scholarly journals The Role of Momordica charantia in Resisting Obesity

2019 ◽  
Vol 16 (18) ◽  
pp. 3251 ◽  
Author(s):  
Fan ◽  
Kim ◽  
Choi ◽  
Tang ◽  
Moon
Keyword(s):  
Therapeutic Potential ◽  
Momordica Charantia ◽  
Lipid Lowering ◽  
Bioactive Components ◽  
Scientific Databases ◽  
Advanced Search ◽  
Online Databases ◽  
Health Products ◽  
Excessive Consumption ◽  
Online Library

Momordica charantia (M. charantia), commonly known as bitter gourd, bitter melon, kugua, balsam pear, or karela, is a tropical and sub-tropical vine belonging to the Cucurbitaceae family. It has been used to treat a variety of diseases in the traditional medicine of China, India, and Sri Lanka. Here, we review the anti-obesity effects of various bioactive components of M. charantia established at the cellular and organismal level. We aim to provide links between various bioactive components of M. charantia and their anti-obesity mechanism. An advanced search was conducted on the worldwide accepted scientific databases via electronic search (Google Scholar, Web of Science, ScienceDirect, ACS Publications, PubMed, Wiley Online Library, SciFinder, CNKI) database with the query TS = “Momordica charantia” and “obesity”. Information was also obtained from International Plant Names Index, Chinese Pharmacopoeia, Chinese herbal classic books, online databases, PhD and MSc dissertations, etc. First, studies showing the anti-obesity effects of M. charantia on the cells and on animals were classified. The major bioactive components that showed anti-obesity activities included proteins, triterpenoids, saponins, phenolics, and conjugated linolenic acids. Their mechanisms included inhibition of fat synthesis, promotion of glucose utilization, and stimulation of auxiliary lipid-lowering activity. Finally, we summarized the risks of excessive consumption of M. charantia and the application. Although further research is necessary to explore various issues, this review establishes the therapeutic potential of M. charantia and it is highly promising candidate for the development of anti-obesity health products and medicines.

Capsella bursa-pastoris (L.) Medic: An Insight into its pharmacology, Expository traditional uses and Extensive Phytochemistry

2020 ◽  
Vol 06 ◽  
Author(s):  
Mohd Akbar Dar ◽  
Reyaz Hassan Mir ◽  
Roohi Mohi-ud-din ◽  
Prince Ahad Mir ◽  
Mubashir Hussain Masood ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Therapeutic Potential ◽  
Chemical Constituents ◽  
Scientific Evidence ◽  
Acetylcholinesterase Inhibitor ◽  
Smooth Muscles ◽  
Scientific Databases ◽  
Wide Range ◽  
Pharmacological Potential ◽  
Online Library

Introduction: Capsella bursa-pastoris(L.) Medic is a traditional herb of the genus Capsella with long-standing Pakistan, India, Iraq, Cyprus, Turkey, Iran, Azarbayjan, Europe, Saudi Arabia, China and many other regions of Asian countries ethnomedical records. Preliminary studies from the animal model have provided valuable scientific evidence for its use, also the novel bioactive compounds. Aim: This review aims to summarize the ethnopharmacology, selected scientific evidence on the pharmacological properties and phytochemistry of C. bursa-pastoris(L.) Medic over the past 38 years while identifying potential areas of further development of this herb as an economical adjunct. Methods: The review covers literature pertaining to the evidence based on ethnopharmacology, therapeutic potential, and phytochemistry of C. bursa-pastoris(L.) Medic spanning from 1980 to 2018 available on Non-English journals and English/Non-English- MS worldwide accepted scientific databases via electronic search (Elsevier, Google Scholar, PubMed, Scopus, Springer, Web of Science, Wiley online library) and Ph.D. thesis databases (e.g., CKNI-China, JAIRO-Japan, Shodhganga-India, Myto-Malaysia, etc.) Result: Evidence suggests that the extracts and some compounds from. bursa-pastoris(L.) Medic possesses antimicrobial, anticancer, anti-inflammatory, smooth muscles contraction, infertility, antioxidant, cardiovascular, sedative, hepatoprotective, acetylcholinesterase inhibitor properties. C. bursa-pastoris besides having pharmacological profile have a acceptable nutritional value also due to its novel bioactive compounds such as phytosterols, phenolics, flavonoids, fatty acids, organic acids, peptides, amino acids. Conclusion: Scientific evidence suggests that there is strong pharmacological potential in developing C. bursa-pastoris (L.) Medic as a drug to be used in the treatment of various disorders from antimicrobial to anticancer therapy. C. bursa-pastoris can be a rich source for the advancement of novel drugs to treat many human diseases due to wide range of chemical constituents present in the plant. Various ethno medical uses and phytochemicals responsible for these uses have not been evaluated yet to their fullest.

