Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years

Salivary gland neoplasms are uncommon, and their epidemiology in Japan has not been well described. We conducted a retrospective review of salivary gland tumors registered in the Hiroshima Tumor Tissue Registry over a period of 39 years. The subjects were 5015 cases ranging in age from 6 to 97 (mean, 54.3) years old. The incidence of both benign tumors and malignant tumors increased with age until 60–69 years and then declined. Among the 5015 salivary gland neoplasms, 3998 (80%) were benign and 1017 (20%) were malignant. Pleomorphic adenoma (PA) was the most frequent benign tumor (68%), followed by Warthin tumor (26%). Adenoid cystic carcinoma (ACC) (27%) and mucoepidermoid carcinoma (MEC) (26%) were the two most frequent malignant tumors. Characteristically, there was a very low incidence of polymorphous adenocarcinoma in Japan. The average annual age-adjusted incidence rate per 100,000 population was 3.3 for benign tumors and 0.8 for malignant tumors. This is the large-scale multi-institutional analysis to describe the characteristics of salivary gland neoplasms, based on the pathological tissue registry data. We hope that the present data can contribute to early diagnosis and effective treatment of salivary gland tumors and to cancer prevention.

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Comprehensive Loss of Heterozygosity Analysis and Identification of a Novel Hotspot at 3p21 in Salivary Gland Neoplasms

Otolaryngology ◽

10.1016/j.otohns.2007.01.017 ◽

2007 ◽

Vol 137 (1) ◽

pp. 119-125 ◽

Cited By ~ 5

Author(s):

Noriyasu Honjo ◽

Mehmet Gunduz ◽

Kunihiro Fukushima ◽

Beyhan Cengiz ◽

Levent B. Beder ◽

...

Keyword(s):

Salivary Gland ◽

Tumor Suppressor ◽

Loss Of Heterozygosity ◽

Tumor Suppressor Genes ◽

Malignant Tumors ◽

Polyacrylamide Gel Electrophoresis ◽

Salivary Gland Tumors ◽

Salivary Gland Neoplasms ◽

Benign Tumors ◽

Suppressor Genes

OBJECTIVES: We sought to assess loss of heterozygosity (LOH) profiles of 3p, 6q, 8q, 10q, 12q, 13q, and 17p and to identify the tumor suppressor genes involved in salivary gland neoplasms. STUDY DESIGN: LOH analysis was performed using 26 microsatellite markers by polymerase chain reaction—polyacrylamide gel electrophoresis method in 20 benign and 6 malignant salivary gland tumors. RESULTS: Overall, LOH was detected in at least one informative locus in 18 of 20 (90%) of benign tumors and in all of 6 cases of malignant tumors. High LOH frequencies were revealed at the loci D3S1307 (22%, 3p26), D3S966 (41%, 3p21), D6S255 (27%, 6q25), D8S166 (25%, 8q12), D8S199 (21%, 8q24), and D10S1765 (28%, 10q23) in benign tumors, defining the hotspot regions for putative tumor suppressor genes. CONCLUSIONS AND SIGNIFICANCE: The hotspot regions defined by the present study suggest that new tumor suppressor genes related to the development of salivary gland tumors may reside at several chromosomal loci, including loci at 3p, 6q, 8q and 10q.

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Epidemiologic Characteristics of Salivary Gland Tumors in an Iranian Population

Shiraz E-Medical Journal ◽

10.5812/semj.107675 ◽

2021 ◽

Vol In Press (In Press) ◽

Author(s):

