scholarly journals Trace Element Levels in Serum Are Potentially Valuable Diagnostic Markers in Dogs

Animals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2316
Author(s):  
Yolanda Cedeño ◽  
Marta Miranda ◽  
Inmaculada Orjales ◽  
Carlos Herrero-Latorre ◽  
Maruska Suárez ◽  
...  
Keyword(s):  
Trace Elements ◽  
Trace Element ◽  
Acute Phase ◽  
Biochemical Parameters ◽  
Indirect Measurement ◽  
Serum Copper ◽  
Serum Selenium ◽  
Acute Phase Reactants ◽  
Additional Tool

The objective of this study was to obtain information about the role of trace element imbalance in the pathogenesis of certain diseases in dogs and to evaluate the suitability of trace element profiling as an additional tool in the diagnosis. Serum trace element concentrations (copper, molybdenum, selenium and zinc) were measured in a cohort of healthy (control) dogs (n = 42) and dogs affected by hepatic (n = 25), gastrointestinal (n = 24), inflammatory/infection (n = 24), and renal (n = 22) diseases. These data were analyzed together with data on basic biochemical parameters (alanine aminotransferase, alkaline phosphatase, blood urea nitrogen, creatinine, albumin, globulin, and glucose) by using chemometric techniques. The chemometric analysis revealed distinctive association patterns between trace elements and biochemical parameters for each clinical disorders. The findings provide clear evidence for the important role of trace elements in disease, particularly in relation to acute phase reactions, with serum copper providing an indirect measurement of ceruloplasmin (positive acute-phase protein) and serum selenium and zinc acting as negative acute phase reactants. Molybdenum may also be a suitable marker of incipient renal disease. Thus, the analysis of trace element profiles, by multielement techniques, in a single serum sample would be a valuable additional tool for the diagnosis of certain diseases.

A Study of Serum Copper and Certain "Acute-Phase Reactants" in Alcoholics

1961 ◽  
Vol 22 (4) ◽  
pp. 544-549 ◽  
Author(s):  
Eugene W. Rice ◽  
Robert E. Olson ◽  
Paul D. Sweeney
Keyword(s):  
Acute Phase ◽  
Serum Copper ◽  
Acute Phase Reactants

Acute‐phase reactants and plasma trace element concentrations in non‐small cell lung cancer patients and controls

1997 ◽  
Vol 28 (3) ◽  
pp. 308-312 ◽  
Author(s):  
Naveed Sattar ◽  
Hazel R. Scott ◽  
Donald C. McMillan ◽  
Dinesh Talwar ◽  
Denis S.J. O'Reilly ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Trace Element ◽  
Cancer Patients ◽  
Acute Phase ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Acute Phase Reactants ◽  
Lung Cancer Patients

scholarly journals Serum Trace Elements Profile in Graves’ Disease Patients with or without Orbitopathy in Northeast China

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Yongping Liu ◽  
Shanshan Liu ◽  
Jinyuan Mao ◽  
Sichen Piao ◽  
Jing Qin ◽  
...  
Keyword(s):  
Trace Elements ◽  
Northeast China ◽  
Thyroid Autoimmunity ◽  
Serum Copper ◽  
High Serum ◽  
Graves Disease ◽  
Serum Selenium ◽  
Specific Antibodies ◽  
Euthyroid Status ◽  
Serum Trace Elements

Objective. The purpose of the present study was to investigate serum trace elements in Graves’ disease (GD) patients with or without orbitopathy in Northeast China. Methods. Patients with newly diagnosed Graves’ disease (HyGD) (n=66), GD patients with euthyroid status or subclinical thyroidism after treatment (EUGD) (n=55), GO patients with euthyroid status or subclinical thyroidism after treatment (GO) (n=57), and normal controls (NC) (n=66) were enrolled in this study. Serum trace elements were measured with ICP-MS. Results. Serum selenium (Se) levels in EUGD group (median: 7.53 µg/dL), HyGD group (median: 6.76 µg/dL), and GO group (median: 7.40 µg/dL) were significantly lower than those in NC group (median: 9.20 µg/dL, all P<0.01). Serum copper (Cu) levels in GO group (median: 95.93 µg/dL) were significantly lower than those in the NC group (median: 113.59 µg/dL, P=0.015). After being adjusted for multivariables, thyroid-specific antibodies grade was associated with low Se levels. Hyperthyroidism and thyroid-specific antibodies grade were associated with high Cu levels. In addition, orbitopathy was associated with low Cu levels. Conclusions. Thyroid autoimmunity was associated with low Se levels. Hyperthyroidism and thyroid autoimmunity may be associated with relatively high serum Cu levels. Alternatively, ophthalmopathy may be related to low serum Cu levels.

