scholarly journals TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgery

2019 ◽  
Vol 8 (3) ◽  
pp. 283 ◽  
Author(s):  
Maria Jiménez-Sousa ◽  
Alejandra Fadrique ◽  
Pilar Liu ◽  
Amanda Fernández-Rodríguez ◽  
Mario Lorenzo-López ◽  
...  
Keyword(s):  
Septic Shock ◽  
Signaling Pathway ◽  
Haplotype Analysis ◽  
Case Control Study ◽  
Inflammatory Responses ◽  
Major Surgery ◽  
Susceptibility To Infection ◽  
Risk Of Death ◽  
First 90 Days ◽  
Control Study

Background: In many immune-related diseases, inflammatory responses and several clinical outcomes are related to increased NF-κB activity. We aimed to evaluate whether SNPs related to the NF-κB signaling pathway are associated with higher susceptibility to infection, septic shock, and septic-shock-related death in European patients who underwent major surgery. Methods: We performed a case-control study on 184 patients with septic shock and 212 with systemic inflammatory response syndrome, and a longitudinal substudy on septic shock patients. Thirty-three SNPs within genes belonging to or regulating the NF-κB signaling pathway were genotyped by Agena Bioscience’s MassARRAY platform. Results: No significant results were found for susceptibility to infection and septic shock in the multivariate analysis after adjusting for multiple comparisons. Regarding septic-shock-related death, patients with TNFAIP3 rs6920220 AA, TNIP1 rs73272842 AA, TNIP1 rs3792783 GG, and TNIP1 rs7708392 CC genotypes had the highest risk of septic-shock-related death in the first 28 and 90 days. Also, the MyD88 rs7744 GG genotype was associated with a higher risk of death during the first 90 days. Haplotype analysis shows us that patients with the TNIP1 GAG haplotype (composed of rs73272842, rs3792783, and rs7708392) had a lower risk of death in the first 28 days and the TNIP1 AGC haplotype was associated with a higher risk of death in the first 90 days. Conclusions: The SNPs in the genes TNFAIP3, TNIP1, and MyD88 were linked to the risk of septic-shock-related death in patients who underwent major surgery.

scholarly journals Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Yanhua Wu ◽  
Zhifang Jia ◽  
Donghui Cao ◽  
Chuan Wang ◽  
Xing Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Analysis ◽  
Distant Metastasis ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Cancer Prognosis ◽  
Radical Operation ◽  
Risk Of Death ◽  
Control Study

Gastric cancer (GC) is one of the most prominent global cancer-related health threats. Genes play a key role in the precise mechanisms of gastric cancer. SNPs in mi-RNAs could affect mRNA expression and then affect the risk and prognosis of GC. Firstly, we have decided to perform a case-control study which included 897 GC patients and 992 controls to evaluate the association of miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, and miR-218 rs11134527 polymorphisms with gastric cancer susceptibility. Secondly, among the 897 GC patients above, 755 cases underwent a radical operation, without distant metastasis and with negative surgical margins included in the survival analysis to evaluate the association of the four SNPs above with gastric cancer prognosis. The C/T or C/C genotypes of rs213210 were related to a lower GC risk (OR = 0.76, 95% CI: 0.62–0.93,P=0.009) compared to the T/T genotype. Rs11134527 in miR-218 was associated with GC survival, and the G/A and G/G genotypes of rs11134527 resulted in a decreased risk of death when compared with the A/A genotype (HR = 0.75, 95% CI: 0.61–0.95,P=0.016). This study found that miR-219-1 rs213210 polymorphism was associated with GC susceptibility and rs11134527 in miR-218 was positively correlated with GC prognosis.

Use of medications that antagonize mediators of inflammatory responses may reduce the risk of delirium in older adults: a nested case-control study

2016 ◽  
Vol 32 (2) ◽  
pp. 208-213 ◽  
Author(s):  
Martin G. Cole ◽  
Jane McCusker ◽  
Machelle Wilchesky ◽  
Philippe Voyer ◽  
Johanne Monette ◽  
...  
Keyword(s):  
Older Adults ◽  
Case Control Study ◽  
Inflammatory Responses ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals DPYD genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from Slovakia

2017 ◽  
Vol 36 (05) ◽  
pp. 557-563
Author(s):  
Tatiana Matáková ◽  
Erika Halašová ◽  
Henrieta Škovierová ◽  
Anton Dzian ◽  
Dušan Dobrota ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Haplotype Analysis ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Control Study

scholarly journals Interstitial Lung Disease Associated with Lung Cancer: A Case–Control Study

2020 ◽  
Vol 9 (3) ◽  
pp. 700
Author(s):  
Quentin Gibiot ◽  
Isabelle Monnet ◽  
Pierre Levy ◽  
Anne-Laure Brun ◽  
Martine Antoine ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Case Control Study ◽  
Standard Of Care ◽  
Case Control ◽  
Risk Of Death ◽  
Increased Risk ◽  
Two Factors ◽  
Control Study