Nafise Shamloo ◽

Alireza Ghanadan ◽

Fahimeh Sadat Hashemian ◽

Maedeh Ghorbanpour

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Malignant Tumors ◽

The Body ◽

Salivary Gland Tumors ◽

Benign Tumors ◽

Cross Sectional ◽

Adenoid Cystic

Background: Salivary gland tumors include a wide variety of benign and malignant tumors in the oral and maxillofacial region. Although these tumors are not common, they are not rare. The prevalence of these tumors varies with regard to age, gender, and their location in the body. Objectives: This study aimed to evaluate the frequency of benign and malignant salivary gland tumors in patients referred to three referral hospitals in Tehran, Iran. Methods: This retrospective cross-sectional study examined the demographic and pathologic records of the patients with salivary gland tumors submitted to the Department of Pathology of Amir Alam, Loghman Hakim, and Shohada Hospitals from 2005 to 2016. In this study, the histological variants of salivary gland tumors and clinical parameters such as age, gender, and the location of the tumor were examined. The clinical data were analyzed using SPSS software version 21. Results: Of 137632 patient records, 1180 cases were salivary gland tumors. Pleomorphic adenoma in 794 cases (67.3%) and adenoid cystic carcinoma in 109 cases (9.2%) were the most common tumors, respectively. Salivary gland tumors were more common in males, and the participants’ mean age was 42.86 ± 16.5 years. The most common site was parotid and minor salivary glands, with 937 (79.4%) and 137 (12%) cases, respectively. Conclusions: In this study, the most common benign tumor was pleomorphic adenoma in the parotid gland, and the most common malignant tumor was adenoid cystic carcinoma in the major salivary glands. Furthermore, benign tumors were more frequent than malignant tumors.

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Dendritic Interstitial and Myofibroblastic Cells at the Border of Salivary Gland Tumors

Archives of Pathology & Laboratory Medicine ◽

10.5858/2001-125-0232-diamca ◽

2001 ◽

Vol 125 (2) ◽

pp. 232-236

Author(s):

Lori Soma ◽

Virginia A. LiVolsi ◽

Zubair W. Baloch

Keyword(s):

Smooth Muscle ◽

Salivary Gland ◽

Malignant Tumors ◽

Smooth Muscle Actin ◽

Staining Intensity ◽

Interstitial Cells ◽

Salivary Gland Tumors ◽

Benign Tumors ◽

Low Grade ◽

Muscle Actin

Abstract Objective.—CD34-positive dendritic interstitial cells may be associated with the regulation of tumor growth. This association has been studied in various human neoplasms, especially skin tumors. In this study, we evaluated the distribution of dendritic interstitial cells and myofibroblastic cells at the tumor periphery of various benign and malignant salivary gland neoplasms. Methods.—Forty-nine cases of salivary gland tumors were selected: 16 pleomorphic adenomas, 12 Warthin tumors, 8 polymorphous low-grade tumors, 5 adenoid cystic carcinomas, 6 acinic cell carcinomas, and 2 mucoepidermoid carcinomas. Immunohistochemical analysis was performed by using antibodies for CD34 (dendritic cells) and α-smooth muscle actin (myofibroblast) on formalin-fixed, paraffin-embedded archival tissue. Staining intensity was graded as marked (3+), moderate (2+), weak (1+), and absent (0). Results.—Staining intensity for CD34 was 3+ in 24 (86%) of 28 benign tumors (pleomorphic adenomas and Warthin tumors) and 6 (29%) of 21 malignant tumors (polymorphous low-grade tumors, acinic cell carcinomas, adenoid cystic carcinomas, and mucoepidermoid carcinomas) and 2+ in 4 (19%) of 21 malignant tumors. None of the benign tumors displayed 2+ staining with CD34. Three (11%) of 28 benign and 11 (52%) of 21 of malignant tumors failed to stain with CD34. α-Smooth muscle actin staining was 3+ in 10 (36%) of 28 benign tumors and 6 (29%) of 21 malignant tumors, and 2+ in 11 (39%) of 28 benign and 2 (9%) of 21 malignant tumors. Five (18%) of 28 benign and 11 (52%) of 21 malignant tumors failed to stain with α-smooth muscle actin. Conclusion.—We conclude that the dendritic interstitial cells and myofibroblastic cells may be associated with the regulation of tumor growth in salivary gland tumors.

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Evaluation of salivary gland tumors- clinically radiologically and pathologically: prospective study

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20211178 ◽

2021 ◽

Vol 7 (4) ◽

pp. 575

Author(s):

Namita Mishra ◽

Neeta Sharma

Keyword(s):

