THE METHOD FOR EVALUATING ADAPTIVE CHANGES IN HUMAN MICROCIRCULATORY-TISSUE SYSTEMS

Author(s):  
A.V. DUNAEV

The work is aimed at developing a new approach to assessing adaptive changes in microcirculatory tissue systems when various loads are exerted on the body (sports or physiological stresses), based on the analysis of oscillations in microcirculatory blood flow and tissue oxygen saturation, measured by laser Doppler flowmetry (LDF) and tissue reflectance oximetry (TRO). The study involved eight healthy volunteers aged 21–49 years. Measurements were taken on the palmar surface of the middle finger of the right hand and the medial surface of the lower part of the forearm. The rhythmic oscillations of LDF and TRO were studied using wavelet analysis. Data analysis revealed resonant and synchronized oscillations in the LDF and TRO signals in the myogenic range as an adaptive change as a result of a reaction to physical activity and psychoemotional stress.

2019 ◽  
Vol 17 (4) ◽  
pp. 33-38 ◽  
Author(s):  
L. V. Mezentseva

Purpose– the study the nonlinear dynamics of microcirculation parameters in human symmetrical organs.Material and Methods. Parameters of microcirculation were measured in healthy volunteers (aged between 50 and 70 years) by means of laser Doppler flowmetry (LDF). LDF signal transducers were fixed symmetrically on the lower parts of the right and left shoulders (3 cm above the elbow bend). The degree of chaoticity of microcirculation parameters as a nonlinear dynamic process was estimated using Hausdorff’s index, relative entropy and characteristics of phase portraits. Along with components of the amplitude-and-frequency range for blood flow fluctuations (myogenic, neurogenic, respiratory, and cardiac) was estimated and correlations between all characteristics of microcirculation in both sides of the body were done.Results.Asymmetry of correlation relationships of nonlinear dynamics parameters and components of the amplitude-andfrequency range for blood flow fluctuations of right and left sides of the body was revealed. Hausdorff index in the left side correlated not only with the average value of perfusion and with the coefficient of variation in the same side (r1 = –0,68; r2 =–0,51), but also with correlation dimension of chaos in the opposite side (r=0,49). Similarly, entropy in the left side correlated not only with the average value of perfusion and coefficient of variation in the left (r1 =0,43; r2 =0,60), but also with the entropy and correlation dimension of chaos in the right side (r1 =0,48; r2 =–0,41). The neurogenic component in the left side positively correlated with the myogenic component in the same side (r=0,71). A positive correlation was observed between the neurogenic component in right side and myogenic component in the opposite side (r=0,57). Asymmetry of correlation relationships was also revealed for the respiratory and cardiac components.Conclusions. Our results illustrate the specific regulation of blood flow in micro vessels of paired organs, which is associated with functional asymmetry. The physiological mechanisms for this asymmetry require further experimental and clinical studies. 


MEDIKORA ◽  
2021 ◽  
Vol 20 (2) ◽  
pp. 125-133
Author(s):  
Aulia Gusdernawati ◽  
Widiyanto Widiyanto ◽  
Ahmad Nasrulloh

