scholarly journals Novel Approach to Tooth Chemistry: Quantification of Human Enamel Apatite in Context for New Biomaterials and Nanomaterials Development

2020 ◽  
Vol 22 (1) ◽  
pp. 279
Author(s):  
Andrzej Kuczumow ◽  
Renata Chałas ◽  
Jakub Nowak ◽  
Wojciech Smułek ◽  
Maciej Jarzębski

A series of linear profiles of the elements of the enamel in human molar teeth were made with the use of an electron microprobe and a Raman microscope. It is postulated that the enamel can be treated as the superposition of variable “overbuilt” enamel on the stable “core” enamel at the macro-, micro- and nanoscale level. The excessive values characterize the “overbuilt enamel”. All the profiles of excessive parameters along the enamel thickness from the enamel surface to the dentin enamel junction (DEJ) can be approximated very precisely with the use of exponential functions, where Ca, P, Cl and F spatial profiles are decaying while Mg, Na, K and CO32− ones are growing distributions. The “overbuilt” apatite formed on the boundary with DEJ, enriched in Na, Mg, OH and carbonates, reacts continuously with Ca, Cl and F, passing into an acid-resistant form of the “overbuilt” enamel. The apparent phases arriving in boundary regions of the “overbuilt enamel” were proposed. Microdiffraction measurements reveal relative variation of energy levels during enamel transformations. Our investigations are the milestones for a further new class of biomaterial and nanomaterial development for biomedical applications.

2019 ◽  
Author(s):  
Antoine Maruani ◽  
Peter A. Szijj ◽  
Calise Bahou ◽  
João C. F. Nogueira ◽  
Stephen Caddick ◽  
...  

<p>Diseases are multifactorial, with redundancies and synergies between various pathways. However, most of the antibody-based therapeutics in clinical trials and on the market interact with only one target thus limiting their efficacy. The targeting of multiple epitopes could improve the therapeutic index of treatment and counteract mechanisms of resistance. To this effect, a new class of therapeutics emerged: bispecific antibodies.</p><p>Bispecific formation using chemical methods is rare and low yielding and/or requires a large excess of one of the two proteins to avoid homodimerisation. In order for chemically prepared bispecifics to deliver their full potential, high-yielding, modular and reliable cross-linking technologies are required. Herein, we describe a novel approach not only for the rapid and high-yielding chemical generation of bispecific antibodies from native antibody fragments, but also for the site-specific dual functionalisation of the resulting bioconjugates. Based on orthogonal clickable functional groups, this strategy enables the assembly of functionalised bispecifics with controlled loading in a modular and convergent manner.</p>


2019 ◽  
Vol 26 (30) ◽  
pp. 5609-5624
Author(s):  
Dijana Saftić ◽  
Željka Ban ◽  
Josipa Matić ◽  
Lidija-Marija Tumirv ◽  
Ivo Piantanida

: Among the most intensively studied classes of small molecules (molecular weight < 650) in biomedical research are small molecules that non-covalently bind to DNA/RNA, and another intensively studied class is nucleobase derivatives. Both classes have been intensively elaborated in many books and reviews. However, conjugates consisting of DNA/RNA binder covalently linked to nucleobase are much less studied and have not been reviewed in the last two decades. Therefore, this review summarized reports on the design of classical DNA/RNA binder – nucleobase conjugates, as well as data about their interactions with various DNA or RNA targets, and even in some cases protein targets are involved. According to these data, the most important structural aspects of selective or even specific recognition between small molecule and target are proposed, and where possible related biochemical and biomedical aspects were discussed. The general conclusion is that this, rather new class of molecules showed an amazing set of recognition tools for numerous DNA or RNA targets in the last two decades, as well as few intriguing in vitro and in vivo selectivities. Several lead research lines show promising advancements toward either novel, highly selective markers or bioactive, potentially druggable molecules.


2018 ◽  
Vol 6 (41) ◽  
pp. 11096-11103 ◽  
Author(s):  
Ho Jin Ma ◽  
Wook Ki Jung ◽  
Youngtae Park ◽  
Do Kyung Kim

Photoluminescence spectrum and energy levels of an Er:Y2O3–MgO nanocomposite.


Author(s):  
S. Kothai ◽  
R. Umamaheswari

Microsponges become imperative in the field of targeted drug delivery and in other biomedical applications. There was a clamant need for designing microsponges incorporating with green synthesised metal nanoparticles rather than the chemical drug in order to reduce the side effects of the drug and thus increasing the effectiveness of nature of the whole material. It provokes us to design this novel approach of loading copper nanoparticles into the microsponges. Here in this work, microsponges based on ethyl cellulose and polyvinyl alcohol were synthesised by Quasi-Emulsion Solvent diffusion method in which copper nanoparticles procured from Hibiscus rosa-sinensis leaf extract was incorporated. The Loaded microsponges were characterised by High Resolution Scanning Electron Microscopy (HR-SEM) and Particle size distribution Analyzer (PSA). The Drug content and Entrapment Efficiency of the microsponges were found out. The antimicrobial and antioxidant activity of the loaded microsponges were evaluated.


2021 ◽  
Author(s):  
Michael Thiel ◽  
◽  
Haifeng Wang ◽  
Dzevat Omeragic ◽  
Jean-Michel Denichou ◽  
...  

