scholarly journals Exercise Ventilatory Inefficiency in Post-COVID-19 Syndrome: Insights from a Prospective Evaluation

2021 ◽  
Vol 10 (12) ◽  
pp. 2591
Author(s):  
Álvaro Aparisi ◽  
Cristina Ybarra-Falcón ◽  
Mario García-Gómez ◽  
Javier Tobar ◽  
Carolina Iglesias-Echeverría ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systemic Disease ◽  
Cardiopulmonary Exercise Test ◽  
Transthoracic Echocardiogram ◽  
Hyperventilation Syndrome ◽  
Walking Test ◽  
Asymptomatic Patients ◽  
Outpatient Group ◽  
Biomarker Analysis

Introduction: Coronavirus disease 2019 (COVID-19) is a systemic disease characterized by a disproportionate inflammatory response in the acute phase. This study sought to identify clinical sequelae and their potential mechanism. Methods: We conducted a prospective single-center study (NCT04689490) of previously hospitalized COVID-19 patients with and without dyspnea during mid-term follow-up. An outpatient group was also evaluated. They underwent serial testing with a cardiopulmonary exercise test (CPET), transthoracic echocardiogram, pulmonary lung test, six-minute walking test, serum biomarker analysis, and quality of life questionaries. Results: Patients with dyspnea (n = 41, 58.6%), compared with asymptomatic patients (n = 29, 41.4%), had a higher proportion of females (73.2 vs. 51.7%; p = 0.065) with comparable age and prevalence of cardiovascular risk factors. There were no significant differences in the transthoracic echocardiogram and pulmonary function test. Patients who complained of persistent dyspnea had a significant decline in predicted peak VO2 consumption (77.8 (64–92.5) vs. 99 (88–105); p < 0.00; p < 0.001), total distance in the six-minute walking test (535 (467–600) vs. 611 (550–650) meters; p = 0.001), and quality of life (KCCQ-23 60.1 ± 18.6 vs. 82.8 ± 11.3; p < 0.001). Additionally, abnormalities in CPET were suggestive of an impaired ventilatory efficiency (VE/VCO2 slope 32 (28.1–37.4) vs. 29.4 (26.9–31.4); p = 0.022) and high PETCO2 (34.5 (32–39) vs. 38 (36–40); p = 0.025). Interpretation: In this study, >50% of COVID-19 survivors present a symptomatic functional impairment irrespective of age or prior hospitalization. Our findings suggest a potential ventilation/perfusion mismatch or hyperventilation syndrome.

scholarly journals Association between depressive symptoms and quality of life in outpatients and inpatients with heart failure

2021 ◽  
Vol 55 ◽  
Author(s):  
Juliana de Melo Vellozo Pereira Tinoco ◽  
Beatriz Paiva e Silva de Souza ◽  
Samara Xavier de Oliveira ◽  
Josiana Araujo de Oliveira ◽  
Evandro Tinoco Mesquita ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Depressive Symptoms ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Ventricular Ejection Fraction ◽  
Outpatient Group ◽  
Heart Failure Questionnaire ◽  
Assess Quality

ABSTRACT Objective: To analyze sociodemographic and clinical characteristics, depressive symptoms and quality of life of patients with heart failure and associate quality of life with depressive symptoms. Method: A cross-sectional study conducted with outpatients and inpatients. Sociodemographic data were collected and questionnaires were applied to assess quality of life (Minnesota Living with Heart Failure Questionnaire) and depressive symptoms (Beck Depression Inventory). Results: The sample consisted of 113 patients. Outpatients were retired (p=0.004), with better education (p=0.034) and higher ventricular ejection fraction (p=0.001). The inpatient group had greater depressive symptoms (18.1±10 vs 14.6±1.3; p=0.036) and lower quality of life (74.1±18.7 vs 40.5±3.4; p<0.001) than the outpatient group. Outpatients with depressive symptom scores from 18 points had worse quality of life scores in 17 of the 21 questions. Conclusion: Inpatients had worse depressive symptoms and quality of life, which was more affected in the physical dimension in those with moderate/severe depressive symptoms. Outpatients with more severe depressive symptoms had worse quality of life in all dimensions.

