scholarly journals Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing

2020 ◽  
Vol 21 (22) ◽  
pp. 8806
Author(s):  
Rita Rezzani ◽  
Caterina Franco ◽  
Rüdiger Hardeland ◽  
Luigi Fabrizio Rodella

For years the thymus gland (TG) and the pineal gland (PG) have been subject of increasingly in-depth studies, but only recently a link that can associate the activities of the two organs has been identified. Considering, on the one hand, the well-known immune activity of thymus and, on the other, the increasingly emerging immunological roles of circadian oscillators and the rhythmically secreted main pineal product, melatonin, many studies aimed to analyse the possible existence of an interaction between these two systems. Moreover, data confirmed that the immune system is functionally associated with the nervous and endocrine systems determining an integrated dynamic network. In addition, recent researches showed a similar, characteristic involution process both in TG and PG. Since the second half of the 20th century, evidence led to the definition of an effectively interacting thymus-pineal axis (TG-PG axis), but much has to be done. In this sense, the aim of this review is to summarize what is actually known about this topic, focusing on the impact of the TG-PG axis on human life and ageing. We would like to give more emphasis to the implications of this dynamical interaction in a possible therapeutic strategy for human health. Moreover, we focused on all the products of TG and PG in order to collect what is known about the role of peptides other than melatonin. The results available today are often unclear and not linear. These peptides have not been well studied and defined over the years. In this review we hope to awake the interest of the scientific community in them and in their future pharmacological applications.

2021 ◽  
Vol 16 (6) ◽  
pp. 21-30
Author(s):  
A. V. Kornev

The paper examines activity as the most important component of human life. The author elucidates the features of activity from the standpoint of various fields of knowledge: philosophy, psychology, sociology. The preference is given to the activity approach, which is based on the category of “substantive activity.” It is substantive in nature and does not simply define the activity as human interaction with the outside world, but reflects the changes that constitute the result of human activity. Various aspects of theoretical and practical activity are touched upon on the example of legal activity, which is of a complex intellectual nature. Legal activity is often characterized through legal practice — one of the varieties of social practices. Some similarities of these categories are reflected, as well as differences between them. The paper gives the author’s definition of legal activity focused on professional legal activity. The definition cannot claim to be universal due to various types of professional legal activity. Nevertheless, it is specified that professional legal activity is always an activity carried out on the basis of law, in legal forms; it is aimed at achieving the goals determined by law. The author demonstrates the impact of digital technologies on various types of legal activities. Especially in the conditions of the pandemic when traditional forms of communication have given way to virtual ones. It is noted that this influence is of a dual nature, that is, on the one hand, it increases the efficiency of communications, and, on the other hand, it leads to some risks and problems, in particular, against the background of the fact that a significant part of our population still does not have access to modern information and communication systems.


Author(s):  
Ruslan Hwan

The purpose of this article is to study the ontological and normative approaches to determining the elemental composition ofmunicipal legal policy. It is shown that the special and strategic role of municipal legal policy is determined and determined primarilyby its human dimension – it is characterized by direct anthropologization and personalization, because it arises at the junction of lawand society, law and man, individual and collective, private and public.It is pointed out that municipal legal policy is essentially a systematic, comprehensive and systematically grounded and formali -zed municipal strategy, which makes it possible to better understand the nature and content of local government and the axiological andexistential value of the territorial community. the human life cycle is carried out – and for the proper organization of such a policy theneed for strategic thinking, strategic planning is objectified – both for further development of territorial communities, through awarenessof the importance of forming a vision of future local development priorities and setting appropriate goals and objectives to achievethem , which includes determining the elemental composition of such a policy.It is proved that the definition of the elemental composition of municipal legal policy is possible in two ways: either by determiningthe elemental composition of policy as such, or by determining the elemental composition of the species characteristics of legalpolicy (state, legislative, etc.). It is argued that the definition of the elemental composition of municipal legal policy is of great importancenot only for determining the axiology of such policy, it has great praxeological potential, because it gives an idea of the structuraland technological characteristics of such policy, the impact of which may contribute to its formation, development , improvement, definition of strategic priorities in the process of its implementation.


2020 ◽  
Vol 21 (2) ◽  
pp. 237-245 ◽  
Author(s):  
Mohamed A. Ragheb ◽  
Marwa H. Soliman ◽  
Emad M. Elzayat ◽  
Mervat S. Mohamed ◽  
Nada El-Ekiaby ◽  
...  

