scholarly journals News about the Role of the Transcription Factor REST in Neurons: From Physiology to Pathology

2019 ◽  
Vol 21 (1) ◽  
pp. 235 ◽  
Author(s):  
Jose M. Garcia-Manteiga ◽  
Rosalba D’Alessandro ◽  
Jacopo Meldolesi
Keyword(s):  
Transcription Factor ◽  
Neurodegenerative Diseases ◽  
The Other ◽  
Brain Diseases ◽  
Strong Decrease ◽  
Future Developments ◽  
The Past

RE-1 silencing transcription factor (REST) (known also as NRSF) is a well-known transcription repressor whose strong decrease induces the distinction of neurons with respect to the other cells. Such distinction depends on the marked increased/decreased expression of specific genes, accompanied by parallel changes of the corresponding proteins. Many properties of REST had been identified in the past. Here we report those identified during the last 5 years. Among physiological discoveries are hundreds of genes governed directly/indirectly by REST, the mechanisms of its neuron/fibroblast conversions, and the cooperations with numerous distinct factors induced at the epigenetic level and essential for REST specific functions. New effects induced in neurons during brain diseases depend on the localization of REST, in the nucleus, where functions and toxicity occur, and in the cytoplasm. The effects of REST, including cell aggression or protection, are variable in neurodegenerative diseases in view of the distinct mechanisms of their pathology. Moreover, cooperations are among the mechanisms that govern the severity of brain cancers, glioblastomas, and medulloblastomas. Interestingly, the role in cancers is relevant also for therapeutic perspectives affecting the REST cooperations. In conclusion, part of the new REST knowledge in physiology and pathology appears promising for future developments in research and brain diseases.

scholarly journals Relationship between Cycling Infrastructure and Transportation Cycling in a Small Urban Area

2021 ◽  
Vol 1 (1) ◽  
pp. 99-112
Author(s):  
Richard Larouche ◽  
Nimesh Patel ◽  
Jennifer L. Copeland
Keyword(s):  
Generalized Linear Models ◽  
Qualitative Data ◽  
Linear Models ◽  
The Other ◽  
Small City ◽  
The Road ◽  
The Past ◽  
Low Prevalence ◽  
The Relationship

The role of infrastructure in encouraging transportation cycling in smaller cities with a low prevalence of cycling remains unclear. To investigate the relationship between the presence of infrastructure and transportation cycling in a small city (Lethbridge, AB, Canada), we interviewed 246 adults along a recently-constructed bicycle boulevard and two comparison streets with no recent changes in cycling infrastructure. One comparison street had a separate multi-use path and the other had no cycling infrastructure. Questions addressed time spent cycling in the past week and 2 years prior and potential socio-demographic and psychosocial correlates of cycling, including safety concerns. Finally, we asked participants what could be done to make cycling safer and more attractive. We examined predictors of cycling using gender-stratified generalized linear models. Women interviewed along the street with a separate path reported cycling more than women on the other streets. A more favorable attitude towards cycling and greater habit strength were associated with more cycling in both men and women. Qualitative data revealed generally positive views about the bicycle boulevard, a need for education about sharing the road and for better cycling infrastructure in general. Our results suggest that, even in smaller cities, cycling infrastructure may encourage cycling, especially among women.

scholarly journals BRN2 is a non-canonical melanoma tumor-suppressor

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Michael Hamm ◽  
Pierre Sohier ◽  
Valérie Petit ◽  
Jérémy H. Raymond ◽  
Véronique Delmas ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Tumor Suppressor ◽  
The Other ◽  
Pi3k Signaling ◽  
Melanoma Tumor ◽  
Temporal Regulation ◽  
Metastatic Colonization ◽  
Pou Domain

AbstractWhile the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A, have been identified, the role of key transcription factors that impose altered transcriptional states in response to deregulated signaling is not well understood. The POU domain transcription factor BRN2 is a key regulator of melanoma invasion, yet its role in melanoma initiation remains unknown. Here, in a BrafV600EPtenF/+ context, we show that BRN2 haplo-insufficiency promotes melanoma initiation and metastasis. However, metastatic colonization is less efficient in the absence of Brn2. Mechanistically, BRN2 directly induces PTEN expression and in consequence represses PI3K signaling. Moreover, MITF, a BRN2 target, represses PTEN transcription. Collectively, our results suggest that on a PTEN heterozygous background somatic deletion of one BRN2 allele and temporal regulation of the other allele elicits melanoma initiation and progression.