scholarly journals Role of Pentraxin-3 in Periodontal Inflammation - A Comprehensive Review

2021 ◽  
pp. 209-219
Author(s):  
Syed Wali Peeran ◽  
Ahmed Elhassan ◽  
Tazeen Dawood ◽  
Karthikeyan Ramalingam ◽  
Syed Ali Peeran ◽  
...  
Keyword(s):  
Acute Phase ◽  
Tissue Injury ◽  
Fluid Phase ◽  
Pentraxin 3 ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Periodontal Inflammation ◽  
Potential Biomarker ◽  
Inflammatory Site

Acute phase reactants like C-reactive protein (CRP), and pentraxin 3 (PTX3) are increased with inflammation and tissue injury. PTX3 is an acute phase protein and a member of the long pentraxin family. CRP is synthesized in the liver but PTX3 is generated locally at the inflammatory site. It is a fluid-phase pattern-recognition molecule that regulates antimicrobial immunity and inflammation by interfering with selectin-dependent neutrophil recruitment and regulating the complement cascade. Hence, PTX3 could be used as a potential biomarker to identify inflammatory response in both acute and chronic diseases. In this review, we discuss the role of PTX3 in periodontal inflammation.

scholarly journals Investigation of some trace elements and hematological and biochemical parameters in the blood of emaciated Omani goats

2021 ◽  
pp. 1960-1965
Author(s):  
Turke Shawaf ◽  
S. Al Bulushi ◽  
M. A. Al-Ali ◽  
A. M. A. Meligy ◽  
M. Salouci ◽  
...  
Keyword(s):  
Trace Elements ◽  
Health Status ◽  
Blood Cell ◽  
Trace Element ◽  
Biochemical Parameters ◽  
Trace Element Analysis ◽  
Element Analysis ◽  
Cell Counts ◽  
Hematological And Biochemical Parameters ◽  
Glutamyl Transferase

Background and Aim: The analysis of hematological and biochemical parameters is widely used in assessing animal health status. Limited information is available on trace element levels and their association with hematological and biochemical parameters in Omani goats suffering from emaciation. Therefore, the current study aimed to determine the levels of some trace elements in emaciated Omani goats and their relationship with hematological and biochemical parameters. Materials and Methods: Goats suffering from emaciation and muscular dystrophy (n=18) were compared with healthy goats (n=12). Venous blood samples for the hematological, biochemical, and trace element analysis were collected from the jugular vein. Results: Emaciated goats showed significantly lower white blood cell, lymphocyte, and red blood cell counts than the healthy goats. In contrast, the percentages of monocytes and eosinophils were higher in emaciated goats than in healthy ones. In addition, emaciated goats showed higher levels of biochemical parameters alkaline phosphatase, alanine aminotransferase, gamma-glutamyl transferase, aspartate aminotransferase, creatine kinase, and total bilirubin but lower levels of albumin than the healthy goats. The results of trace element analysis revealed lower concentrations of zinc, iron, and selenium in serum from emaciated goats than in serum from healthy goats. Conclusion: This study identified significant differences in the serum levels of some trace elements and hematological and biochemical parameters between healthy and emaciated Omani goats. The identified differences represent valuable diagnostic biomarkers for the evaluation of the health status of Omani goats.

scholarly journals Role of serum copper and lipid profile in cardiovascular diseases patients of Southern Rajasthan