scholarly journals Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2297
Author(s):  
Faisal Omar ◽  
Abu Montakim Tareq ◽  
Ali M. Alqahtani ◽  
Kuldeep Dhama ◽  
Mohammed Abu Sayeed ◽  
...  
Keyword(s):  
Indole Alkaloids ◽  
Lipid Lowering ◽  
Moderate Activity ◽  
Pharmacological Activities ◽  
Comprehensive Overview ◽  
Scientific Databases ◽  
Lead Compounds ◽  
Indole Compounds ◽  
Pharmacological Potential ◽  
Online Library

Plant-based indole alkaloids are very rich in pharmacological activities, and the indole nucleus is considered to contribute greatly to these activities. This review’s fundamental objective is to summarize the pharmacological potential of indole alkaloids that have been derived from plants and provide a detailed evaluation of their established pharmacological activities, which may contribute to identifying new lead compounds. The study was performed by searching various scientific databases, including Springer, Elsevier, ACS Publications, Taylor and Francis, Thieme, Wiley Online Library, ProQuest, MDPI, and online scientific books. A total of 100 indole compounds were identified and reviewed. The most active compounds possessed a variety of pharmacological activities, including anticancer, antibacterial, antiviral, antimalarial, antifungal, anti-inflammatory, antidepressant, analgesic, hypotensive, anticholinesterase, antiplatelet, antidiarrheal, spasmolytic, antileishmanial, lipid-lowering, antimycobacterial, and antidiabetic activities. Although some compounds have potent activity, some only have mild-to-moderate activity. The pharmacokinetic profiles of some of the identified compounds, such as brucine, mitragynine, 7-hydroxymitragynine, vindoline, and harmane, were also reviewed. Most of these compounds showed promising pharmacological activity. An in-depth pharmacological evaluation of these compounds should be performed to determine whether any of these indoles may serve as new leads.

Phytochemistry, Traditional Uses and Pharmacological properties of Enhydra fluctuans Lour: A Comprehensive Review.

2020 ◽  
Vol 21 ◽  
Author(s):  
Antica Barua ◽  
Muhammad Shaiful Alam ◽  
Md. Junaid ◽  
Yeasmin Akter ◽  
Syeda Samira Afrose ◽  
...  
Keyword(s):  
Sesquiterpene Lactone ◽  
Chemical Constituents ◽  
Phytochemical Analysis ◽  
Microbial Infection ◽  
Scientific Databases ◽  
Traditional Uses ◽  
Cns Depressant ◽  
Isoflavone Glycoside ◽  
Online Library ◽  
Pharmacologically Active

Background: Enhydra fluctuans Lour, a tropical herb, commonly known as helencha or harkuch, belonging to family Asteraceae, and is an edible semi-aquatic herbaceous vegetable plant with serrate leaves, grows commonly in different parts of the world. Enhydra fluctuans possesses potential pharmacological role against inflammation, cancer, diarrhea, microbial infection, diabetes, and so on. Aim of the review: This review aims to provide the most current information on the botanical characterization, distribution, traditional uses, chemical constituents, as well as the pharmacological activities of Enhydra fluctuans Lour. Materials and methods: The recently updated information on Enhydra fluctuans was gathered from scientific journals, books, and worldwide accepted scientific databases via a library and electronic search (PubMed, Elsevier, Google Scholar, Springer, Scopus, Web of Science, Wiley online library. All of the full-text articles and abstracts related to Enhydra were screened. The most important and relevant articles were carefully chosen for study in this review. Results: Crude extracts and isolated compounds of Enhydra fluctuans Lour has been reported pharmacologically active against cytoprotective, analgesic and anti-inflammatory, antimicrobial, anticancer, anti-diarrhoeal, antihelmintic, CNS depressant, hepatoprotective, thrombolytic, antidiabetic, anti-oxidant, phagocytic and cytotoxic, and neuroprotective potential activities. Discussion: Phytochemical analysis from different studies has reported Germacranolide, Sesquiterpene lactone, Flavonoid, Essential oil, Steroid, Diterpenoid, Melampolide, Sesquiterpene lactone, Isoflavone glycoside as major compounds of Enhydra fluctuans Lour. Conclusions: However, more research is important to explore the mode of action of bioactive components of the plant and its therapeutic capabilities.

