scholarly journals Glycemic Control during Pregnancy—A Predictor of Vitamin C Status at Labor in Type 1 Diabetic Women?

Antioxidants ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 153
Author(s):  
Bente Juhl ◽  
Finn F. Lauszus ◽  
Jens Lykkesfeldt
Keyword(s):  
Glycemic Control ◽  
Vitamin C ◽  
Experimental Studies ◽  
Late Pregnancy ◽  
First Trimester ◽  
Cross Sectional Study ◽  
Third Trimester ◽  
Cross Sectional ◽  
Increased Risk

Several experimental studies have suggested that vitamin C (vitC) deficiency during pregnancy may be detrimental to fetal development, and observational studies have shown that vitC status is lower during pregnancy and in people with diabetes. A cross-sectional study in pregnant type 1 diabetic women found that poor maternal vitC status was a significant predictor for obstetric complications of pregnancy when measured within four weeks before labor. The plasma vitC concentration was significantly negatively correlated to HbA1c, the biomarker of glycemic control well-known to be associated with the outcome of the diabetic pregnancy. Here, we evaluated HbA1c during pregnancy in relation to the measured vitC levels in late pregnancy based on data from 46 women from the same cohort. Regression analysis showed that HbA1c of first trimester, the combined mean HbA1c of first and second trimester, mean HbA1c of the whole pregnancy (first, second and third trimester combined), and HbA1c of third trimester alone were all associated with vitC in late pregnancy (p = 0.03, n = 45; p = 0.034, n = 43; p = 0.017, n = 42; and p = 0.008, n = 46, respectively). In third trimester, when adjusted for creatinine clearance, the association between vitC and HbA1c persisted (p = 0.029). Women in third trimester with HbA1c above 7.0% had an increased risk of having poor vitC status compared to women with HbA1c below this level (11 out of 21 vs. 2 out of 25 women, p < 0.001). The results suggest that high HbA1c is associated with poor maternal vitC status and potentially inadequate supply of vitC for the neonate. HbA1c may thus be a relevant substitute biomarker for identifying pregnant women who might benefit from vitC supplementation.

scholarly journals Glycemic control associated factors in type 1 diabetes mellitus patients: a cross sectional study

2015 ◽  
Vol 7 (S1) ◽  
Author(s):  
Patrícia Ramos Guzatti ◽  
Amely PS Balthazar ◽  
Maria Heloisa Busi da Silva Canalli ◽  
Thais Fagnani Machado
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Association of glycemic variability and hypoglycemia with distal symmetrical polyneuropathy in adults with type 1 diabetes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ziyang Shen ◽  
Hemin Jiang ◽  
Rong Huang ◽  
Yunting Zhou ◽  
Qian Li ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Variability ◽  
Mean Amplitude ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
C Peptide ◽  
Nocturnal Hypoglycemia ◽  
Increased Risk ◽  
Distal Symmetrical Polyneuropathy

AbstractPrevious studies exploring the influence of glycemic variability (GV) on the pathogenesis of distal symmetrical polyneuropathy (DSPN) in type 1 diabetes (T1DM) produced conflicting results. The aim of this study was to assess the relationship between GV and DSPN in T1DM. Adults with T1DM were included in this cross-sectional study and asked to undergo 3-day CGM. GV quantified by coefficient of variation (CV) and mean amplitude of glucose excursions (MAGE) were obtained from CGM. Clinical characteristics and biochemical assessments were collected for analysis. The study comprised 152 T1DM patients (53.9% males) with mean age of 44.2 year. Higher levels of age and duration of diabetes and lower levels of total cholesterol, LDL, fasting C-peptide and postprandial C-peptide were observed in DSPN subjects. DSPN groups displayed a higher blood glucose between 00:00 and 12:59 according to the CGM profile. Higher MAGE and CV were associated with increased risk of DSPN in the fully adjusted model. Meanwhile, a significant association between measurements of hypoglycemia, especially nocturnal hypoglycemia, and DSPN was found after multiple tests. CGM parameters describing the glycemic variability and hypoglycemia were potential risk factors for DSPN in adults with T1DM.

