scholarly journals Alzheimer’s Disease and Specialized Pro-Resolving Lipid Mediators: Do MaR1, RvD1, and NPD1 Show Promise for Prevention and Treatment?

2020 ◽  
Vol 21 (16) ◽  
pp. 5783 ◽  
Author(s):  
Keishi Miyazawa ◽  
Hisanori Fukunaga ◽  
Yasuko Tatewaki ◽  
Yumi Takano ◽  
Shuzo Yamamoto ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lipid Mediators ◽  
Major Contributor ◽  
Resolvin D1 ◽  
The Public ◽  
Aging Society ◽  
Neuroprotectin D1 ◽  
Chronic Neuroinflammation ◽  
Progressive Cognitive Impairment

Alzheimer’s disease (AD) is a common neurodegenerative disease and a major contributor to progressive cognitive impairment in an aging society. As the pathophysiology of AD involves chronic neuroinflammation, the resolution of inflammation and the group of lipid mediators that actively regulate it—i.e., specialized pro-resolving lipid mediators (SPMs)—attracted attention in recent years as therapeutic targets. This review focuses on the following three specific SPMs and summarizes their relationships to AD, as they were shown to effectively address and reduce the risk of AD-related neuroinflammation: maresin 1 (MaR1), resolvin D1 (RvD1), and neuroprotectin D1 (NPD1). These three SPMs are metabolites of docosahexaenoic acid (DHA), which is contained in fish oils and is thus easily available to the public. They are expected to become incorporated into promising avenues for preventing and treating AD in the future.

scholarly journals Cerebrospinal Fluid Profile of Lipid Mediators In Alzheimer’s Disease

2021 ◽  
Author(s):  
Khanh Van Do ◽  
Erik Hjorth ◽  
Ying Wang ◽  
Bokkyoo Jun ◽  
Marie-Audrey I. Kautzmann ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Cognitive Impairment ◽  
Lipid Mediators ◽  
Replication Studies ◽  
Neuroprotectin D1 ◽  
Chronic Neuroinflammation ◽  
Liquid Chromatography Tandem Mass ◽  
Amyloid Aβ

Abstract Background: Alzheimer's disease (AD) develops into dementia over a period of several years, during which subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) are used as intermediary diagnoses of increasing severity. Chronic neuroinflammation resulting from insufficient resolution is involved in the pathogenesis of AD and is associated with cognitive impairment. Specialized pro-resolving lipid mediators (LMs) that promote the resolution of inflammation may be valuable markers in AD diagnosis and as therapeutic targets.Methods: Liquid chromatography-tandem mass spectrometry was used to analyze pro-resolving and pro-inflammatory LMs in cerebrospinal fluid (CSF) from patients with cognitive impairment ranging from subjective impairment to a diagnosis of AD, and correlated to cognition, CSF tau and β-amyloid (Aβ), and an inflammation biomarker (YKL-40). Results: RvD4, neuroprotectin D1, MaR1, and RvE4 were lower in AD and/or MCI compared to SCI. The pro-inflammatory LTB4 and 15-HETE were higher in AD and MCI, respectively, while PGD2 and PGE2 were decreased in AD, compared to SCI. RvD4 was also negatively correlated to AD tangle biomarkers. Many differences were dependent on gender.Conclusion: In this exploratory study of the lipidome in CSF of AD, MCI and SCI, the results indicate a gender-dependent shift in the LM profile from pro-resolving to pro-inflammatory in progression to AD, suggesting that it may be of use as a biomarker when followed by confirmation by replication studies.

Effect Of Nhexane Extract Of Caryota No Seed On Markers Of Neurodegeneration And Fecundity In Drosophila Melanogaster

2020 ◽  
Vol 6 (5) ◽  
pp. 1-7
Author(s):  
Chinonye A Maduagwuna ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drosophila Melanogaster ◽  
Neurodegenerative Diseases ◽  
Cognitive Functions ◽  
The Elderly ◽  
Common Cause ◽  
Chronic Neuroinflammation

Study background: Chronic neuroinflammation is a common emerging hallmark of several neurodegenerative diseases. Alzheimer’s Disease (AD) is the most common cause of dementia among the elderly and is characterized by loss of memory and other cognitive functions.

scholarly journals Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e15816 ◽  
Author(s):  
Yuhai Zhao ◽  
Frederic Calon ◽  
Carl Julien ◽  
Jeremy W. Winkler ◽  
Nicos A. Petasis ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Docosahexaenoic Acid ◽  
Neuronal Survival ◽  
Disease Models ◽  
Neuroprotectin D1

Toward a More Nuanced Perception of Alzheimer’s Disease

2012 ◽  
Vol 27 (6) ◽  
pp. 388-396 ◽  
Author(s):  
Baldwin Van Gorp ◽  
Tom Vercruysse ◽  
Jan Van den Bulck
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Experimental Design ◽  
Fear Of Death ◽  
The Public ◽  
Starting Point

