scholarly journals Applications of Ultrasound-Mediated Drug Delivery and Gene Therapy

2021 ◽  
Vol 22 (21) ◽  
pp. 11491
Author(s):  
Juliana Sitta ◽  
Candace M. Howard
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Targeted Drug Delivery ◽  
Viral Vectors ◽  
Biological Effects ◽  
Ultrasound Contrast Agents ◽  
Host Immune System ◽  
Dual Vector ◽  
Effective Delivery ◽  
Concurrent Development

Gene therapy has continuously evolved throughout the years since its first proposal to develop more specific and effective transfection, capable of treating a myriad of health conditions. Viral vectors are some of the most common and most efficient vehicles for gene transfer. However, the safe and effective delivery of gene therapy remains a major obstacle. Ultrasound contrast agents in the form of microbubbles have provided a unique solution to fulfill the need to shield the vectors from the host immune system and the need for site specific targeted therapy. Since the discovery of the biophysical and biological effects of microbubble sonification, multiple developments have been made to enhance its applicability in targeted drug delivery. The concurrent development of viral vectors and recent research on dual vector strategies have shown promising results. This review will explore the mechanisms and recent advancements in the knowledge of ultrasound-mediated microbubbles in targeting gene and drug therapy.

scholarly journals Gene Therapy: The Molecular Bandage for Treating Genetic Disorders

1970 ◽  
Vol 3 (1) ◽  
pp. 24-27
Author(s):  
Md Manjurul Karim
Keyword(s):  
Gene Therapy ◽  
Viral Vectors ◽  
Genetic Disorders ◽  
Clinical Status ◽  
Genetic Material ◽  
Review Article ◽  
Cell Tissue ◽  
Efficient Gene ◽  
Effective Delivery ◽  
A Cell

The concept of gene therapy involves the transfer of genetic material into a cell, tissue, or whole organ, with a view to curing a disease or at least improving the clinical status of a patient. Much of its success relies heavily on the development of an effective delivery system that is capable of efficient gene transfer in a variety of tissues, without causing any associated pathogenic effects. Viral vectors currently offer the best choice for efficient gene delivery, what has been discussed in this review article. Their performance and pathogenecity has been evaluated in animal models, and encouraging results form the basis for clinical trials to treat genetic disorders and acquired diseases. Despite some initial success in these trials, vector development remains a seminal concern for improved gene therapy technologies. DOI: http://dx.doi.org/10.3329/akmmcj.v3i1.10110 AKMMCJ 2012; 3(1): 24-27

scholarly journals Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment

2015 ◽  
Vol 65 (2) ◽  
pp. 105-116 ◽  
Author(s):  
Hanqing Liu ◽  
Zhigang Tu ◽  
Fan Feng ◽  
Haifeng Shi ◽  
Keping Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Targeted Drug Delivery ◽  
Viral Vectors ◽  
Organic Molecules ◽  
Surface Modifications ◽  
General Concept ◽  
Biologically Active ◽  
Small Organic Molecules ◽  
Working Mechanisms

Abstract A virosome is an innovative hybrid drug delivery system with advantages of both viral and non-viral vectors. Studies have shown that a virosome can carry various biologically active molecules, such as nucleic acids, peptides, proteins and small organic molecules. Targeted drug delivery using virosome-based systems can be achieved through surface modifications of virosomes. A number of virosome- -based prophylactic and therapeutic products with high safety profiles are currently available in the market. Cancer treatment is a big battlefield for virosome-based drug delivery systems. This review provides an overview of the general concept, preparation procedures, working mechanisms, preclinical studies and clinical applications of virosomes in cancer treatment.

scholarly journals Application of Non-Viral Vectors in Drug Delivery and Gene Therapy

Polymers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 3307
Author(s):  
Shuaikai Ren ◽  
Mengjie Wang ◽  
Chunxin Wang ◽  
Yan Wang ◽  
Changjiao Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Targeted Delivery ◽  
Viral Vectors ◽  
Mesoporous Silica Nanoparticles ◽  
Low Cost ◽  
Physicochemical Characteristics ◽  
Future Research ◽  
Synthesis Methods ◽  
Therapeutic Effects

Vectors and carriers play an indispensable role in gene therapy and drug delivery. Non-viral vectors are widely developed and applied in clinical practice due to their low immunogenicity, good biocompatibility, easy synthesis and modification, and low cost of production. This review summarized a variety of non-viral vectors and carriers including polymers, liposomes, gold nanoparticles, mesoporous silica nanoparticles and carbon nanotubes from the aspects of physicochemical characteristics, synthesis methods, functional modifications, and research applications. Notably, non-viral vectors can enhance the absorption of cargos, prolong the circulation time, improve therapeutic effects, and provide targeted delivery. Additional studies focused on recent innovation of novel synthesis techniques for vector materials. We also elaborated on the problems and future research directions in the development of non-viral vectors, which provided a theoretical basis for their broad applications.

Biomolecular-conjugated nanoparticles for biomedical applications

2016 ◽  
Vol 1 (01) ◽  
Author(s):  
Prachi Goyal ◽  
Kamani Parmar ◽  
Sonika Gupta ◽  
Mukesh Sharma ◽  
M. P. Dobhal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Targeted Drug Delivery ◽  
Molecular Motors ◽  
Biomedical Applications ◽  
Biological Functions ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug ◽  
Cellular Compartments

Bimolecular-conjugated nanoparticles (NP) demonstrate unique properties with wide-ranging applications in the diagnosis of infectious diseases as well as application in gene therapy and drug delivery therapies. The unique properties and utility of NP arise from a variety of attributes, including the similar size of nanoparticles and biomolecules. Biological functions depend primarily on units that have nanoscale dimensions, such as viruses, ribosomes, molecular motors and components of the extra cellular matrix. In addition, engineered devices at the nanoscale are small enough to interact directly with sub-cellular compartments and to probe intracellular events. This review focuses on the methods of nanoparticle interaction with different biomolecules such as antibodies, DNA, lipids, and proteins. More specifically, there is discussion about bioconjugation linkage and a summary of potential biomedical applications of bio-conjugated nanoparticles as targeted drug delivery vehicles.

Sign in / Sign up

Export Citation Format

Share Document