scholarly journals The Effect of Complete Dentures on the Quality of Life of Edentulous Patients in the South Indian Population Based on Gender and Systemic Disease

Cureus ◽  
2019 ◽  
Author(s):  
Madhankumar Seenivasan ◽  
Fathima Banu ◽  
Athiban Inbarajan ◽  
Parthasarathy Natarajan ◽  
Shanmuganathan Natarajan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Indian Population ◽  
Systemic Disease ◽  
Population Based ◽  
South Indian Population ◽  
Complete Dentures ◽  
The South ◽  
South Indian ◽  
Edentulous Patients

scholarly journals The Effects of a Comprehensive Rehabilitation Program Involving Traditional Chinese Medicine in Severe and Critical COVID-19 Patients: a Clinical Study

2021 ◽  
Author(s):  
Yi Ren ◽  
Yujin Wang ◽  
Huabao Liu ◽  
Fangzheng Mou ◽  
Xiaofeng Yan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rehabilitation Program ◽  
Ct Scans ◽  
Walking Test ◽  
Quality Of Life Scale ◽  
Life Scale ◽  
St George's Respiratory Questionnaire ◽  
Comprehensive Rehabilitation ◽  
Tcm Syndrome

Abstract Background: A year ago, a new type of coronavirus emerged. Once treated for severe and critical COVID-19 infections, patients are discharged from the hospital for further treatment and rehabilitation. The aim of this study was to evaluate the efficacy and safety of a newly developed comprehensive rehabilitation program based on traditional Chinese medicine (TCM) in the rehabilitation of patients with severe and critical COVID-19.Methods: We recruited a total of 72 patients who had suffered from severe and critical COVID-19 infections and were undergoing rehabilitation in Chongqing, China. A comprehensive rehabilitation program was formulated according to the TCM syndromes of these patients. Specific treatments included oral TCM, Baduanjin, Moxibustion, Acupoint application, and foot baths. Prior to the initiation of treatment, and four weeks after the initiation of treatment, we carried out a range of assessments, including the TCM Syndrome curative effect score, the modified Medical Research Council (mMRC) dyspnea score, the St. George's Respiratory Questionnaire, the Short Form (SF)-36 Quality of Life Scale, and the 6-minute walking test. We also carried out CT scans, serology tests. Statistical analysis was also conducted to evaluate the efficacy and safety of TCM on severe and critical COVID-19 patients.Results: Analysis showed that there were significant differences (P < 0.05) when compared before and after four weeks of TCM treatment, in terms of the TCM syndrome curative effect score, mMRC dyspnea score, St. George's Respiratory Questionnaire score, SF-36 Quality of Life Scale score, and the 6-minute walking test. We also identified significant differences (P < 0.05) between these two timepoints, with regards to the neutrophil ratio, lymphoid cell ratio, lymphocytes, platelets, red blood cells, and hemoglobin. There were no significant differences when compared between the two timepoints with regards to white blood cells and neutrophils (P > 0.05). The efficacy of chest CT scans was 83.9%. Logistic regression showed that the CT scans of patients who did not take the TCM decoction did not improve significantly. The higher a patient’s score on the 6-minute walking test, the higher the probability of no significant improvement on the CT scan.Conclusions: A comprehensive rehabilitation program based on TCM improved a number of clinical parameters in patients suffering from severe and critical COVID-19 infections, including quality of life, clinical symptoms, exercise endurance, and respiratory function. TCM also enhanced lymphocytes, lymphocyte ratio, platelet, red blood cell (RBC) count, and hemoglobin content. TCM also appeared to contribute to the absorption of lung lesions.

