scholarly journals MEG-Derived Symptom-Sensitive Biomarkers with Long-Term Test-Retest Reliability

Diagnostics ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 84
Author(s):  
Don Krieger ◽  
Paul Shepard ◽  
Ryan Soose ◽  
Ava Puccio ◽  
Sue Beers ◽  
...  
Keyword(s):  
Psychological Health ◽  
Severity Index ◽  
Brief Symptom Inventory ◽  
Good Test ◽  
Retest Reliability ◽  
Linear Classifiers ◽  
Clinical Syndromes ◽  
Test Retest Reliability

Neuroelectric measures derived from human magnetoencephalographic (MEG) recordings hold promise as aides to diagnosis and treatment monitoring and targeting for chronic sequelae of traumatic brain injury (TBI). This study tests novel MEG-derived regional brain measures of tonic neuroelectric activation for long-term test-retest reliability and sensitivity to symptoms. Resting state MEG recordings were obtained from a normative cohort (CamCAN, baseline: n = 613; mean 16-month follow-up: n = 245) and a chronic symptomatic TBI cohort (TEAM-TBI, baseline: n = 62; mean 6-month follow-up: n = 40). The MEG-derived neuroelectric measures were corrected for the empty-room contribution using a random forest classifier. The mean 16-month correlation between baseline and 16-month follow-up CamCAN measures was 0.67; test-retest reliability was markedly improved in this study compared with previous work. The TEAM-TBI cohort was screened for depression, somatization, and anxiety with the Brief Symptom Inventory and for insomnia with the Insomnia Severity Index and was assessed via adjudication for six clinical syndromes: chronic pain, psychological health, and oculomotor, vestibular, cognitive, and sleep dysfunction. Linear classifiers constructed from the 136 regional measures from each TEAM-TBI cohort member distinguished those with and without each symptom, p < 0.0003 for each, i.e., the tonic regional neuroelectric measures of activation are sensitive to the presence/absence of these symptoms and clinical syndromes. The novel regional MEG-derived neuroelectric measures obtained and tested in this study demonstrate the necessary and sufficient properties to be clinically useful, i.e., good test-retest reliability, sensitivity to symptoms in each individual, and obtainable using automatic processing without human judgement or intervention.

scholarly journals Symptom-Dependent Changes in MEG-Derived Neuroelectric Brain Activity in Traumatic Brain Injury Patients with Chronic Symptoms

2021 ◽  
Vol 9 (2) ◽  
pp. 20
Author(s):  
Don Krieger ◽  
Paul Shepard ◽  
Ryan Soose ◽  
Ava M. Puccio ◽  
Sue Beers ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Activity ◽  
Severity Index ◽  
Brief Symptom Inventory ◽  
Good Test ◽  
Retest Reliability ◽  
Test Retest Reliability

Neuroelectric measures derived from human magnetoencephalographic (MEG) recordings hold promise as aides to diagnosis and treatment monitoring and targeting for chronic sequelae of traumatic brain injury (TBI). This study tests novel MEG-derived regional brain measures of tonic neuroelectric activation for long-term test-retest reliability and sensitivity to symptoms. Resting state MEG recordings were obtained from a normative cohort, Cambridge Centre for Ageing and Neuroscience (CamCAN), baseline: n = 619; mean 16-month follow-up: n = 253) and a chronic symptomatic TBI cohort, Targeted Evaluation, Action and Monitoring of Traumatic Brain Injury (TEAM-TBI), baseline: n = 64; mean 6-month follow-up: n = 39). For the CamCAN cohort, MEG-derived neuroelectric measures showed good long-term test-retest reliability for most of the 103 automatically identified stereotypic regions. The TEAM-TBI cohort was screened for depression, somatization, and anxiety with the Brief Symptom Inventory and for insomnia with the Insomnia Severity Index. Linear classifiers constructed from the 103 regional measures from each TEAM-TBI cohort member distinguished those with and without each symptom, with p < 0.01 for each—i.e., the tonic regional neuroelectric measures of activation are sensitive to the presence/absence of these symptoms. The novel regional MEG-derived neuroelectric measures obtained and tested in this study demonstrate the necessary and sufficient properties to be clinically useful—i.e., good test-retest reliability, sensitivity to symptoms in each individual, and obtainable using automatic processing without human judgement or intervention.

