scholarly journals Polyester Polymeric Nanoparticles as Platforms in the Development of Novel Nanomedicines for Cancer Treatment

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3387
Author(s):  
Enrique Niza ◽  
Alberto Ocaña ◽  
José Antonio Castro-Osma ◽  
Iván Bravo ◽  
Carlos Alonso-Moreno
Keyword(s):  
Cancer Treatment ◽  
Large Scale ◽  
Raw Materials ◽  
Polymeric Nanoparticles ◽  
Scale Production ◽  
Polymeric Nanoparticle ◽  
Clinical Investigations ◽  
Large Scale Production ◽  
Materials Used ◽  
The Many

Many therapeutic agents have failed in their clinical development, due to the toxic effects associated with non-transformed tissues. In this context, nanotechnology has been exploited to overcome such limitations, and also improve navigation across biological barriers. Amongst the many materials used in nanomedicine, with promising properties as therapeutic carriers, the following one stands out: biodegradable and biocompatible polymers. Polymeric nanoparticles are ideal candidates for drug delivery, given the versatility of raw materials and their feasibility in large-scale production. Furthermore, polymeric nanoparticles show great potential for easy surface modifications to optimize pharmacokinetics, including the half-life in circulation and targeted tissue delivery. Herein, we provide an overview of the current applications of polymeric nanoparticles as platforms in the development of novel nanomedicines for cancer treatment. In particular, we will focus on the raw materials that are widely used for polymeric nanoparticle generation, current methods for formulation, mechanism of action, and clinical investigations.

An Improved And Suitable Method For Large Scale Produdcion Of Α-Monochlorocyclodecanone

2021 ◽  
Vol 18 ◽  
Author(s):  
Wenhua Ou ◽  
Ruolin Wang ◽  
Ruonan Liu ◽  
Hong Huang
Keyword(s):  
Silica Gel ◽  
Large Scale ◽  
Raw Materials ◽  
Separation Method ◽  
Suitable Method ◽  
Scale Production ◽  
Reaction Conditions ◽  
Environment Friendly ◽  
Large Scale Production ◽  
Ideal Approach

: α-Monochlorocyclododecanone was synthesized from cyclododecane and 1,3-Dichloro-5,5-dimethylhydantoin (DCDMH) catalyzed with silica gel in MeOH. The product was obtained by crystallization with nearly 85% yield. The presented method used cheap raw materials, mild reaction conditions, simple separation method and environment-friendly process. Additionally, the current synthesis provided an ideal approach for large-scale production.

Strength and Impotence. The Developing Countries and the Development in New Territories

1974 ◽  
Vol 9 (2-3) ◽  
pp. 167-177
Author(s):  
Willy Østreng
Keyword(s):  
Large Scale ◽  
Raw Materials ◽  
Developed Countries ◽  
Economic Effects ◽  
Scale Production ◽  
Underdeveloped Countries ◽  
The North ◽  
Large Scale Production ◽  
The Developed Countries ◽  
The Third World

This article examines the possible political and economic effects of large-scale mineral extraction from the seabed. The findings presented indicate that development in new territories may conceivably serve to exacerbate existing conflict dimensions, notably the North/South dimension in global politics. Because of the developed countries' monopoly on know-how and economic capability, exploration and exploitation of the inorganic resources of the ocean floor has de facto been the exclusive domain of these countries. On the basis of this the author shows that if large-scale production of seabed resources should become a reality in the near future, the underdeveloped countries will be forced to watch it from the sidelines. As a consequence, the exploitation of offshore raw materials will probably contribute to the further widening of the gap between developed and underdeveloped countries. Further commenting on the fact that the latter today are the main producers of the most promising seabed resources, the author expresses the view that exploitation will have a detrimental effect on the economics of the Third World countries, since it might lead to overproduction and price reductions.

