scholarly journals Editorial for the Special Issue “New Strategies in Cancer Pharmacotherapy: Development of Hormonal Antineoplastic Drugs, Cytotoxic Drugs and Targeted Therapies”

2020 ◽  
Vol 21 (11) ◽  
pp. 4081
Author(s):  
Carlos Martínez-Campa ◽  
Carolina Alonso-González
Keyword(s):  
Targeted Therapies ◽  
Cytotoxic Drugs ◽  
Antineoplastic Drugs ◽  
Special Issue ◽  
New Strategies

The Special Issue entitled “New Strategies in Cancer Pharmacotherapy: Development of Hormonal Antineoplastic Drugs, Cytotoxic Drugs and Targeted Therapies” was conceived with the idea of compiling information on the latest advances in the treatment of both hormone-dependent and hormone-independent cancers [...]

scholarly journals A Multi-Objective Approach for Anti-Osteosarcoma Cancer Agents Discovery through Drug Repurposing

2020 ◽  
Vol 13 (11) ◽  
pp. 409
Author(s):  
Alejandro Cabrera-Andrade ◽  
Andrés López-Cortés ◽  
Gabriela Jaramillo-Koupermann ◽  
Humberto González-Díaz ◽  
Alejandro Pazos ◽  
...  
Keyword(s):  
Desirability Function ◽  
Survival Rates ◽  
Drug Repurposing ◽  
Limiting Factors ◽  
Antineoplastic Drugs ◽  
Final Model ◽  
Multi Objective ◽  
Acute Complications ◽  
Objective Model ◽  
New Strategies

Osteosarcoma is the most common type of primary malignant bone tumor. Although nowadays 5-year survival rates can reach up to 60–70%, acute complications and late effects of osteosarcoma therapy are two of the limiting factors in treatments. We developed a multi-objective algorithm for the repurposing of new anti-osteosarcoma drugs, based on the modeling of molecules with described activity for HOS, MG63, SAOS2, and U2OS cell lines in the ChEMBL database. Several predictive models were obtained for each cell line and those with accuracy greater than 0.8 were integrated into a desirability function for the final multi-objective model. An exhaustive exploration of model combinations was carried out to obtain the best multi-objective model in virtual screening. For the top 1% of the screened list, the final model showed a BEDROC = 0.562, EF = 27.6, and AUC = 0.653. The repositioning was performed on 2218 molecules described in DrugBank. Within the top-ranked drugs, we found: temsirolimus, paclitaxel, sirolimus, everolimus, and cabazitaxel, which are antineoplastic drugs described in clinical trials for cancer in general. Interestingly, we found several broad-spectrum antibiotics and antiretroviral agents. This powerful model predicts several drugs that should be studied in depth to find new chemotherapy regimens and to propose new strategies for osteosarcoma treatment.

scholarly journals Editorial on Special Issue “Biorefinery: Current Status, Challenges, and New Strategies”

2021 ◽  
Vol 11 (10) ◽  
pp. 4674
Author(s):  
Kwang Ho Kim ◽  
Chang Geun Yoo
Keyword(s):  
Global Warming ◽  
Fossil Fuels ◽  
Energy Crisis ◽  
Current Status ◽  
Special Issue ◽  
Significant Research ◽  
New Strategies

The overdependence on fossil fuels has raised concerns about global warming and the energy crisis, which has warranted significant research to find alternatives [...]

scholarly journals Drug-induced colorectal cancer persister cells show increased mutation rate

2021 ◽  
Author(s):  
Mariangela Russo ◽  
Simone Pompei ◽  
Alberto Sogari ◽  
Mattia Corigliano ◽  
Giovanni Crisafulli ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mutation Rate ◽  
Targeted Therapies ◽  
Tumor Recurrence ◽  
Fold Increase ◽  
Compelling Evidence ◽  
Experimental Characterization ◽  
Persister Cells ◽  
Drug Induced ◽  
New Strategies

Compelling evidence shows that cancer persister cells limit the efficacy of targeted therapies. However, it is unclear whether persister cells are induced by anticancer drugs, and if their mutation rate quantitatively increases during treatment. Here, combining experimental characterization and mathematical modeling, we show that, in colorectal cancer, persisters are induced by drug treatment and show a 7- to 50-fold increase of mutation rate when exposed to clinically approved targeted therapies. These findings reveal that treatment may influence persistence and mutability in cancer cells and pinpoints new strategies to restrict tumor recurrence.

scholarly journals Special Issue on Molecular and Translational Research on Colorectal Cancer 2.0

2021 ◽  
Vol 22 (14) ◽  
pp. 7479
Author(s):  
Alessandro Passardi ◽  
Emanuela Scarpi ◽  
Paola Ulivi
Keyword(s):  
Colorectal Cancer ◽  
Translational Research ◽  
Current Knowledge ◽  
Prognostic Biomarkers ◽  
Special Issue ◽  
Therapeutic Approaches ◽  
New Targets ◽  
Scientific Papers ◽  
Anticancer Treatment ◽  
New Strategies

The present editorial aims to summarise the six scientific papers that have contributed to this Special Issue, focusing on different aspects of molecular and translational research on colorectal cancer. We believe that the present Special Issue might contribute to the expansion of the current knowledge concerning potential molecular predictive and/or prognostic biomarkers in CRC, as well as new targets for anticancer treatment. This may help in identifying new strategies to improve diagnostic and therapeutic approaches.

Editorial Dynamics and Control of Aerospace and Vertical Transportation Systems

2014 ◽  
Vol 706 ◽  
pp. 1-5
Author(s):  
José M. Balthazar ◽  
Paulo Batista Gonçalves ◽  
Stefan Kaczmarczyk ◽  
André Fenili ◽  
Marcos Silveira ◽  
...  
Keyword(s):  
Nonlinear Dynamics ◽  
Transportation Systems ◽  
Special Issue ◽  
Science And Engineering ◽  
International Conference ◽  
Dynamics And Control ◽  
Vibration Problems ◽  
And Control ◽  
New Strategies ◽  
Selection Of

This Special Issue presents a selection of papers initially presented at the 11th International Conference on Vibration Problems (ICOVP-2013), held from 9 to 12 September 2013 in Lisbon, Portugal. The main topics of this Special Issue are linear and, mainly, nonlinear dynamics, chaos and control of systems and structures and their applications in different field of science and engineering. According to the goal of the Special Issue, the selected contributions are divided into three major parts: “Vibration Problems in Vertical Transportation Systems”, “Nonlinear Dynamics, Chaos and Control of Elastic Structures” and “New Strategies and Challenges for Aerospace and Ocean Structures Dynamics and Control”.

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