Epidemiology of Endometriosis in Spain and Its Autonomous Communities: A Large, Nationwide Study

A retrospective population-based study aimed to assess the incidence of endometriosis in the general population in Spain and in each of its autonomous communities. The authors used the incidence of diagnosed endometriosis in the minimum basic dataset at discharge in the national hospital discharge registry of Spain. This analysis was carried out with hospital data with a diagnosis of endometriosis (International Classification of Diseases (ICD)-9 code 617.xx and ICD-10 code N80.xx) and covered the period from 1 January 2014 to 31 December 2017 and a population of 12,775,911 women of reproductive age (15–54 years). The data were then analyzed at the national level and separately for each autonomous community. This nationwide Spanish study estimated the overall incidence of endometriosis among autonomous communities in Spain to be 16.1 per 10,000 women (range, 6.8 to 24). The mean age of the 20,547 women diagnosed with endometriosis during the study period was 36.8 ± 5.4 years. The types (proportions) of endometriosis were uterine (28.4%), tubo-ovarian (35.2%), peritoneal (8.1%), vesical (6.8%) and intestinal (3.2%) endometriosis. Further studies are needed to assess the reasons for the decrease in the observed incidence and for the significant differences in the regional incidence rates of this disease.

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Links Between Strokes and Hereditary Hemorrhagic Telangiectasia: A Population-Based Study

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/cjn.2018.360 ◽

2018 ◽

Vol 46 (1) ◽

pp. 44-50

Author(s):

Farah N. Chowdhury ◽

G. Sanjaya Chandrarathne ◽

Kristopher D. Masilamani ◽

Jennifer T. N. LaBranche ◽

Shaun Malo ◽

...

Keyword(s):

General Population ◽

Hereditary Hemorrhagic Telangiectasia ◽

Female Gender ◽

International Classification Of Diseases ◽

Population Based ◽

Stroke Subtype ◽

Stroke Incidence ◽

Centre Of Excellence ◽

Classification Of Diseases ◽

Icd 10

AbstractBackgroundHereditary hemorrhagic telangiectasia (HHT) is a disease of abnormal vasculature where patients are predisposed to strokes of multiple etiologies. We assessed yearly stroke incidence among Albertans with HHT and compared with the general population. Given the tendency for stroke in HHT patients, we expected HHT patients to have higher stroke incidence, in particular at younger ages.MethodsPopulation-based administrative health data on inpatient and ambulatory admissions were extracted over a 16-year period using International Classification of Diseases (ICD)-9 and ICD-10, Canada codes. We analyzed overall occurrence of strokes in Alberta by age, gender, stroke subtype, and diagnosis of HHT.ResultsThe age-standardized incidence rate of stroke in HHT was 450 per 100,000 compared with 260 per 100,000 in the general population with a rate ratio of 1.73 (95% confidence interval (CI) [1.046-2.842]). This study found a higher HHT prevalence in Alberta (1 in 3800) compared to the world average of 1 in 5000. Women were also more likely to be diagnosed with HHT, with a 3.25:1 female gender preponderance in the yearly incidence.InterpretationThis study not only shows that HHT patients are at higher risk of having a stroke but also quantifies that risk using an age-adjusted metric in Alberta. This province has a higher than expected disease burden of HHT, with the majority of cases affecting women. Our study found that acute ischemic strokes and transient ischemic attacks are far more common than hemorrhage in HHT. As HHT is a rare, multi-system, chronic disease, these patients should be referred to an HHT Centre of Excellence.

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Symptoms and characteristics of cancer patient visits to an emergency room.

