scholarly journals Bioprinting Technology in Skin, Heart, Pancreas and Cartilage Tissues: Progress and Challenges in Clinical Practice

2021 ◽  
Vol 18 (20) ◽  
pp. 10806
Author(s):  
Eleonora Di Piazza ◽  
Elisabetta Pandolfi ◽  
Ilaria Cacciotti ◽  
Andrea Del Fattore ◽  
Alberto Eugenio Tozzi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Clinical Practice ◽  
Additive Manufacturing ◽  
Tissue Type ◽  
Clinical Use ◽  
Manufacturing Technique ◽  
Regulatory Guidelines ◽  
Good Manufacturing Practices ◽  
Wide Gap ◽  
And Cartilage

Bioprinting is an emerging additive manufacturing technique which shows an outstanding potential for shaping customized functional substitutes for tissue engineering. Its introduction into the clinical space in order to replace injured organs could ideally overcome the limitations faced with allografts. Presently, even though there have been years of prolific research in the field, there is a wide gap to bridge in order to bring bioprinting from “bench to bedside”. This is due to the fact that bioprinted designs have not yet reached the complexity required for clinical use, nor have clear GMP (good manufacturing practices) rules or precise regulatory guidelines been established. This review provides an overview of some of the most recent and remarkable achievements for skin, heart, pancreas and cartilage bioprinting breakthroughs while highlighting the critical shortcomings for each tissue type which is keeping this technique from becoming widespread reality.

Scaffolds for tissue engineering produced by inkjet printing

2012 ◽  
Vol 2 (3) ◽  
Author(s):  
Yi Zhang ◽  
Christopher Tse ◽  
Davood Rouholamin ◽  
Patrick Smith
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Inkjet Printing ◽  
Manufacturing Technique ◽  
Production Route ◽  
Different Types

AbstractThis review discusses the use of scaffolds in tissue engineering and summarises the means by which they might be fabricated. The review identifies the main features a scaffold should have, and discusses the progress that has been made towards obtaining these targets. In particular, the review focuses on inkjet printing as a viable production route and discusses why this additive manufacturing technique holds considerable appeal and promise. The article concludes with an overview of the current challenges in this field and reviews the different types of material that can be used for scaffolds.

Regeneration von Knochendefekten mit computergesteuerter Herstellung von Gerüstträgern

2013 ◽  
Vol 22 (03) ◽  
pp. 180-187 ◽  
Author(s):  
J. Henke ◽  
J. T. Schantz ◽  
D. W. Hutmacher
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Custom Made

ZusammenfassungDie Behandlung ausgedehnter Knochen-defekte nach Traumata oder durch Tumoren stellt nach wie vor eine signifikante Heraus-forderung im klinischen Alltag dar. Aufgrund der bestehenden Limitationen aktueller Therapiestandards haben Knochen-Tissue-Engineering (TE)-Verfahren zunehmend an Bedeutung gewonnen. Die Entwicklung von Additive-Manufacturing (AM)-Verfahren hat dabei eine grundlegende Innovation ausgelöst: Durch AM lassen sich dreidimensionale Gerüstträger in einem computergestützten Schichtfür-Schicht-Verfahren aus digitalen 3D-Vorlagen erstellen. Wurden mittels AM zunächst nur Modelle zur haptischen Darstellung knöcherner Pathologika und zur Planung von Operationen hergestellt, so ist es mit der Entwicklung nun möglich, detaillierte Scaffoldstrukturen zur Tissue-Engineering-Anwendung im Knochen zu fabrizieren. Die umfassende Kontrolle der internen Scaffoldstruktur und der äußeren Scaffoldmaße erlaubt eine Custom-made-Anwendung mit auf den individuellen Knochendefekt und die entsprechenden (mechanischen etc.) Anforderungen abgestimmten Konstrukten. Ein zukünftiges Feld ist das automatisierte ultrastrukturelle Design von TE-Konstrukten aus Scaffold-Biomaterialien in Kombination mit lebenden Zellen und biologisch aktiven Wachstumsfaktoren zur Nachbildung natürlicher (knöcherner) Organstrukturen.

Regenereation in periodontics

2018 ◽  
Author(s):  
Murtaza Kaderi ◽  
Mohsin Ali ◽  
Alfiya Ali ◽  
Tasneem Kaderi
Keyword(s):  
Tissue Engineering ◽  
Clinical Practice ◽  
Periodontal Disease ◽  
Disease Progression ◽  
Tissue Regeneration ◽  
Surgical Procedures ◽  
Periodontal Regeneration ◽  
Guided Tissue Regeneration ◽  
Periodontal Tissues ◽  
Extensive Documentation

The goals of periodontal therapy are to arrest of periodontal disease progression and to attain the regeneration of the periodontal apparatus. Osseous grafting and Guided tissue regeneration (GTR) are the two techniques with the most extensive documentation of periodontal regeneration. However, these techniques offer limited potential towards regenerating the periodontal tissues. Recent surgical procedures and application of newer materials aim at greater and more predictable regeneration with the concept of tissue engineering for enhanced periodontal regeneration and functional attachment have been developed, analyzed, and employed in clinical practice

scholarly journals 3D Printing for Soft Tissue Regeneration and Applications in Medicine