Background: Doxorubicin (DOX) is the most common drugs used in cancer therapy, including Hepatocellular Carcinoma (HCC). Drug resistance, is one of chemotherapy’s significant problems. Emerging studies have shown that microRNAs (miRNAs) could participate in regulating this mechanism. Nevertheless, the impact of miRNAs on HCC chemoresistance is still enigmatic. Objective: Investigating the role of miR-520c-3p in enhancement of anti-tumor effect of DOX against HepG2 cells. Methods: Expression profile for liver related miRNAs (384 miRNAs) has been analyzed on HepG2 cells treated with DOX using qRT-PCR. miR-520c-3p, the most deregulated miRNA, was selected for combination treatment with DOX. Expression level for LEF1, CDK2, CDH1, VIM, Mcl-1 and TP53 was evaluated in miR-520c-3p transfected cells. Cell viability, colony formation, wound healing as well as apoptosis assays have been demonstrated. Furthermore, Mcl-1 protein level was measured using western blot technique. Results: The present data indicated that miR-520c-3p overexpression could render HepG2 cells chemo-sensitive to DOX through enhancing its suppressive effects on proliferation, migration, and induction of apoptosis. The suppressive effect of miR-520c-3p involved altering the expression levels of some key regulators of cell cycle, proliferation, migration and apoptosis including LEF1, CDK2, CDH1, VIM, Mcl-1 and TP53. Interestingly, Mcl-1 was found to be one of the potential targets of miR-520c-3p, and its protein expression level was down-regulated upon miR-520c-3p overexpression. Conclusion: Our data referred to the tumor suppressor function of miR-520c-3p that could modulate chemosensitivity of HepG2 cells toward DOX treatment, providing a promising therapeutic strategy in HCC.


2021 ◽  
Vol 58 (2) ◽  
pp. 151-169
Author(s):  
Timur V. Khamdamov ◽  
Mikhail Yu. Voloshin ◽  

In the modern Russian philosophy, discussions about the phenomenon of computer simulations in the scientific research practice of conducting experiments are just beginning to pass the stage of initiation in small interdisciplinary groups studying this new direction for the philosophy of science. At the same time, in Western philosophy by the current moment there have been formed entire directions for the study of computer simulations. Different groups of researchers in different ways form ideas about the basic characteristics of simulations: from skeptical views on their nature, which are of no philosophical interest, to extremely revolutionary attitudes that assign simulations to the main role in the next expected turn of philosophy, comparable in its power to the linguistic turn in early XX century. One of the main controversial issues in Western philosophical thought was the search for relevant criteria and signs of simulations that could create a solid basis for formulating a rigorous definition of this phenomenon. Thus, through the definition, researchers first of all try, on the one hand, to solve the taxonomic problem of the correlation and interconnection of simulations with other types of experiment: natural, laboratory, mental, mathematical. On the other hand, to reveal for philosophy ontological and epistemological foundations of simulations, which carry the potential of new philosophical knowledge. This article is devoted to a brief review of the existing concepts of representatives of Western schools of thought on the phenomenon of computer simulations in the context of the philosophy of science. The structure of the review is built on three basic conceptual directions: 1) definition of the term "computer simulation"; 2) computer simulations as an experiment; 3) the epistemic value of simulations. Such a review can become the subject of discussion for Russian researchers interested in the impact of computer simulations on science and philosophy.