Jerzy Topolski’s Marxist Anthropocentrism

2021 ◽  
Vol 15 (3) ◽  
pp. 361-377
Author(s):  
Ewa Domańska ◽  
Paul Vickers
Keyword(s):  
Historical Materialism ◽  
Philosophy Of History ◽  
Marxist Theory ◽  
Collective Agency ◽  
Future Developments ◽  
The Past ◽  
Current State ◽  
The World ◽  
Separate Discipline

Abstract In this article I demonstrate that the ideas outlined in Jerzy Topolski’s Methodology of History (Polish 1968, English translation 1976) could not only offer a reference point for and indeed enrich ongoing debates in the philosophy of history, but also help to set directions for future developments in the field. To support my argument, I focus on two themes addressed in Topolski’s work: 1) the understanding of the methodology of history as a separate discipline and its role both in defending the autonomy of history and in creating an integrated knowledge of the past, which I read here through the lens of the current merging of the humanities and natural sciences; and 2) the role of a Marxist anthropocentrism based on the notion of humans as the creators of history, which I consider here in the context of the ongoing critique of anthropocentrism. I point to the value of continuing to use concepts drawn from Marxist vocabulary, such as alienation, emancipation, exploitation and overdetermination, for interpreting the current state of the world and humanity. I stress that Marxist anthropocentrism, with its support for individual and collective agency, remains crucial to the creation of emancipatory theories and visions of the future, even if it has faced criticism for its Eurocentrism and might seem rather familiar and predictable when viewed in the context of the contemporary humanities. Nevertheless, new manifestations of Marxist theory, in the form of posthumanist Marxism and an interspecies historical materialism that transcends anthropocentrism, might play an important role in redefining the humanities and humanity, including its functions and tasks within human and multispecies communities.

scholarly journals The role of morality in social cognition

2019 ◽  
Author(s):  
Jennifer Lauren Ray ◽  
Peter Mende-Siedlecki ◽  
Ana P. Gantman ◽  
Jay Joseph Van Bavel
Keyword(s):  
Social Cognition ◽  
Social Perception ◽  
Impression Formation ◽  
Factor Models ◽  
The Other ◽  
One Dimension ◽  
Primary Role ◽  
The Past ◽  
Important Basis

Over the past few decades, two-factor models of social cognition have emerged as the dominant framework for understanding impression formation. Despite the differences in the labels, there is wide agreement that one dimension reflects sociability potential, and the other, competence. One way in which the various two-factor models do clearly differ, however, is in the way the dimensions incorporate or produce evaluations of morality. Aristotle saw morality as the most important basis on which to form positive evaluations, because competence and sociability could only be virtuous, sincere, and trustworthy if expressed through a moral character. This chapter highlights research demonstrating the unique and possibly primary role of morality in social cognition. We clarify the dynamic, interactive, and conjoint effects of morality on social perception, and argue morality, competence, and sociability are three influential and interactive dimensions of social perception.

