal manifestation of Graves’ disease, is an autoimmune inflammation of orbital soft tissue. We report the study assessing the effect of immunosuppressive treatment with methylprednisolone on selected antioxidant parameters in patients with Graves’ disease with active thyroid-associated orbitopathy. Patients and Methods Activity and serum levels of selected antioxidant parameters as well as lipid peroxidation products were determined in a group of 56 patients with active thyroid-associated orbitopathy at three time-points: at baseline, after the discontinuation of intravenous methylprednisolone treatment and at 3 months after the discontinuation of additional oral methylprednisolone treatment. A control group consisted of 20 healthy age- and sex-matched volunteers. Results We found an increased activity of superoxide dismutase and glutathione peroxidase and increased serum levels of uric acid, malondialdehyde and conjugated dienes, as well as a reduced activity of paraoxonase-1 and reduced serum vitamin C level in the study group at baseline. Systemic intravenous and oral methylprednisolone therapy led to normalization of activity and concentration of the most studied parameters. Conclusion Results of our study confirmed that oxidative stress is one of the factors involved in the pathogenesis of thyroid-associated orbitopathy and the methyloprednisolone treatment is effective in reducing both clinical symptoms and oxidative stress in patients with this disease.

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