The Origin of Puuc Slate Ware: New Data from Sayil, Yucatan, Mexico

1995 ◽  
Vol 6 ◽  
pp. 119-134 ◽  
Author(s):  
Michael P. Smyth ◽  
Christopher D. Dore ◽  
Hector Neff ◽  
Michael D. Glascock
Keyword(s):  
Large Scale ◽  
Raw Materials ◽  
Compositional Analysis ◽  
Classic Period ◽  
Scale Production ◽  
Local Production ◽  
Comprehensive Investigation ◽  
Terminal Classic ◽  
Large Scale Production ◽  
Major Producer

AbstractThis paper reports results of the first neutron-activation analysis (NAA) of ancient pottery wares and clays from the Puuc region of Yucatan. Based on ceramics from Sayil, this investigation seeks to expand exploration into the nature of commercialization during the Terminal Classic period (A.D. 800–1000). This research sought to: (a) establish the chemical composition of major Puuc wares, (b) begin to define potential raw materials and production loci at Sayil, and (c) explore the question of whether Sayil was a major producer and exporter of ceramic wares. Compositional analysis reveals that three of the four major Puuc wares (Puuc Slate, Puuc Unslipped, and Puuc Red) exhibit some degree of chemical distinctiveness, suggesting discrete production units. Compositional analysis of clays from Sayil and Loltun Cave indicates that Puuc Slate and Puuc Red Ware are compatible with clays locally available at Sayil, supporting local production of these wares, whereas Puuc Unslipped Ware initially appears to be closer compositionally to clays from Loltun. In addition, Puuc Slate is an important ware found throughout northern Yucatan that shows evidence of large-scale production at Sayil. This analysis represents the first steps of a comprehensive investigation into the Maya economy of Terminal Classic Yucatan.

scholarly journals Biosurfactants – Nature's Solution for Today's Cleaning Challenges

2021 ◽  
Vol 75 (9) ◽  
pp. 752-756
Author(s):  
Jakob J. Mueller ◽  
Hans H. Wenk
Keyword(s):  
Large Scale ◽  
Raw Materials ◽  
Biological Molecules ◽  
Raw Material ◽  
Scale Production ◽  
Sustainable Solutions ◽  
Natural Substances ◽  
Head Groups ◽  
Large Scale Production ◽  
Recent Developments

Biosurfactants are surface-active molecules, developed by nature through evolution and naturally produced by different microorganisms. The most prominent examples are rhamnolipids and sophorolipids, molecules which contain hydrophilic sugar head groups and hydrophobic alkyl residues leading to an amphiphilic behavior with unique properties. Recent developments in the field of biotechnology enable the large-scale production of these biological molecules. The raw material basis is 100% renewable since sugars and oils are used as major raw materials. Additionally, biosurfactants are fully biodegradable, which allows the path back into the natural cycles. In comparison to established standard surfactants like SLES/SLS (sodium laureth (ether) sulfates) or betaines, rhamnolipids are much milder and, at the same time, show similar or even better performance in household or personal care applications. Foam behavior, solubilization and cleaning effectiveness are examples where these natural substances give excellent results compared to the synthetic benchmarks. The commercialization of biosurfactants at industrial scale now offers alternatives to consumers seeking sustainable solutions, without compromising performance. Biosurfactants combine both and set a new standard for surfactant applications.

scholarly journals Challenges in Enzymatic Route of Mannitol Production

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Sheelendra Mangal Bhatt ◽  
Anand Mohan ◽  
Suresh Kumar Srivastava
Keyword(s):  
Large Scale ◽  
Raw Materials ◽  
Product Formation ◽  
Product Inhibition ◽  
Scale Production ◽  
Food Sector ◽  
Large Scale Production ◽  
Mannitol Production ◽  
Enzymatic Route ◽  
Industrial Level

Mannitol is an important biochemical often used as medicine and in food sector, yet its biotechnological is not preffered in Industry for large scale production, which may be due to the multistep mechanism involved in hydrogenation and reduction. This paper is a comparative preview covering present chemical and biotechnological approaches existing today for mannitol production at industrial scale. Biotechnological routes are suitable for adaptation at industrial level for mannitol production, and whatever concerns are there had been discussed in detail, namely, raw materials, broad range of enzymes with high activity at elevated temperature suitable for use in reactor, cofactor limitation, reduced by-product formation, end product inhibition, and reduced utilization of mannitol for enhancing the yield with maximum volumetric productivity.

