scholarly journals Obesity and Cancer: 27-Hydroxycholesterol, the Missing Link

2020 ◽  
Vol 21 (14) ◽  
pp. 4822
Author(s):  
Arvand Asghari ◽  
Michihisa Umetani
Keyword(s):  
United States ◽  
Cardiovascular Disease ◽  
Estrogen Receptor ◽  
Risk Factor ◽  
Cause Of Death ◽  
The United States ◽  
Missing Link ◽  
Receptor Modulator ◽  
Obesity And Cancer

Obesity is currently affecting more than 40% of the Americans, and if it progresses with this rate, soon one out of two Americans will be obese. Obesity is an important risk factor for several disorders including cardiovascular disease, the first cause of death in the United States. Cancer follows as the second deadliest disease, and a link between obesity and cancer has been suggested. However, it is very hard to establish an exact connection between obesity and cancers due to the multifactorial nature of obesity. Hypercholesterolemia is a comorbidity of obesity and also linked to several cancers. Recently a cholesterol metabolite 27-hydroxycholesterol (27HC) was found to be an endogenous selective estrogen receptor modulator (SERM), which opened new doors toward several interesting studies on the role of this molecule in biological disorders. It is speculated that 27HC might be the missing link in the obesity and cancer chain. Here, we explored the effects of 27-hydroxycholesterol on obesity and cancers with a focus on the SERM capacity of 27HC.

Identifying Properties for an Aortic Stent-Graft That Counteracts Hypertension

2018 ◽  
Author(s):  
Shannen B. Kizilski ◽  
Omid Amili ◽  
Filippo Coletti ◽  
Rumi Faizer ◽  
Victor H. Barocas
Keyword(s):  
United States ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Stent Graft ◽  
American Heart Association ◽  
American Heart ◽  
Heart Association ◽  
The United States ◽  
Aortic Stent Graft

In 2017, the American Heart Association reported that one third of deaths in the United States, and 31% of deaths worldwide, are attributed to cardiovascular disease (CVD) [1]. A risk factor pervasive across most types of CVD is chronic high blood pressure, or hypertension [2].

Development of a Thrombus Mimic in Abdominal Aortic Aneurysms

2007 ◽  
Author(s):  
John H. Ashton ◽  
Jonathan P. Vande Geest
Keyword(s):  
United States ◽  
Cause Of Death ◽  
Growth And Development ◽  
Abdominal Aortic Aneurysms ◽  
The United States ◽  
Aortic Aneurysms ◽  
Western World ◽  
Abdominal Aortic ◽  
Significant Disease

Abdominal aortic aneurysms (AAAs) represent a significant disease in the western world as rupture of AAA is currently the 15th leading cause of death in the United States [1,2]. The rate of incidence of this disease is also thought to be increasing given the aging population. While AAA rupture is attributed to the gradual weakening of the wall, the mechanisms of aneurysm initiation, growth, and development remain relatively unclear. The role of biomechanics in the diagnosis and prevention of AAA rupture has been reported [3].

scholarly journals Aspirin for primary prevention of cardiovaascular events: what are the evidances?

2019 ◽  
Vol 38 (3) ◽  
pp. 145
Author(s):  
Yenny Yenny
Keyword(s):  
Public Health ◽  
United States ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Primary Prevention ◽  
Cardiovascular Events ◽  
The United States ◽  
The Public

Cardiovascular disease (CVD) is the leading cause of mortality in the United States, accounting for about 1 in 3 deaths.(1) In view of the healthcare and economic burdens of cardiovascular disease, the public health aim should be the prevention of cardiovascular events through risk factor optimization.

scholarly journals The relationship between Statins and the risk of lung cancer

2018 ◽  
Vol 5 (5) ◽  
pp. 2268-2270
Author(s):  
Hamid Salehiniya ◽  
Khadijah Allah Bakeshei ◽  
Fatemeh Allah Bakeshei ◽  
Abdollah Mohammadian-Hafshejani
Keyword(s):  
United States ◽  
Lung Cancer ◽  
Cardiovascular Disease ◽  
Cause Of Death ◽  
The United States ◽  
Cholesterol Lowering ◽  
The Relationship

Lung cancer is the leading cause of death from cancer. There are annually around 1600000 of new cases and more than 1400000 deaths from this disease worldwide. Lung cancer accounted for 26% of death from cancer in females in the United States in 2012 and 29% of death from cancer in males. Statins are known as the most commonly prescribed drugs worldwide. Statins are usually used as the cholesterol-lowering drugs. The recent studies have proved the benefits of Statins in reducing the mortality and incidence of cardiovascular disease and stroke.

