scholarly journals Efficacy of Prolonged-Release Melatonin 2 mg (PRM 2 mg) Prescribed for Insomnia in Hospitalized Patients for COVID-19: A Retrospective Observational Study

2021 ◽  
Vol 10 (24) ◽  
pp. 5857
Author(s):  
Carolina Bologna ◽  
Pasquale Madonna ◽  
Eduardo Pone
Keyword(s):  
Intensive Care ◽  
Observational Study ◽  
Control Group ◽  
Prolonged Release ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Duration Of Therapy ◽  
Non Invasive Ventilation ◽  
Duration Of Hospitalization ◽  
Insomnia Treatment

Background: we have observed the effect of insomnia treatment in clinical and prognostic differences of patients admitted for COVID-19 pneumonia in respiratory sub-intensive units that were administered a prolonged-release melatonin 2 mg (PRM 2 mg) therapy versus a group of patients out of therapy. Materials and Methods: We evaluated 40 patients on prolonged-release melatonin 2 mg (PRM 2 mg) therapy versus a control group of 40 patients out of therapy. Results: patients in the PRM 2 mg group had a shorter duration of therapy with non-invasive ventilation (5.2 ± 3.0 vs. 12.5 ± 4.2; p < 0.001), with a shorter stay in sub-intensive care (12.3 ± 3.2 vs. 20.1 ± 6.1; p < 0.001), and, therefore, a shorter overall duration of hospitalization (31.3 ± 6.8 vs. 34.3 ± 6.9 p = 0.03). In addition, a lower incidence of delirium was found (2.2 ± 1.1 vs. 3.3 ± 1.3; p < 0.001). Conclusions: A significant increase in sleep hours and a reduction in delirium episodes occurs in hospitalized insomniac patients treated with PRM 2 mg, compared to untreated patients. Based on these preliminary results, we can assume that there are benefits of prolonged-release melatonin 2 mg in COVID-19 therapy.

Patient Compliance to Non-Invasive Ventilation in Sub-Intensive Care Unit: An Observational Study

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Alessia D’Orazio ◽  
Antonella Dragonetti ◽  
Giorgio Campagnola ◽  
Cristina Garza ◽  
Fabrizio Bert ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Observational Study ◽  
Patient Compliance ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation

Effectiveness of hydrocolloid nasal dressing pads in preventing nasal ulceration in preterm infants using non-invasive ventilation

MedPharmRes ◽  
2021 ◽  
Vol 5 (4) ◽  
pp. 46-51
Author(s):  
Chau Vu Bao Nguyen ◽  
Tinh Thu Nguyen ◽  
Tam Thi Thanh Pham ◽  
Sen Thi Hong Lam ◽  
Le An Pham ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Neonatal Intensive Care ◽  
Nasal Cannula ◽  
The Other ◽  
Control Group ◽  
Invasive Ventilation ◽  
Nasal Bridge ◽  
Non Invasive ◽  
Hydrocolloid Dressing ◽  
Non Invasive Ventilation

Background: The use of non-invasive ventilation (NIV) in preterm infants is becoming increasingly common. The use of cannula in NIV can cause ulceration of the nasal bridge with the current practices using the thin foam patches. This study aims to evaluate the effectiveness of hydrocolloid nasal dressing pads in preventing nasal ulceration comparing to that of the thin foam patches. Methods: A prospective cohort study using hydrocolloid dressing pads (1 November to 30 April 2020) was compared to that of a historical control group using thin foam dressing (1 April to 15 October 2019) to evaluate the effectiveness of hydrocolloid dressing pads. All participants were preterm infants (less than 37 weeks of gestational age) and used nasal cannula NIV at the Department of Neonatal Intensive Care (NICU), Children's Hospital 1. Results: 71 infants used hydrocolloid dressing pads, and 42 used ordinary thin foam nasal dressings. In the hydrocolloid dressings group, two infants (2.8%) had nasal ulcers; among them, one was mild, and the other was moderate. In comparison, ten infants (23.8%) using thin foam dressings developed ulcers, of which seven were mild, two were moderate, and one was severe. Using hydrocolloid nasal dressings significantly reduced nasal ulceration compared to thin foam dressings (OR = 0.09, 95%CI = 0.02 – 0.45). Conclusion: Using hydrocolloid nasal dressings for preterm infants on nasal cannula NIV significantly reduced nasal ulceration compared to ordinary thin foam dressings.

scholarly journals Observational case-control study of non-invasive ventilation in patients with ARDS

2016 ◽  
Vol 69 (1) ◽  
Author(s):  
G. Domenighetti ◽  
A. Moccia ◽  
R. Gayer
Keyword(s):  
Mortality Rate ◽  
Control Group ◽  
Invasive Ventilation ◽  
Suitable Alternative ◽  
Real Effects ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Organ Failures ◽  
Distant Organ ◽  
Control Study

Background. The application of non-invasive pressure support ventilation (NIPSV) in patients with acute lung injury or ARDS remains controversial despite recent promising results. Data in rather homogeneous ARDS groups is lacking. Objective. To compare the outcome of NIPSV-treated patients satisfying the diagnostic criteria for primary (pulmonary) ARDS (ARDSp) and presenting without distant organ failures at admission, with those of a matched control group treated in the same ICU with endotracheal mechanical ventilation (ETMV). Methods. We applied NIPSV in 12 immunocompetent and collaborative patients who met the above cited criteria. NIPSV failure rate, short-term oxygenation, length of stay, mortality rate and complications were analyzed and compared with a control group of 12 intubated ARDSp-patients matched for age, SAPS II, PaO2/FiO2 and pH at admission. Results. NIPSV failed in 4 patients developing distant organ failures. Compared to the ETMV control group, NIPSV success patients had reduced cumulative time on ventilation (p = 0.001) and length of ICU stay (p = 0.004). After the first 60’ of ventilation, oxygenation improved more in the NIPSV than in the ETMV group (146 ± 52 mmHg vs 109 ± 34 mmHg; p = 0.05). The overall ICU mortality rate did not differ significantly between the groups but tended to be higher in the NIPSV group. Conclusions. In ARDSp patients without distant organ failures at admission and during the disease course, NIPSV might be a suitable alternative to invasive ventilation; however, the real effects on outcome of NIPSV applied to stable homogeneous subgroups of ARDS patients merit further investigations in randomised studies.

Predicting the success of non-invasive ventilation in preventing intubation and re-intubation in the paediatric intensive care unit

2011 ◽  
Vol 37 (12) ◽  
pp. 1994-2001 ◽  
Author(s):  
Christopher S. James ◽  
Christopher P. J. Hallewell ◽  
Dominique P. L. James ◽  
Angie Wade ◽  
Quen Q. Mok
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Paediatric Intensive Care Unit ◽  
Paediatric Intensive Care ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation
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