A Review on the Role of miR-149-5p in the Carcinogenesis
miR-149 is an miRNA with essential roles in carcinogenesis. This miRNA is encoded by the MIR149 gene on 2q37.3. The miR-149 hairpin produces miR-149-5p and miR-149-3p, which are the “guide” and the sister “passenger” strands, respectively. Deep sequencing experiments have shown higher prevalence of miR-149-5p compared with miR-149-3p. Notably, both oncogenic and tumor suppressive roles have been reported for miR-149-5p. In this review, we summarize the impact of miR-149-5p in the tumorigenesis and elaborate mechanisms of its involvement in this process in a variety of neoplastic conditions based on three lines of evidence, i.e., in vitro, in vivo and clinical settings.
2019 ◽
Vol 20
(11)
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pp. 2675
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2010 ◽
Vol 23
(7)
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pp. 962-976
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1997 ◽
Vol 16
(11)
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pp. 629-635
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Keyword(s):
Keyword(s):