scholarly journals Maternal haemoglobin and neo-natal haemoglobin status: a hospital based study in Ranchi, Jharkhand, India

2018 ◽  
Vol 5 (3) ◽  
pp. 774
Author(s):  
Priyanka Chaturvedi ◽  
Deepak Chaturvedi ◽  
Prita Naz Dubraj ◽  
A. K. Chaudhary
Keyword(s):  
First Trimester ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Pregnant Mother ◽  
Third Trimester ◽  
Cross Sectional ◽  
Cord Clamping ◽  
Iron Requirement ◽  
The Difference

Background: Haemoglobin of foetus increases with advancing gestational age. During pregnancy, fetal demand for iron increases maternal daily iron requirement from first trimester to third trimester. Late cord clamping may result in delivery of extra blood as well as iron to newborn. The cause of worry here is that maternal anaemia is a significant cause of direct and indirect morbidity and mortality both for pregnant mother and her foetus/neonate.Methods: To determine maternal and neonatal haemoglobin status we conducted a cross sectional study comprising 217 pregnant women and their children in Ranchi, Jharkhand, India.Results: Mean neonatal haemoglobin in controls was 18.13±1.14 g/dl whereas that in cases was 17.21±1.38 g/dl and the difference was statistically significant. Among the 97 cases 23 mothers had babies with neonatal haemoglobin below 14g/dl. In controls only 17 out of 120 mothers had babies with neonatal haemoglobin below 14g/dl (p value<0.01).Conclusions: Present study demonstrated that the neonatal haemoglobin is lower in anemic mothers and that the decrease appears to be proportional to the degree of anemia.

scholarly journals Plasma Xanthine Oxidoreductase Activity Associated with Glycemic Control in Patients with Pre-Dialysis Chronic Kidney Disease

2021 ◽  
pp. 1-9
Author(s):  
Shinya Nakatani ◽  
Eiji Ishimura ◽  
Takayo Murase ◽  
Takashi Nakamura ◽  
Ayumi Nakatani ◽  
...  
Keyword(s):  
Uric Acid ◽  
Glycemic Control ◽  
Multiple Regression ◽  
Plasma Glucose ◽  
Hemoglobin A1c ◽  
Cross Sectional Study ◽  
Xanthine Oxidoreductase ◽  
Oxidoreductase Activity ◽  
Cross Sectional ◽  
Increased Risk

<b><i>Introduction:</i></b> Xanthine oxidoreductase (XOR) activity plays an important role as a pivotal source of reactive oxygen species, which is associated with cardiovascular disease (CVD) events. Patients with CKD have increased risk of CVD events. In the present study, factors associated with plasma XOR activity in pre-dialysis CKD patients were investigated. <b><i>Methods:</i></b> In this cross-sectional study, plasma XOR activity in 118 pre-dialysis CKD patients (age 68 [57–75] years; 64 males, 26 with diabetes mellitus [DM]) was determined using a newly established highly sensitive assay based on (<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N<sub>2</sub>) xanthine and liquid chromatography/triple quadrupole mass spectrometry. <b><i>Results:</i></b> Plasma glucose, hemoglobin A1c, and estimated glomerular filtration (eGFR) were significantly and positively correlated with plasma logarithmically transformed XOR (ln-XOR) activity. In multiple regression analyses, eGFR and hemoglobin A1c or plasma glucose were significantly, independently, and positively associated with plasma ln-XOR activity after adjusting for several confounders. Plasma XOR activity was significantly higher in CKD patients with (<i>n</i> = 26) than in those without (<i>n</i> = 92) DM (62.7 [32.3–122] vs. 25.7 [13.4–45.8] pmol/h/mL, <i>p</i> &#x3c; 0.001). A total of 38 patients were taking uric acid-lowering drugs. Multiple regression analysis of CKD patients not administered uric acid-lowering drugs (<i>n</i> = 80) showed no significant association between eGFR and plasma ln-XOR activity. In contrast, association between glycemic control and plasma ln-XOR activity was significant even in CKD patients without uric acid-lowering drug treatment. <b><i>Conclusions:</i></b> These results indicate the importance of glycemic control in CKD patients in regard to decreased XOR, possibly leading to a decrease in CVD events.

