Multiple Facets of Plant-Microbiome Associations in Unlocking the Communication Paradigm through Extracellular Vesicles. s

2021 ◽  
Vol 22 ◽  
Author(s):  
Kanika Khanna ◽  
Sukhmeen Kaur Kohli ◽  
Vinod Kumar ◽  
Jaspreet Kour ◽  
Arun Dev Singh ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
Stress Responses ◽  
Protein Trafficking ◽  
Immune Surveillance ◽  
Long Distance ◽  
Communication Paradigm ◽  
Distance Communication ◽  
Metabolic Activities ◽  
A Chain ◽  
Plant Microbiome

: Communication among different species across kingdoms occurs through a chain of regulatory molecules that are transferred around cellular boundaries. These molecules are also crucial for defense, virulence and pathogenesis. In the past, the transport of proteins in long distance communication was observed, but in the present era, the discovery of extracellular vesicles (EVs) has changed our understanding of molecular communication. EVs are not only involved in cell signaling and immunity, but also can transfer information by sRNAs, forming a basis for interactions among a wide variety of organisms. Despite extensive research on EVs in other areas, their role in communication between plants and the plant microbiome has been lacking. EVs are potentially involved in protein trafficking along with transport of lipids and nucleic acids. Interactions between hosts and their microbiomes may also be mediated by EVs, which can be involved in stress responses, immune surveillance and defense, virulence and signaling along with many metabolic activities within plant microbiomes. In this review, we have focused on recent information about the role of EVs and the molecules they transport between hosts and microbes. The connection between biofilms and the generation of EVs is also considered. These findings enhance our knowledge about plant-microbiome interactions in terms of immunity and virulence and challenge the conventional viewpoint of inter-kingdom signaling.

scholarly journals Hematological Malignancy-Derived Small Extracellular Vesicles and Tumor Microenvironment: The Art of Turning Foes into Friends

Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 511 ◽  
Author(s):  
Ernesto Gargiulo ◽  
Jerome Paggetti ◽  
Etienne Moussay
Keyword(s):  
Tumor Microenvironment ◽  
Extracellular Vesicles ◽  
Hematological Malignancy ◽  
Immune Surveillance ◽  
Genetic Material ◽  
Membrane Receptors ◽  
Cancer Cell Proliferation ◽  
Long Distance ◽  
Target Cell Membrane ◽  
Distance Communication

Small extracellular vesicles (small EVs) are commonly released by all cells, and are found in all body fluids. They are implicated in cell to cell short- and long-distance communication through the transfer of genetic material and proteins, as well as interactions between target cell membrane receptors and ligands anchored on small EV membrane. Beyond their canonical functions in healthy tissues, small EVs are strategically used by tumors to communicate with the cellular microenvironment and to establish a proper niche which would ultimately allow cancer cell proliferation, escape from the immune surveillance, and metastasis formation. In this review, we highlight the effects of hematological malignancy-derived small EVs on immune and stromal cells in the tumor microenvironment.

scholarly journals Extracellular vesicles and immunogenic stress in cancer

2021 ◽  
Vol 12 (10) ◽  
Author(s):  
Qi Wu ◽  
Hanpu Zhang ◽  
Si Sun ◽  
Lijun Wang ◽  
Shengrong Sun
Keyword(s):  
Cancer Cells ◽  
Extracellular Vesicles ◽  
Stress Responses ◽  
Stromal Cells ◽  
Immune Status ◽  
Immune Surveillance ◽  
Cell Communication ◽  
Treatment Strategies ◽  
Stress Reactions ◽  
Damage Response

AbstractTumor progression requires bidirectional cell-to-cell communication within a complex tumor microenvironment (TME). Extracellular vesicles (EVs) as carriers have the capacity to shuttle regulatory molecules, including nucleic acids, proteins, and lipids, between cancer cells and multiple stromal cells, inducing remarkable phenotypic alterations in the TME. Recently proposed the concept “immunogenic stress”, which means in some stressed microenvironment, cancer cells can release EVs containing specific immunoregulatory mediators, depending on the initiating stress-associated pathway, thereby provoking the changes of immune status in the TME. Considerable evidence has revealed that the intracellular mechanisms underlying the response to diverse stresses are mainly autophagy, endoplasmic reticulum (ER) stress reactions and the DNA damage response (DDR). In addition, the activation of immunogenic stress responses endows hosts with immune surveillance capacity; in contrast, several cargoes in EVs under immunogenic stress trigger a passive immune response by mediating the function of immune cells. This review discusses the current understanding of the immunogenic stress pathways in cancer and describes the interrelation between EVs and immunogenic stress to propose potential treatment strategies and biomarkers.

