scholarly journals Improvement of Superficial and Deep Cutaneous Microcirculation Due to Axillary Plexus Anesthesia Impaired by Smoking

2021 ◽  
Vol 10 (10) ◽  
pp. 2114
Author(s):  
Talia Bosselmann ◽  
Jonas Kolbenschlag ◽  
Ole Goertz ◽  
Peter Zahn ◽  
Lukas Prantl ◽  
...  
Keyword(s):  
Anesthetic Management ◽  
Tissue Oxygen Saturation ◽  
Maximum Increase ◽  
Reconstructive Procedures ◽  
Doppler Flowmetry ◽  
Cutaneous Microcirculation ◽  
Peripheral Nerve Blockade ◽  
Significant Impairment ◽  
Vascular Physiology ◽  
Nicotine Consumption

Background: Understanding microvascular physiology is key to any reconstructive procedure. Current concepts in anesthesia increasingly involve regional peripheral nerve blockade during microvascular reconstructive procedures. Whereas favorable effects on perfusion due to these techniques have been reported earlier, little evidence focusing on its effects in most peripheral vascular compartments is available. Methods: A total of 30 patients who were to receive axillary plexus blockade (APB) were included. Microcirculatory assessment of the dependent extremity was conducted utilizing combined laser-Doppler flowmetry and white light spectroscopy. Two probes (1–2 and 7–8 mm penetration depth) were used to assess changes in microcirculation. Results: APB resulted in significant changes to both superficial and deep cutaneous microcirculation. Changes in blood flow were most prominent in superficial layers with a maximum increase of +617% compared to baseline values. Significantly lower values of +292% were observed in deep measurements. Consecutively, a significant enhancement in tissue oxygen saturation was observed. Further analysis revealed a significant impairment of perfusion characteristics due to reported nicotine consumption (max Bf: +936% vs. +176%). Conclusion: Cutaneous microcirculation is strongly affected by APB, with significant differences regarding microvascular anatomy and vascular physiology. Smoking significantly diminishes the elicited improvements in perfusion. Our findings could influence reconstructive strategies as well as dependent perioperative anesthetic management.

THE METHOD FOR EVALUATING ADAPTIVE CHANGES IN HUMAN MICROCIRCULATORY-TISSUE SYSTEMS

2020 ◽  
Vol 4 (1) ◽  
pp. 88-99
Author(s):  
A.V. DUNAEV
Keyword(s):  
Middle Finger ◽  
Analysis Data ◽  
The Body ◽  
Tissue Oxygen Saturation ◽  
Doppler Flowmetry ◽  
New Approach ◽  
Adaptive Changes ◽  
Palmar Surface ◽  
Tissue Systems ◽  
The Right

The work is aimed at developing a new approach to assessing adaptive changes in microcirculatory tissue systems when various loads are exerted on the body (sports or physiological stresses), based on the analysis of oscillations in microcirculatory blood flow and tissue oxygen saturation, measured by laser Doppler flowmetry (LDF) and tissue reflectance oximetry (TRO). The study involved eight healthy volunteers aged 21–49 years. Measurements were taken on the palmar surface of the middle finger of the right hand and the medial surface of the lower part of the forearm. The rhythmic oscillations of LDF and TRO were studied using wavelet analysis. Data analysis revealed resonant and synchronized oscillations in the LDF and TRO signals in the myogenic range as an adaptive change as a result of a reaction to physical activity and psychoemotional stress.

scholarly journals Vascular and neural mechanisms of ACh-mediated vasodilation in the forearm cutaneous microcirculation

2002 ◽  
Vol 92 (2) ◽  
pp. 780-788 ◽  
Author(s):  
Martin Berghoff ◽  
Madeera Kathpal ◽  
Sonja Kilo ◽  
Max J. Hilz ◽  
Roy Freeman
Keyword(s):  
Nerve Fibers ◽  
Axon Reflex ◽  
Doppler Flowmetry ◽  
Relative Contribution ◽  
C Fibers ◽  
Cutaneous Microcirculation ◽  
C Fiber ◽  
Dose Dependent Fashion ◽  
Cutaneous Perfusion ◽  
Dose Dependent