Placental Therapy as Panacea: An Insight to Its Therapeutic Potential

2020 ◽  
Vol 06 ◽  
Author(s):  
Sayed Md Mumtaz ◽  
Madhu Gupta ◽  
Ramesh K. Goyal
Keyword(s):  
Tissue Regeneration ◽  
Therapeutic Potential ◽  
Biologically Active ◽  
Bioactive Components ◽  
Biochemical Mechanisms ◽  
Clinically Significant ◽  
Available Information ◽  
Clinical Potential ◽  
Placental Extract

Abstract:: The placenta that maintains and regulates the growth of fetus, consists of various biological treasures nutrients such as cytomedines, vitamins, trace elements, amino acids, peptides, growth factors and other biologically active constituents. Their therapeutic usefulness can well define in the terms of biochemical mechanisms of various components present in it. Biomedical waste derived extract is also a panacea for treatment of various diseases. Placental therapy has been reported specifically to have potent action on recovery of diseases and tissue regeneration. Placental bioactive components and their multi targeting identity prompted us to compile the précised information on placental extract products. However, some findings are needed to be explored by scientific community to prove their clinical potential with clinically significant statistical conclusions. In the light of available information and the usefulness of the placental extract, it is necessary for the development of various formulations for various unmet meet for the treatment as well as access their adverse effects as well as contradictions and precisely evaluated in the short and in the long-term periods.

Wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) extract and its bioactive components suppress Propionibacterium acnes-induced inflammation

2012 ◽  
Vol 135 (3) ◽  
pp. 976-984 ◽  
Author(s):  
Chin Hsu ◽  
Tsung-Hsien Tsai ◽  
You-Yi Li ◽  
Wen-Huey Wu ◽  
Ching-Jang Huang ◽  
...  
Keyword(s):  
Propionibacterium Acnes ◽  
Momordica Charantia ◽  
Bitter Melon ◽  
Bioactive Components

Stakeholder identification and classification: a sustainability marketing perspective

2016 ◽  
Vol 39 (1) ◽  
pp. 35-61 ◽  
Author(s):  
Vinod Kumar ◽  
Zillur Rahman ◽  
A. A. Kazmi
Keyword(s):  
Future Research ◽  
Relevant Research ◽  
Research Papers ◽  
Content Type ◽  
Classification Schemes ◽  
Simplified Approach ◽  
Stakeholder Identification ◽  
Advanced Search ◽  
Online Databases ◽  
The Subject

Purpose – This paper aims to review the literature on stakeholder identification and classification related to sustainability marketing from 1998 to 2012 and provides a generalized approach to stakeholder identification and classification in the field of sustainability marketing. Design/methodology/approach – Beginning with brief introductions of the key concepts, the research discusses landmark studies on the subject in detail. The review process then begins by identifying and selecting relevant research papers from various online databases. Finally, 60 research papers are found suitable for the review and are examined to theoretically analyze the stakeholder identification and classification schemes used in sustainability marketing literature. Findings – This study identifies trends of growth in stakeholder identification and classification literature. In addition, there are two major findings. First, stakeholder identification can be done with the help of previous studies, with support from managers or via a combination of both. Second, future research can adopt generic stakeholder classification schemes or relative classification schemes based on dimensions of sustainability to classify stakeholders in relation to sustainability marketing. In relative stakeholder classification, regulatory stakeholders may be considered separately. Research limitations/implications – While the literature review may be incomplete, as it uses only a title-based advanced search, researchers and practitioners can still benefit from this simplified approach to manage stakeholders. Originality/value – The study introduces a generalized approach to stakeholder identification and classification related to sustainability marketing and provides a bibliography from 1998 to 2012 that can be used by academics and managers.

scholarly journals Characteristics of Selected Antioxidative and Bioactive Compounds in Meat and Animal Origin Products

Antioxidants ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 335 ◽  
Author(s):  
Bartosz Kulczyński ◽  
Andrzej Sidor ◽  
Anna Gramza-Michałowska
Keyword(s):  
Nutritional Value ◽  
Bioactive Peptides ◽  
Meat Products ◽  
Lipid Lowering ◽  
Animal Origin ◽  
Accurate Information ◽  
Immunomodulatory Activity ◽  
Bioactive Components ◽  
Health Promoting ◽  
Complexes With Metal Ions