scholarly journals Reshaping the tumor microenvironment: extracellular vesicles as messengers of cancer cells

2020 ◽  
Vol 41 (11) ◽  
pp. 1461-1470
Author(s):  
Bibek Bhatta ◽  
Tomer Cooks
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Extracellular Vesicles ◽  
Cancer Progression ◽  
Cell Contact ◽  
Long Distance ◽  
Donor Cells ◽  
Distance Communication ◽  
Direct Cell ◽  
Cancer Types

Abstract The tumor microenvironment (TME) comprises an assortment of immune and non-immune cells. The interactions between the cancer cells and their surrounding TME are known to be a cardinal factor in all stages of cancer progression, from initiation to metastasis. Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) are considered two of the most abundant TME members associated with poor prognosis in various cancer types. Intercellular communication between the cancer cells and TME cells might occur via direct cell–cell contact or achieved through secreted factors such as cytokines, growth factors and extracellular vesicles (EVs). EVs are released by almost every cell type and by cancer cells in particular. EVs are loaded with unique molecular cargos that might include DNA, proteins, RNA and lipids, commonly reflecting the physiological traits of their donor cells. Once released, EVs are capable of initiating short- and long-distance communication in an autocrine, paracrine and endocrine fashion. The molecular cargos within the EVs are able to impart phenotypic changes at the receiving end thus allowing EV-releasing cancer cells to deliver messages to TME cells and tighten their grasp over the cancerous tissue. In this concise review, we aim to document the bidirectional EV-based communication between cancer cell, TAMs and CAFs, tilting the balance in favor of cancer progression and metastasis.

scholarly journals A Long-Distance Communication Architecture for Medical Devices Based on LoRaWAN Protocol

Electronics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 940
Author(s):  
Nicoleta Cristina Gaitan
Keyword(s):  
Energy Consumption ◽  
Long Range ◽  
Medical Devices ◽  
Low Energy ◽  
Area Network ◽  
Wide Area Network ◽  
Long Distance ◽  
Communication Architecture ◽  
Low Energy Consumption ◽  
Distance Communication

Recent market studies show that the market for remote monitoring devices of different medical parameters will grow exponentially. Globally, more than 4 million individuals will be monitored remotely from the perspective of different health parameters by 2023. Of particular importance is the way of remote transmission of the information acquired from the medical sensors. At this time, there are several methods such as Bluetooth, WI-FI, or other wireless communication interfaces. Recently, the communication based on LoRa (Long Range) technology has had an explosive development that allows the transmission of information over long distances with low energy consumption. The implementation of the IoT (Internet of Things) applications using LoRa devices based on open Long Range Wide-Area Network (LoRaWAN) protocol for long distances with low energy consumption can also be used in the medical field. Therefore, in this paper, we proposed and developed a long-distance communication architecture for medical devices based on the LoRaWAN protocol that allows data communications over a distance of more than 10 km.

scholarly journals Quantum repeaters based on concatenated bosonic and discrete-variable quantum codes

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Filip Rozpędek ◽  
Kyungjoo Noh ◽  
Qian Xu ◽  
Saikat Guha ◽  
Liang Jiang
Keyword(s):  
Continuous Variable ◽  
Quantum Codes ◽  
Discrete Variable ◽  
Long Distance ◽  
Concatenated Code ◽  
Different Types ◽  
Optical Modes ◽  
Distance Communication ◽  
Quantum Repeaters ◽  
Quantum Error

AbstractWe propose an architecture of quantum-error-correction-based quantum repeaters that combines techniques used in discrete- and continuous-variable quantum information. Specifically, we propose to encode the transmitted qubits in a concatenated code consisting of two levels. On the first level we use a continuous-variable GKP code encoding the qubit in a single bosonic mode. On the second level we use a small discrete-variable code. Such an architecture has two important features. Firstly, errors on each of the two levels are corrected in repeaters of two different types. This enables for achieving performance needed in practical scenarios with a reduced cost with respect to an architecture for which all repeaters are the same. Secondly, the use of continuous-variable GKP code on the lower level generates additional analog information which enhances the error-correcting capabilities of the second-level code such that long-distance communication becomes possible with encodings consisting of only four or seven optical modes.

scholarly journals A microbiota–root–shoot circuit favours Arabidopsis growth over defence under suboptimal light

