scholarly journals Hematological Malignancy-Derived Small Extracellular Vesicles and Tumor Microenvironment: The Art of Turning Foes into Friends

Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 511 ◽  
Author(s):  
Ernesto Gargiulo ◽  
Jerome Paggetti ◽  
Etienne Moussay
Keyword(s):  
Tumor Microenvironment ◽  
Extracellular Vesicles ◽  
Hematological Malignancy ◽  
Immune Surveillance ◽  
Genetic Material ◽  
Membrane Receptors ◽  
Cancer Cell Proliferation ◽  
Long Distance ◽  
Target Cell Membrane ◽  
Distance Communication

Small extracellular vesicles (small EVs) are commonly released by all cells, and are found in all body fluids. They are implicated in cell to cell short- and long-distance communication through the transfer of genetic material and proteins, as well as interactions between target cell membrane receptors and ligands anchored on small EV membrane. Beyond their canonical functions in healthy tissues, small EVs are strategically used by tumors to communicate with the cellular microenvironment and to establish a proper niche which would ultimately allow cancer cell proliferation, escape from the immune surveillance, and metastasis formation. In this review, we highlight the effects of hematological malignancy-derived small EVs on immune and stromal cells in the tumor microenvironment.

Multiple Facets of Plant-Microbiome Associations in Unlocking the Communication Paradigm through Extracellular Vesicles. s

2021 ◽  
Vol 22 ◽  
Author(s):  
Kanika Khanna ◽  
Sukhmeen Kaur Kohli ◽  
Vinod Kumar ◽  
Jaspreet Kour ◽  
Arun Dev Singh ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
Stress Responses ◽  
Protein Trafficking ◽  
Immune Surveillance ◽  
Long Distance ◽  
Communication Paradigm ◽  
Distance Communication ◽  
Metabolic Activities ◽  
A Chain ◽  
Plant Microbiome

: Communication among different species across kingdoms occurs through a chain of regulatory molecules that are transferred around cellular boundaries. These molecules are also crucial for defense, virulence and pathogenesis. In the past, the transport of proteins in long distance communication was observed, but in the present era, the discovery of extracellular vesicles (EVs) has changed our understanding of molecular communication. EVs are not only involved in cell signaling and immunity, but also can transfer information by sRNAs, forming a basis for interactions among a wide variety of organisms. Despite extensive research on EVs in other areas, their role in communication between plants and the plant microbiome has been lacking. EVs are potentially involved in protein trafficking along with transport of lipids and nucleic acids. Interactions between hosts and their microbiomes may also be mediated by EVs, which can be involved in stress responses, immune surveillance and defense, virulence and signaling along with many metabolic activities within plant microbiomes. In this review, we have focused on recent information about the role of EVs and the molecules they transport between hosts and microbes. The connection between biofilms and the generation of EVs is also considered. These findings enhance our knowledge about plant-microbiome interactions in terms of immunity and virulence and challenge the conventional viewpoint of inter-kingdom signaling.

scholarly journals Reshaping the tumor microenvironment: extracellular vesicles as messengers of cancer cells

2020 ◽  
Vol 41 (11) ◽  
pp. 1461-1470
Author(s):  
Bibek Bhatta ◽  
Tomer Cooks
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Extracellular Vesicles ◽  
Cancer Progression ◽  
Cell Contact ◽  
Long Distance ◽  
Donor Cells ◽  
Distance Communication ◽  
Direct Cell ◽  
Cancer Types

Abstract The tumor microenvironment (TME) comprises an assortment of immune and non-immune cells. The interactions between the cancer cells and their surrounding TME are known to be a cardinal factor in all stages of cancer progression, from initiation to metastasis. Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) are considered two of the most abundant TME members associated with poor prognosis in various cancer types. Intercellular communication between the cancer cells and TME cells might occur via direct cell–cell contact or achieved through secreted factors such as cytokines, growth factors and extracellular vesicles (EVs). EVs are released by almost every cell type and by cancer cells in particular. EVs are loaded with unique molecular cargos that might include DNA, proteins, RNA and lipids, commonly reflecting the physiological traits of their donor cells. Once released, EVs are capable of initiating short- and long-distance communication in an autocrine, paracrine and endocrine fashion. The molecular cargos within the EVs are able to impart phenotypic changes at the receiving end thus allowing EV-releasing cancer cells to deliver messages to TME cells and tighten their grasp over the cancerous tissue. In this concise review, we aim to document the bidirectional EV-based communication between cancer cell, TAMs and CAFs, tilting the balance in favor of cancer progression and metastasis.

scholarly journals A Long-Distance Communication Architecture for Medical Devices Based on LoRaWAN Protocol

Electronics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 940
Author(s):  
Nicoleta Cristina Gaitan
Keyword(s):  
Energy Consumption ◽  
Long Range ◽  
Medical Devices ◽  
Low Energy ◽  
Area Network ◽  
Wide Area Network ◽  
Long Distance ◽  
Communication Architecture ◽  
Low Energy Consumption ◽  
Distance Communication

