scholarly journals The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes

Diagnostics ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 105 ◽  
Author(s):  
Magdalena Kołodziej ◽  
Arleta Waszczykowska ◽  
Irmina Korzeniewska-Dyl ◽  
Aleksandra Pyziak-Skupien ◽  
Konrad Walczak ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Ganglion Cells ◽  
Control Group ◽  
Study Group ◽  
Fiber Layer ◽  
Preclinical Phase ◽  
Gender And Age ◽  
Disc Area ◽  
Lower Disc

The aim of the study was to analyze the thickness of individual retinal layers in patients with type 1 diabetes (T1D) in comparison to the control group and in relation to markers of diabetes metabolic control. The study group consisted of 111 patients with an average of 6-years of T1D duration. The control group included 36 gender- and age-matched individuals. In all patients optical coherence tomography (OCT) study was performed using HD-OCT Cirrus 5000 with evaluation of optic nerve head (ONH) parameters, thickness of retinal nerve fiber layer (RNFL) with its quadrants, macular full-thickness parameters, ganglion cells with inner plexus layer (GCIPL) and choroidal thickness (CT). Lower disc area value was observed in the study group as compared to controls (p = 0.0215). Negative correlations were found both between age at examination and rim area (R = −0.28, p = 0.0007) and between superior RNFL thickness and duration of diabetes (R = −0.20, p = 0.0336). Positive correlation between center thickness and SD for average glycemia (R = 0.30, p = 0.0071) was noted. Temporal CT correlated positively with age at examination (R = 0.21, p = 0.0127). The selected parameters the HD-OCT study may in the future serve as potential markers of preclinical phase of DR in patients with T1D.

scholarly journals Measurement of corneal thickness, optic nerve sheath diameter and retinal nerve fiber layer as potential new non-invasive methods in assessing a risk of cerebral edema in type 1 diabetes in children

2018 ◽  
Vol 55 (12) ◽  
pp. 1295-1301 ◽  
Author(s):  
Krzysztof Jeziorny ◽  
Anna Niwald ◽  
Agnieszka Moll ◽  
Katarzyna Piasecka ◽  
Aleksandra Pyziak-Skupien ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Optic Nerve ◽  
Corneal Thickness ◽  
Optic Nerve Sheath Diameter ◽  
Study Group ◽  
Newly Diagnosed ◽  
Fiber Layer ◽  
Non Invasive ◽  
Nerve Sheath

Abstract Aims Some patients with diabetic ketoacidosis develop cerebral edema (CE) in the course of type 1 diabetes mellitus (T1D), which may result in central nervous system disorders and high mortality. The imperfection of existing neuroimaging techniques for early recognition of CE forces us to search for the new and non-invasive methods. The aim of the study was to assess the usefulness of new methods (pachymetry, transorbital ultrasonography—USG, optical coherence tomography—OCT study) in the assessment of the risk of CE occurrence in children with newly diagnosed T1D. Methods The study group included 50 children with newly diagnosed T1D, 54 patients with long-term T1D as a reference group and 40 children without glucose tolerance disorders as controls. In all subjects, a corneal thickness (CCT) index with pachymeter, optic nerve sheath diameter (ONSD) using transorbital USG and retinal nerve fiber layer (RNFL) during OCT study were measured and compared with selected clinical parameters of T1D. Results In patients from a study group at onset of T1D, the higher CCT (p < 0.001) and ONSD (p < 0.001) values were observed as compared to the results obtained after 48 h of metabolic compensation. The ONSD correlated negatively with pH value (r = − 0.64; p < 0.001), BE (r = − 0.54, p < 0.001) and HCO3− (r = − 0.50; p < 0.001). A positive correlation between RNFL and Na+ levels (r = 0.47; p < 0.005) was also observed. Conclusions Transorbital USG and pachymetry may serve as the potential promising methods for the non-invasive assessment of the increased risk of development of CE in patients with T1D.