Motion analysis in sports can help athletes and coaches as material for evaluating movement in improving movement and improving athlete performance with a predetermined training program. The purpose of this study was to analyze the motion of the topspin technique in table tennis. This research is a qualitative research by describing the results of the video analysis of the topspin technique movement which is accessed from youtube, then using the Kinovea application instrument. The subjects in this study were the top ranked players, which consisted of five of the best male athletes at the world level in the table tennis game. Based on the analysis data above, it was found that the average bending of the elbow at the ready position was 92.80, the swing position before hitting the ball was 142.40, when hitting the ball was 117.80, and after hitting the ball was 73.40. The results of the average elbow distance from the center point when the ready position is 68.728 cm, when the swing position before hitting the ball is 23.532 cm, when hitting the ball with a distance of 50.88 cm and during further motion 150.768 cm. The results of the analysis of the inclination angle of the body when the ready position is 161.60, when swinging the hand 152.60, when hitting the ball 150.60, and for further motion with a body inclination of 1660. The results of the analysis of the bending of the right leg when the position is 149.80, the position of swinging the right leg 125.40, and when the ball hits it forms an angle of 125.60 and when it continues to move 42.60. The average results of the analysis of the left leg bending angle when the ready position is 151.20, the swinging position with the left leg bending is 126.20, in the position of the ball hitting an angle of 130.40, and accompanied by a follow-up motion to form the left foot angle of 1460. The average foot distance when hitting the topspin, in the ready position is 186 cm, during the backswing the foot distance is 196.638 cm, and when hitting the ball is 198.81 cm, and accompanied by a follow-up motion of 195.886 cm. Biomechanical analysis of the topspin technique from several stages starting from the ready position to the advanced motion carried out by each athlete according to their respective body anatomy and following the position when hitting the ball.Analisis biomekanika teknik topspin pada permainan tenis mejaAbstrakAnalisis gerak pada olahraga dapat membantu atlet dan pelatih sebagai bahan evaluasi gerakan dalam memperbaiki gerakan dan meningkatkan performa atlet dengan program latihan yang telah ditentukan. Tujuan penelitian ini ialah menganalisis gerak teknik topspin dalam permainan tenis meja. Penelitian ini merupakan penelitian kualitatif dengan mendeskripsikan hasil analisis video gerakan teknik topspin yang diakses dari youtube, kemudian menggunakan instrumen aplikasi Kinovea. Subyek dalam penelitian ini men top ranked players yang berjumlah lima orang atlet putra terbaik ditingkat dunia pada permainan tenis meja. Berdasarkan dari data analisis diatas ditemukan nilai rerata tekukan siku pada saat posisi siap 92,80, posisi ayunan sebelum memukul bola 142,40, saat memukul bola 117,80, dan sesudah memukul bola sebesar 73,40. Hasil rerata jarak siku dari titik pusat saat posisi siap 68,728 cm, saat posisi ayunan sebelum memukul bola 23,532 cm, saat memukul bola dengan jarak 50,88 cm dan saat gerak lanjutan 150,768 cm. Hasil analisis sudut kecondongan tubuh saat posisi siap 161,60, saat mengayunkan tangan 152,60, saat memukul bola 150,60, dan untuk gerak lanjutan dengan kecondongan tubuh 1660. Hasil analisis tekukan kaki kanan saat posisi 149,80, posisi mengayunkan kaki kanan 125,40, dan saat perkenaan bola membentuk sudut 125,60 dan saat gerak lanjutan 42,60. Hasil rerata analisis sudut tekukan kaki kiri saat posisi siap 151,20, posisi mengayungkan tangan dengan tekukan kaki kiri 126,20, pada posisis perkenaan bola membentuk sudut 130,40, serta diiringi dengan gerak lanjutan membentuk sudut kaki kiri 1460. Hasil rerata jarak kaki saat melakukan pukulan topspin, pada posisi siap 186cm, saat backswing jarak kaki 196,638 cm, dan saat perkenaan bola 198,81 cm, serta di iringi gerak lanjutan 195,886 cm. Analisis biomekanik teknik topspin dari beberapa tahapan dimulai dari posisi siap hingga gerak lanjutan yang dilakukan masing-masing atlet sesuai anatomi tubuh masing-masing serta mengikuti posisi saat perkenaan bola.


2020 ◽  
Vol 16 (1) ◽  
pp. 1-5
Author(s):  
Ojashwi Nepal ◽  
Samjhana Thapa ◽  
Roshan Kasti ◽  
Reena Kumari Jha ◽  
Mrigendra Amatya