Starting point of this study was the assumption that Alzheimer’s disease is made worse for the person who has the disease by the negative regard in which the illness is held by society. The aim was to test by means of a campaign advertisement whether more nuanced counterframes could have an impact while remaining credible and comprehensible to the public. A sample of thousand people living in Belgium evaluated the campaign in an experimental design. This revealed that all the versions tested achieved a high average evaluation. The ad in which the heading referred to the fear of death and degeneration was judged to be most attention-grabbing, easier to understand, and more credible than the alternative heading with the idea that someone with Alzheimer’s could still enjoy playing cards. Together, these findings provided a basis for the use of counterframes to generating a more nuanced image of Alzheimer’s disease.

scholarly journals 1α,25-Dihydroxyvitamin D3 and Resolvin D1 Retune the Balance between Amyloid-β Phagocytosis and Inflammation in Alzheimer's Disease Patients

2013 ◽  
Vol 34 (1) ◽  
pp. 155-170 ◽  
Author(s):  
Mathew T. Mizwicki ◽  
Guanghao Liu ◽  
Milan Fiala ◽  
Larry Magpantay ◽  
James Sayre ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Resolvin D1 ◽  
Dihydroxyvitamin D3

scholarly journals The Impact of Experience with a Family Member with Alzheimer’s Disease on Views about the Disease across Five Countries

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Robert J. Blendon ◽  
John M. Benson ◽  
Elizabeth M. Wikler ◽  
Kathleen J. Weldon ◽  
Jean Georges ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family Member ◽  
Public Spending ◽  
The United States ◽  
Direct Experience ◽  
Fatal Disease ◽  
The Public ◽  
Educational Campaigns ◽  
The Impact

The objective of this paper is to understand how the public’s beliefs in five countries may change as more families have direct experience with Alzheimer’s disease. The data are derived from a questionnaire survey conducted by telephone (landline and cell) with 2678 randomly selected adults in France, Germany, Poland, Spain, and the United States. The paper analyzes the beliefs and anticipated behavior of those in each country who report having had a family member with Alzheimer’s disease versus those who do not. In one or more countries, differences were found between the two groups in their concern about getting Alzheimer’s disease, knowledge that the disease is fatal, awareness of certain symptoms, and support for increased public spending. The results suggest that as more people have experience with a family member who has Alzheimer’s disease, the public will generally become more concerned about Alzheimer’s disease and more likely to recognize that Alzheimer’s disease is a fatal disease. The findings suggest that other beliefs may only be affected if there are future major educational campaigns about the disease. The publics in individual countries, with differing cultures and health systems, are likely to respond in different ways as more families have experience with Alzheimer’s disease.

scholarly journals The utility of questionnaires in cognitive and functional assessment in Alzheimer's disease

2010 ◽  
Vol 23 (2) ◽  
pp. 333-334
Author(s):  
V M Aziz ◽  
J. Yagoub ◽  
K. Saba ◽  
M. Asaad
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Functional Assessment ◽  
Clinical Picture ◽  
Behavioral Changes ◽  
Cognitive Domains ◽  
Amnesic Syndrome ◽  
Insidious Onset ◽  
Progressive Cognitive Impairment

Alzheimer's disease (AD) manifests clinically with an insidious onset and slow but progressive cognitive impairment. The clinical picture of AD can be classified into cognitive and behavioral changes. The initial deficit usually manifests as an amnesic syndrome which may progress very gradually for several years before impairment in other cognitive domains, such as language, semantic memory and visuospatial function, becomes apparent (Hodges and Patterson, 1995).

scholarly journals Reducing the Risk of Alzheimer’s Disease and Maintaining Brain Health in an Aging Society

2018 ◽  
Vol 133 (3) ◽  
pp. 225-229 ◽  
Author(s):  
Melinda Kelley ◽  
Brigette Ulin ◽  
Lisa C. McGuire
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Health ◽  
Aging Society

Accessibility in public space as perceived by people with Alzheimer’s disease

Dementia ◽  
2011 ◽  
Vol 10 (4) ◽  
pp. 587-602 ◽  
Author(s):  
Anna Brorsson ◽  
Annika Öhman ◽  
Stefan Lundberg ◽  
Louise Nygård
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Public Space ◽  
Theory Approach ◽  
The Public ◽  
People With Dementia ◽  
Core Category ◽  
Problematic Situations ◽  
The Relationship ◽  
Grounded Theory Approach

Most people with dementia remain living at home as long as possible after being diagnosed, and hence their lives also include activities in the public space. The aim of this study was to illuminate experiences of accessibility in public space in people with Alzheimer’s disease. A qualitative grounded theory approach with repeated in-depth interviews was used. The core category, accessibility as a constantly changing experience, was characterized by changes in the relationship between informants and public space. Changes in the relationship took place in activities and use of place and related to familiarity and comfort, individual motives and interests, and planning and protecting. Other changes occurred in places and problematic situations related to everyday technologies, crowded places with high tempo and noise, and change of landmarks. These changes reduced feelings of accessibility and increased difficulties in carrying out activities in public space. These findings may be helpful when providing support, and supporting community living.

Prostaglandins and other lipid mediators in Alzheimer’s disease

2002 ◽  
Vol 68-69 ◽  
pp. 197-210 ◽  
Author(s):  
Nicolas G Bazan ◽  
Vittorio Colangelo ◽  
Walter J Lukiw
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lipid Mediators
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