Evaluation of Thiol/Disulfide Homeostasis in Pediatric Patients with Diabetic Ketoacidosis

2020 ◽  
Vol 23 (3) ◽  
pp. 185-190
Author(s):  
Mutlu U. Yazıcı ◽  
Ganime Ayar ◽  
Semra Çetinkaya ◽  
Meliksah Keskin ◽  
Ebru Azapağası ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Ketoacidosis ◽  
Measurement Method ◽  
Pediatric Patients ◽  
Demographic Data ◽  
Pediatric Intensive Care ◽  
Control Group ◽  
Gender And Age ◽  
One Year

Aim and Objective: This study aimed to investigate the value of Thiol/Disulfide homeostasis in pediatric diabetic ketoacidosis patients suffering from type 1 diabetes mellitus. Materials and Methods: This study featured children who were diagnosed with diabetic ketoacidosis and who were consecutively admitted to pediatric intensive care within one year of their diagnosis. Thiol/disulfide homeostasis was evaluated in 45 pediatric patients suffering from DKA, as well as 45 healthy controls of parallel gender and age. Thiol/disulfide homeostasis parameters were measured using a novel automated measurement method and the correlation between demographic data and parameters was measured. Results: Pediatric patients were found to have low native thiols, total thiols and disulfide levels with type 1 diabetes after DKA (331.82±106.40, 362.71±113.31, 17.02±5.33 μmol/L, respectively) as compared to the control group (445.08±24.41, 481.21± 28.47, 18.06±5.12 μmol/L, respectively). Conclusion: Thiol/disulfide homeostasis was distorted in pediatric patients with DKA. Furthermore, it was found that they are not likely to return to normal, immediately after treatment.

scholarly journals Assessment of Serum Concentrations of Ghrelin, Obestatin, Omentin-1, and Apelin in Children with Type 1 Diabetes

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Agnieszka Polkowska ◽  
Izabela Szczepaniak ◽  
Artur Bossowski
Keyword(s):  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Disease Duration ◽  
Serum Levels ◽  
The Body ◽  
Control Group ◽  
Study Group ◽  
Newly Diagnosed ◽  
Serum Concentrations

The increasing knowledge on the functions of gastric peptides and adipokines in the body allows the assumption of their major role linking the process of food intake, nutritional status, and body growth, largely through the regulation of glucose metabolism and insulin resistance. The aim of the study was the assessment of serum levels of selected gastric peptides and adipocytokines in children with type 1 diabetes, with respect to the disease duration. The study involved 80 children aged 4–18 years (M/F -37/43). Children with type 1 diabetes (n=46) were compared to the control group (n=34). The study group was divided into 4 subgroups: (I) patients with newly diagnosed type 1 diabetes, after an episode of ketoacidosis (n=10), (II) patients with type 1 diabetes of duration no longer than 5 years (n=9), (III) patients with 5 to 10 years of DT1 (n=20), and (IV) patients with type 1 diabetes of duration longer than 10 years (n=7). The concentrations of gastric peptide and adipocytokines across all subgroups were lower than in the control group. The differences were statistically significant (p<0.0001), which may be of importance in the development of the disease complications.

scholarly journals Serum Osteoprotegrin, Total Srankl and Their Determinants in Adolescents with Type 1 Diabetes

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Type 1 Diabetes ◽  
Metabolic Control ◽  
Nuclear Factor Κb ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Study Group ◽  
Clinical Factors ◽  
Significant Difference ◽  
Control Of Diabetes

