scholarly journals Localization of ZIP14 and ZIP8 in HIBCPP Cells

2020 ◽  
Vol 10 (8) ◽  
pp. 534
Author(s):  
Shannon E. Morgan ◽  
Horst Schroten ◽  
Hiroshi Ishikawa ◽  
Ningning Zhao
Keyword(s):  
Cerebrospinal Fluid ◽  
Epithelial Cells ◽  
Cell Line ◽  
Cell Monolayer ◽  
Choroid Plexus Papilloma ◽  
Single Layer ◽  
Human Choroid Plexus ◽  
First Time ◽  
The Brain ◽  
Plexus Papilloma

The blood–cerebrospinal fluid barrier (BCB) is important in maintaining brain manganese (Mn) homeostasis. This barrier consists of a single layer of epithelial cells, connected by tight junctions, that restrict the passage of nutrients to only allow molecules to be carried through the membrane by a transporter. These epithelial cells are polarized with asymmetrical blood-facing and cerebrospinal fluid-facing sides. Here, we have established a polarized model of a human choroid plexus papilloma cell line, HIBCPP. For the first time, Mn importers ZIP14 and ZIP8 were identified in HIBCPP cells and were found to be enriched at the basolateral and apical sides of the cell monolayer, respectively. The localization of each ZIP protein adds to the understanding of Mn transport across the HIBCPP BCB model to help understand the mechanism of Mn homeostasis within the brain.

Chemotaxis of T-cells after infection of human choroid plexus papilloma cells with Echovirus 30 in an in vitro model of the blood–cerebrospinal fluid barrier

2012 ◽  
Vol 170 (1-2) ◽  
pp. 66-74 ◽  
Author(s):  
Henriette Schneider ◽  
Claudia Ellen Weber ◽  
Julia Schoeller ◽  
Ulrike Steinmann ◽  
Julia Borkowski ◽  
...  
Keyword(s):  
T Cells ◽  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
In Vitro Model ◽  
Choroid Plexus Papilloma ◽  
Echovirus 30 ◽  
Human Choroid Plexus ◽  
Vitro Model ◽  
Plexus Papilloma

scholarly journals Choroid plexus papillomas are induced by c-Myc overexpression in the choroid plexus via a T-cell inflammatory mechanism

2019 ◽  
Vol 21 (Supplement_4) ◽  
pp. iv9-iv10
Author(s):  
Ashirwad Merve ◽  
Xinyu Zhang ◽  
Nicola Pomella ◽  
Serena Acquati ◽  
Joerg Hoeck ◽  
...  
Keyword(s):  
T Cell ◽  
Mouse Model ◽  
Choroid Plexus ◽  
Tumour Size ◽  
Choroid Plexus Papilloma ◽  
Experimental Models ◽  
Chemotherapeutic Agents ◽  
Human Choroid Plexus ◽  
Choroid Plexus Papillomas ◽  
Plexus Papilloma

Abstract Choroid plexus tumours (CPT) account for up to 20% of brain tumours in children under 2 years of age. Histologically CPTs are classified into three categories - Choroid Plexus Papilloma (CPP), Atypical Choroid Plexus Papilloma (ACPP) and Choroid Plexus Carcinoma (CPC). Recent literature demonstrates that CPP and ACPP are molecularly distinct from CPC. Initial management for CPT include surgery followed by adjuvant therapy in selected patients. Currently there are no disease-specific chemotherapeutic agents available, possibly because of their rarity and paucity of faithful pre-clinical experimental models. In this study we show that c-Myc overexpression in the choroid plexus epithelium induces T-cell inflammation-dependent choroid plexus papillomas in a mouse model. We demonstrate that c-MYC is expressed in a substantial proportion of human choroid plexus tumours and that this subgroup of tumours is characterised by an inflammatory transcriptome and significant inflammatory infiltrates. We observed that triple transgenic compound mutant mouse model with c-Myc overexpression in an immune-suppressed background led to a decreased incidence of CPP and reduced tumour bulk. A reduced tumour size was also observed when c-Myc overexpressing mice were treated with anti-CD3 antibodies. Our data raise the possibility that benign choroid plexus tumours expressing c-MYC could be amenable to medical therapy with anti-inflammatory drugs.