Background: Public transport drivers are constantly being exposed to stimuli and are at risk of disorder of peripheral nervous system which can be further complicated by comorbidities. Thus, we wanted to examine intactness of tactile discriminatory ability in healthy drivers by comparing it to healthy samples of non-driving population. Since two point discrimination (TPD) test is frequently used for neurological assessment of tactile stimulation we determined and compared various locations in hands of two populations. Methods: Participants were asked to answer whether they feel one point or two points touch by blunted end of simple compass divider in their hand. The minimum distance between the points at which the participants could answer correctly was noted as two point discrimination value. Results: Drivers had TPD range of 2-4mm with mean 2.53±0.62 and, 1-4mm with mean 2.6±0.72 at middle finger of right and left hand respectively. Following t-test between drivers versus students, significant difference in the mean TPD value in the proximal palm supplied by median nerve (p=0.016) and proximal palm corresponding to ulnar nerve (p=0.032) on the right hand was found. On the left hand, significant difference in the mean TPD value is found in the proximal palm corresponding to median nerve (p=0.008) and ulnar nerve (p=0.043) respectively.   Conclusion: Healthy public transport drivers have less tactile discriminating prowess at proximal palmar surface of hand. Examined distal phalanges and distal palm showed no significant difference in mean of TPD values for healthy drivers versus students.


Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 436
Author(s):  
Andrey A. Fedorovich ◽  
Yulia I. Loktionova ◽  
Elena V. Zharkikh ◽  
Maria A. Mikhailova ◽  
Julia A. Popova ◽  
...  

In this study we demonstrate what kind of relative alterations can be expected in average perfusion and blood flow oscillations during postural changes being measured in the skin of limbs and on the brow of the forehead by wearable laser Doppler flowmetry (LDF) sensors. The aims of the study were to evaluate the dynamics of cutaneous blood perfusion and the regulatory mechanisms of blood microcirculation in the areas of interest, and evaluate the possible significance of those effects for the diagnostics based on blood perfusion monitoring. The study involved 10 conditionally healthy volunteers (44 ± 12 years). Wearable laser Doppler flowmetry monitors were fixed at six points on the body: two devices were fixed on the forehead, on the brow; two were on the distal thirds of the right and left forearms; and two were on the distal thirds of the right and left lower legs. The protocol was used to record three body positions on the tilt table for orthostatic test for each volunteer in the following sequence: (a) supine body position; (b) upright body position (+75°); (c) tilted with the feet elevated above the head and the inclination of body axis of 15° (−15°, Trendelenburg position). Skin blood perfusion was recorded for 10 min in each body position, followed by the amplitude–frequency analysis of the registered signals using wavelet decomposition. The measurements were supplemented with the blood pressure and heart rate for every body position analysed. The results identified a statistically significant transformation in microcirculation parameters of the average level of skin blood perfusion and oscillations of amplitudes of neurogenic, myogenic and cardiac sensors caused by the postural changes. In paper, we present the analysis of microcirculation in the skin of the forehead, which for the first time was carried out in various positions of the body. The area is supplied by the internal carotid artery system and can be of particular interest for evaluation of the sufficiency of blood supply for the brain.


Author(s):  
Anne Phillips

No one wants to be treated like an object, regarded as an item of property, or put up for sale. Yet many people frame personal autonomy in terms of self-ownership, representing themselves as property owners with the right to do as they wish with their bodies. Others do not use the language of property, but are similarly insistent on the rights of free individuals to decide for themselves whether to engage in commercial transactions for sex, reproduction, or organ sales. Drawing on analyses of rape, surrogacy, and markets in human organs, this book challenges notions of freedom based on ownership of our bodies and argues against the normalization of markets in bodily services and parts. The book explores the risks associated with metaphors of property and the reasons why the commodification of the body remains problematic. The book asks what is wrong with thinking of oneself as the owner of one's body? What is wrong with making our bodies available for rent or sale? What, if anything, is the difference between markets in sex, reproduction, or human body parts, and the other markets we commonly applaud? The book contends that body markets occupy the outer edges of a continuum that is, in some way, a feature of all labor markets. But it also emphasizes that we all have bodies, and considers the implications of this otherwise banal fact for equality. Bodies remind us of shared vulnerability, alerting us to the common experience of living as embodied beings in the same world. Examining the complex issue of body exceptionalism, the book demonstrates that treating the body as property makes human equality harder to comprehend.