Recent market studies show that the market for remote monitoring devices of different medical parameters will grow exponentially. Globally, more than 4 million individuals will be monitored remotely from the perspective of different health parameters by 2023. Of particular importance is the way of remote transmission of the information acquired from the medical sensors. At this time, there are several methods such as Bluetooth, WI-FI, or other wireless communication interfaces. Recently, the communication based on LoRa (Long Range) technology has had an explosive development that allows the transmission of information over long distances with low energy consumption. The implementation of the IoT (Internet of Things) applications using LoRa devices based on open Long Range Wide-Area Network (LoRaWAN) protocol for long distances with low energy consumption can also be used in the medical field. Therefore, in this paper, we proposed and developed a long-distance communication architecture for medical devices based on the LoRaWAN protocol that allows data communications over a distance of more than 10 km.

scholarly journals 695 Oral delivery of a microbial extracellular vesicle induces potent anti-tumor immunity in mice

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A737-A737
Author(s):  
Loise Francisco-Anderson ◽  
Loise Francisco-Anderson ◽  
Mary Abdou ◽  
Michael Goldberg ◽  
Erin Troy ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Tumor Growth ◽  
Extracellular Vesicles ◽  
Tumor Immunity ◽  
Extracellular Vesicle ◽  
The Body ◽  
Checkpoint Inhibition ◽  
Small Intestinal ◽  
The Impact

BackgroundThe small intestinal axis (SINTAX) is a network of anatomic and functional connections between the small intestine and the rest of the body. It acts as an immunosurveillance system, integrating signals from the environment that affect physiological processes throughout the body. The impact of events in the gut in the control of tumor immunity is beginning to be appreciated. We have previously shown that an orally delivered single strain of commensal bacteria induces anti-tumor immunity preclinically via pattern recognition receptor-mediated activation of innate and adaptive immunity. Some bacteria produce extracellular vesicles (EVs) that share molecular content with the parent bacterium in a particle that is roughly 1/1000th the volume in a non-replicating form. We report here an orally-delivered and gut-restricted bacterial EV which potently attenuates tumor growth to a greater extent than whole bacteria or checkpoint inhibition.MethodsEDP1908 is a preparation of extracellular vesicles produced by a gram-stain negative strain of bacterium of the Oscillospiraceae family isolated from a human donor. EDP1908 was selected for its immunostimulatory profile in a screen of EVs from a range of distinct microbial strains. Its mechanism of action was determined by ex vivo analysis of the tumor microenvironment (TME) and by in vitro functional studies with murine and human cells.ResultsOral treatment of tumor-bearing mice with EDP1908 shows superior control of tumor growth compared to checkpoint inhibition (anti-PD-1) or an intact microbe. EDP1908 significantly increased the percentage of IFNγ and TNF producing CD8+ CTLs, NK cells, NKT cells and CD4+ cells in the tumor microenvironment (TME). EDP1908 also increased tumor-infiltrating dendritic cells (DC1 and DC2). Analysis of cytokines in the TME showed significant increases in IP-10 and IFNg production in mice treated with EDP1908, creating an environment conducive to the recruitment and activation of anti-tumor lymphocytes.ConclusionsThis is the first report of striking anti-tumor effects of an orally delivered microbial extracellular vesicle. These data point to oral EVs as a new class of immunotherapeutic drugs. They are particularly effective at harnessing the biology of the small intestinal axis, acting locally on host cells in the gut to control distal immune responses within the TME. EDP1908 is in preclinical development for the treatment of cancer.Ethics ApprovalPreclinical murine studies were conducted under the approval of the Avastus Preclinical Services’ Ethics Board. Human in vitro samples were attained by approval of the IntegReview Ethics Board; informed consent was obtained from all subjects.

scholarly journals The Role of Extracellular Vesicles in the Development of a Cancer Stem Cell Microenvironment Niche and Potential Therapeutic Targets

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2435
Author(s):  
Thomas J. Brown ◽  
Victoria James
Keyword(s):  
Systematic Review ◽  
Tumor Microenvironment ◽  
Extracellular Vesicles ◽  
Multiple Cancer ◽  
Therapeutic Targeting ◽  
Small Component ◽  
Facilitated Communication ◽  
Cell Microenvironment ◽  
Cancer Types

Cancer stem cells (CSCs) have increasingly been shown to be a crucial element of heterogenous tumors. Although a relatively small component of the population, they increase the resistance to treatment and the likelihood of recurrence. In recent years, it has been shown, across multiple cancer types (e.g., colorectal, breast and prostate), that reciprocal communication between cancer and the microenvironment exists, which is, in part, facilitated by extracellular vesicles (EVs). However, the mechanisms of this method of communication and its influence on CSC populations is less well-understood. Therefore, the aim of this systematic review is to determine the evidence that supports the role of EVs in the manipulation of the tumor microenvironment to promote the survival of CSCs. Embase and PubMed were used to identify all studies on the topic, which were screened using PRISMA guidelines, resulting in the inclusion of 16 studies. These 16 studies reported on the EV content, pathways altered by EVs and therapeutic targeting of CSC through EV-mediated changes to the microenvironment. In conclusion, these studies demonstrated the role of EV-facilitated communication in maintaining CSCs via manipulation of the tumor microenvironment, demonstrating the potential of creating therapeutics to target CSCs. However, further works are needed to fully understand the targetable mechanisms upon which future therapeutics can be based.