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.15_suppl.e18306 ◽

2019 ◽

Vol 37 (15_suppl) ◽

pp. e18306-e18306

Author(s):

Michael Gallaway ◽

Nimi Idaikkadar

Keyword(s):

Cancer Patients ◽

Acute Care ◽

International Classification Of Diseases ◽

Population Based ◽

P Value ◽

Surveillance Program ◽

Cancer Type ◽

Classification Of Diseases ◽

Icd 10 ◽

Ed Visits

e18306 Background: Cancer patients are increasingly likely to visit an emergency department (ED) for acute care compared to the general population. Cancer patients who visit the ED often have long wait times, increased exposure to infection, and lesser quality treatment. The Centers for Medicare & Medicaid Services (CMS) is encouraging efforts to decrease survivor acute care visits. The purpose of this study was to examine cancer-related ED visits using a national population-based sample to understand why they are seeking care in an ED. Methods: A retrospective cohort study of U.S. patients who visited EDs between June 1, 2017 and May 31, 2018 was conducted using the National Syndromic Surveillance Program (NSSP) BioSense Platform. Cancer patients were identified using International Classification of Diseases, 10th Revision (ICD-10) codes for any cancer type and specifically for cancers of the bladder, female breast, cervix, colon and rectum, kidney, liver, lung, ovary, pancreas, prostate, or uterus. Symptoms were identified using syndromic definitions and key-word queries. Significance testing (p-value ≤0.01), was used to assess differences in the prevalence of symptoms by cancer type. Results: There were 97 million visits to EDs during the study period, 710,297 (0.8%) were among cancer survivors. Slightly more were female (50.1%) than male (49.5%); more were aged 65 or older (53.6%) than 18-64 (1.4-35.3%). The most common symptoms were pain (19%), gastrointestinal (14%), respiratory (12%), neurologic (5%), fever (5%), and injury (4%). Prevalence of symptoms differed significantly by cancer type. Some symptoms were higher among those with specific cancer types compared to all cancers in aggregate: pain (cervical, liver, pancreas); gastrointestinal (pancreas, liver, colorectal); respiratory (lung); neurologic (liver, lung), fever (pancreas, liver), injury (prostate), and bleeding (colorectal, liver). Conclusions: Use of NSSP data enabled a descriptive characterization of more than half of the U.S. ED visits among cancer patients. These comprehensive findings inform best practices to reduce unplanned acute care and help inform possible modifications in treatment and care protocols among survivors of specific cancers.

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Epidemiology and Medication Pattern Change of Psoriatic Diseases in Taiwan from 2000 to 2013: A Nationwide, Population-based Cohort Study

The Journal of Rheumatology ◽

10.3899/jrheum.170516 ◽

2018 ◽

Vol 45 (3) ◽

pp. 385-392 ◽

Cited By ~ 9

Author(s):

James Cheng-Chung Wei ◽

Lin-Hong Shi ◽

Jing-Yang Huang ◽

Xue-Fen Wu ◽

Rui Wu ◽

...

Keyword(s):

Anatomical Therapeutic Chemical ◽

International Classification Of Diseases ◽

Population Based ◽

Incidence Rates ◽

Research Database ◽

Chi Square ◽

Classification Code ◽

Classification Of Diseases ◽

Taiwan National Health Insurance

Objective.To analyze the trend of prevalence and incidence rates for psoriatic arthritis (PsA) and psoriasis in Taiwan, and to determine the changes in medication patterns.Methods.Data were collected from the Taiwan National Health Insurance Research Database, which covered at least 95% of the population from 2000 to 2013. International Classification of Diseases, 9th edition (ICD-9) was used to identify PsA (ICD-9 696.0) and other psoriasis (ICD-9 696.1). Medications were identified by Anatomical Therapeutic Chemical Classification code. We calculated the annual age standardized prevalence and incidence rate of PsA and psoriasis in individuals aged ≥ 16 years from 2000 to 2013, and used the Poisson regression to test the trends by Wald chi-square statistic.Results.The prevalence (per 100,000 population) of psoriatic diseases between 2000 and 2013 increased from 11.12 to 37.75 for PsA, and from 179.2 to 281.5 for psoriasis. The incidence (per 100,000 person-yrs) increased from 3.64 to 6.91 in PsA, while there was no significant change in psoriasis. Prevalence and incidence in PsA were more rapidly increased than in psoriasis. Sex ratio (men to women) of PsA decreased from 2.0 to 1.5 in 2000 and 2013, respectively. There was an increase in the use of disease-modifying antirheumatic drugs (DMARD), especially biologics, which is significantly different from topical therapies.Conclusion.The prevalence and incidence rates of psoriatic disease, especially PsA, were increasing in Taiwan. The medication pattern showed an increase in DMARD and biologics, while use of topical therapies decreased.