Aim: The aim of the study was to evaluate the levels of osteoprotegerin (OPG), receptor activator of nuclear factor –κB ligand (s-RANKL), OPG/sRANKL ratio and sRANKL/OPG ratio in adolescent patients with type 1 diabetes mellitus (T1DM), and to assess their correlation with the following factors: patients’ gender, age, metabolic control, age of the diagnosis and duration of the disease. Patients and Methods: 60 T1DM patients (32 girls and 28 boys, mean±SD age: 15.0±1.9 years, diabetes duration: 5.1±3.9 years, age of the diagnosis: 9.9±3.9 years, HbA1c: 7.9±1.4%) and 18 healthy matched controls were included. Osteoprotegerin and total sRANKL (free and bound sRANKL) were measured by ELISA (enzyme-linked immunosorbent assay). Results: There were no statistically significant differences in serum OPG levels between patients and controls (51.56±12.05 vs. 50.98±13.55pmol/L, p=0.84. No correlation betweengender and OPG levels both in the study and control group has been reported, although OPG levels were significantly lower in diabetic boys (2.59±0.67 pmol/L) than in control boys (3.30±1.01 pmol/l) (p = 0.031). Tetryl analysis (qualifications) dependent on OPG levels has demonstrated statistically significant correlation between the study group and clinical factors such as: gender, age of the diagnosis and duration of the disease, but not with the age. Only the tendency toward correlation between OPG and metabolic control of diabetes (p=0.093) has been observed. No statistically significant differences in sRANKL levels between the study group and controls has been identified. In patients with T1DM no correlation between RANKL levels and clinical factors such as gender, duration of the disease, age of the diagnosis and metabolic control has been reported. Only negative correlation between RANKL level and patients’ age (p = 0.002) has been observed. No correlationbetween OPG and RANKL levels has been demonstrated. No statistically significant differences in OPG/RANKL ratios between the study group and controls has been reported, the only significant difference in these ratios was observed between control females and males (p = 0.019), but not in the study group. A positive correlation between OPG/RANKL ratio and OPG level with the age has been demonstrated in the study group.

Features of the ovarian reserve of women of reproductive age suffering from autoimmune diseases

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (5) ◽  
pp. 27-30
Author(s):  
Elena N. Andreeva ◽  
Olga R. Grigoryan ◽  
Yulia S. Absatarova ◽  
Irina S. Yarovaya ◽  
Robert K. Mikheev
Keyword(s):  
Type 1 Diabetes ◽  
Thyroid Gland ◽  
Autoimmune Diseases ◽  
Ovarian Reserve ◽  
Reproductive Potential ◽  
Reproductive Age ◽  
Control Group ◽  
Antithyroid Antibodies ◽  
Healthy Women

The reproductive potential of a woman depends on indicators of the ovarian reserve, such as the anti-Muller hormone (AMH) and the number of antral follicles (NAF). Autoimmune diseases have a significant effect on fertility and contribute to the development of premature ovarian failure. Aim.To evaluate the parameters of the ovarian reserve in patients with type 1 diabetes mellitus, carriers of antibodies to the thyroid gland in a state of euthyroidism and compare them with similar parameters in healthy women. Materials and methods.In the first block of the study, the level of AMH, follicle-stimulating hormone, luteinizing hormone, NAF was studied among 224 women with diabetes and 230 healthy women in the control group. In block II, the level of the above hormonal indices was studied in 35 carriers of antithyroid antibodies in the state of euthyroidism and 35 healthy women. Results.In patients with type 1 diabetes, the level of AMH, NAF was statistically significantly lower when compared with the control group. Among carriers of antithyroid antibodies and healthy women, no difference in AMH and NAF was found. Conclusion.The autoimmune processes accompanying diabetes are more influenced by the ovarian reserve indices than autoimmune aggression to the tissues of the thyroid gland.

scholarly journals One repeated transplantation of allogeneic umbilical cord mesenchymal stromal cells in type 1 diabetes: an open parallel controlled clinical study

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jing Lu ◽  
Shan-mei Shen ◽  
Qing Ling ◽  
Bin Wang ◽  
Li-rong Li ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Stromal Cells ◽  
Treated Group ◽  
Control Group ◽  
Adult Onset ◽  
Β Cell ◽  
Juvenile Onset ◽  
C Peptide