2018 ◽  
Vol 12 (2) ◽  
pp. 260-278
Author(s):  
Christoph Demmerling

Abstract The following article argues that fictional texts can be distinguished from non-fictional texts in a prototypical way, even if the concept of the fictional cannot be defined in classical terms. In order to be able to characterize fictional texts, semantic, pragmatic, and reader-conditioned factors have to be taken into account. With reference to Frege, Searle, and Gabriel, the article recalls some proposals for how we might define fictional speech. Underscored in particular is the role of reception for the classification of a text as fictional. I make the case, from a philosophical perspective, for the view that fictional texts represent worlds that do not exist even though these worlds obviously can, and de facto do, contain many elements that are familiar to us from our world. I call these worlds reading worlds and explain the relationship between reading worlds and the life world of readers. This will help support the argument that the encounter with fictional literature can invoke real feelings and that such feelings are by no means irrational, as some defenders of the paradox of fiction would like us to believe. It is the exemplary character of fictional texts that enables us to make connections between the reading worlds and the life world. First and foremost, the article discusses the question of what it is that readers’ feelings are in fact related to. The widespread view that these feelings are primarily related to the characters or events represented in a text proves too simple and needs to be amended. Whoever is sad because of the fate of a fictive character imagines how he or she would fare if in a similar situation. He or she would feel sad as it relates to his or her own situation. And it is this feeling on behalf of one’s self that is the presupposition of sympathy for a fictive character. While reading, the feelings related to fictive characters and content are intertwined with the feelings related to one’s own personal concerns. The feelings one has on his or her own behalf belong to the feelings related to fictive characters; the former are the presupposition of the latter. If we look at the matter in this way, a new perspective opens up on the paradox of fiction. Generally speaking, the discussion surrounding the paradox of fiction is really about readers’ feelings as they relate to fictive persons or content. The question is then how it is possible to have them, since fictive persons and situations do not exist. If, however, the emotional relation to fictive characters and situations is conceived of as mediated by the feelings one has on one’s own behalf, the paradox loses its confusing effect since the imputation of existence no longer plays a central role. Instead, the conjecture that the events in a fictional story could have happened in one’s own life is important. The reader imagines that a story had or could have happened to him or herself. Readers are therefore often moved by a fictive event because they relate what happened in a story to themselves. They have understood the literary event as something that is humanly relevant in a general sense, and they see it as exemplary for human life as such. This is the decisive factor which gives rise to a connection between fiction and reality. The emotional relation to fictive characters happens on the basis of emotions that we would have for our own sake were we confronted with an occurrence like the one being narrated. What happens to the characters in a fictional text could also happen to readers. This is enough to stimulate corresponding feelings. We neither have to assume the existence of fictive characters nor do we have to suspend our knowledge about the fictive character of events or take part in a game of make-believe. But we do have to be able to regard the events in a fictional text as exemplary for human life. The representation of an occurrence in a novel exhibits a number of commonalities with the representation of something that could happen in the future. Consciousness of the future would seem to be a presupposition for developing feelings for something that is only represented. This requires the power of imagination. One has to be able to imagine what is happening to the characters involved in the occurrence being narrated in a fictional text, ›empathize‹ with them, and ultimately one has to be able to imagine that he or she could also be entangled in the same event and what it would be like. Without the use of these skills, it would remain a mystery how reading a fictional text can lead to feelings and how fictive occurrences can be related to reality. The fate of Anna Karenina can move us, we can sympathize with her, because reading the novel confronts us with possibilities that could affect our own lives. The imagination of such possibilities stimulates feelings that are related to us and to our lives. On that basis, we can participate in the fate of fictive characters without having to imagine that they really exist.


2020 ◽  
Vol 14 (1) ◽  
pp. 73-87
Author(s):  
Nina Gorenc

The research behind this paper is set in the context of the 2016 US presidential election that has come to symbolize the post-truth era. We conducted a literature review on the 2016 election, with the aim to better understand the impact of computational propaganda on the election outcome and on the behaviour of voters. The paper opens with a definition of post-truth society and related concepts such as fake news and computational propaganda. It explores the changes of political communication in a digital environment and analyses the role of social media in the 2016 election. It probes into phenomena such as the trivialization of politics and the loss of credibility of political actors, which are both common in post-truth societies. The reviewed literature seems to indicate that social media have become strong actors on the political stage, but so far not the predominant source of political information and influence on the behaviour of voters. The paper makes two important contributions. Firstly, drawing on the concept of post-truth society, it analyses the role of computational propaganda in the 2016 presidential election, and secondly, it attempts to explain the paradox of general political apathy on one hand, and increased political activism on the other. These are some of the challenges we are now facing, and in order to be able to cope with them it is important to acknowledge and understand them.