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Proteinuria and Psoriasis Risk: A Nationwide Population-Based Study

Journal of Clinical Medicine ◽

10.3390/jcm10112356 ◽

2021 ◽

Vol 10 (11) ◽

pp. 2356

Author(s):

Eun Hui Bae ◽

Bongseong Kim ◽

Su Hyun Song ◽

Tae Ryom Oh ◽

Sang Heon Suh ◽

...

Keyword(s):

International Classification Of Diseases ◽

Population Based ◽

Renal Outcome ◽

Persistent Proteinuria ◽

Inflammatory Dermatosis ◽

Classification Of Diseases ◽

Icd 10 ◽

Stage Renal Disease ◽

End Stage

Psoriasis, a chronic inflammatory dermatosis, has been associated with chronic kidney disease or end-stage renal disease. However, the association of the changes or amount of proteinuria with psoriasis development has not been evaluated. Using the Korean National Health Screening database, we assessed psoriasis development until 2018 in 6,576,851 Koreans who underwent health examinations in 2009 and 2011. Psoriasis was defined using the International Classification of Diseases, 10th revision (ICD-10) code L40. The risk of psoriasis was evaluated according to change in proteinuria (never [Neg (no proteinuria)/Neg], new [Neg/Pos (proteinuria present)], past [Pos/Neg] and persistent [Pos/Pos] proteinuria) and the proteinuria amount. During a median 7.23-year follow-up, 162,468 (2.47%) individuals developed psoriasis. After adjustments, the hazard ratio (HR) for psoriasis was higher in the persistent proteinuria group (1.32 [1.24–1.40]) than in the never proteinuria group. The past proteinuria group showed better renal outcome (1.03 [1.00–1.07]) than the new (1.05 [1.01–1.07]) and never proteinuria (reference, 1.00) groups did. The amount of random urine proteinuria was associated with increased HR for psoriasis. Subgroup analyses for age, sex, estimated glomerular filtration rate (eGFR), hypertension and diabetes showed that the persistent proteinuria group had a higher risk of psoriasis than the never proteinuria group, especially at eGFR < 60 mL/min/1.73 m2. Persistent proteinuria is associated with psoriasis risk, and the proteinuria amount significantly affects psoriasis development.

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Incidence of mental disorders in the population of municipal areas of the Сhelyabinsk region in the remote period after accidental radioactive contamination

Medico-Biological and Socio-Psychological Problems of Safety in Emergency Situations ◽

10.25016/2541-7487-2021-0-1-22-30 ◽

2021 ◽

pp. 22-30

Author(s):

E. Y. Burtovaia ◽

A. V. Akleyev ◽

L. P. Barkovskaia ◽

T. E. Kantina ◽

E. A. Litvinchuk

Keyword(s):