The relative contribution of endothelial vasodilating factors to acetylcholine (ACh)-mediated vasodilation in the forearm cutaneous microcirculation is unclear. The aims of this study were to investigate the contributions of prostanoids and cutaneous C fibers to basal cutaneous blood flow (CuBF) and ACh-mediated vasodilation. ACh was iontophoresed into the forearm, and cutaneous perfusion was measured by laser-Doppler flowmetry. To inhibit the production of prostanoids, four doses of acetylsalicylic acid (ASA; 81, 648, 972, and 1,944 mg) were administered orally. Cutaneous nerve fibers were blocked with topical anesthesia. Cyclooxygenase inhibition did not change basal CuBF or endothelium-mediated vasodilation to ACh. In contrast, ASA (972 and 1,944 mg) significantly reduced the C-fiber-mediated axon reflex in a dose-dependent fashion. Blockade of C-fiber function significantly reduced axon reflex-mediated vasodilation but did not affect basal CuBF or endothelium-dependent vasodilation. The findings suggest that prostanoids do not contribute significantly to basal CuBF or endothelium-dependent vasodilation in the forearm microcirculation. In contrast, prostanoids are mediators of the ACh-provoked axon reflex.

Effects of Nitric Oxide on Blood Flow and Mucociliary Activity in the Human Nose

1998 ◽  
Vol 107 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Thomas Runer ◽  
Sven Lindberg
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Beat Frequency ◽  
Ciliary Beat Frequency ◽  
Maximum Increase ◽  
No Donor ◽  
Doppler Flowmetry ◽  
Human Nose

In an animal model, nitric oxide (NO) has been shown to increase mucociliary activity in vivo and ciliary beat frequency in vitro. The aim of the present study was to investigate the effects of NO on blood flow and mucociliary activity in the human nose. The concentration of NO in nasal air was measured with a chemiluminescence technique after nebulizing the NO donor sodium nitroprusside (SNP) at a dose of 3.0 mg into the nose in six volunteers, and was found to increase by 50.1% ± 10.0% (mean ± SEM; p <.001) after the SNP challenge. Blood flow measured by laser Doppler flowmetry increased by 67.3% ± 15.5% (p <.05) after challenge with SNP at 1.0 mg, and by 75.4% ± 18.5% at 3.0 mg (p <.01; n = 6). The higher dose, which produced no subjective side effects, was then used in the mucociliary experiments. The maximum increase in nasal mucociliary activity was 57.2% ± 6.7% at 3.0 mg of SNP (n = 5). The findings support the view that NO regulates mucociliary activity and blood flow in the human nasal mucosa.

Assessment of cutaneous microcirculation by laser Doppler flowmetry in type 1 diabetes

2019 ◽  
Vol 124 ◽  
pp. 91-96 ◽  
Author(s):  
Michele Sorelli ◽  
Piergiorgio Francia ◽  
Leonardo Bocchi ◽  
Alessandra De Bellis ◽  
Roberto Anichini
Keyword(s):  
Type 1 Diabetes ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Cutaneous Microcirculation

scholarly journals Acute dairy milk ingestion does not improve nitric oxide-dependent vasodilation in the cutaneous microcirculation

2016 ◽  
Vol 116 (2) ◽  
pp. 204-210 ◽  
Author(s):  
Billie K. Alba ◽  
Anna E. Stanhewicz ◽  
W. Larry Kenney ◽  
Lacy M. Alexander
Keyword(s):  
Nitric Oxide ◽  
Epidemiological Studies ◽  
Protein Supplementation ◽  
Local Skin ◽  
Doppler Flowmetry ◽  
Cutaneous Vasodilation ◽  
Cutaneous Microcirculation ◽  
Age Related ◽  
Milk Ingestion ◽  
Dairy Milk

AbstractIn epidemiological studies, chronic dairy milk consumption is associated with improved vascular health and reduced age-related increases in blood pressure. Although milk protein supplementation augments conduit artery flow-mediated dilation, whether or not acute dairy milk intake may improve microvascular function remains unclear. We hypothesised that dairy milk would increase direct measurement of endothelial nitric oxide (NO)-dependent cutaneous vasodilation in response to local skin heating. Eleven men and women (61 (sem2) years) ingested two or four servings (473 and 946 ml) of 1 % dairy milk or a rice beverage on each of 4 separate study days. In a subset of five subjects, an additional protocol was completed after 473 ml of water ingestion. Once a stable blood flow occurred, 15 mm-NG-nitro-l-arginine methyl ester was perfused (intradermal microdialysis) to quantify NO-dependent vasodilation. Red-blood-cell flux (RBF) was measured by laser-Doppler flowmetry, and cutaneous vascular conductance (CVC=RBF/mean arterial pressure) was calculated and normalised to maximum (%CVCmax; 28 mm-sodium nitroprusside). Full expression of cutaneous vasodilation was not different among dairy milk, rice beverage and water, and there was no effect of serving size on the total vasodilatory response. Contrary to our hypothesis, NO-dependent vasodilation was lower for dairy milk than rice beverage (D: 49 (sem5), R: 55 (sem5) %CVCmax;P<0·01). Acute dairy milk ingestion does not augment NO-dependent vasodilation in the cutaneous microcirculation compared with a rice beverage control.