Salivary Gland ◽

Diagnostic Accuracy ◽

Clinical Presentation ◽

Malignant Tumors ◽

Needle Aspiration ◽

Salivary Gland Tumors ◽

Benign Tumors ◽

Aspiration Cytology ◽

Fine Needle ◽

Needle Aspiration Cytology

Background: Salivary gland tumors are difficult to differentiate based solely on clinical presentation or cytological findings due to their overlapping pictures. Often inadequate samples from cytology pose a challenge in preoperative diagnosis. Histopathology is considered the gold standard in diagnosing these tumors. The purpose of this study was to determine clinical, radiological, and cytological findings of these tumors and to assess the accuracy of these results with that of histopathological diagnosis.Methods: Prospectively 52 patients with salivary gland swellings were enrolled between 2007-2009. Cases with inflammatory swelling were excluded from the study. Demographic, clinical history, preoperatively ultrasonography, cytology, and histopathological data were collected and analyzed.Results: Most cases (65.38%) had parotid gland involvement. Benign tumors were common (80.76%) with pleomorphic adenoma as the most common one. Malignant tumors comprised 19.23%. Mucoepidermoid carcinoma and adenoid cystic carcinoma were common malignant tumors. Local swelling was the most common clinical presentation, and no facial nerve involvement was reported. The hard palate was the most common minor salivary gland affected predominantly by benign tumors. The diagnostic accuracy of fine-needle aspiration cytology was 96.15%, followed by clinical and radiological diagnostic accuracy of 92.31% and 86.54%, respectively. Using McNemar's test, a significant agreement was found between clinical and histological diagnosis (p=0.1336) and between FNAC and histological diagnosis (p=0.4975).Conclusions: Fine needle aspiration cytology is a highly accurate, sensitive, and specific screening technique. It is safe and reliable, though minimally invasive. Ultrasonography-guided cytology along with clinical, and radiological findings could enhance the pre-operative diagnostic accuracy in distinguishing salivary gland tumors.

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Histopathologic Profile of Salivary Gland Tumors among Specimens from a Tertiary Care Hospital: A Descriptive Cross-sectional Study

Journal of Nepal Medical Association ◽

10.31729/jnma.4898 ◽

2020 ◽

Vol 58 (230) ◽

Author(s):

Dilasma Ghartimagar ◽

Arnab Ghosh ◽

Manish Kiran Shrestha ◽

Sushma Thapa ◽

Om Prakash Talwar

Keyword(s):

Salivary Gland ◽

Malignant Tumors ◽

Cross Sectional Study ◽

Salivary Gland Tumors ◽

Benign Tumors ◽

Care Hospital ◽

Sectional Study ◽

Medical Sciences ◽

Cross Sectional ◽

Female Ratio

Introduction: Salivary gland tumors are rare, comprising about 3% of all head and neck neoplasms. About 80% of the tumors are in parotids, 10% in submandibular glands and the remainders are distributed in sublingual and minor salivary glands. This study was conducted to evaluate the relative frequencies, types, site of distribution and the histopathological features of salivary gland tumors. Methods: A descriptive cross-sectional study was conducted in the Department of Pathology, Manipal College of Medical Sciences, Pokhara from January 2011 to December 2019. Ethical approval was taken from the institutional review committee of Manipal College of Medical Sciences (Ref: 314). Convenient sampling was done among specimen. Data were entered in Microsoft Excel and analyzed using Statistical Package for the Social Sciences version 21. Results: Among the 130 specimens, the patients’ age ranged from 6 to 78 years with a mean age of 37.26 years for benign tumors and 48.45 years for malignant tumors. There was female predominance with a male to female ratio of 1:1.36. There were 98 cases of benign tumors, commonest being pleomorphic adenoma with 82 (83.67%) cases which was noticed more frequently in fourth decade of life. Among the 32 malignant tumors, mucoepidermoid carcinoma was the commonest tumor 20 (62.5%), followed by adenoid cystic carcinoma 7 (23.33%). Conclusions: Benign salivary gland tumors were more common than malignant tumors and the most common site of location was the parotid for both the benign and malignant tumors. Female outnumbered the male population in benign tumors whereas males were slightly more than females in malignant tumors. This study corroborated well with other previously published studies.

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RANK and RANKL Expression in Salivary Gland Tumors

Ear Nose & Throat Journal ◽

10.1177/0145561320930640 ◽

2020 ◽

Vol 99 (7) ◽

pp. 475-480

Author(s):

Figen Aslan ◽

Ülkü Küçük

Keyword(s):