Nature Plants ◽  
2021 ◽  
Author(s):  
Shiji Hou ◽  
Thorsten Thiergart ◽  
Nathan Vannier ◽  
Fantin Mesny ◽  
Jörg Ziegler ◽  
...  
Keyword(s):  
Stress Responses ◽  
Photosynthetically Active Radiation ◽  
Bacterial Community Composition ◽  
Light Condition ◽  
Long Distance ◽  
Active Radiation ◽  
Light Manipulation ◽  
Growth Deficiency ◽  
Dependent Growth ◽  
Control Light

AbstractBidirectional root–shoot signalling is probably key in orchestrating stress responses and ensuring plant survival. Here, we show that Arabidopsis thaliana responses to microbial root commensals and light are interconnected along a microbiota–root–shoot axis. Microbiota and light manipulation experiments in a gnotobiotic plant system reveal that low photosynthetically active radiation perceived by leaves induces long-distance modulation of root bacterial communities but not fungal or oomycete communities. Reciprocally, microbial commensals alleviate plant growth deficiency under low photosynthetically active radiation. This growth rescue was associated with reduced microbiota-induced aboveground defence responses and altered resistance to foliar pathogens compared with the control light condition. Inspection of a set of A. thaliana mutants reveals that this microbiota- and light-dependent growth–defence trade-off is directly explained by belowground bacterial community composition and requires the host transcriptional regulator MYC2. Our work indicates that aboveground stress responses in plants can be modulated by signals from microbial root commensals.

CONVERGENCE IMPROVEMENT OF ADAPTIVE LATTICE ALGORITHM WITH FUZZY BASED ADAPTIVE GAIN

1999 ◽  
Vol 09 (01n02) ◽  
pp. 125-132
Author(s):  
GEUN-TAEK RYU ◽  
DAE-SUNG KIM ◽  
DAE-YOUNG LEE ◽  
SUNG-HWAN HAN ◽  
HYEON-DEOK BAE
Keyword(s):  
Adaptive Filters ◽  
Communication Channel ◽  
Long Distance ◽  
Input And Output ◽  
Forward Prediction ◽  
Adaptation Procedure ◽  
Distance Communication ◽  
One Step ◽  
Input Variables ◽  
Lattice Algorithm

The choice of the adaptive gain is important to the performance of LMS-based adaptive filters. Depending on application areas, the realization structure of the filters is also important. This letter presents an adaptive lattice algorithm which adjusts the adaptive gain of LMS using fuzzy if-then rules determined by matching input and output variables during adaptation procedure. In each lattice filter stage, this filter adjusts the adaptive gain as the output of the fuzzy logic which has two input variables, normalized squared forward prediction error and one step previous adaptive gain. The proposed algorithm is applied to echo canceling problem of long distance communication channel. The simulation results are compared with NLMS on TDL and lattice structures.

Basic communication sciences

1969 ◽  
Vol 308 (1493) ◽  
pp. 183-198
Keyword(s):  
Long Distance ◽  
Earth Station ◽  
Early Communication ◽  
Technical Developments ◽  
Radiated Power ◽  
The Earth ◽  
Distance Communication ◽  
Quality Of Transmission ◽  
Communication Equipment

The feasibility and utility of long-distance communication via Earth-orbiting satellites has been demonstrated during recent years and it is appropriate therefore to focus attention on the more important scientific studies and technical developments that will be needed if full use is to be made of this valuable mode of communication in the future. The early communication satellites (the Telstar and Relay series) were pioneers in a relatively unknown propagation environment. The satellites themselves were conceptually simple and the communication equipment consisted essentially of a frequency-changing transponder with an r. f. power output of a few watts and a bandwidth some tens of megahertz. Carrier frequencies in the range 2 to 6 GHz were employed; typically either 2 or 6 GHz was used for transmission and 4 GHz for reception at the Earth station. To obtain an adequate signal/noise ratio at the output of the Earth station receiver, frequency modulation was employed, the frequency deviations being greater than those used on terrestrial microwave links. Launcher limitations and other factors meant that the satellites had to be placed in inclined elliptical orbits (see figure 1) with maximum heights of only a few thousand miles. Nevertheless, these satellites demonstrated that some hundreds of frequency-division multiplex telephony circuits, or a television channel, could be achieved with generally satisfactory quality of transmission. It is to be noted, however, that the satellite transponders accommodated only one, or at the most two, r. f. carriers at any time, and that the transmission performance was at times marginal due to limitations of the satellite effective radiated power. Furthermore, these relatively low orbit satellites provided communication in periods of generally less than an hour at a time and required continuous tracking by the Earth station aerials, due to movement of the satellites relative to the Earth.

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