2014 ◽  
Vol 8 (1) ◽  
pp. 22 ◽  
Author(s):  
David Michael Bourne

Technology has an ever increasing impact on how we work and live. Article adressed the issue of the impact of technology in two key areas of language learning. On the one side learners increasingly used technology to translate. Given this trend, was there any real need to learn a language. On the other side, educational institutions increasingly used technology to rate language proficiency. Given this trend, would the work of the teacher become less and less important. The survey was conducted by using quantitative method. The respondents’ age range was 18-25. There were 53 respondents, 35% were male and 65% were female. The instrument was a questionaire having 9 questions describing the students’ reliance on computer in translation. It can be concluded that learners of English indicate that they accept and welcome the role of technology in language learning, but there is a doubt that the role and participation of humans in the learning process will be completely replaced. The human element remains an important ingredient. (EE)


Author(s):  
Steven Moran ◽  
Nicholas A. Lester ◽  
Eitan Grossman

In this paper, we investigate evolutionarily recent changes in the distributions of speech sounds in the world's languages. In particular, we explore the impact of language contact in the past two millennia on today's distributions. Based on three extensive databases of phonological inventories, we analyse the discrepancies between the distribution of speech sounds of ancient and reconstructed languages, on the one hand, and those in present-day languages, on the other. Furthermore, we analyse the degree to which the diffusion of speech sounds via language contact played a role in these discrepancies. We find evidence for substantive differences between ancient and present-day distributions, as well as for the important role of language contact in shaping these distributions over time. Moreover, our findings suggest that the distributions of speech sounds across geographic macro-areas were homogenized to an observable extent in recent millennia. Our findings suggest that what we call the Implicit Uniformitarian Hypothesis, at least with respect to the composition of phonological inventories, cannot be held uncritically. Linguists who would like to draw inferences about human language based on present-day cross-linguistic distributions must consider their theories in light of even short-term language evolution. This article is part of the theme issue ‘Reconstructing prehistoric languages’.


Author(s):  
Viktoriia Bondarenko ◽  
Viktoriia Vasiuta ◽  
Kateryna Pisarenko

The article deals with the question of the influence of marketing communications on consumer behavior. Today, in order to increase sales, it is no longer enough for companies to just improve their product or service, improve its quality. Among all marketing tools, marketing communications play a special role. The relevance of the topic is due to the need for a theoretical substantiation of the influence of the marketing communication environment on consumer behavior. The purpose of the article is to study the role of marketing communications and their impact on consumer behavior. As a result of this study, the role of marketing communications in the formation of consumer behavior has been substantiated from the standpoint of the main theories and concepts that form the subject areas of marketing communications research. The effectiveness of marketing policy depends on the correct choice of communication tools. The tools of the communication complex are highlighted and characterized. It has been proved that marketing communications influence the formation of consumer behavior in three aspects: informational, emotional, and behavioral. The scientific approaches of scientists to the definition of the process of making a consumer’s decision to purchase are analyzed. The stages of the consumer’s decision-making process to purchase a product are highlighted. Today, integrated marketing communications are considered more effective. They represent the most complete marketing communications system that includes all elements from advertising to packaging. Special attention is paid to the issue of the effectiveness of the impact of marketing communications on consumer behavior. The sequence of determining the effectiveness of the impact of marketing communications on consumer behavior is indicated. It is noted that for effective promotion of goods, only the informational component of communications is not enough. When developing a marketing communications system, it is necessary to take into account personal values. This will increase the degree of influence on consumer behavior. The main goal of marketing communications is to motivate consumer behavior. The use of modern marketing communications through a variety of means can increase the effectiveness of influencing consumer behavior.


2021 ◽  
Vol 2 (48) ◽  
pp. 120-125
Author(s):  
O. P. Vashkiv ◽  
◽  
S. B. Smereka ◽  

The article is aimed at studying the features of energy saving at a manufacturing enterprise and establishing a cause-and-effect relationship between energy saving and product competitiveness. Due to analyzing and generalizing the research results of domestic and foreign scientists the views of researchers on the process of energy saving at a manufacturing enterprise are systematized; the growing role of energy saving in ensuring energy efficiency and, consequently, product competitiveness is established. The research results show that energy saving at an enterprise is one of its most important assets, the impact of which on the level of product competitiveness is becoming increasingly important in the face of the exacerbating energy and environmental crises. Energy saving, basically focusing on the intensification of production processes and use of energy and energy resources, on the one hand, reduces the level of specific energy consumption and, consequently, the price of the released product while maintaining or increasing its quality; on the other hand, it reduces the carbon loading on the environment, thus contributes to the growth of the company's image among its consumers and partners. Both components are the most important factors in ensuring product competitiveness. The development and implementation of energy saving measures at industrial enterprises, with regard to the industry-specific character of economic entities, market conditions, and the requirements of environmental standards can serve as prospects for further research


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