Abstract Background The preservation or restoration of β cell function in type 1 diabetes (T1D) remains as an attractive and challengeable therapeutic target. Mesenchymal stromal cells (MSCs) are multipotent cells with high capacity of immunoregulation, which emerged as a promising cell-based therapy for many immune disorders. The objective of this study was to examine the efficacy and safety of one repeated transplantation of allogeneic MSCs in individuals with T1D. Methods This was a nonrandomized, open-label, parallel-armed prospective study. MSCs were isolated from umbilical cord (UC) of healthy donors. Fifty-three participants including 33 adult-onset (≥ 18 years) and 20 juvenile-onset T1D were enrolled. Twenty-seven subjects (MSC-treated group) received an initial systemic infusion of allogeneic UC-MSCs, followed by a repeat course at 3 months, whereas the control group (n = 26) only received standard care based on intensive insulin therapy. Data at 1-year follow-up was reported in this study. The primary endpoint was clinical remission defined as a 10% increase from baseline in the level of fasting and/or postprandial C-peptide. The secondary endpoints included side effects, serum levels of HbA1c, changes in fasting and postprandial C-peptide, and daily insulin doses. Results After 1-year follow-up, 40.7% subjects in MSC-treated group achieved the primary endpoint, significantly higher than that in the control arm. Three subjects in MSC-treated group, in contrast to none in control group, achieved insulin independence and maintained insulin free for 3 to 12 months. Among the adult-onset T1D, the percent change of postprandial C-peptide was significantly increased in MSC-treated group than in the control group. However, changes in fasting or postprandial C-peptide were not significantly different between groups among the juvenile-onset T1D. Multivariable logistic regression assay indicated that lower fasting C-peptide and higher dose of UC-MSC correlated with achievement of clinical remission after transplantation. No severe side effects were observed. Conclusion One repeated intravenous dose of allogeneic UC-MSCs is safe in people with recent-onset T1D and may result in better islet β cell preservation during the first year after diagnosis compared to standard treatment alone. Trial registration ChiCTR2100045434. Registered on April 15, 2021—retrospectively registered, http://www.chictr.org.cn/

scholarly journals Glycated haemoglobin variations in paediatric type 1 diabetes: the impact of season, gender and age

2013 ◽  
Vol 103 (4) ◽  
pp. 398-403 ◽  
Author(s):  
L Hanberger ◽  
K Åkesson ◽  
U Samuelsson
Keyword(s):  
Type 1 Diabetes ◽  
Glycated Haemoglobin ◽  
Gender And Age ◽  
The Impact

Autoimmune thyroid disease in patients with anti-GAD positive type 1 diabetes mellitus

Open Medicine ◽  
2009 ◽  
Vol 4 (4) ◽  
pp. 415-422
Author(s):  
Kamile Gul ◽  
Ihsan Ustun ◽  
Yusuf Aydin ◽  
Dilek Berker ◽  
Halil Erol ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Statistical Significance ◽  
Control Group ◽  
Acid Decarboxylase ◽  
Thyroid Peroxidase ◽  
The Difference ◽  
Type 1 Dm

AbstractThe aim of the study was to determine the frequency and titers of anti-thyroid peroxidase (Anti-TPO), anti-thyroglobulin (Anti-TG), and anti-glutamic acid decarboxylase (Anti-GAD) antibodies in Turkish patients with type 1 diabetes mellitus (DM), and to compare the frequency of anti-TPO and anti-TG titers in the presence or absence of anti-GAD. A total of 104 patients including 56 males and 48 females with type 1 DM and their age-, gender-, and body mass index-matched control group, including 31 males and 27 females, 58 cases in total with an age range of 15-50 years, were recruited into this study. In patients with type 1 DM, positive anti-GAD was detected in 30.8% (n=32). In patients with positive anti-GAD, rate of positive anti-TPO was 37.5%; however, in patients with negative anti-GAD, the rate of positive anti-TPO was 9.7% and the difference was statistically significant (p=0.001). In patients with positive anti-GAD, the rate of positive anti-TG was 18.8%. In patients with negative anti-GAD, the rate of positive anti-TG was 2.8%, and the difference between them was statistically significant (p=0.005). In patients with positive and negative anti-GAD, rates of both positive anti-TPO and anti-TG were 15.6% and 1.4%, respectively, with the difference showing statistical significance (p=0.004). Thyroid autoimmunity in type 1 DM patients with positive anti-GAD was apparently higher; therefore, these patients should be followed more frequently and carefully.

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