scholarly journals STATE OF CUTANEOUS MICROCIRCULATION IN PATIENTS WITH OBESITY

2021 ◽  
Vol 74 (9) ◽  
pp. 2039-2043
Author(s):  
Iana O. Andreieva ◽  
Olha I. Riznyk ◽  
Sergii P. Myrnyi ◽  
Nikolai N. Surmylo
Keyword(s):  
Vascular Pathology ◽  
Control Group ◽  
Class Iii ◽  
Doppler Flowmetry ◽  
Cutaneous Microcirculation ◽  
Class Iii Obesity ◽  
Biological Tests ◽  
Normal Body Weight ◽  
And Gender ◽  
Cardio Vascular

The aim: To determine the influence of obesity on cutaneous microcirculation in patients with different stages of obesity and without cardio-vascular pathologies. Materials and methods: The 67 eligible patients with obesity were enrolled into the main group in this research. 20 healthy patients with normal body weight were included in the control group in this study. The mean age and gender were similar among the groups. Each patient underwent a clinical evaluation during the consultation, biological tests, electrocardiogram, Laser Doppler flowmetry. Results: There was a significant decrease in IM and σ in patients with class II obesity and class III obesity compared with control group. IV was decreased in all groups, but the significant differences were recorded only among patients with obesity and not among overweight patients. During wavelet analysis a significant decrease of the AmaxE was detected in all 4 groups (by 14,7%, 37,7%, 52,4%, 57,4% respectively, P < 0,05). The most significant changes were recorded in the heart spectrum (AmaxC). Conclusions: Overweight patients and patients with obesity without cardio-vascular pathology have initial manifestations of microcirculatory disorders, which deteriorate with an increase of BMI. Changes in microcirculation in patients with obesity characterized by the significant decrease of microvessels perfusion, decreasing endothelial and increasing heart specter modulations. Only high BMI was found to be associated with impaired microcirculation endothelial function (AmaxE B=0.446, 95% CI [0,15, 0,92]) according to the results of regression analysis.

scholarly journals Oral Glucose Load and Human Cutaneous Microcirculation: An Insight into Flowmotion Assessed by Wavelet Transform

Biology ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 953
Author(s):  
Henrique Silva ◽  
Jernej Šorli ◽  
Helena Lenasi
Keyword(s):  
Wavelet Transform ◽  
Reactive Hyperemia ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Short Term ◽  
Doppler Flowmetry ◽  
Chronic Hyperglycemia ◽  
Cutaneous Microcirculation ◽  
The Impact

Microcirculation in vivo has been assessed using non-invasive technologies such as laser Doppler flowmetry (LDF). In contrast to chronic hyperglycemia, known to induce microvascular dysfunction, the effects of short-term elevations in blood glucose on microcirculation are controversial. We aimed to assess the impact of an oral glucose load (OGL) on the cutaneous microcirculation of healthy subjects, quantified by LDF and coupled with wavelet transform (WT) as an interpretation tool. On two separate occasions, sixteen subjects drank either a glucose solution (75 g in 250 mL water) or water (equal volume). LDF signals were obtained in two anatomical sites (forearm and finger pulp) before and after each load (pre-load and post-load, respectively), in resting conditions and during post-occlusive reactive hyperemia (PORH). The WT allowed decomposition of the LDF signals into their spectral components (cardiac, respiratory, myogenic, sympathetic, endothelial NO-dependent). The OGL blunted the PORH response in the forearm, which was not observed with the water load. Significant differences were found for the cardiac and sympathetic components in the glucose and water groups between the pre-load and post-load periods. These results suggest that an OGL induces a short-term subtle microvascular impairment, probably involving a modulation of the sympathetic nervous system.

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