2019 ◽  
Vol 7 (11) ◽  
pp. 4249
Author(s):  
Parul Dhanak ◽  
Neha Sharma ◽  
Ashish Sharma
Keyword(s):  
Trace Elements ◽  
Lipid Profile ◽  
Lipoprotein Metabolism ◽  
Significant Negative Correlation ◽  
Serum Copper ◽  
Copper Level ◽  
Serum Concentrations ◽  
Lipid Levels ◽  
Adult Men

Background: It is clear that deficiencies of some trace elements cause marked alterations in lipid and lipoprotein metabolism. The mechanisms of their effects are not completely obvious and inspite of intense research, the role of these microelements need further elucidation. Thus, the objective of this study is to evaluate the correlations of serum concentrations of trace elements including copper with lipid profile parameters of adult men in Southern Rajasthan.Methods: Present study was conducted in Cardiology and Biochemistry Department in GMCH, Udaipur during the year 2019. A total of 150 MI cases/controls were selected. Blood sample was collected by vein puncture using an aseptic technique. The blood was allowed to settle at 37ºC and then centrifuged at 3000 rpm for 15 min. Serum was then separated and stored at -20ºC until analysis.Results: The study cases had significantly higher lipid values than those of controls (p<0.001). In cases the copper levels are higher than the controls. Copper levels were more in males 95.40±18.93 than in females 86.93±14.54 (p<0.05). Lipid levels were higher in urban population related to rural, TC (238.47 V/s 266.59), TG (219.83 V/s 202.40), HDL (64.39 V/s 54.19) and LDL (131.28 V/s 139.48) (p<0.05). Significant negative correlation was seen in study group between serum copper levels and TC (r=-0.288, p<0.05), TG (r =-0.236, p<0.05), HDL (r=-0.946, p<0.05) and VLDL levels (r=0.102, p<0.05). This indicates that as copper level reduces lipids increases.Conclusions:Our findings indicate the possible effect of Cu level in serum lipid profile and this effect may be due to the role of Cu as an antioxidant. The correlations between the serum concentrations of trace elements with lipid profile in physiological concentrations may not be the same as the changes observed during deficiencies of the trace elements as in hyperlipidemic patients 

scholarly journals The role of the seagrass <i>Posidonia oceanica</i> in the cycling of trace elements

2012 ◽  
Vol 9 (3) ◽  
pp. 2623-2653 ◽  
Author(s):  
C. Sanz-Lázaro ◽  
P. Malea ◽  
E. T. Apostolaki ◽  
I. Kalantzi ◽  
A. Marín ◽  
...  
Keyword(s):  
Trace Elements ◽  
Trace Element ◽  
Posidonia Oceanica ◽  
Trophic Levels ◽  
Toxic Trace Elements ◽  
Relevant Role ◽  
Potentially Toxic Trace Elements ◽  
The Mediterranean ◽  
Element Transfer

Abstract. The aim of this work was to study the role of the seagrass Posidonia oceanica on the cycling of a wide set of trace elements (Ag, As, Ba, Bi, Cd, Co, Cr, Cs, Cu, Fe, Ga, Li, Mn, Ni, Pb, Rb, Sr, Tl, V and Zn). We measured the concentration of these trace elements in the different compartments of P. oceanica (leaves, rhizomes, roots and epibiota) in a non-polluted seagrass meadow representative of the Mediterranean and calculated the annual budget from a mass balance. We provide novel data on accumulation dynamics of many trace elements in P. oceanica compartments and demonstrate that trace element accumulation patterns are mainly determined by plant compartment rather than by temporal variability. Epibiota was the compartment which showed the greatest concentrations for most trace elements. Thus, they constitute a key compartment when estimating trace element transfer to higher trophic levels by P. oceanica. For most trace elements, translocation seemed to be low and acropetal. Zn, Cd, Sr and Rb were the trace elements that showed the highest release rate through decomposition of plant detritus, while Cs, Tl and Bi the lowest. P. oceanica acts as a sink of potentially toxic trace elements (Ni, Cr, As and Ag), which can be sequestered, decreasing their bioavailability. P. oceanica may have a relevant role in the cycling of trace elements in the Mediterranean.

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