Oral mucosal manifestations of systemic disease

2021 ◽  
pp. 175573802110451
Author(s):  
Rebecca Iles ◽  
Melanie Simms ◽  
Alistair Ledsam
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Oral Mucosa ◽  
Systemic Disease ◽  
Health Related Quality ◽  
Diagnosis And Management ◽  
Wide Range ◽  
Related Quality ◽  
Health Related

Disorders spanning a wide range of body systems may, directly or indirectly, impact upon the orofacial tissues. Specifically, the oral mucosa may be the first, or most severely affected site of systemic disease, posing significant implications for oral health-related quality of life. It is not uncommon for patients to present to their GP with orofacial symptoms, therefore a firm understanding of how systemic disease can manifest in this way is important. This article will discuss oral mucosal presentations of systemic disease, aiming to improve understanding and recognition of these conditions, allowing appropriate referral for investigation, diagnosis and management.

Dermatology

2018 ◽  
Author(s):  
Gemma Simcox
Keyword(s):  
Quality Of Life ◽  
Skin Disease ◽  
Skin Diseases ◽  
Systemic Disease ◽  
Management Plan ◽  
Dermatological Examination ◽  
Common Skin ◽  
Life Threatening ◽  
The Uk

Skin disease has a serious impact on an individual’s quality of life. It is well recognized that conditions such as psoriasis may have a similar impact on a patient’s quality of life to chronic diseases such as diabetes, hypertension, and depression. Skin problems account for approximately 20% of all patient consultations in primary care in the UK. It is important that clinicians are able to diagnose common skin diseases such as acne, eczema, psoriasis, and cutaneous malignancies and initiate an appropriate management plan. This requires the ability to take a full history and conduct a complete examination. A complete dermatological examination involves examination of the entire skin, mucous membranes, hair, and nails. The description of cutaneous pathologies should include the location and distribution of lesions. The morphology of a lesion or each component of a generalized eruption should be noted. Other organ systems may also need to be examined. The questions in this chapter will test your knowledge of the skin problems that are frequently encountered in non-specialist clinical practice. Other more rare skin disorders are also covered, either because they are potentially life-threatening or because they are a sign of systemic disease. The questions are designed to improve your ability to recognize the morphology and distribution of cutaneous physical signs. Hopefully you will find these questions stimulating and an aid to improving your knowledge of skin disease.

A OSTEOPOROSE PODE AGRAVAR A DOENÇA PERIODONTAL?: UMA REVISÃO DE LITERATURA

2015 ◽  
Vol 6 (2) ◽  
Author(s):  
Roberta Catapano Naves ◽  
Tainá Bulhões ◽  
Leonardo Costa ◽  
Monica Dourado Barbosa ◽  
Susyane Almeida
Keyword(s):  
Public Health ◽  
Quality Of Life ◽  
Alveolar Bone ◽  
Population Aging ◽  
Systemic Disease ◽  
Bone Fragility ◽  
Present Knowledge ◽  
Long Bones ◽  
Mineral Density

With the population aging, the chronic diseases related to the seniors, as the osteoporosis, increased generating a problem of public health that affects the quality of life of the population directly. The osteoporosis is a systemic disease that causes the mineral unbalance of the bones causing bone fragility and increase in the probability of fractures. Besides the long bones, it can attack the alveolar processes of the jawbone and of the jaw, could worsen the disease periodontal and to take to the dental loss. The objective of this work is to approach, through a revision of the literature, the present knowledge about the possible influence of the osteoporosis in the periodontal disease and in the levels of the alveolar bone mineral density.

