scholarly journals Characterizing Malignant Melanoma Clinically Resembling Seborrheic Keratosis Using Deep Knowledge Transfer

Cancers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 6300
Author(s):  
Panagiota Spyridonos ◽  
George Gaitanis ◽  
Aristidis Likas ◽  
Ioannis Bassukas

Malignant melanomas resembling seborrheic keratosis (SK-like MMs) are atypical, challenging to diagnose melanoma cases that carry the risk of delayed diagnosis and inadequate treatment. On the other hand, SK may mimic melanoma, producing a ‘false positive’ with unnecessary lesion excisions. The present study proposes a computer-based approach using dermoscopy images for the characterization of SΚ-like MMs. Dermoscopic images were retrieved from the International Skin Imaging Collaboration archive. Exploiting image embeddings from pretrained convolutional network VGG16, we trained a support vector machine (SVM) classification model on a data set of 667 images. SVM optimal hyperparameter selection was carried out using the Bayesian optimization method. The classifier was tested on an independent data set of 311 images with atypical appearance: MMs had an absence of pigmented network and had an existence of milia-like cysts. SK lacked milia-like cysts and had a pigmented network. Atypical MMs were characterized with a sensitivity and specificity of 78.6% and 84.5%, respectively. The advent of deep learning in image recognition has attracted the interest of computer science towards improved skin lesion diagnosis. Open-source, public access archives of skin images empower further the implementation and validation of computer-based systems that might contribute significantly to complex clinical diagnostic problems such as the characterization of SK-like MMs.

2020 ◽  
Vol 44 (8) ◽  
pp. 851-860
Author(s):  
Joy Eliaerts ◽  
Natalie Meert ◽  
Pierre Dardenne ◽  
Vincent Baeten ◽  
Juan-Antonio Fernandez Pierna ◽  
...  

Abstract Spectroscopic techniques combined with chemometrics are a promising tool for analysis of seized drug powders. In this study, the performance of three spectroscopic techniques [Mid-InfraRed (MIR), Raman and Near-InfraRed (NIR)] was compared. In total, 364 seized powders were analyzed and consisted of 276 cocaine powders (with concentrations ranging from 4 to 99 w%) and 88 powders without cocaine. A classification model (using Support Vector Machines [SVM] discriminant analysis) and a quantification model (using SVM regression) were constructed with each spectral dataset in order to discriminate cocaine powders from other powders and quantify cocaine in powders classified as cocaine positive. The performances of the models were compared with gas chromatography coupled with mass spectrometry (GC–MS) and gas chromatography with flame-ionization detection (GC–FID). Different evaluation criteria were used: number of false negatives (FNs), number of false positives (FPs), accuracy, root mean square error of cross-validation (RMSECV) and determination coefficients (R2). Ten colored powders were excluded from the classification data set due to fluorescence background observed in Raman spectra. For the classification, the best accuracy (99.7%) was obtained with MIR spectra. With Raman and NIR spectra, the accuracy was 99.5% and 98.9%, respectively. For the quantification, the best results were obtained with NIR spectra. The cocaine content was determined with a RMSECV of 3.79% and a R2 of 0.97. The performance of MIR and Raman to predict cocaine concentrations was lower than NIR, with RMSECV of 6.76% and 6.79%, respectively and both with a R2 of 0.90. The three spectroscopic techniques can be applied for both classification and quantification of cocaine, but some differences in performance were detected. The best classification was obtained with MIR spectra. For quantification, however, the RMSECV of MIR and Raman was twice as high in comparison with NIR. Spectroscopic techniques combined with chemometrics can reduce the workload for confirmation analysis (e.g., chromatography based) and therefore save time and resources.


2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Johannes Masino ◽  
Jakob Thumm ◽  
Guillaume Levasseur ◽  
Michael Frey ◽  
Frank Gauterin ◽  
...  

This work aims at classifying the road condition with data mining methods using simple acceleration sensors and gyroscopes installed in vehicles. Two classifiers are developed with a support vector machine (SVM) to distinguish between different types of road surfaces, such as asphalt and concrete, and obstacles, such as potholes or railway crossings. From the sensor signals, frequency-based features are extracted, evaluated automatically with MANOVA. The selected features and their meaning to predict the classes are discussed. The best features are used for designing the classifiers. Finally, the methods, which are developed and applied in this work, are implemented in a Matlab toolbox with a graphical user interface. The toolbox visualizes the classification results on maps, thus enabling manual verification of the results. The accuracy of the cross-validation of classifying obstacles yields 81.0% on average and of classifying road material 96.1% on average. The results are discussed on a comprehensive exemplary data set.


