scholarly journals Crosslinking Collagen Constructs: Achieving Cellular Selectivity Through Modifications of Physical and Chemical Properties

2020 ◽  
Vol 10 (19) ◽  
pp. 6911
Author(s):  
Malavika Nair ◽  
Serena M. Best ◽  
Ruth E. Cameron

Collagen-based constructs have emerged in recent years as ideal candidates for tissue engineering implants. For many biomedical applications, collagen is crosslinked in order to improve the strength, stiffness and stability of the construct. However, the crosslinking process may also result in unintended changes to cell viability, adhesion or proliferation on the treated structures. This review provides a brief overview of some of both the most commonly used and novel crosslinkers used with collagen, and suggests a framework by which crosslinking methods can be compared and selected for a given tissue engineering application.

Author(s):  
Guili Ge ◽  
Lin Li ◽  
Dan Wang ◽  
Mingjian Chen ◽  
Zhaoyang Zeng ◽  
...  

Carbon dots (CDs) are a new type of carbon nanomaterial that have unique physical and chemical properties, good biocompatibility, low toxicity, easy surface functionalization, making them widely used in biological...


2021 ◽  
Vol 2 (10) ◽  
pp. 977-984
Author(s):  
Divya Chauhan ◽  
Mohammad Ashfaq ◽  
Neetu Talreja ◽  
Ramalinga Viswanathan Managalraja

Recently 2D materials are booming in the field of energy, environment, and biomedical application. Incorporation of metal/non-metal within 2D materials significantly influences the physical and chemical properties, making them intriguing materials for various applications. The advancement of 2D material requires strategic modification by manipulating the electronic structure, which remains a challenge. Herein, we describe 2D materials for the environment, energy, and biomedical application. A predominant aim of this short communication is to summarize the literature on the advanced environment, energy, and biomedical application (especially COVID-19).


2014 ◽  
Vol 25 (9) ◽  
pp. 2153-2162 ◽  
Author(s):  
Luciane Madureira Almeida ◽  
Juliana Ferreira Floriano ◽  
Thuanne Pires Ribeiro ◽  
Lais Nogueira Magno ◽  
Lígia Souza Lima Silveira da Mota ◽  
...  

2020 ◽  
Vol 28 ◽  
Author(s):  
Shan Liu ◽  
Xing-Xiang Ji ◽  
Jie-Fang Zhu

Background: Natural biopolymers have drawn extensive attention because of their great biocompatibility, biodegradability, renewability, and the availability of various reactive functional groups for modifying and introducing novel components. In the last few years, numerous natural biopolymer composites have been exploited to improve their physical and chemical properties and add new functionalities. Methods: Herein, we summarize the current progress of three common classes of natural biopolymer-based composites including alginate, chitosan, and gelatin. Results: The morphology characteristics, preparation methods, and unique functionalities of these biopolymer composites are also analyzed and discussed. Results: The morphology characteristics, preparation methods, and unique functionalities of these biopolymer composites are also analyzed and discussed. Conclusion: Finally, the article offers an overview of recent progress of the main biomedical applications such as tissue engineering, wound-healing, and drug delivery, which inspires further progress of biopolymer composites with tailored mechanical property and stable characteristics for pharmaceutical and biomedical applications.


The Analyst ◽  
2016 ◽  
Vol 141 (11) ◽  
pp. 3126-3140 ◽  
Author(s):  
Xiao-Rong Song ◽  
Nirmal Goswami ◽  
Huang-Hao Yang ◽  
Jianping Xie

Metal nanoclusters (NCs) are emerging as a new class of functional nanomaterials in the area of biological sensing, labelling, imaging and therapy due to their unique physical and chemical properties, such as ultrasmall size, HOMO–LUMO transition, strong luminescence together with good photostability and biocompatibility.


2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Feng Feng ◽  
Peixia Wang ◽  
Yihe Zhang ◽  
Qi An ◽  
Yue Lin ◽  
...  

Natural nanominerals (NNMs) are progressively deposited during earth’s formation. They have shown a broad range of applications from industrial catalysis, environmental treatment, and earth science to pharmaceutics due to their unique nanostructures and characteristics. Here, we first report that NNMs have intrinsic enzyme-like properties and show good biocompatibility. First, we characterized the morphology and structure of the six most representative NNMs including sepiolite, attapulgite, halloysite, montmorillonite, kaolinite, and diatomite by SEM, TEM, and XRD. Then, we quantitatively tested their peroxidase- (POD-), catalase- (CAT-), oxidase- (OXD-), and superoxide dismutase- (SOD-) like activities. The results indicate that different kinds of NNMs show varying degrees of POD-like, CAT-like, and SOD-like activities and minor OXD-like activity. Finally, we tested their cytotoxicity and found that the selected representative NNMs have no or less influence on cell viability, showing high biosafety. At present, NNMs have been widely used, mostly focusing on the physical and chemical properties, such as luminescence and conductivity. Our work promotes the understanding of NNMs, providing a new direction for the better application of NNMs.


Nano LIFE ◽  
2016 ◽  
Vol 06 (03n04) ◽  
pp. 1642011 ◽  
Author(s):  
Emily G. Westbrook

Tissue engineering is intended to manipulate living cells to help develop substitutes for native tissues or remodel tissue. Bioartificial tissues are commonly explored in various tissue engineering ventures to overcome the disadvantages of working with native tissue. Poly(propylene fumarate) is a potential biomaterial for bioartificial bone grafts. The polymer’s many desirable physical and chemical properties have drawn significant research interest. This miniature review is intended to cover a small portion of the investigations of poly(propylene fumarate) as a bone tissue engineering biomaterial.


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