Mental Disorders ◽

Behavioral Disorders ◽

Radioactive Contamination ◽

Descriptive Analysis ◽

International Classification Of Diseases ◽

Incidence Rates ◽

Wide Range ◽

Classification Of Diseases ◽

Icd 10 ◽

Chelyabinsk Region

Relevance. Both Russian and foreign researchers pay attention to the mental disorders in people with a history of accidental radiation exposure. A wide range of mental pathologies have been observed among the Chernobyl NPP clean-up workers, victims of the accident at the Fukushima Daiichi NPP, etc.Intention – To assess primary incidence of mental disorders and behavioral disorders in residents of the municipal areas of the Chelyabinsk region affected by radioactive contamination.Methodology. Primary incidence rates of mental disorders and behavioral disorders (F00–09, F20–99 ICD-10) were assessed for the period from 2005 to 2018 in residents of municipal areas of the Chelyabinsk regions (Kunashaksky, Krasnoarmeysky, Argayashsky, Kaslinsky, Sosnovsky districts) affected by radioactive contamination in 1949–1951 and 1957 as a result of the activities of the “Mayak” production association. These data were compared to that from non-contaminated Etkulsky district with similar population and economic activity. Mental disorders were classified according to the groups of the chapter V “Mental and behavioral disorders” of the International Classification of Diseases of the 10th revision (ICD-10). Incidence was calculated per 10 thousand population (0/000). Descriptive analysis of the registered primary incidence of mental disorders in residents of these districts of the Chelyabinsk region is presented.Results and discussion. The primary incidence rate of mental disorders in the Chelyabinsk region (49.1 ± 3.6) 0/000 significantly (p < 0.001) exceeds those in the Sverdlovsk (30.3 ± 4.2), Kurgan (30.2 ± 6.9) 0/000 regions and overall estimates for the Russian Federation (32.9 ± 3.8) 0/000 . In the remote period, primary incidence rates of mental disorders in the residents of some radioactively contaminated districts were higher vs Etkulsky district, but significantly lower than overall rates in the Chelyabinsk region (p < 0.001). Taking into account the territorial distribution of the exposed residents and their offspring in the Chelyabinsk region, mental retardation in residents of the Kunashak district should be closely monitored.Conclusion. Mental morbidity in areas accidentally contaminated more than 70 years ago now reflects the general trend of deterioration in the mental health of the population of the Chelyabinsk region. It can be assumed that the incidence of mental disorders in the population of the Chelyabinsk region is determined by a constellation of interacting factors (socio-economic, personal-psychological, radiation, informational and others), among which socially determined mechanisms of the mental pathology prevail.

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Benefit packages for chronic disease outpatients in the New Rural Cooperative Medical Scheme in 32 Chinese counties

F1000Research ◽

10.12688/f1000research.2-137.v1 ◽

2013 ◽

Vol 2 ◽

pp. 137

Author(s):

Chuangzhou Xu ◽

Christian A Gericke

Keyword(s):

Chronic Disease ◽

Chronic Diseases ◽

National Level ◽

Analytical Framework ◽

International Classification Of Diseases ◽

World Health ◽

Increased Risk ◽

Classification Of Diseases ◽

Icd 10 ◽

Cooperative Medical Scheme

Introduction: Chronic disease has become a major problem affecting the health of the Chinese population. In response to this situation, the New Rural Cooperative Medical Scheme (NRCMS) has begun to provide health cover for outpatients with chronic disease expenses, made possible by the increased risk pool of previous years. We compare the differences between Benefit Packages for Chronic Diseases Outpatients (BPCDO) in order to produce a reference for policy makers.Methods: Information on the various BPCDO was located by searching the official NRCMS website in Chinese, using certain criteria to select the ideal BPCDO. Population coverage, service coverage and cost of coverage were chosen to form the analytical framework for this paper. The diseases were classified according to the World Health Organisation's (WHO) International Classification of Diseases (ICD-10).Results: To avoid “moral hazard”, complex processes have been created. This has resulted in chronic disease patients finding it very difficult to become beneficiaries. Forty-one types of chronic diseases were listed in 32 different BPCDO. We found that different counties have different co-payment rates, deductible lines, ceilings, coverage of drugs and tests, appointed hospitals and reimbursement frequencies.Conclusion: High mortality diseases and diseases with a heavier cost burden should be the priority on the list of reimbursement. The BPCDO scheme should be introduced urgently at the national level. It should include twenty-one types of disease and eight essential factors.

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Association Between Neonates With Laryngomalacia and Neonatal Abstinence Syndrome

Annals of Otology Rhinology & Laryngology ◽

10.1177/00034894211048278 ◽

2021 ◽

pp. 000348942110482

Author(s):

Elizabeth J. Abraham ◽

David O’Neil Danis ◽

Jessica R. Levi

Keyword(s):