scholarly journals APPLICATION OF WASTE BANANA PEELS AS BIODEGRADABLE PLASTIC

2019 ◽  
Vol 1 (2) ◽  
pp. 128-130
Author(s):  
NUR ATHIRAH HUZAISHAM
Keyword(s):  
Large Scale ◽  
Value Added ◽  
Biodegradable Plastic ◽  
Organic Polymer ◽  
Banana Peel ◽  
Scale Production ◽  
Plastic Pollution ◽  
Synthetic Materials ◽  
Large Scale Production ◽  
Materials Used

The world today seems unimaginable without plastics or synthetic organic polymer, however their large-scale production and use only dates back to 1950 (1). The resulting rapid growth in plastics production is remarkable, surpassing most other man-made materials. The study presents the utilization of banana peel as biodegradable plastic to substitute the existing non-biodegradable plastic. The objectives of this research are to aims to develop and produce biodegradable plastic that will substitute the existing non-biodegradable plastic to help in saving the environment as well as to compare the properties of biodegradable plastic based on banana peel with the commercial biodegradable plastic. The use of waste banana peel in this study is mainly to replace the synthetic materials used in the conventional biodegradable plastic. Furthermore, the environmental pollutions can be reduced due to the usage of waste banana peels to produce a new value-added biodegradable plastic.   Keywords : Banana peel, biodegradable plastic, pollution, environment

Enzymes: A Very Short Introduction

2020 ◽  
Author(s):  
Paul Engel
Keyword(s):  
Food Production ◽  
Large Scale ◽  
Waste Treatment ◽  
Living Organism ◽  
Scale Production ◽  
Short Introduction ◽  
Large Scale Production ◽  
Working Together ◽  
Speed Up ◽  
The Many

Enzymes: A Very Short Introduction explores enzymes, the tiny molecular machines that make life possible. These proteins speed up chemical reactions inside a living organism many millionfold. Working together, teams of enzymes carry out all the processes that can be collectively recognized as life, from making DNA to digesting food. This VSI explains how this works, before going on to reveal how these catalysts of such extraordinary power and exquisite selectivity have evolved. It also examines the many varied ways in which individual enzymes are used nowadays as tools—in medical diagnosis and therapy, washing powders, food production, waste treatment, and chemical synthesis. New vistas have opened up through application of molecular genetics, not only allowing cheap, large-scale production of pure enzymes but also making possible new, tailor-made enzymes.

scholarly journals Efficient Mercury Removal at Ultralow Metal Concentrations by Cysteine Functionalized Carbon-Coated Magnetite

2020 ◽  
Vol 10 (22) ◽  
pp. 8262
Author(s):  
Assadawoot Srikhaow ◽  
Teera Butburee ◽  
Weeraphat Pon-On ◽  
Toemsak Srikhirin ◽  
Kanchana Uraisin ◽  
...  
Keyword(s):  
Large Scale ◽  
Raw Materials ◽  
Aqueous Media ◽  
Contaminated Water ◽  
Scale Production ◽  
Efficient Removal ◽  
Metal Concentrations ◽  
Practical Applications ◽  
Large Scale Production ◽  
Carbon Coated

This work reports the preparation and utility of cysteine-functionalized carbon-coated Fe3O4 materials (Cys-C@Fe3O4) as efficient sorbents for remediation of Hg(II)-contaminated water. Efficient removal (90%) of Hg(II) from 1000 ppb aqueous solutions is possible, at very low Cys-C@Fe3O4 sorbent loadings (0.01 g sorbent per liter of Hg(II) solution). At low metal concentrations (5–100 ppb Hg(II)), where adsorption is typically slow, Hg(II) removal efficiencies of 94–99.4% were achievable, resulting in final Hg(II) levels of <1.0 ppb. From adsorption isotherms, the Hg(II) adsorption capacity for Cys-C@Fe3O4 is 94.33 mg g−1, around three times that of carbon-coated Fe3O4 material. The highest partition coefficient (PC) of 2312.5 mgg−1µM−1 was achieved at the initial Hg (II) concentration of 100 ppb, while significantly high PC values of 300 mgg−1µM−1 and above were also obtained in the ultralow concentration range (≤20 ppb). Cys-C@Fe3O4 exhibits excellent selectivity for Hg(II) when tested in the presence of Pb(II), Ni(II), and Cu(II) ions, is easily separable from aqueous media by application of an external magnet, and can be regenerated for three subsequent uses without compromising Hg(II) uptake. Derived from commercially available raw materials, it is highly possible to achieve large-scale production of the functional sorbent for practical applications.