Screening for Neurocognitive Impairment in Pediatric Cancer Long-Term Survivors

2008 ◽  
Vol 26 (25) ◽  
pp. 4138-4143 ◽  
Author(s):  
Kevin R. Krull ◽  
M. Fatih Okcu ◽  
Brian Potter ◽  
Neelam Jain ◽  
ZoAnn Dreyer ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Screening Method ◽  
Reliability And Validity ◽  
Parent Rating ◽  
Good Test ◽  
Validity Data ◽  
Retest Reliability ◽  
Test Retest Reliability

Purpose Recent studies suggest that up to 40% of childhood cancer survivors may experience neurocognitive problems, a finding that has led the Children's Oncology Group to recommend regular evaluation. However, for a variety of reasons, including costs, time restraints, health insurance, and access to professional resources, these guidelines are often difficult to implement. We report reliability and validity data on a brief neurocognitive screening method that could be used to routinely screen patients in need of comprehensive follow-up. Patients and Methods Two hundred forty consecutive patients were screened during their annual visits to a long-term survivor clinic using standard neurocognitive measures and brief parent rating. From this total, 48 patients had a second screening, and 52 patients had a comprehensive follow-up evaluation. Test-retest reliability and predictive and discriminative validity were examined. Results Good test-retest reliability was demonstrated, with an overall r = 0.72 and all individual subtest correlations greater than r = 0.40. Although means tended to improve from first to second testing, no significant changes were detected (all P > .10). The screen accurately predicted global intellect (F6,45 = 11.81, P < .0001), reading skills (F6,45 = 4.74, P < .001), and mathematics (F6,45 = 3.35, P < .008). Parent rating was a marginal indicator of global intellect only. Conclusion The brief neurocognitive screening was a better predictor of child functioning than specific parent rating. This brief measure, which can be completed in 30 minutes, is a practical and reliable method to identify cancer survivors in need of further neurocognitive follow-up.

Test-Retest Reliability of the Frankfurt Complaint Questionnaire

2011 ◽  
Vol 108 (2) ◽  
pp. 503-506 ◽  
Author(s):  
Gwenolé Loas ◽  
Valerie Yon ◽  
Jean Louis Monestès ◽  
Manuel J. Cuesta
Keyword(s):  
Spanish Version ◽  
Subjective Experiences ◽  
Retest Reliability ◽  
French Version ◽  
Follow Up Studies ◽  
Test Retest Reliability

Long-term reliability of the Frankfurt Complaint Questionnaire (FCQ) was investigated in two follow-up studies of participants with psychosis using a test-retest method. In the first study ( N = 56), the duration of the follow-up ranged from 6 months to 2 years; Spearman rho was .62 for the abridged (18 items) Spanish version of the questionnaire. In Study 2 ( N = 21), in participants with stable schizophrenia, the follow-up ranged from 8 to 11 years; test-retest Spearman rho was .83 for the French version of the questionnaire. Subjective experiences could constitute, in psychosis-prone people, traits or markers of psychotic vulnerability.

scholarly journals E-Cigarette Demand: Impact of Commodity Definitions and Test–Retest Reliability

2020 ◽  
Author(s):  
Justin C Strickland ◽  
Olga A Vsevolozhskaya ◽  
William W Stoops
Keyword(s):  
Effect Size ◽  
Discriminant Validity ◽  
Good Test ◽  
Retest Reliability ◽  
Cigarette Demand ◽  
Convergent And Discriminant Validity ◽  
Human Participants ◽  
Puff Intensity ◽  
Test Retest Reliability