Choroidal epithelial cyst

1977 ◽  
Vol 47 (6) ◽  
pp. 955-960 ◽  
Author(s):  
Atsuo Koto ◽  
Dikran S. Horoupian ◽  
Kenneth Shulman
Keyword(s):  
Cerebrospinal Fluid ◽  
Electron Microscope ◽  
Epithelial Cells ◽  
Basement Membrane ◽  
Single Layer ◽  
Epithelial Cyst ◽  
Content Type ◽  
Choroidal Epithelium ◽  
Surgical Extirpation ◽  
Fine Print

✓ A supratentorial cyst in the leptomeninges of an 8-month-old infant was studied with the electron microscope. The lining of the cyst consisted of a single layer of pegshaped epithelial cells rich in organelles and glycogen. Their free border had numerous microvilli but no cilia, and their basal portions rested on a basement membrane. Tight junctions and interdigitations were frequent between contiguous cells. The blood vessels were fenestrated. Since these features characterize developing choroidal epithelial cells, we felt the diagnosis of choroidal epithelial cyst was justified. Cysts lined by choroidal epithelium may continue to secrete cerebrospinal fluid after surgical extirpation when this is incomplete. Accumulation of the fluid in the partially excised cyst bed may therefore account for recurrence of symptoms.

scholarly journals Cerebrospinal fluid cytology of choroid plexus tumor: A report of two cases

CytoJournal ◽  
2019 ◽  
Vol 16 ◽  
pp. 9
Author(s):  
Manjari Kishore ◽  
Prajwala Gupta ◽  
Minakshi Bhardwaj
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Choroid Plexus Papilloma ◽  
Female Child ◽  
Pediatric Brain Tumors ◽  
Choroid Plexus Tumor ◽  
The Central Nervous System ◽  
Pediatric Brain ◽  
Plexus Papilloma ◽  
Fluid Cytology

Choroid plexus tumors (CPTs) are relatively uncommon tumors of the central nervous system, constituting approximately 5% of all pediatric brain tumors. Although squash cytology of CPT has been described in literature, shedding of tumor cells into cerebrospinal fluid (CSF) has rarely been described. We report two such cases of atypical choroid plexus papilloma in a 5-month-old male child and a 12-year-old female child, where characteristic cytomorphology of CPT was noted in the CSF.

Diagnosis of CHOROID PLEXUS PAPILLOMA (CPP) in a child by findings with flow cytometry in cerebrospinal fluid (CSF) analysis

2019 ◽  
Vol 493 ◽  
pp. S249
Author(s):  
S. Domenech Manteca ◽  
D. Armas Méndez ◽  
I. Martinez Roda ◽  
B. Fernández Da Vila ◽  
R. Perez Garay ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Choroid Plexus Papilloma ◽  
Csf Analysis ◽  
Plexus Papilloma

scholarly journals Choroid plexus papilloma and Aicardi syndrome: case report

2002 ◽  
Vol 60 (4) ◽  
pp. 1008-1010 ◽  
Author(s):  
Geraldo Pianetti Filho ◽  
Luiz Fernando Fonseca ◽  
Márcia Cristina da Silva
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Choroid Plexus ◽  
Choroid Plexus Papilloma ◽  
Imaging Studies ◽  
Baby Girl ◽  
The Third ◽  
Aicardi Syndrome ◽  
The Brain ◽  
Plexus Papilloma

A case of Aicardi syndrome associated with a choroid plexus papilloma of the third and both lateral ventricles in a 15 months old baby girl is repported. The tumor was completely removed via three craniotomies. Reports of the literature with the association of choroid plexus papilloma and Aicardi syndrome are rare. We suggest that children diagnosed with Aicardi syndrome should routinely undergo imaging studies of the brain, such as computed tomography or magnetic resonance.

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