Conclusion: Summary and Recommendations

CNS Spectrums ◽  
2008 ◽  
Vol 13 (S10) ◽  
pp. 13-14 ◽  
Author(s):  
John W. Newcomer ◽  
Henry A. Nasrallah ◽  
Roger S. McIntyre ◽  
Charles H. Hennekens ◽  
Suzanne Vogel-Scibilia
Keyword(s):  
Infectious Disease ◽  
United States ◽  
Cardiovascular Disease ◽  
Cause Of Death ◽  
Metabolic Disorders ◽  
Developed Countries ◽  
The United States ◽  
Special Population ◽  
The Us ◽  
The World

Cardiovascular disease (CVD) remains the number one cause of death in the United States and most developed countries and is expected to remain so for much of this century. Rates of obesity have increased 2–4-fold over the last 2 decades in the US and this condition is linked with early development of hypertension, hyperlipidemia, diabetes, and atherosclerosis. The prevalence of diabetes is also increasing, and the rise of diabetes in young people 18–29 years of age was 40% in the period between 1990 and 2001. The World Heart Federation (WHF) has estimated that CVD will become the number one cause of death in the world by 2020, surpassing infectious disease in developing countries. Metabolic disorders are on the rise in general. However, as highlighted in the discussions presented in this supplement, patients with serious mental illness appear to represent a special population who are particularly vulnerable, with rates that surpass the general population.

Abstract 14669: Prevalence of Elevated Lp(a) Levels in 629,858 Subjects From a Referral Laboratory Population in the United States

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Justin White ◽  
Steve Varvel ◽  
Sotirios Tsimikas
Keyword(s):  
United States ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Antisense Oligonucleotides ◽  
Independent Risk Factor ◽  
The United States ◽  
Large Datasets ◽  
Laboratory Population ◽  
Diagnostic Laboratory ◽  
The Mean

Background: Elevated Lp(a) is now accepted as a causal, independent risk factor for cardiovascular disease. Data suggest that ~20% of subjects living in the Copenhagen area have elevated Lp(a) levels (>50 mg/dL. Lp(a) <50 mg/dL has been recommended as a desirable level, but similar large datasets in varied populations have not been available from other countries. Methods: We analyzed fasting Lp(a) in 629,858 subjects from the large referral dataset from Health Diagnostic Laboratory measured in years 2010 to 2014 to assess prevalence of elevated Lp(a). Lp(a) mass levels were measured by immunoturbidometric assay and expressed as mg/dL. Results: Median age of the subjects was 56, and 53.7% were female. Lp(a) levels were skewed rightward (Figure). The mean±SD levels were 31±38 mg/dL and median (IQR) levels were 15 (7-43) mg/dL, with range 0-571 mg/dL. Females had higher median (IQR) Lp(a) levels than males [16 (8-47) vs. 13 (6-38), p<0.0001]. Lp(a) percentile levels at 75%, 80%, 90%, 95% and 99% were >43 mg/dL, >55 mg/dL, >85 mg/dL, >109 mg/dL, and >169 mg/dL, respectively. Lp(a) levels >30 mg/dL and >50 mg/dL were present in 31.8% and 21.8% of subjects, respectively Conclusion: This is the largest database to assess the distribution of Lp(a). Lp(a) levels >30 and >50 mg/dL were common, constituting 31.8% and 21.8% of this referral laboratory population, and are consistent with the Copenhagen data. These data will help to define new global guidelines and therapeutic targets for new Lp(a) lowering therapies, such as antisense oligonucleotides directed to apo(a).

The Role of Gender and Sensation Seeking in Film Choice

2008 ◽  
Vol 20 (3) ◽  
pp. 97-105 ◽  
Author(s):  
Smita C. Banerjee ◽  
Kathryn Greene ◽  
Marina Krcmar ◽  
Zhanna Bagdasarov ◽  
Dovile Ruginyte
Keyword(s):  
United States ◽  
Undergraduate Students ◽  
Sensation Seeking ◽  
Negative Mood ◽  
Positive Mood ◽  
The United States ◽  
High Arousal ◽  
Subject Design ◽  
Happy Mood

This study demonstrates the significance of individual difference factors, particularly gender and sensation seeking, in predicting media choice (examined through hypothetical descriptions of films that participants anticipated they would view). This study used a 2 (Positive mood/negative mood) × 2 (High arousal/low arousal) within-subject design with 544 undergraduate students recruited from a large northeastern university in the United States. Results showed that happy films and high arousal films were preferred over sad films and low-arousal films, respectively. In terms of gender differences, female viewers reported a greater preference than male viewers for happy-mood films. Also, male viewers reported a greater preference for high-arousal films compared to female viewers, and female viewers reported a greater preference for low-arousal films compared to male viewers. Finally, high sensation seekers reported a preference for high-arousal films. Implications for research design and importance of exploring media characteristics are discussed.

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