Abstract Introduction Behavioral economic demand provides a multidimensional understanding of reinforcement. Commodity purchase tasks are an efficient method for measuring demand in human participants. One challenge in translating these procedures to electronic nicotine delivery systems (ENDS or e-cigarettes) is defining commodity units given the lack of standardization in the e-cigarette marketplace. Aims and Methods The purpose of this study was to directly compare methods of operationalizinge-cigarette purchases, puffs, cartridges, and mLs liquid, using a within-subject design. Participants (N = 132) reporting past week e-cigarette use were recruited using crowdsourcing. Purchase tasks were completed operationalizing e-cigarette units as puffs or cartridges at baseline and puffs or mLs liquid at a 3-month follow-up. Results Bivariate associations supported convergent and discriminant validity with the largest effect size correlations for intensity and elasticity observed for the puff version. Interaction models suggested that product preferences moderated the relationship between time-to-first use and cartridge demand with larger effect size correlations among persons reporting a preference for JUULs, but weaker relationships among persons reporting other device preferences. Puff intensity (rxx = .61) and elasticity (rxx = .62) showed good test–retest reliability for participants reporting stable consumption, but poor test–retest reliability for individuals with changed consumption levels (intensity rxx = −.08; elasticity rxx = −.10). Conclusions This study highlights the relevance of commodity definitions in the e-cigarette purchase task. Puffs as an experimental commodity may provide flexibility for studying e-cigarette demand in heterogenous or unknown populations, whereas more tailored or personalized approaches like cartridge or mL-based tasks will likely be helpful when studying known subgroups. Implications The commodity purchase task procedure is widely used for understanding cigarette and e-cigarette demand in nicotine dependence research. This study evaluates the importance of operational definitions of e-cigarette commodities in the purchase task (ie, puffs, cartridges, or mLs liquid). Puffs may provide a more flexible commodity unit when evaluating e-cigarette demand in general or heterogenous populations, whereas device-specific units may prove more valuable when studying populations with consistent and known product use.

scholarly journals Test-Retest Reliability of Homeostatic Plasticity in the Human Primary Motor Cortex

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Tribikram Thapa ◽  
Siobhan M. Schabrun
Keyword(s):  
Motor Cortex ◽  
Brain Stimulation ◽  
Primary Motor Cortex ◽  
Homeostatic Plasticity ◽  
Anodal Tdcs ◽  
Noninvasive Brain Stimulation ◽  
Retest Reliability ◽  
Test Retest Reliability

Homeostatic plasticity regulates synaptic activity by preventing uncontrolled increases (long-term potentiation) or decreases (long-term depression) in synaptic efficacy. Homeostatic plasticity can be induced and assessed in the human primary motor cortex (M1) using noninvasive brain stimulation. However, the reliability of this methodology has not been investigated. Here, we examined the test-retest reliability of homeostatic plasticity induced and assessed in M1 using noninvasive brain stimulation in ten, right-handed, healthy volunteers on days 0, 2, 7, and 14. Homeostatic plasticity was induced in the left M1 using two blocks of anodal transcranial direct current stimulation (tDCS) applied for 7 min and 5 min, separated by a 3 min interval. To assess homeostatic plasticity, 15 motor-evoked potentials to single-pulse transcranial magnetic stimulation were recorded at baseline, between the two blocks of anodal tDCS, and at 0 min, 10 min, and 20 min follow-up. Test-retest reliability was evaluated using intraclass correlation coefficients (ICCs). Moderate-to-good test-retest reliability was observed for the M1 homeostatic plasticity response at all follow-up time points (0 min, 10 min, and 20 min, ICC range: 0.43–0.67) at intervals up to 2 weeks. The greatest reliability was observed when the homeostatic response was assessed at 10 min follow-up (ICC>0.61). These data suggest that M1 homeostatic plasticity can be reliably induced and assessed in healthy individuals using two blocks of anodal tDCS at intervals of 48 hours, 7 days, and 2 weeks.

Short-term and long-term test-retest reliability of the Nasality Severity Index 2.0

2016 ◽  
Vol 62 ◽  
pp. 1-11 ◽  
Author(s):  
Kim Bettens ◽  
Floris L. Wuyts ◽  
Evelien D’haeseleer ◽  
Anke Luyten ◽  
Iris Meerschman ◽  
...  
Keyword(s):  
Severity Index ◽  
Short Term ◽  
Retest Reliability ◽  
Test Retest Reliability

Test–Retest Reliability of Social Cognition Screening Questionnaire–Taiwan Version in People With Schizophrenia