Author(s):  
Corey Brettschneider

How should a liberal democracy respond to hate groups and others that oppose the ideal of free and equal citizenship? The democratic state faces the hard choice of either protecting the rights of hate groups and allowing their views to spread, or banning their views and violating citizens' rights to freedoms of expression, association, and religion. Avoiding the familiar yet problematic responses to these issues, this book proposes a new approach called value democracy. The theory of value democracy argues that the state should protect the right to express illiberal beliefs, but the state should also engage in democratic persuasion when it speaks through its various expressive capacities: publicly criticizing, and giving reasons to reject, hate-based or other discriminatory viewpoints. Distinguishing between two kinds of state action—expressive and coercive—the book contends that public criticism of viewpoints advocating discrimination based on race, gender, or sexual orientation should be pursued through the state's expressive capacities as speaker, educator, and spender. When the state uses its expressive capacities to promote the values of free and equal citizenship, it engages in democratic persuasion. By using democratic persuasion, the state can both respect rights and counter hateful or discriminatory viewpoints. The book extends this analysis from freedom of expression to the freedoms of religion and association, and shows that value democracy can uphold the protection of these freedoms while promoting equality for all citizens.


2013 ◽  
Vol 7 (1) ◽  
pp. 7
Author(s):  
Doni Budiono

The  authority  of justice in Indonesia  is executed by  the Supreme Courts and  the  justice  boards/body under the Supreme Courts, including  the general  justice, religious affairs justice, military justice,  state administration  justice,  and  the Constitution Court. According to  certainty in  the Act of  Tax Court, Article1, clause  (5),  tax  dispute   refers to the legal dispute arising in the  taxation  affairs between the  tax payer or the  body  responsible for the  tax with   the government   executives  ( Directorate General of Tax) as the consequence of   the issue of  the decree for the  appeal  to the Tax  Court in accordance with the  tax Act, including the  charge  against the  execution of collection   in accordance with the  Act of Tax Collection by force. The  formation of Tax Court is  designed by  the Executives, in this case, the  Department of Finance, specifically  the Directorate   General  of Tax  which has the right to issue  law  more technical about  tax accord to Article 14,  letter A,  President Decree  no. 44  year 1974,  concerning the  basic  organization of the Department.  Based on  it,  it  is clear that  in addition to execute the government  rules and policy,  this body  has to execute judicial   rules and policy. This is against the  principles of  Judicative  Power/Authority in Indonesia,  which   clearly states that this body  should be under the Supreme Court.   Therefore. It is suggested that   the Act  No UU no.14 Year 2012 concerning  Tax Court   be revised  in accordance with the system of  Power Division  of Justice  as  stated in 45 Constitutions.


2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1477-1481
Author(s):  
Ishwari Gaikwad ◽  
Priyanka Shelotkar

The current world situation is both frightening and alarming due to the massive disruption caused by the Covid-19 pandemic. The next few days are censorious as we need to be very precautious in our daily regimen as well as dietary habits. Ayurveda offers knowledge about food based on certain reasoning. Indecent food custom is the chief cause for the rising development of health disorders in the current era. In classical texts of Ayurveda, the concept of diet explained well, ranging from their natural sources, properties and specific utility in pathological as well as physiological manner. In this work, the review of the relevant literature of Ahara (Diet) was carried out from Charak Samhita and other texts, newspapers, articles, web page related to the same.  Every human being is unique with respect to his Prakriti (Physical and mental temperament), Agni (Digestive capacity), Koshtha  (Nature of bowel) etc. For that reason, the specificity of the individual should be kept in mind. Ahara, when consumed in the appropriate amount at the right moment following all Niyamas (Guidelines) given in Ayurveda texts, gives immunity and keeps the body in a healthy state during pandemics such as Covid-19. Ultimately, this will help the human body to maintain its strength for life. This article reviews the concept of diet viz. combination of foods, their quantity and quality, methods of preparation and processing, which are to be followed during pandemics and are essential in maintenance and endorsement of health and preclusion of diseases.