Interstitial lung disease (ILD) seems to be associated with an increased risk of lung cancer (LC) and to have a poorer prognosis than LC without ILD. The frequency of ILD in an LC cohort and its prognosis implication need to be better elucidated. This retrospective, observational, cohort study evaluated the frequency of ILD among LC patients (LC–ILD) diagnosed over a 2-year period. LC–ILD patients’ characteristics were compared to those with LC without ILD (LC–noILD). Lastly, we conducted a case–control study within this cohort, matching three LC–noILDs to each LC–ILD patient, to evaluate the ILD impact on LC patients’ prognoses. Among 906 LC patients, 49 (5.4%) also had ILD. Comparing LC–ILD to LC–noILD patients, respectively, more were men (85.7% vs. 66.2%; p = 0.02); adenocarcinomas were less frequent (47.1% vs. 58.7%, p = 0.08); median [range] and overall survival was shorter: (9 [range: 0.1–39.4] vs. 17.5 [range: 0.8–50.4] months; p = 0.01). Multivariate analysis (hazard ratio [95% confidence interval]) retained two factors independently associated with LC risk of death: ILD (1.79 [1.22–2.62]; p = 0.003) and standard-of-care management (0.49 [0.33–0.72]; p < 0.001). Approximately 5% of patients with a new LC diagnosis had associated ILD. ILD was a major prognosis factor for LC and should be taken into consideration for LC management. Further studies are needed to determine the best therapeutic strategy for the LC–ILD population.

Common variation in KLKB1 and essential hypertension risk: tagging-SNP haplotype analysis in a case-control study

2007 ◽  
Vol 121 (3-4) ◽  
pp. 327-335 ◽  
Author(s):  
Xiangfeng Lu ◽  
Weiyan Zhao ◽  
Jianfeng Huang ◽  
Hongfan Li ◽  
Wei Yang ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Haplotype Analysis ◽  
Case Control Study ◽  
Case Control ◽  
Tagging Snp ◽  
Common Variation ◽  
Hypertension Risk ◽  
Control Study

BENEFICIAL OUTCOME EFFECT OF ACTIVATED PROTEIN C IN PATIENTS WITH SEPTIC SHOCK: A CASE-CONTROL STUDY

CHEST Journal ◽  
2009 ◽  
Vol 136 (4) ◽  
pp. 45S
Author(s):  
Jean-Louis Teboul ◽  
Philippe Aegerter ◽  
Xavier Monnet ◽  
Hatem Ksouri ◽  
Patricia Martel ◽  
...  
Keyword(s):  
Septic Shock ◽  
Protein C ◽  
Case Control Study ◽  
Activated Protein C ◽  
Case Control ◽  
Beneficial Outcome ◽  
Control Study

The significance of ascites in patients with pancreatic cancer: A case-control study.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 445-445 ◽  
Author(s):  
Bhargavi Pulluri ◽  
Anjaneya Kathait ◽  
Hua-Ling Tsai ◽  
Amanda L. Blackford ◽  
Joseph M. Herman ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Overall Survival ◽  
Case Control Study ◽  
Case Control ◽  
Disease Stage ◽  
Lymph Node Status ◽  
Poor Prognostic Factor ◽  
Resectable Disease ◽  
Risk Of Death ◽  
Control Study

445 Background: Malignant ascites confers a poor prognosis in patients with metastatic pancreatic cancer (PC). It is unknown if radiographic ascites in patients with localized disease is a poor prognostic factor and if this finding should be sufficient to avoid upfront local therapies. We aimed to evaluate the survival outcomes of patients with PC and ascites. Methods: Retrospective case control study with overall survival as primary outcome. Eighty newly diagnosed PC patients with ascites (case group) and 80 similar controls without ascites were collected.Cases and controls were matched on age, gender, stage, ECOG performance, surgical treatment, lymph node status and margin status. Overall survival was compared between groups with Cox proportional hazards models by stages, and with a gamma frailty term to account for the correlation between matched pairs on entire cohort. Results: The 80 matched cases included 19 with resectable disease, 9 borderline resectable, 22 locally advanced and 31 with metastatic disease. 29 patients underwent pancreaticoduodenectomy. Table 1 summarizes the overall survival. Ascites patients had higher risk of death compared to patients without ascites (conditional hazard ratio = 1.58 (95% CI: 1.11-2.27), p=0.01). Conclusions: PC patients with ascites have poor overall survival compared to patients without ascites. Even in the setting of resectable disease, survival is similar to patients with advanced disease. This data suggest that all patients with ascites regardless of disease stage should be considered for systemic chemotherapy prior to attempting local treatments. [Table: see text]

scholarly journals Severe Altered Immune Status After Burn Injury Is Associated With Bacterial Infection and Septic Shock