2021 ◽  
Vol 75 (Supplement_2) ◽  
pp. 7512500023p1-7512500023p1
Author(s):  
Shu-Chun Lee ◽  
Yi-Ching Wu ◽  
David Leland Roberts ◽  
Kuang-Pei Tseng ◽  
Wen-Yin Chen
Keyword(s):  
Social Cognition ◽  
Random Measurement Error ◽  
Good Test ◽  
Retest Reliability ◽  
Screening Questionnaire ◽  
The Core ◽  
Random Measurement ◽  
The Social ◽  
Test Retest Reliability ◽  
Multiple Domains

Abstract Date Presented 04/19/21 The Social Cognition Screening Questionnaire–Taiwan version (SCSQT) was designed to assess multiple domains of social cognition in people with schizophrenia in Taiwan. The SCSQT contains five subscales and provides estimates of the core domains of mentalizing and social perception and an overall social cognition score. Our validation of SCSQT indicated that the SCSQT had good test–retest reliability, acceptable random measurement error, and negligible practice effects. Primary Author and Speaker: Shu-Chun Lee Additional Authors and Speakers: Trudy Mallinson Contributing Authors: Alison M. Cogan, Ann Guernon, Katherine O'Brien, and Piper Hansen

Developing a measure to assess clinicians’ ability to reflect on key staff–patient dynamics in forensic settings

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Adam Polnay ◽  
Helen Walker ◽  
Christopher Gallacher
Keyword(s):  
Reflective Practice ◽  
Factor Structure ◽  
Internal Consistency ◽  
Self Report ◽  
Face Validity ◽  
Good Test ◽  
Data Set ◽  
Retest Reliability ◽  
Content Type ◽  
Test Retest Reliability

Purpose Relational dynamics between patients and staff in forensic settings can be complicated and demanding for both sides. Reflective practice groups (RPGs) bring clinicians together to reflect on these dynamics. To date, evaluation of RPGs has lacked quantitative focus and a suitable quantitative tool. Therefore, a self-report tool was designed. This paper aims to pilot The Relational Aspects of CarE (TRACE) scale with clinicians in a high-secure hospital and investigate its psychometric properties. Design/methodology/approach A multi-professional sample of 80 clinicians were recruited, completing TRACE and attitudes to personality disorder questionnaire (APDQ). Exploratory factor analysis (EFA) determined factor structure and internal consistency of TRACE. A subset was selected to measure test–retest reliability. TRACE was cross-validated against the APDQ. Findings EFA found five factors underlying the 20 TRACE items: “awareness of common responses,” “discussing and normalising feelings;” “utilising feelings,” “wish to care” and “awareness of complicated affects.” This factor structure is complex, but items clustered logically to key areas originally used to generate items. Internal consistency (α = 0.66, 95% confidence interval (CI) = 0.55–0.76) demonstrated borderline acceptability. TRACE demonstrated good test–retest reliability (intra-class correlation = 0.94, 95% CI = 0.78–0.98) and face validity. TRACE indicated a slight negative correlation with APDQ. A larger data set is needed to substantiate these preliminary findings. Practical implications Early indications suggested TRACE was valid and reliable, suitable to measure the effectiveness of reflective practice. Originality/value The TRACE was a distinctive measure that filled a methodological gap in the literature.

The TAPS Project. 9: The Reliability of the Patient Attitude Questionnaire

1993 ◽  
Vol 162 (S19) ◽  
pp. 25-29 ◽  
Author(s):  
Graham Thornicroft ◽  
Christopher Gooch ◽  
Catherine O'Driscoll ◽  
Sawsan Reda
Keyword(s):  
Living Arrangements ◽  
Psychiatric Patients ◽  
Kappa Coefficient ◽  
Attitudinal Change ◽  
Attitude Questionnaire ◽  
Retest Reliability ◽  
Patient Attitude ◽  
The Mean ◽  
Test Retest Reliability

The development of the hospital and community versions of the Patient Attitude Questionnaire is described. The instrument rates the attitudes of psychiatric patients towards their treatment settings and staff, and is framed specifically to assess attitudinal change during the transfer of patients from hospital. For the items rated using the kappa coefficient of agreement, the mean test-retest reliability value was 0.51, and the average inter-rater value was 0.82. This study shows that long-term psychiatric patients are able to give clear and consistent views about their living arrangements - views that should be sought and respected by staff.

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