Geriatric Dentistry and Prevention: Research and Public Policy (Reaction Paper)

1991 ◽  
Vol 5 (1) ◽  
pp. 74-77 ◽  
Author(s):  
C. Meyerowitz
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Oral Health ◽  
Dental Health ◽  
Systemic Disease ◽  
The Elderly ◽  
Health Needs ◽  
Oral Disease ◽  
Geriatric Dentistry

The population of older adults is heterogeneous and can be divided into many subgroups: the young-old, the old-old, the healthy, the sick, the frail, the mentally and physically handicapped, the ambulatory, the chair-bound, house-bound or institution-bound, and the economically advantaged and disadvantaged. This diversity is extremely important to the discussion of the oral health needs, preventive health strategies, and research agenda for the elderly. As life expectancy increases, more attention is being paid to disease prevention so that the quality of life in old age can be improved. However, the link among oral health, systemic disease, and quality of life in the elderly needs to be better-defined. There is some evidence in the literature that indicates that coronal and root caries appear to be major health problems for the elderly. This needs to be corroborated in longitudinal studies. Although periodontal disease prevalence and severity are high in some subgroups of the elderly, these appear to be in decline in the general population. Dental health-care workers must be cognizant of the oral conditions associated with systemic disease and the use of medication, a major concern in older adults. Prevention of oral disease in the elderly requires early intervention, education of the dental health team, and innovative uses of well-established preventive agents such as fluoride. An extensive research effort is needed to answer basic and applied questions regarding the oral health needs of the elderly. Federal and private funding will be necessary. The dental profession will have to demonstrate and be persuasive that money spent on research and care for the elderly is money well spent.

scholarly journals Efficacy of microsurgical tumor removal for treatment of patients with intracanalicular vestibular schwannoma presenting with disabling vestibular symptoms

2017 ◽  
Vol 126 (5) ◽  
pp. 1514-1519 ◽  
Author(s):  
Madjid Samii ◽  
Hussam Metwali ◽  
Venelin Gerganov
Keyword(s):  
Quality Of Life ◽  
Vestibular Schwannoma ◽  
Symptom Relief ◽  
Vestibular Dysfunction ◽  
Control Group ◽  
Surgical Removal ◽  
Asymptomatic Patients ◽  
Significant Difference ◽  
Vestibular Symptoms

OBJECTIVEThe aim of this study was to analyze the efficacy and risks of microsurgery via the hearing-preserving retrosigmoid approach in patients with intracanalicular vestibular schwannoma (VS) suffering from disabling vestibular symptoms, with special attention to vertigo.METHODSThis is a retrospective analysis of 19 patients with intracanalicular VS and disabling vestibular dysfunction as the main or only symptom (Group A). All of the patients reported having had disabling vertigo attacks. Subjective evaluation of the impairment of patients was performed before surgery, 3 weeks after surgery, 3 months after surgery, and 1 year after surgery, using the Dizziness Handicap Inventory (DHI). The main outcome measures were improvement in quality of life as measured using the DHI, and general and functional outcomes, in particular facial function and hearing. Patient age, preoperative tumor size, preoperative DHI score, and preservation of the nontumorous vestibular nerve were tested using a multivariate regression analysis to determine factors affecting the postoperative DHI score. The Mann-Whitney U-test was used to compare the postoperative DHI score at 3 weeks, 3 months, and 1 year after surgery with a control group of 19 randomly selected patients with intracanalicular VSs, who presented without vestibular symptoms (Group B). The occurrence of early postoperative discrete vertigo attacks was also compared between groups.RESULTSThe preoperative DHI score was ≥ 54 in all patients. All patients reported having had disabling rotational vertigo before surgery. The only significant factor to affect the DHI outcome 3 weeks and 3 months after surgery was the preoperative DHI score. The DHI outcome after 1 year was not affected by the preoperative DHI score. Compared with the control group, the DHI score at 3 weeks and 3 months after surgery was significantly worse. There was no significant difference between the groups after 1 year. Vertigo was improved in all patients and completely resolved after 1 year in 17 patients.CONCLUSIONSDisabling vestibular dysfunction that affects quality of life should be considered an indication for surgery, even in otherwise asymptomatic patients with intracanalicular VS. Surgical removal of the tumor is safe and very effective in regard to symptom relief. All patients had excellent facial nerve function within 1 year after surgery, with a very good chance of hearing preservation.

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