2021 ◽  
Vol 11 (12) ◽  
pp. 3110-3116
Author(s):  
Jansi Rani Sella Veluswami ◽  
M. Ezhil Prasanth ◽  
K. Harini ◽  
U. Ajaykumar

Melanoma skin cancer is a common disease that develops in the melanocytes that produces melanin. In this work, a deep hybrid learning model is engaged to distinguish the skin cancer and classify them. The dataset used contains two classes of skin cancer–benign and malignant. Since the dataset is imbalanced between the number of images in malignant lesions and benign lesions, augmentation technique is used to balance it. To improve the clarity of the images, the images are then enhanced using Contrast Limited Adaptive Histogram Equalization Technique (CLAHE) technique. To detect only the affected lesion area, the lesions are segmented using the neural network based ensemble model which is the result of combining the segmentation algorithms of Fully Convolutional Network (FCN), SegNet and U-Net which produces a binary image of the skin and the lesion, where the lesion is represented with white and the skin is represented by black. These binary images are further classified using different pre-trained models like Inception ResNet V2, Inception V3, Resnet 50, Densenet and CNN. Following that fine tuning of the best performing pre-trained model is carried out to improve the performance of classification. To further improve the performance of the classification model, a method of combining deep learning (DL) and machine learning (ML) is carried out. Using this hybrid approach, the feature extraction is done using DL models and the classification is performed by Support Vector Machine (SVM). This computer aided tool will assist doctors in diagnosing the disease faster than the traditional method. There is a significant improvement of nearly 4% increase in the performance of the proposed method is presented.


2011 ◽  
Vol 3 ◽  
pp. BECB.S7503 ◽  
Author(s):  
Sangeetha Subramaniam ◽  
Monica Mehrotra ◽  
Dinesh Gupta

There is an urgent need to develop novel anti-malarials in view of the increasing disease burden and growing resistance of the currently used drugs against the malarial parasites. Proliferation inhibitors targeting P. falciparum intraerythrocytic cycle are one of the important classes of compounds being explored for its potential to be novel antimalarials. Support Vector Machine (SVM) based model developed by us can facilitate rapid screening of large and diverse chemical libraries by reducing false hits and prioritising compounds before setting up expensive High Throughput Screening experiment. The SVM model, trained with molecular descriptors of proliferation inhibitors and non-inhibitors, displayed a satisfactory performance on cross validations and independent data set, with an average accuracy of 83% and AUC of 0.88. Intriguingly, the method displayed remarkable accuracy for the recently submitted P. falciparum whole cell screening datasets. The method also predicted several inhibitors in the National Cancer Institute diversity set, mostly similar to the known inhibitors.


2020 ◽  
Vol 28 (4) ◽  
pp. 546-557
Author(s):  
Gonzalo de la Torre-Abaitua ◽  
Luis F Lago-Fernández ◽  
David Arroyo

Abstract In cybersecurity, there is a call for adaptive, accurate and efficient procedures to identifying performance shortcomings and security breaches. The increasing complexity of both Internet services and traffic determines a scenario that in many cases impedes the proper deployment of intrusion detection and prevention systems. Although it is a common practice to monitor network and applications activity, there is not a general methodology to codify and interpret the recorded events. Moreover, this lack of methodology somehow erodes the possibility of diagnosing whether event detection and recording is adequately performed. As a result, there is an urge to construct general codification and classification procedures to be applied on any type of security event in any activity log. This work is focused on defining such a method using the so-called normalized compression distance (NCD). NCD is parameter-free and can be applied to determine the distance between events expressed using strings. As a first step in the concretion of a methodology for the integral interpretation of security events, this work is devoted to the characterization of web logs. On the grounds of the NCD, we propose an anomaly-based procedure for identifying web attacks from web logs. Given a web query as stored in a security log, a NCD-based feature vector is created and classified using a support vector machine. The method is tested using the CSIC-2010 data set, and the results are analyzed with respect to similar proposals.


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Swetha Parvatha Reddy Chandrasekhara ◽  
Mohan G. Kabadi ◽  
Srivinay Srivinay

Purpose This study has mainly aimed to compare and contrast two completely different image processing algorithms that are very adaptive for detecting prostate cancer using wearable Internet of Things (IoT) devices. Cancer in these modern times is still considered as one of the most dreaded disease, which is continuously pestering the mankind over a past few decades. According to Indian Council of Medical Research, India alone registers about 11.5 lakh cancer related cases every year and closely up to 8 lakh people die with cancer related issues each year. Earlier the incidence of prostate cancer was commonly seen in men aged above 60 years, but a recent study has revealed that this type of cancer has been on rise even in men between the age groups of 35 and 60 years as well. These findings make it even more necessary to prioritize the research on diagnosing the prostate cancer at an early stage, so that the patients can be cured and can lead a normal life. Design/methodology/approach The research focuses on two types of feature extraction algorithms, namely, scale invariant feature transform (SIFT) and gray level co-occurrence matrix (GLCM) that are commonly used in medical image processing, in an attempt to discover and improve the gap present in the potential detection of prostate cancer in medical IoT. Later the results obtained by these two strategies are classified separately using a machine learning based classification model called multi-class support vector machine (SVM). Owing to the advantage of better tissue discrimination and contrast resolution, magnetic resonance imaging images have been considered for this study. The classification results obtained for both the SIFT as well as GLCM methods are then compared to check, which feature extraction strategy provides the most accurate results for diagnosing the prostate cancer. Findings The potential of both the models has been evaluated in terms of three aspects, namely, accuracy, sensitivity and specificity. Each model’s result was checked against diversified ranges of training and test data set. It was found that the SIFT-multiclass SVM model achieved a highest performance rate of 99.9451% accuracy, 100% sensitivity and 99% specificity at 40:60 ratio of the training and testing data set. Originality/value The SIFT-multi SVM versus GLCM-multi SVM based comparison has been introduced for the first time to perceive the best model to be used for the accurate diagnosis of prostate cancer. The performance of the classification for each of the feature extraction strategies is enumerated in terms of accuracy, sensitivity and specificity.