Meat and meat products have a high nutritional value. Besides major components, meat is rich in bioactive components, primarily taurine, l-carnitine, choline, alpha-lipoic acid, conjugated linoleic acid, glutathione, creatine, coenzyme Q10 and bioactive peptides. Many studies have reported their antioxidant and health-promoting properties connected with their lipid-lowering, antihypertensive, anti-inflammatory, immunomodulatory activity and protecting the organism against oxidative stress. The antioxidant activity of meat components results, among others, from the capability of scavenging reactive oxygen and nitrogen species, forming complexes with metal ions and protecting cells against damage. This review is focused to gather accurate information about meat components with antioxidant and biological activity.

Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

Planta Medica ◽  
2020 ◽  
Author(s):  
Deise Cristina Drummond Xavier Paes Lopes ◽  
Temistocles Barroso de Oliveira ◽  
Alessandra Lifsitch Viçosa ◽  
Simone Sacramento Valverde ◽  
Eduardo Ricci Júnior
Keyword(s):  
Web Of Science ◽  
Citation Index ◽  
Therapeutic Potential ◽  
Inflammatory Activity ◽  
Traditional Use ◽  
Scientific Databases ◽  
Research And Innovation ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Patent Survey

AbstractCompositae is the largest family of flowering plants, with more than 1600 genera and 22 000 species. It has many economic uses in foods, cosmetics, and pharmaceutics. The literature reports its numerous medicinal benefits and recognized anti-inflammatory activity. Thus, this study evaluated the technological trends of anti-inflammatory activity of Compositae, based on the survey of scientific databases, articles, and patents, as well as the website of the Brazilian National Health Regulatory Agency (ANVISA), which is responsible for registering and controlling of healthcare and cosmetic products in the Brazil. The survey was conducted between 2008 and 2018, in the databases Science Direct, Lilacs, PubMed, and Web of Science (main collection), as well as the SciELO Citation Index. The patent survey was carried out on the basis of the Derwent Innovations Index, an important source for worldwide patent consultation, which covers 20 y of registered patents. Despite the numerous studies involving species of the Compositae family in different models of anti-inflammatory activity, there are few records of patents or products on the market from these species for that purpose. Some species have a traditional use and are present even in the Phytotherapic Summary of the Brazilian Pharmacopeia. This review confirms the therapeutic potential of Compositae for the development of anti-inflammatory drugs and reinforces the need to develop competencies and reduce technological bottlenecks to promote research and innovation in biodiversity products.

scholarly journals Metformin Ameliorates Ethanol-Induced Liver Triglyceride Accumulation by LKB1/AMPK/ACC Pathway

2021 ◽  
Author(s):  
Fotian Xie ◽  
Dongmei Wang ◽  
Kwok Fai So ◽  
Jia Xiao ◽  
Yi Lv
Keyword(s):  
Lipid Accumulation ◽  
Therapeutic Potential ◽  
Lipid Lowering ◽  
Liver Triglyceride ◽  
Hepatic Lipid Accumulation ◽  
Triglyceride Accumulation ◽  
Lipid Formation

Abstract Background: Hepatic lipid accumulation is one of the main pathological features of alcoholic liver disease. Metformin is an AMPK activator that has been shown to have lipid lowering effects. The purpose of this study was to investigate whether metformin had a beneficial effect on lipid accumulation in the pathogenesis of ALD.Methods: AML12 cells and male C57BL/6 mice were used to establish ALD models in vitro and in vivo, respectively. The effects of metformin on hepatocyte lipid accumulation and ALD progression in mice were detected. The role of LKB1/AMPK/ACC axis in metformin against ethanol-induced lipid accumulation was evaluated by siRNA and AAV-shRNA interference.Results: Metformin reduced the ethanol-induced lipid accumulation in AML12 cells through activating AMPK/ACC and SREBP1c and inhibiting PPARα. In addition, compared with control mice, metformin treatment inhibited ethanol-induced liver adipose accumulation and the increase of ALT and AST in serum. Interference with LKB1 attenuated the effect of metformin on ethanol-induced lipid accumulation both in vitro and in vivo.Conclusion: Metformin protects against lipid formation in ALD by activating LKB1/AMPK/ACC axis. Thus, metformin has therapeutic potential for the prevention of ALD.

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