scholarly journals Identifying the Risk Factors and the Prevalence of Poor Glycemic Control among Diabetic Outpatients in a Rural Region in Saudi Arabia

2021 ◽  
pp. 15-23
Author(s):  
Ziyad S. Almalki ◽  
Nehad Jaser Ahmed ◽  
Abdullah K. Alahmari ◽  
Ahmed M. Alshehri ◽  
Sheikah Abdullah Alyahya ◽  
...  
Keyword(s):  
Risk Factors ◽  
Saudi Arabia ◽  
Glycemic Control ◽  
Cross Sectional Study ◽  
Poor Glycemic Control ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Rural Region ◽  
Increased Risk ◽  
Hba1c Levels

Aim: This cross-sectional study aimed to assess the prevalence of poor glycemic control and risk factors associated with it among diabetic patients in the central rural region of Saudi Arabia. Methods: The study included a review of diabetic patients’ medical record in King Khaled Hospital in Al-Kharj from the beginning of January 2019 to the end of June 2019. Poor glycemic control was defined as the current use of diabetic-lowering medication associated with HbA1c levels ≥7%. Multivariate analysis was done to identify the associated factors of poor glycemic control. Results: Of 1,010 consecutive outpatients’ diabetic patients were involved in the study sample, poor glycemic control presented in 496 (49.1%). Individuals who were at risk to have poor glycemic control those between 45 and 65 years with odds ratio (OR) of 1.927 (95% CI: 1.143–3.248), obese 1.496 (95% CI: 1.085–2.063) and diagnosed with asthma 2.062 (95% CI: 1.637–3.504). Conclusion: The extent of poor glycemic control in the study sample was found high. Age, obesity, and having asthma are the most important factors of increased risk of poor glycemic control. Improving glycemic control would need rigorous efforts by addressing these factors.

scholarly journals Experiencing earthquake in the first trimester of the fetal life increases subsequent diabetes risk in the adulthood: a cross-sectional study

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Na Li ◽  
Mei Song ◽  
Lan Wang ◽  
Xiao-chuan Zhao ◽  
Ran Wang ◽  
...  
Keyword(s):  
First Trimester ◽  
Cross Sectional Study ◽  
Diabetes Risk ◽  
Exposed Group ◽  
Term Effect ◽  
Fetal Life ◽  
Exposure Group ◽  
Tangshan Earthquake ◽  
Cross Sectional ◽  
Increased Risk

Abstract Objective To investigate the long-term effect of prenatal exposure to earthquake stress on diabetes risk in the adulthood. Methods This study included employees of Tangshan Kailuan Mining Group between July 29, 1976 and April 28, 1977. The exposure group included subjects who experienced the Tangshan Earthquake during their prenatal period and who had lived in Tangshan since birth. The non-exposure group included subjects who were born 1–1.9 years after the earthquake and who had lived in Tangshan since birth. A questionnaire was designed that included sociodemographic information, conditions during pregnancy, and earthquake experience. Anthropometric measurements including height and weight, body mass index (BMI), waist circumference were made. Fasting plasma glucose (FPG) and lipid profiles were also determined. Results Totally 947 subjects were included with 397 subjects in the exposed group and 550 subjects in the non-exposed group. The diabetes rate is significant different in these four groups(χ2 =8.045, P = 0.045). Moreover, 11.8, 7.5 and 8.0% of the subjects who were exposed to earthquake in the 1st, 2nd, and 3rd trimester of pregnancy had diabetes. 5.1% of the subjects had diabetes in non-exposure group. Our multivariate analysis showed that 1st trimester (OR 2.481, 95%CI 1.02, 6.034; P = 0.045) and loss of family members during earthquake (OR 2.452, 95%CI 1.293, 4.653; P = 0.006) were associated with significantly increased risk of diabetes. Conclusions Exposure to earthquake during the first trimester of pregnancy and experience of family member loss in the earthquake significantly increased the subsequent risk of diabetes in the middle age (36–39 years of age). Our data suggest that earthquake experience in the early pregnancy has a longer-term effect on diabetes risk during adulthood.

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