2020 ◽  
Vol 11 (SPL1) ◽  
pp. 832-838
Author(s):  
Roshna Sukheoji Bhutada ◽  
Renu Rathi ◽  
Devyani Dasar

WHO declared Covid 19 /SARS -COV-2 as a global pandemic.Till date, there is no medicine for COVID-19. If the Infection arises in the body then the defence mechanism activated against infection. A recent study suggests that temporarily augmenting the body's immune system in the early stages of COVID-19 can help patient to avoid severe symptoms as it is rightly said prevention is better than cure. Ayurveda approaches to develop physiological reactions to facilitate immunity. Planning of diet is most important to boost immunity.As per many researches to provide supplementary food which contains Zinc, Vitamin C,Vitamin D and immunity boosting foodsuch as citrus natural products, custard apple, apple, papaya is among the Fruits. Vegetables include broccoli, onion, garlic and green leafy vegetables. Nuts, ginger, turmeric, pepper, egg yolk, shellfish, mushroom. The need of the hour is a quick boost to immune system to keep it fit, fighting. One should get the right amount of nutrients from the diet, supplementation regimen to boost immune system.In this review, there are few common supplements and super food studies have been included. It might be a torch bearer as sample menu and their alternatives are given for a normal adult. Needy may change contemplated according to age, sex, body mass index and daily physical activities.


Impact ◽  
2018 ◽  
Vol 2018 (3) ◽  
pp. 26-28
Author(s):  
Jonathan Dawson ◽  
Richard Oreffo

Gels made from clay could provide an environment able to stimulate stem-cells due to their ability to bind biological molecules. That molecules stick to clay has been known by scientists since the 1960s. Doctors observed that absorption into the blood stream of certain drugs was severely reduced when patients were also receiving clay-based antacid or anti-diarrhoeal treatments. This curious phenomenon was realized to be due to binding of the drugs by clay particles. This interaction is now routinely harnessed in the design of tablets to carefully control the release and action of a drug. Dr Dawson now proposes to use this property of clay to create micro-environments that could stimulate stem cells to regenerate damaged tissues such as bone, cartilage or skin. The rich electrostatic properties of nano (1 millionth of a millimetre) -scale clay particles which mediate these interactions could allow two hurdles facing the development of stem-cell based regenerative therapies to be overcome simultaneously. The first challenge - to deliver and hold stem cells at the right location in the body - is met by the ability of clays to self-organise into gels via the electrostatic interactions of the particles with each other. Cells mixed with a low concentration (less than 4%) of clay particles can be injected into the body and held in the right place by the gel, eliminating, in many situations, the need for surgery. Clay particles can also interact with large structural molecules (polymers) which are frequently used in the development of materials (or 'scaffolds'), designed to host stem cells. These interactions can greatly improve the strength of such structures and could be applied to preserve their stability at the site of injury until regeneration is complete. While several gels and scaffold materials have been designed to deliver and hold stem cells at the site of regeneration, the ability of clay nanoparticles to overcome a second critical hurdle facing stem-cell therapy is what makes them especially exciting. Essential to directing the activity of stem-cells is the carefully controlled provision of key biological signalling molecules. However, the open structures of conventional scaffolds or gels, while essential for the diffusion of nutrients to the cells, means their ability to hold the signalling molecules in the same location as the cells is limited. The ability of clay nano-particles to bind biological molecules presents a unique opportunity to create local environments at a site of injury or disease that can stimulate and control stem-cell driven repair. Dr Dawson's early studies investigated the ability of clay gels to stimulate the growth of new blood vessels by incorporating a key molecular signal that stimulates this process, vascular endothelial growth factor (VEGF). In a manner reminiscent of the observations made in the 60s, Dr Dawson and colleagues observed that adding a drop of clay gel to a solution containing VEGF caused, after a few hours, the disappearance of VEGF from the solution as it became bound to the gel. When placed in an experimental injury model, the gel-bound VEGF stimulated a cluster of new blood vessels to form. These exciting results indicate the potential of clay nanoparticles to create tailor-made micro-environments to foster stem cell regeneration. Dr Dawson is developing this approach as a means of first exploring the biological signals necessary to successfully control stem cell behaviour for regeneration and then, using the same approach, to provide stem cells with these signals to stimulate regeneration in the body. The project will seek to test this approach to regenerate bone lost to cancer or hip replacement failure. If successful the same technology may be applied to harness stem cells for the treatment of a whole host of different scenarios, from burn victims to those suffering with diabetes or Parkinson's.


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