Biomedicines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 336
Author(s):  
Sven Pantermehl ◽  
Steffen Emmert ◽  
Aenne Foth ◽  
Niels Grabow ◽  
Said Alkildani ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Soft Tissue ◽  
3D Printing ◽  
Tissue Regeneration ◽  
Research Area ◽  
Modern Medicine ◽  
Soft Tissue Regeneration ◽  
General Overview

The use of additive manufacturing (AM) technologies is a relatively young research area in modern medicine. This technology offers a fast and effective way of producing implants, tissues, or entire organs individually adapted to the needs of a patient. Today, a large number of different 3D printing technologies with individual application areas are available. This review is intended to provide a general overview of these various printing technologies and their function for medical use. For this purpose, the design and functionality of the different applications are presented and their individual strengths and weaknesses are explained. Where possible, previous studies using the respective technologies in the field of tissue engineering are briefly summarized.

scholarly journals Ultra-Wideband Flat Metamaterial GRIN Lenses Assisted with Additive Manufacturing Technique

2020 ◽  
pp. 1-1
Author(s):  
Shiyu Zhang ◽  
Ravi Kumar Arya ◽  
William G. Whittow ◽  
Darren Cadman ◽  
Raj Mittra ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Ultra Wideband ◽  
Manufacturing Technique

scholarly journals Additive manufacturing of PLA-based scaffolds intended for bone regeneration and strategies to improve their biological properties

e-Polymers ◽  
2020 ◽  
Vol 20 (1) ◽  
pp. 571-599
Author(s):  
Ricardo Donate ◽  
Mario Monzón ◽  
María Elena Alemán-Domínguez
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Bone Regeneration ◽  
Polylactic Acid ◽  
State Of The Art ◽  
Biological Properties ◽  
Design Stage ◽  
Bone Scaffolds ◽  
Regeneration Of Bone

AbstractPolylactic acid (PLA) is one of the most commonly used materials in the biomedical sector because of its processability, mechanical properties and biocompatibility. Among the different techniques that are feasible to process this biomaterial, additive manufacturing (AM) has gained attention recently, as it provides the possibility of tuning the design of the structures. This flexibility in the design stage allows the customization of the parts in order to optimize their use in the tissue engineering field. In the recent years, the application of PLA for the manufacture of bone scaffolds has been especially relevant, since numerous studies have proven the potential of this biomaterial for bone regeneration. This review contains a description of the specific requirements in the regeneration of bone and how the state of the art have tried to address them with different strategies to develop PLA-based scaffolds by AM techniques and with improved biofunctionality.

scholarly journals Scaffolds for Growth Factor Delivery as Applied to Bone Tissue Engineering

2012 ◽  
Vol 2012 ◽  
pp. 1-25 ◽  
Author(s):  
Keith A. Blackwood ◽  
Nathalie Bock ◽  
Tim R. Dargaville ◽  
Maria Ann Woodruff
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Donor Site ◽  
Structural Features ◽  
Donor Site Morbidity ◽  
Tissue Type ◽  
Specific Cell ◽  
Growth Factor Delivery

There remains a substantial shortfall in the treatment of severe skeletal injuries. The current gold standard of autologous bone grafting from the same patient has many undesirable side effects associated such as donor site morbidity. Tissue engineering seeks to offer a solution to this problem. The primary requirements for tissue-engineered scaffolds have already been well established, and many materials, such as polyesters, present themselves as potential candidates for bone defects; they have comparable structural features, but they often lack the required osteoconductivity to promote adequate bone regeneration. By combining these materials with biological growth factors, which promote the infiltration of cells into the scaffold as well as the differentiation into the specific cell and tissue type, it is possible to increase the formation of new bone. However due to the cost and potential complications associated with growth factors, controlling the rate of release is an important design consideration when developing new bone tissue engineering strategies. This paper will cover recent research in the area of encapsulation and release of growth factors within a variety of different polymeric scaffolds.

scholarly journals Advances in 3D Printing for Tissue Engineering

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3149
Author(s):  
Angelika Zaszczyńska ◽  
Maryla Moczulska-Heljak ◽  
Arkadiusz Gradys ◽  
Paweł Sajkiewicz
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Complex Structure ◽  
Three Dimensional ◽  
Computer Assisted ◽  
Scaffold Fabrication ◽  
Manufacturing Techniques ◽  
Printing Techniques ◽  
State Of Art

Tissue engineering (TE) scaffolds have enormous significance for the possibility of regeneration of complex tissue structures or even whole organs. Three-dimensional (3D) printing techniques allow fabricating TE scaffolds, having an extremely complex structure, in a repeatable and precise manner. Moreover, they enable the easy application of computer-assisted methods to TE scaffold design. The latest additive manufacturing techniques open up opportunities not otherwise available. This study aimed to summarize the state-of-art field of 3D printing techniques in applications for tissue engineering with a focus on the latest advancements. The following topics are discussed: systematics of the available 3D printing techniques applied for TE scaffold fabrication; overview of 3D printable biomaterials and advancements in 3D-printing-assisted tissue engineering.

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