International Classification Of Diseases ◽

Population Based ◽

Withdrawal Symptoms ◽

Neonatal Abstinence Syndrome ◽

Abstinence Syndrome ◽

Classification Of Diseases ◽

Icd 10 ◽

Neonatal Withdrawal ◽

Registry Analysis

Objective: Laryngomalacia (LM) is the most common congenital anomaly of the larynx. The cause of LM is still largely unknown, but a neurological mechanism has gained the most acceptance. There have not been any studies examining the prevalence of LM in infants with Neonatal Abstinence Syndrome (NAS). The aim of our study is to determine if infants with NAS are more likely to be diagnosed with LM. Methods: This study was a population-based inpatient registry analysis. We examined nationwide neonatal discharges in 2016 using the Kids’ Inpatient Database (KID). Only patients listed as neonates were included. The International Classification of Diseases, 10th revision, Clinical Modification (ICD-10-CM) codes for neonatal withdrawal symptoms from maternal use of drugs of addiction (P96.1) and diagnoses denoting LM were used. To quantify associations between the LM and NAS groups, prevalence rates and odds ratios (ORs) were used. Results: There were 3 970 065 weighted neonatal discharges in the 2016 KID. Among patients included in our dataset, 0.809% (32 128) had NAS and 0.075% (2974) had LM. There was an increased odds ratio for neonates with NAS and LM (OR of 2.85, 95% CI = 2.24-3.63) compared to infants without NAS. Multiple logistic regression accounting for possible confounders produced an adjusted OR of 1.68 (95% CI = 1.29-2.19). Conclusion: Our study found an association between NAS and LM. This suggests that prenatal exposure to opioids or possibly the sequelae of withdrawal symptoms may be risk factors for the development of LM.

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Gastrointestinal perforations in patients with rheumatoid arthritis treated with biological disease-modifying antirheumatic drugs in Sweden: a nationwide cohort study

RMD Open ◽

10.1136/rmdopen-2020-001201 ◽

2020 ◽

Vol 6 (2) ◽

pp. e001201 ◽

Cited By ~ 1

Author(s):

Andrei Barbulescu ◽

Bénédicte Delcoigne ◽

Johan Askling ◽

Thomas Frisell

Keyword(s):

Cohort Study ◽

General Population ◽

Treatment Guidelines ◽

International Classification Of Diseases ◽

Incidence Rates ◽

Classification Of Diseases ◽

Icd 10 ◽

Population Controls ◽

Necrosis Factor

ObjectivesTo compare incidence rates of gastrointestinal (GI) perforations between patients with RA and the general population, and between patients treated with tumour necrosis factor inhibitors (TNFi) and non-TNFi biologics.MethodsIn this nationwide cohort study, a total of 63 532 patients with RA, with 26 050 biological treatment episodes (TNFi, rituximab, abatacept or tocilizumab) and 76 304 general population controls, were followed between 2009 and 2017 until the first outcome event. The main outcome was hospitalisation or death due to lower GI perforations, identified according to a prespecified list of ICD-10 (International Classification of Diseases, 10th revision) codes. Inverse probability of treatment weighting was used for adjustment.ResultsThe sex-standardised and age-standardised incidence rates of lower GI perforations were 1.1 (95% CI 1.0 to 1.3) events per 1000 person-years among general population controls, 1.6 (1.5–1.7) among bionaïve patients and ranged from 1.8 (1.4–3.6) (TNFi) to 4.5 (2.7–10.4) (tocilizumab) among biologics-treated patients. After adjustment for glucocorticoid use, the risk in bionaïve, TNFi-treated, abatacept-treated or rituximab-treated patients with RA was no longer different from the general population, while for tocilizumab it remained significantly higher. Comparing tocilizumab to TNFi, the adjusted HR for lower GI perforations was 2.2 (1.3–3.8), corresponding to one additional GI perforation per 451 patient-years treated with tocilizumab instead of TNFi.ConclusionTocilizumab was associated with a higher risk of lower GI perforations compared with alternative biologics. In absolute numbers, the risk remained low on all biologics commonly used to treat RA, but the accumulated evidence across settings and outcome definitions supports that this risk should be considered in treatment guidelines for RA.

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Incidence and Survival Trends of Pancreatic Cancer in Girona: Impact of the Change in Patient Care in the Last 25 Years

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17249538 ◽

2020 ◽

Vol 17 (24) ◽

pp. 9538

Author(s):

Adelaida García-Velasco ◽

Lluís Zacarías-Pons ◽

Helena Teixidor ◽

Marc Valeros ◽

Raquel Liñan ◽

...