Faulting is one type of structural trap for hydrocarbon reservoirs. With more and more fields moving toward the brownfield or mature operations stage of life, the opportunity to target bypassed or attic oil in the vicinity of bounding fault(s) is becoming more and more attractive to operators. However, without an effective logging-while-drilling (LWD) tool to locate and map a fault parallel to the well trajectory, it has been challenging and potentially high risk to optimally place a well to drain oil reserves near the fault. Operators often plan these horizontal wells at a significant distance away from the mapped fault position to avoid impacts to the well construction and production of the well. Often, the interpreted fault position, based on seismic data, can have significant lateral uncertainty, and uncertainties attached to standard well survey measurements make it challenging to place the well near the fault. This often results in the wells being placed much farther from the fault than expected, which is not optimal for maximizing recovery. In other cases, due to uncertainty in the location of the fault, the wells would accidentally penetrate the side faults and cause drilling and other issues. Conventional remote boundary detection LWD tools do not assist with locating the fault position, as they only detect formation boundaries above or below the trajectory and not to the side. In this paper, the authors propose a novel approach for mapping features like a fault parallel to the well trajectory, which was previously impossible to map accurately. This new approach utilizes a new class of deep directional resistivity measurements acquired by a reservoir mapping-while-drilling tool. The deep directional resistivity measurements are input to a newly devised inversion algorithm, resulting in high-resolution reservoir mapping on the transverse plane, which is perpendicular to the well path. These new measurements have a strong sensitivity to resistivity in contrast to the sides of the wellbore, making them suitable for side fault detection. The new inversion in the transverse plane is not limited to detecting a side fault; it can also map any feature on the transverse plane to the well path, which further broadens the application of this technology. Using the deep directional resistivity data acquired from a horizontal ultra-ERD well recently drilled in the Wandoo Field offshore Western Australia, the authors tested this approach against the well results and existing control wells. Excellent mapping of the main side fault up to 30 m to the side of the well was achieved with the new approach. Furthermore, the inversion reveals other interesting features like lateral formation thickness variations and the casing of a nearby well. In addition, the methodology of utilizing this new approach for guiding geosteering parallel to side fault in real time is elaborated, and the future applications are discussed.


Author(s):  
Y. A. S. El-Masry ◽  
Y. Abd Elmaboud ◽  
M. A. Abdel-Sattar

Abstract Gold nanoparticles (AuNPs) are increasingly being widely used in several biomedical applications for their compatibility of synthesis and less toxicity. The mixture of gold and titanium oxide nanoparticles is suspended in water to make a new class of nanofluid, which is called a hybrid nanofluid. The problem of direct current (DC)/alternating current (AC) magnetohydrodynamic (MHD) micropump of the hybrid nanofluid through a porous medium in the gap between vertical coaxial microtubes with heat transfer has been discussed. The mathematical model is established and then solved with the help of the Laplace transform. The inversion of the transformed functions is calculated numerically. The velocity, the flowrate, the pressure, and the heat transfer are discussed graphically. The higher concentration of the mixture of particles enhances the stream so that the required pressure is small. Moreover, it is found that the variation of the Nusselt number is noticeable by increasing the concentrations of nanoparticles, but this variation vanishes near the outer tube.


Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2849 ◽  
Author(s):  
Renan Araújo ◽  
Soraya Santos ◽  
Elizabeth Igne Ferreira ◽  
Jeanine Giarolla

Dendrimers are nanoscopic compounds, which are monodispersed, and they are generally considered as homogeneous. PAMAM (polyamidoamine) was introduced in 1985, by Donald A. Tomalia, as a new class of polymers, named ‘starburst polymers’. This important contribution of Professor Tomalia opened a new research field involving nanotechnological approaches. From then on, many groups have been using PAMAM for diverse applications in many areas, including biomedical applications. The possibility of either linking drugs and bioactive compounds, or entrapping them into the dendrimer frame can improve many relevant biological properties, such as bioavailability, solubility, and selectivity. Directing groups to reach selective delivery in a specific organ is one of the advanced applications of PAMAM. In this review, structural and safety aspects of PAMAM and its derivatives are discussed, and some relevant applications are briefly presented. Emphasis has been given to gene delivery and targeting drugs, as advanced delivery systems using PAMAM and an incentive for its use on neglected diseases are briefly mentioned.


Author(s):  
K. Darshana Abeyrathna ◽  
Ole-Christoffer Granmo ◽  
Xuan Zhang ◽  
Lei Jiao ◽  
Morten Goodwin

Relying simply on bitwise operators, the recently introduced Tsetlin machine (TM) has provided competitive pattern classification accuracy in several benchmarks, including text understanding. In this paper, we introduce the regression Tsetlin machine (RTM), a new class of TMs designed for continuous input and output, targeting nonlinear regression problems. In all brevity, we convert continuous input into a binary representation based on thresholding, and transform the propositional formula formed by the TM into an aggregated continuous output. Our empirical comparison of the RTM with state-of-the-art regression techniques reveals either superior or on par performance on five datasets. This article is part of the theme issue ‘Harmonizing energy-autonomous computing and intelligence’.


2010 ◽  
Vol 441 ◽  
pp. 235-267 ◽  
Author(s):  
Blanca González ◽  
Carlos López de Laorden ◽  
Montserrat Colilla ◽  
Maria Vallet-Regí

Dendrimers are a relatively new class of molecules that display a variety of potentially useful architecture-induced properties. In this chapter, we firstly present a general description of this interesting class of macromolecules, making special emphasis in their current biomedical applications. The combination of dendrimers with ceramics, traditionally used in the biomedical field, provides synergistic features and functions to the resulting hybrid materials. After the dendrimers introduction, an overall description of mesoporous silicas, iron oxide nanoparticles and carbon nanotubes bioceramics, is presented. Finally, recent research examples of dendrimer-functionalized ceramics, both from the synthetic and biomedical applicative points of view, are reviewed.


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