scholarly journals EXPLORATION OF MICROORGANISMS AS A POTENTIAL SOURCE OF XANTHINE OXIDASE INHIBITORS: AN UPDATED REVIEW

2018 ◽  
Vol 10 (12) ◽  
pp. 1 ◽  
Author(s):  
Uma Rajeswari Batchu ◽  
Joshna Rani Surapaneni
Keyword(s):  
Uric Acid ◽  
Xanthine Oxidase ◽  
Large Scale ◽  
Enzyme Inhibitors ◽  
Rational Drug Design ◽  
Scale Production ◽  
Clinical Investigations ◽  
Large Scale Production ◽  
Xanthine Oxidase Inhibitors ◽  
Rational Drug

Nowadays the prevalence of hyperuricemia has significantly increased in which serum uric acid levels are exceeding the normal range. Gout is the predominant clinical implication of the hyperuricemia, but many clinical investigations have confirmed that hyperuricemia is an independent risk factor for cardiovascular disease (CVD), hypertension, diabetes, and many other diseases. The xanthine oxidase (XO) converts hypoxanthine to xanthine and ultimately to uric acid, and the irreversibly accumulated uric acid causes hyperuricemia associated with gout. Hence specific and selective xanthine oxidase inhibitors (XOI) are potentially powerful tools for inactivating target XO in the pathogenic process of hyperuricemia (Gout). The objective of the current study was to overview the various XOI isolated from the microorganisms. Microorganisms have been employed for several decades for the large-scale production of a variety of bio-chemicals ranging from alcohol to antibiotics and as well as enzyme inhibitors. Currently available XOI (allopurinol and febuxostat) for the treatment of gout have been exhibiting serious side effects. Thus, there is a need to search for new molecules to treat hyperuricemia and its associated disorders. At present, microbes have been unexplored in the development of successful products for the management of XO-related diseases. Hence, the present review focused on novel XOI produced from various microbial species such as Actinobacteria, lichens, bacteria, endophytic fungi and mushrooms, which can be expected to play an important role in the ongoing transition from the empirical screening to the real rational drug design. 

scholarly journals Economic Perspective in the Production of Silver Nanoparticles on the Bacterial Cellulose Membrane as Antibacterial Material

2019 ◽  
Vol 4 (1) ◽  
pp. 17
Author(s):  
Asep NANDIYANTO
Keyword(s):  
Silver Nanoparticles ◽  
Economic Evaluation ◽  
Large Scale ◽  
Raw Materials ◽  
Chemical Reduction ◽  
Ideal Condition ◽  
Cellulose Membrane ◽  
Scale Production ◽  
Ag Nps ◽  
Large Scale Production

Silver nanoparticles (Ag NPs) are the most frequently studied material with superiority as antibacterial that currently increasing the production of Ag NPs. Hence, feasibility study is needed for the development on the production of Ag NPs in industrial scale, especially in Indonesia and other developing countries. The chemical reduction with sodium citrate is used to produce Ag NPs. The purpose of this study is to analysis the prospect of large-scale industrial production in engineering perspective and economic evaluation. This study also gave recommendations for profitability of the production. Perspective of engineering in the production gave information about capability of large-scale production because the easy process and low-cost apparatuses of production can be done. Various economic parameters were used to completed the analysis. Then, the ideal condition to the worst issues of production was estimated to completed the calculation of economic evaluation by effects of raw materials. From this study, those all parameters gave positive result which mean it has good profitability. However, further analysis of strategies in sales and investment must be done in the future to developing the production of Ag NPs that promising in capability on large-scale production.

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