Keyword(s):

Pancreatic Cancer ◽

International Classification Of Diseases ◽

Population Based ◽

Incidence Rates ◽

Future Research ◽

Kaplan Meier ◽

Standard Population ◽

European Standard Population ◽

Classification Of Diseases ◽

Incident Cases

(1) Background: We investigated the incidence and survival trends for pancreatic cancer (PC) over the last 25 years in the Girona region, Catalonia, Spain; (2) Methods: Data were extracted from the population-based Girona Cancer Registry. Incident PC cases during 1994–2015 were classified using the International Classification of Diseases for Oncology Third Edition (ICD-O-3). Incidence rates age-adjusted to the European standard population (ASRE) and world standard population (ASRW) were obtained. Trends were assessed using the estimated annual percentage of change (EAPC) of the ASRE13. Observed and relative survivals (RS) were estimated with the Kaplan–Meier and Pohar Perme methods, respectively; (3) Results: We identified 1602 PC incident cases. According to histology, 44.4% of cases were exocrine PC, 4.1% neuroendocrine, and 51.1% malignant-non-specified. The crude incidence rate (CR) for PC was 11.43 cases-per-100,000 inhabitants/year. A significant increase of incidence with age and over the study period was observed. PC overall 5-year RS was 7.05% (95% confidence interval (CI) 5.63; 8.84). Longer overall survival was observed in patients with neuroendocrine tumours (5-year RS 61.45%; 95% CI 47.47; 79.55). Trends in 5-year RS for the whole cohort rose from 3.27% (95% CI 1.69–6.35) in 1994–1998 to 13.1% (95% CI 9.98; 17.2) in 2010–2015; (4) Conclusions: Incidence rates of PC in Girona have increased in the last two decades. There is a moderate but encouraging increase in survival thorough the study period. These results can be used as baseline for future research.

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Multidimensional tracking of phenotypes and organ involvement in a complete nationwide systemic sclerosis cohort

Rheumatology ◽

10.1093/rheumatology/keaa026 ◽

2020 ◽

Vol 59 (10) ◽

pp. 2920-2929 ◽

Cited By ~ 4

Author(s):

Håvard Fretheim ◽

Anne-Kristine Halse ◽

Marit Seip ◽

Helle Bitter ◽

Marianne Wallenius ◽

...

Keyword(s):

Disease Burden ◽

National Level ◽

International Classification Of Diseases ◽

Population Based ◽

Multiple Organ ◽

Organ Involvement ◽

Hypertension Detection ◽

Detection Rates ◽

Level Data ◽

Classification Of Diseases

Abstract Objective SSc is a severe, heterogeneous multi-organ disease where population-based estimates on phenotypic spectrum, overall disease burden and societal impact are largely missing. Here the objective was to provide the first-ever complete national-level data on phenotype and major organ afflictions in SSc. Methods A stepwise strategy was applied to find and characterize every SSc patient resident in Norway from 2000 to 2012. First we identified every case in the country registered with an International Classification of Diseases, Tenth Revision code for SSc (M34). Next we manually reviewed all cases coded as M34 to determine whether they met the 1980 ACR and/or 2013 ACR/EULAR classification criteria for SSc and could be included in the Norwegian SSc cohort (Nor-SSc). Finally, all disease features from SSc onset to study end were reviewed. Results The Nor-SSc cohort included 815 SSc patients. The mean age at diagnosis was 53 years, with 84% females and 77% limited cutaneous SSc. The estimated incidence increased from 4 per million in 2000 to 13 per million in 2012. We identified high cumulative frequencies of internal organ involvement, coexistence of multiple organ afflictions across disease subsets and autoantibody status and stable frequencies of pulmonary arterial hypertension across haemodynamic definitions, but indications of referral-related differences in pulmonary hypertension detection rates across the study area. Conclusion This nationwide cohort study provides new, unbiased evidence for a high disease burden in SSc patients of Caucasian descent and indicates the existence of hurdles preventing equality of assessment across the SSc population.

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