scholarly journals Simulation of Cold Atmospheric Plasma Generated by Floating-Electrode Dielectric Barrier Pulsed Discharge Used for the Cancer Cell Necrosis

Coatings ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1405
Author(s):  
Samira Elaissi ◽  
Kamel Charrada

A numerical simulation of a pulsed floating electrode dielectric barrier discharge (FE-DBD) at atmospheric pressure, used for melanoma cancer cell therapy, is performed using a plasma model in COMSOL Multiphysics software. Distributions of electron density, space charge, and electric field are presented at different instants of the pulsed argon discharge. Significant results related to the characteristics of the plasma device used, the inter-electrodes distance, and the power supply are obtained to improve the efficiency of FE-DBD apparatus for melanoma cancer cell treatment. The FE-DBD presents a higher sensitivity to short pulse durations, related to the accumulated charge over the dielectric barrier around the powered electrode. At higher applied voltage, more energy is injected into the discharge channel and an increase in electron density and electric consumed power is noted. Anticancer activity provided by the FE-DBD plasma is improved using a small interelectrode distance with a high electron emission coefficient and a high dielectric constant with a small dielectric thickness, allowing higher electron density, generating reactive species responsible for the apoptosis of tumor cells.

2020 ◽  
Vol 15 (0) ◽  
pp. 2401042-2401042
Author(s):  
Hiroki HACHIKUBO ◽  
Atsushi OKAMOTO ◽  
Takaaki FUJITA ◽  
Hideki ARIMOTO ◽  
Ryosuke OCHIAI ◽  
...  

Author(s):  
H. Alasam

The possibility that intrathymic T-cell differentiation involves stem cell-lymphoid interactions in embryos led us to study the ultrastructure of epithelial cell in normal embryonic thymus. Studies in adult thymus showed that it produces several peptides that induce T-cell differentiation. Several of them have been chemically characterized, such as thymosin α 1, thymopoietin, thymic humoral factor or the serum thymic factor. It was suggested that most of these factors are secreted by populations of A and B-epithelial cells.Embryonic materials were obtained from inbred matings of Swiss Albino mice. Thymuses were disected from embryos 17 days old and prepared for transmission electron microscopy. Our studies showed that embryonic thymus at this stage contains undifferentiated and differentiated epithelial cells, large lymphoblasts, medium and few small lymphocytes (Fig. 5). No differences were found between cortical and medullary epithelial cells, in contrast to the findings of Van Vliet et al,. Epithelial cells were mostly of the A-type with low electron density in both cytoplasm and nucleus. However few B-type with high electron density were also found (Fig. 7).


1994 ◽  
Vol 358 ◽  
Author(s):  
G. Gumbs

ABSTRACTA self-consistent many-body theory is developed to study the effect of temperature and electron density on the interband absorption coefficient and the frequency-dependent refractive index for an array of isolated quantum wires. The peaks in the absorption coefficient correspond to interband transitions resulting in the resonant absorption of light. The oscillations in the derivative spectrum are due to the quantization of the energy levels related to the in-plane confining potential for such reduced dimensional systems. There are appreciable changes in the absorption spectrum when the electron density or temperature is increased. One interband transition peak is suppressed in the high electron density limit and the thermal depopulation effect on the electron subbands can be easily seen when the temperature is high. We also find that the exciton coupling weakens the shoulder features in the absorption spectrum. This study is relevant to optical characterization of the confining potential and the areal density of electrons using photoreflectance. By using incident light with tunable frequencies in the interband excitation regime, contactless photoreflectance measurements may be carried out and the data compared with our calculations. By fitting the numerical results to the peak positions of the photoreflectance spectrum, the number of electrons in each wire may be extracted.


2017 ◽  
Vol 28 (4) ◽  
pp. 759-764 ◽  
Author(s):  
Chen-Guang Wang ◽  
Zhi-Hai Cheng ◽  
Xiao-Hui Qiu ◽  
Wei Ji

Molecules ◽  
2017 ◽  
Vol 22 (11) ◽  
pp. 1940 ◽  
Author(s):  
Laetitia Nivelle ◽  
Jane Hubert ◽  
Eric Courot ◽  
Nicolas Borie ◽  
Jean-Hugues Renault ◽  
...  

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