ATP-binding cassette transporters and neurodegenerative diseases

2021 ◽  
Author(s):  
Jared S. Katzeff ◽  
Woojin Scott Kim
Keyword(s):  
Neurodegenerative Diseases ◽  
Abc Transporters ◽  
Brain Diseases ◽  
Atp Binding ◽  
Future Directions ◽  
Diverse Range ◽  
The Brain ◽  
Lateral Sclerosis ◽  
Atp Binding Cassette

Abstract ATP-binding cassette (ABC) transporters are one of the largest groups of transporter families in humans. ABC transporters mediate the translocation of a diverse range of substrates across cellular membranes, including amino acids, nucleosides, lipids, sugars and xenobiotics. Neurodegenerative diseases are a group of brain diseases that detrimentally affect neurons and other brain cells and are usually associated with deposits of pathogenic proteins in the brain. Major neurodegenerative diseases include Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. ABC transporters are highly expressed in the brain and have been implicated in a number of pathological processes underlying neurodegenerative diseases. This review outlines the current understanding of the role of ABC transporters in neurodegenerative diseases, focusing on some of the most important pathways, and also suggests future directions for research in this field.

From midden to megalith? The Mesolithic-Neolithic transition in western Britain

2007 ◽  
Author(s):  
Vicki Cummings
Keyword(s):  
Transition Process ◽  
The Other ◽  
Irish Sea ◽  
Technological Transformation ◽  
Neolithic Transition ◽  
Isle Of Man ◽  
The Past ◽  
Hunting And Gathering ◽  
The Irish Sea

The transition from the Mesolithic to the Neolithic in Britain and Ireland remains one of the most debated and contested transitions of prehistory. Much more complex than a simple transition from hunting and gathering to farming, the Mesolithic–Neolithic transition in Britain has been discussed not only as an economic and technological transformation, but also as an ideological one. In western Britain in particular, with its wealth of Neolithic monuments, considerable emphasis has been placed on the role of monumentality in the transition process. Over the past decade the author‧s research has concentrated on the early Neolithic monumental traditions of western Britain, a deliberate focus on areas outside the more ‘luminous’ centres of Wessex, the Cotswold–Severn region, and Orkney. This chapter discusses the transition in western Britain, with an emphasis on the monuments of this region. In particular, it discusses the areas around the Irish Sea – west Wales, the Isle of Man, south-west and western Scotland – as well as referring to the sequence on the other side of the Irish Sea, specifically eastern Ireland.

When Cultural Evolution Calls for Translation Revolution

2018 ◽  
pp. 161-178
Author(s):  
Vanessa Lopes Lourenço Hanes
Keyword(s):  
Cultural Evolution ◽  
Written Language ◽  
The Other ◽  
Past Century ◽  
Linguistic Identity ◽  
The Past ◽  
Publishing Houses ◽  
The One

Given the massive changes that Brazil has undergone in the past century, particularly in distancing itself linguistically from its former colonizer, this study is an attempt to determine the role of translation in the country's cultural evolution. Translational approaches have developed along opposing poles: on the one hand, a strong resistance to incorporating orally-driven alterations in the written language, while on the other, a slow, halting movement toward convergence of the two, and both approaches are charged with political and ideological intentionality. Publishing houses, editors and translators are gatekeepers and agents whose activities provide a glimpse into the mechanism of national linguistic identity, either contributing to or resisting the myth of a homogenized Portuguese language.

scholarly journals Prison Leave in Finland: Legal and Empirical Fundamentals of an Established Practice

2019 ◽  
Vol 26 (2) ◽  
pp. 177-193 ◽  
Author(s):  
A. Keinänen ◽  
M. Kilpeläinen ◽  
J. Pajuoja ◽  
S. Tyni
Keyword(s):  
Common Ground ◽  
Application Rate ◽  
Common Type ◽  
The Other ◽  
Prison Sentence ◽  
Negative Effects ◽  
Legal Rules ◽  
Criminal Sanctions ◽  
The Past