2021 ◽  
Vol 12 ◽  
Author(s):  
Hélène Moins-Teisserenc ◽  
Debora Jorge Cordeiro ◽  
Vincent Audigier ◽  
Quentin Ressaire ◽  
Mourad Benyamina ◽  
...  
Keyword(s):  
Septic Shock ◽  
Innate Immunity ◽  
Bacterial Infection ◽  
Adaptive Immunity ◽  
Bacterial Infections ◽  
Burn Injury ◽  
Inflammatory Responses ◽  
Burn Patients ◽  
Down Regulation ◽  
Risk Of Death

Introduction: Burn injury is associated with a high risk of death. Whether a pattern of immune and inflammatory responses after burn is associated with outcome is unknown. The aim of this study was to explore the association between systemic immune and inflammatory responses and outcome in severely-ill burn patients.Materials and Methods: Innate immunity, adaptive immunity, activation and stress and inflammation biomarkers were collected at admission and days 2, 7, 14, and 28 in severely-ill adult burn patients. Primary endpoint was mortality at day 90, secondary endpoint was secondary infections. Healthy donors (HD) served as controls. Multiple Factorial Analysis (MFA) was used to identify patterns of immune response.Results: 50 patients were included. Age was 49.2 (44.2–54.2) years, total burn body surface area was 38.0% (32.7–43.3). Burn injury showed an upregulation of adaptive immunity and activation biomarkers and a down regulation of innate immunity and stress/inflammation biomarkers. High interleukin-10 (IL-10) at admission was associated with risk of death. However, no cluster of immune/inflammatory biomarkers at early timepoints was associated with mortality. HLA-DR molecules on monocytes at admission were associated with bacterial infections and septic shock. Later altered immune/inflammatory responses in patients who died may had been driven by the development of septic shock.Conclusion: Burn injury induced an early and profound upregulation of adaptive immunity and activation biomarkers and a down regulation of innate immunity and stress/inflammation biomarkers. Immune and inflammatory responses were associated with bacterial infection and septic shock. Absence of immune recovery patterns was associated with poor prognosis.

scholarly journals Fluid resuscitation and outcomes in heart failure patients with severe sepsis or septic shock: A retrospective case-control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256368
Author(s):  
Roshan Acharya ◽  
Aakash Patel ◽  
Evan Schultz ◽  
Michael Bourgeois ◽  
Natalie Kandinata ◽  
...  
Keyword(s):  
Heart Failure ◽  
Septic Shock ◽  
Mechanical Ventilation ◽  
Severe Sepsis ◽  
Case Control Study ◽  
Case Control ◽  
Retrospective Case ◽  
Fluid Bolus ◽  
Baseline Characteristics ◽  
Control Study

Background The use of ≥30 mL/Kg fluid bolus in congestive heart failure (CHF) patients presenting with severe sepsis or septic shock remained controversial due to the paucity of data. Methods The retrospective case-control study included 671 adult patients who presented to the emergency department of a tertiary care hospital from January 01, 2017 to December 31, 2019 with severe sepsis or septic shock. Patients were categorized into the CHF group and the non-CHF group. The primary outcome was to evaluate the compliance with ≥30 mL/Kg fluid bolus within 6 hours of presentation. The comparison of baseline characteristics and secondary outcomes were done between the groups who received ≥30 mL/Kg fluid bolus. For the subgroup analysis of the CHF group, it was divided based on if they received ≥30 mL/Kg fluid bolus or not, and comparison was done for baseline characteristics and secondary outcomes. Univariate and multivariable analyses were performed to explore the differences between the groups for in-hospital mortality and mechanical ventilation. Results The use of ≥30 mL/Kg fluid bolus was low in both the CHF and non-CHF groups [39% vs. 66% (p<0.05)]. Mortality was higher in the CHF group [33% vs 18% (p<0.05)]. Multivariable analysis revealed that the use of ≥30 mL/Kg fluid bolus decreased the chances of mortality by 12% [OR 0.88, 95% CI 0.82–0.95 (p<0.05)]. The use of ≥30 mL/Kg fluid bolus did not increase the odds of mechanical ventilation [OR 0.99, 95% CI 0.93–1.05 (p = 0.78)]. In subgroup analysis, the use of ≥30 mL/Kg fluid bolus decreased the chances of mortality by 5% [OR 0.95, 95% CI 0.90–0.99, (p<0.05)] and did not increase the odds of mechanical ventilation. The presence of the low ejection fraction did not influence the chance of getting fluid bolus. Conclusion The use of ≥30 mL/Kg fluid bolus seems to confer protection against in-hospital mortality and is not associated with increased chances of mechanical ventilation in heart failure patients presenting with severe sepsis or septic shock.

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