scholarly journals Quantum repeaters based on concatenated bosonic and discrete-variable quantum codes

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Filip Rozpędek ◽  
Kyungjoo Noh ◽  
Qian Xu ◽  
Saikat Guha ◽  
Liang Jiang
Keyword(s):  
Continuous Variable ◽  
Quantum Codes ◽  
Discrete Variable ◽  
Long Distance ◽  
Concatenated Code ◽  
Different Types ◽  
Optical Modes ◽  
Distance Communication ◽  
Quantum Repeaters ◽  
Quantum Error

AbstractWe propose an architecture of quantum-error-correction-based quantum repeaters that combines techniques used in discrete- and continuous-variable quantum information. Specifically, we propose to encode the transmitted qubits in a concatenated code consisting of two levels. On the first level we use a continuous-variable GKP code encoding the qubit in a single bosonic mode. On the second level we use a small discrete-variable code. Such an architecture has two important features. Firstly, errors on each of the two levels are corrected in repeaters of two different types. This enables for achieving performance needed in practical scenarios with a reduced cost with respect to an architecture for which all repeaters are the same. Secondly, the use of continuous-variable GKP code on the lower level generates additional analog information which enhances the error-correcting capabilities of the second-level code such that long-distance communication becomes possible with encodings consisting of only four or seven optical modes.

CONVERGENCE IMPROVEMENT OF ADAPTIVE LATTICE ALGORITHM WITH FUZZY BASED ADAPTIVE GAIN

1999 ◽  
Vol 09 (01n02) ◽  
pp. 125-132
Author(s):  
GEUN-TAEK RYU ◽  
DAE-SUNG KIM ◽  
DAE-YOUNG LEE ◽  
SUNG-HWAN HAN ◽  
HYEON-DEOK BAE
Keyword(s):  
Adaptive Filters ◽  
Communication Channel ◽  
Long Distance ◽  
Input And Output ◽  
Forward Prediction ◽  
Adaptation Procedure ◽  
Distance Communication ◽  
One Step ◽  
Input Variables ◽  
Lattice Algorithm

The choice of the adaptive gain is important to the performance of LMS-based adaptive filters. Depending on application areas, the realization structure of the filters is also important. This letter presents an adaptive lattice algorithm which adjusts the adaptive gain of LMS using fuzzy if-then rules determined by matching input and output variables during adaptation procedure. In each lattice filter stage, this filter adjusts the adaptive gain as the output of the fuzzy logic which has two input variables, normalized squared forward prediction error and one step previous adaptive gain. The proposed algorithm is applied to echo canceling problem of long distance communication channel. The simulation results are compared with NLMS on TDL and lattice structures.

Basic communication sciences

1969 ◽  
Vol 308 (1493) ◽  
pp. 183-198
Keyword(s):  
Long Distance ◽  
Earth Station ◽  
Early Communication ◽  
Technical Developments ◽  
Radiated Power ◽  
The Earth ◽  
Distance Communication ◽  
Quality Of Transmission ◽  
Communication Equipment

The feasibility and utility of long-distance communication via Earth-orbiting satellites has been demonstrated during recent years and it is appropriate therefore to focus attention on the more important scientific studies and technical developments that will be needed if full use is to be made of this valuable mode of communication in the future. The early communication satellites (the Telstar and Relay series) were pioneers in a relatively unknown propagation environment. The satellites themselves were conceptually simple and the communication equipment consisted essentially of a frequency-changing transponder with an r. f. power output of a few watts and a bandwidth some tens of megahertz. Carrier frequencies in the range 2 to 6 GHz were employed; typically either 2 or 6 GHz was used for transmission and 4 GHz for reception at the Earth station. To obtain an adequate signal/noise ratio at the output of the Earth station receiver, frequency modulation was employed, the frequency deviations being greater than those used on terrestrial microwave links. Launcher limitations and other factors meant that the satellites had to be placed in inclined elliptical orbits (see figure 1) with maximum heights of only a few thousand miles. Nevertheless, these satellites demonstrated that some hundreds of frequency-division multiplex telephony circuits, or a television channel, could be achieved with generally satisfactory quality of transmission. It is to be noted, however, that the satellite transponders accommodated only one, or at the most two, r. f. carriers at any time, and that the transmission performance was at times marginal due to limitations of the satellite effective radiated power. Furthermore, these relatively low orbit satellites provided communication in periods of generally less than an hour at a time and required continuous tracking by the Earth station aerials, due to movement of the satellites relative to the Earth.

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