AbstractPrison leave was introduced into the Finnish legal system in 1971, with the aim to reduce negative effects of institutionalization and disadvantages caused by the length of the prison sentence. After the total reform of prison legislation in 2006, the role of the prison leave has become even more central; the number of prisoners has decreased, but the amount of prison leave has increased. Historically, the length of the sentence has been the most common ground for prison leave. A prisoner can be granted a prison leave when two thirds of the prison term has been served, for example, after 2 years if the length of the total sentence served in prison is 3 years. However, during the past 10 years, prison leave based on an important reason has grown into the most common type of prison leave. This indicates a structural change from the rigid legal rules to a more flexible practice. In 2018, there were about 17,000 prison leave applications, and over 13,000 of those were granted, i.e. 79%. The conditions were breached 466 times, which is 3.5% of all prison leaves. The most common breaches of prison leave conditions were returning from a prison leave after the set time limit or under the influence of alcohol or drugs. The majority of prison leave applications are decided in the prisons. On the other hand, for example, the decision on the prison leave of a life-sentenced prisoner is made by the Criminal Sanctions Agency. There have been significant differences in the probability of granting prison leave, which are emphasized especially in the practices of closed prisons. Among those prisoners who serve longer than 1 year in prison, the application rate of prison leave rises over 90%. For the sentences under 3 months, it is less than 20%.

Indigenous approaches to the past: ‘Creative histories’ at the Hyde Park Barracks, Sydney

2020 ◽  
Vol 9 (1) ◽  
pp. 83-102 ◽  
Author(s):  
Kiera Lindsey
Keyword(s):  
Visual Art ◽  
The Other ◽  
Cultural Relations ◽  
Form And Function ◽  
The Past ◽  
Cultural Responses ◽  
And Function ◽  
The Way

This article discusses a recent art project created by the Wiradjuri and Kamilaroi artist Jonathon Jones, which was commissioned to commemorate the opening of the revitalized Hyde Park Barracks in Sydney in early 2020. Jones’ work involves a dramatic installation of red and white crushed stones laid throughout the grounds of the barracks, merging the image of the emu footprint with that of the English broad convict arrow to ‘consider Australia’s layered history and contemporary cultural relations’. This work was accompanied by a ‘specially-curated programme’ of performances, workshops, storytelling and Artist Talks. Together, these elements were designed to unpack how certain ‘stories determine the ways we came together as a nation’. As one of the speakers of the Artist Talk’s programme, I had a unique opportunity to experiment with what colleagues and I have been calling ‘Creative histories’ in reference to the way some artists and historians are choosing to communicate their research about the past in ways that experiment with form and function and push disciplinary or generic boundaries. This article reflects upon how these two distinct creative history projects – one visual art, the other performative – renegotiate the complex and contested pasts of the Hyde Park Barracks. I suggest that both examples speak to the role of memory and creativity in shaping cultural responses to Australia’s colonial past, while Jones' programme illustrates how Indigenous artists and academics are making a profound intervention into contemporary understandings of how history is ‘done’ in Australia.

scholarly journals Role of DBP in the Circadian Oscillatory Mechanism

2000 ◽  
Vol 20 (13) ◽  
pp. 4773-4781 ◽  
Author(s):  
Shun Yamaguchi ◽  
Shigeru Mitsui ◽  
Lily Yan ◽  
Kazuhiro Yagita ◽  
Shigeru Miyake ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Leucine Zipper ◽  
The Other ◽  
Suprachiasmatic Nuclei ◽  
Transcription Factor Family ◽  
Transcript Levels ◽  
Oscillatory Mechanism ◽  
Central Clock ◽  
E Boxes

ABSTRACT Transcript levels of DBP, a member of the PAR leucine zipper transcription factor family, exhibit a robust rhythm in suprachiasmatic nuclei, the mammalian circadian center. Here we report that DBP is able to activate the promoter of a putative clock oscillating gene,mPer1, by directly binding to the mPer1promoter. The mPer1 promoter is cooperatively activated by DBP and CLOCK-BMAL1. On the other hand, dbp transcription is activated by CLOCK-BMAL1 through E-boxes and inhibited by the mPER and mCRY proteins, as is the case for mPer1. Thus, a clock-controlled dbp gene may play an important role in central clock oscillation.

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