Author(s):  
Prabira Kumar Sethy ◽  
Santi Kumari Behera ◽  
Pradyumna Kumar Ratha ◽  
Preesat Biswas

The detection of coronavirus (COVID-19) is now a critical task for the medical practitioner. The coronavirus spread so quickly between people and approaches 100,000 people worldwide. In this consequence, it is very much essential to identify the infected people so that prevention of spread can be taken. In this paper, the deep feature plus support vector machine (SVM) based methodology is suggested for detection of coronavirus infected patient using X-ray images. For classification, SVM is used instead of deep learning based classifier, as the later one need a large dataset for training and validation. The deep features from the fully connected layer of CNN model are extracted and fed to SVM for classification purpose. The SVM classifies the corona affected X-ray images from others. The methodology consists of three categories of Xray images, i.e., COVID-19, pneumonia and normal. The method is beneficial for the medical practitioner to classify among the COVID-19 patient, pneumonia patient and healthy people. SVM is evaluated for detection of COVID-19 using the deep features of different 13 number of CNN models. The SVM produced the best results using the deep feature of ResNet50. The classification model, i.e. ResNet50 plus SVM achieved accuracy, sensitivity, FPR and F1 score of 95.33%,95.33%,2.33% and 95.34% respectively for detection of COVID-19 (ignoring SARS, MERS and ARDS). Again, the highest accuracy achieved by ResNet50 plus SVM is 98.66%. The result is based on the Xray images available in the repository of GitHub and Kaggle. As the data set is in hundreds, the classification based on SVM is more robust compared to the transfer learning approach. Also, a comparison analysis of other traditional classification method is carried out. The traditional methods are local binary patterns (LBP) plus SVM, histogram of oriented gradients (HOG) plus SVM and Gray Level Co-occurrence Matrix (GLCM) plus SVM. In traditional image classification method, LBP plus SVM achieved 93.4% of accuracy.


Aerospace ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 47 ◽  
Author(s):  
Tomás Madeira ◽  
Rui Melício ◽  
Duarte Valério ◽  
Luis Santos

In the aviation sector, human factors are the primary cause of safety incidents. Intelligent prediction systems, which are capable of evaluating human state and managing risk, have been developed over the years to identify and prevent human factors. However, the lack of large useful labelled data has often been a drawback to the development of these systems. This study presents a methodology to identify and classify human factor categories from aviation incident reports. For feature extraction, a text pre-processing and Natural Language Processing (NLP) pipeline is developed. For data modelling, semi-supervised Label Spreading (LS) and supervised Support Vector Machine (SVM) techniques are considered. Random search and Bayesian optimization methods are applied for hyper-parameter analysis and the improvement of model performance, as measured by the Micro F1 score. The best predictive models achieved a Micro F1 score of 0.900, 0.779, and 0.875, for each level of the taxonomic framework, respectively. The results of the proposed method indicate that favourable predicting performances can be achieved for the classification of human factors based on text data. Notwithstanding, a larger data set would be recommended in future research.


2020 ◽  
Vol 10 (19) ◽  
pp. 6890
Author(s):  
Steve Koshy Mathew ◽  
Yu Zhang

Engine fault diagnosis aims to assist engineers in undertaking vehicle maintenance in an efficient manner. This paper presents an automatic model and hyperparameter selection scheme for engine combustion fault classification, using acoustic signals captured from cylinder heads of the engine. Wavelet Packet Transform (WPT) is utilized for time–frequency analysis, and statistical features are extracted from both high- and low-level WPT coefficients. Then, the extracted features are used to compare three models: (i) standard classification model; (ii) Bayesian optimization for automatic model and hyperparameters selection; and (iii) Principle Component Analysis (PCA) for feature space dimensionality reduction combined with Bayesian optimization. The latter two models both demonstrated improved accuracy and the other performance metrics compared to the standard model. Moreover, with similar accuracy level, PCA with Bayesian optimized model achieved around 20% less total evaluation time and 8–19% less testing time, compared to the second model, for all fault conditions, which thus shows a promising solution for further development in real-time engine fault diagnosis.


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