scholarly journals The Complex Network between MYC Oncogene and microRNAs in Gastric Cancer: An Overview

2020 ◽  
Vol 21 (5) ◽  
pp. 1782 ◽  
Author(s):  
Ana Carolina Anauate ◽  
Mariana Ferreira Leal ◽  
Danielle Queiroz Calcagno ◽  
Carolina Oliveira Gigek ◽  
Bruno Takao Real Karia ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Drug Resistance ◽  
Complex Network ◽  
Causes Of Death ◽  
Noncoding Rnas ◽  
Protein Translation ◽  
Cancer Development ◽  
Cancer Treatments ◽  
Myc Oncogene

Despite the advancements in cancer treatments, gastric cancer is still one of the leading causes of death worldwide. In this context, it is of great interest to discover new and more effective ways of treating this disease. Accumulated evidences have demonstrated the amplification of 8q24.21 region in gastric tumors. Furthermore, this is the region where the widely known MYC oncogene and different microRNAs are located. MYC deregulation is key in tumorigenesis in various types of tissues, once it is associated with cell proliferation, survival, and drug resistance. microRNAs are a class of noncoding RNAs that negatively regulate the protein translation, and which deregulation is related with gastric cancer development. However, little is understood about the interactions between microRNAs and MYC. Here, we overview the MYC role and its relationship with the microRNAs network in gastric cancer aiming to identify potential targets useful to be used in clinic, not only as biomarkers, but also as molecules for development of promising therapies.

scholarly journals MicroRNA Role in Thyroid Cancer Development

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Francesca Marini ◽  
Ettore Luzi ◽  
Maria Luisa Brandi
Keyword(s):  
Thyroid Cancer ◽  
Messenger Rna ◽  
Noncoding Rnas ◽  
Protein Translation ◽  
Cancer Development ◽  
Regulate Gene Expression ◽  
Rna Targets ◽  
Mirna Deregulation ◽  
Cell Maintenance

MicroRNAs (miRNAs) are endogenous noncoding RNAs that negatively regulate gene expression by binding the 3′noncoding region of the messenger RNA targets inducing their cleavage or blocking the protein translation. They play important roles in multiple biological and metabolic processes, including developmental timing, signal transduction, and cell maintenance and differentiation. Their deregulation can predispose to diseases and cancer. miRNA expression has been demonstrated to be deregulated in many types of human tumors, including thyroid cancers, and could be responsible for tumor initiation and progression. In this paper we reviewed the available data on miRNA deregulation in different thyroid tumors and describe the putative role of miRNA in thyroid cancer development.

Melanoma associated antigen (MAGE)-A3 promotes cell proliferation and chemotherapeutic drug resistance in gastric cancer

2016 ◽  
Vol 39 (2) ◽  
pp. 175-186 ◽  
Author(s):  
Chen Xie ◽  
Vinod Vijay Subhash ◽  
Arpita Datta ◽  
Natalia Liem ◽  
Shi Hui Tan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Drug Resistance ◽  
Chemotherapeutic Drug

scholarly journals Dysregulation of lncRNA in Helicobacter pylori-Infected Gastric Cancer Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Leila Yousefi ◽  
Hamid Owaysee Osquee ◽  
Reza Ghotaslou ◽  
Mohammad Ahangarzadeh Rezaee ◽  
Tahereh Pirzadeh ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Noncoding Rnas ◽  
Bacterial Virulence ◽  
Cancer Development ◽  
Biological Macromolecules ◽  
Gastric Cancer Cells ◽  
Protein Coding ◽  
Protein Coding Genes ◽  
H Pylori

Helicobacter pylori (H. pylori) infection is the most common cause of gastric cancer (GC). This microorganism is genetically diverse; GC is caused by several genetic deregulations in addition to environmental factors and bacterial virulence factors. lncRNAs (long noncoding RNAs) are significant biological macromolecules in GC, have specific functions in diseases, and could be therapeutic targets. Altered lncRNAs can lead to the abnormal expression of adjacent protein-coding genes, which may be important in cancer development. Their mechanisms have not been well understood, so we are going to investigate the risk of GC in a population with both high lncRNA and H. pylori infection.

scholarly journals Noncoding RNAs in gastric cancer: implications for drug resistance

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Ling Wei ◽  
Jujie Sun ◽  
Nasha Zhang ◽  
Yan Zheng ◽  
Xingwu Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Drug Resistance ◽  
Noncoding Rnas

scholarly journals Glutathione S-Transferases in Cancer

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 701
Author(s):  
Rahul Raj Singh ◽  
Katie M. Reindl
Keyword(s):  
Cell Proliferation ◽  
Drug Resistance ◽  
Clinical Trials ◽  
Antioxidant Enzymes ◽  
Cancer Treatment ◽  
Cell Survival ◽  
Structural Similarity ◽  
Cancer Development ◽  
Pharmacological Studies ◽  
Glutathione S Transferases

In humans, the glutathione S-transferases (GST) protein family is composed of seven members that present remarkable structural similarity and some degree of overlapping functionalities. GST proteins are crucial antioxidant enzymes that regulate stress-induced signaling pathways. Interestingly, overactive GST proteins are a frequent feature of many human cancers. Recent evidence has revealed that the biology of most GST proteins is complex and multifaceted and that these proteins actively participate in tumorigenic processes such as cell survival, cell proliferation, and drug resistance. Structural and pharmacological studies have identified various GST inhibitors, and these molecules have progressed to clinical trials for the treatment of cancer and other diseases. In this review, we discuss recent findings in GST protein biology and their roles in cancer development, their contribution in chemoresistance, and the development of GST inhibitors for cancer treatment.

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