Salivary Gland ◽

Malignant Tumors ◽

Nuclear Factor Κb ◽

Clinicopathological Features ◽

Salivary Gland Tumors ◽

Benign Tumors ◽

Nuclear Factor ◽

Rankl Expression ◽

Positive Expression ◽

Receptor Activator

Objectives: The pathogenesis and molecular basis of salivary gland tumors (SGT) are not well understood. We investigated the expression of receptor activator of nuclear factor κB (RANK) and RANK ligand (RANKL) in benign and malignant SGTs and their relationship with clinicopathological features. Methods: Fifty malignant and 38 benign SGTs were analyzed in this study. We evaluated the correlation between RANK and RANKL expression and benign and malignant tumors, as well as the correlation between clinicopathological prognostic parameters and RANK and RANKL expression. Results: Receptor activator of nuclear factor κB was positive in 82% (41) malignant SGTs and in 34.2% (13) benign SGTs. Receptor activator of nuclear factor κB ligand was expressed in 28% (14) malignant and 5.3% (2) benign tumors. Receptor activator of nuclear factor κB and RANKL expression were significantly different between benign and malignant SGTs ( P < .001, P = .006, respectively). However, a relationship was not found between positive expression of RANK or RANKL and clinicopathological features. Conclusions: In our study, RANK and RANKL expression was found to be higher in malignant SGTs compared to benign SGTs and RANK was more sensitive than RANKL. In addition, RANK and RANKL expression was higher in some malignant histological subtypes. Based on these results, we think that RANK and RANKL expression in SGTs and its potential as a target for treatment should continue to be investigated.

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2021 Update on Diagnostic Markers and Translocation in Salivary Gland Tumors

International Journal of Molecular Sciences ◽

10.3390/ijms22136771 ◽

2021 ◽

Vol 22 (13) ◽

pp. 6771

Author(s):

Malin Tordis Meyer ◽

Christoph Watermann ◽

Thomas Dreyer ◽

Süleyman Ergün ◽

Srikanth Karnati

Keyword(s):

Salivary Gland ◽

Malignant Tumors ◽

Salivary Gland Tumor ◽

Incidence Rates ◽

Salivary Gland Tumors ◽

Gland Tumor ◽

Adenoid Cystic ◽

Recent Developments ◽

Tumor Entity ◽

Low Incidence

Salivary gland tumors are a rare tumor entity within malignant tumors of all tissues. The most common are malignant mucoepidermoid carcinoma, adenoid cystic carcinoma, and acinic cell carcinoma. Pleomorphic adenoma is the most recurrent form of benign salivary gland tumor. Due to their low incidence rates and complex histological patterns, they are difficult to diagnose accurately. Malignant tumors of the salivary glands are challenging in terms of differentiation because of their variability in histochemistry and translocations. Therefore, the primary goal of the study was to review the current literature to identify the recent developments in histochemical diagnostics and translocations for differentiating salivary gland tumors.

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Minor salivary gland tumors in a south American population

Archive of oncology ◽

10.2298/aoo1003056c ◽

2010 ◽

Vol 18 (3) ◽

pp. 56-59 ◽

Cited By ~ 5

Author(s):

Barros Conceição ◽

Silva Gurgel ◽

Caymmi Gomes ◽

Gonçalves Agra ◽

de Kruschewsky ◽

...

Keyword(s):

Salivary Gland ◽

Malignant Tumors ◽

Minor Salivary Gland ◽

Salivary Gland Tumors ◽

Benign Tumors ◽

South American ◽

South American Population ◽

Female Predominance ◽

Minor Salivary Gland Tumors ◽

Clinical Records

Background: Salivary gland tumors are uncommon. This study aimed to investigate both clinical and epidemiological aspects of minor salivary gland tumors in a Brazilian population. Methods: From 1976 to 2007, data obtained from clinical records and histological diagnoses were reviewed according to the WHO. Results: A total of 217 MSGTs were identified. Pleomorphic adenomas (83%) and adenoid cystic carcinomas (28.8%) were the most frequent ones. The mean age of patients with benign and malignant tumors was 54.7 and 44.7 years, respectively. There was a female predominance and the palate was the most affected location. Surgery was the treatment of choice, but adjuvant radiotherapy and/or chemotherapy were also used. Recurrence rate of benign and malignant tumors was respectively 11.2% and 20.4%. Conclusion: this population showed a relatively higher proportion of malignant tumors, and these tumors were associated with a higher rate of recurrence when compared to benign tumors. However, the overall recurrence of 16.2% was also within the reported range for these tumors. In addition, despite the results of this study are similar to previous series found in the literature, it provides an important insight into the epidemiology of patients presenting minor salivary gland tumors.

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Salivary Gland Neoplasms in Indian Paediatric Population Visiting a Dental Institution

International Healthcare Research Journal ◽

10.26440/ihrj/0301.04.521072 ◽

2019 ◽

Vol 2 (12) ◽

pp. 316-320

Author(s):

Jyoti M Biradar ◽

Gayithri H Kulkarni ◽

Harish Shrinivas Kulkarni ◽

Sudha Shidagauda Patil ◽

Ashish Shrikant Satapute ◽

...

Keyword(s):

Salivary Gland ◽

Malignant Tumors ◽

Maxillofacial Surgery ◽

Female Gender ◽

Salivary Gland Tumors ◽

Research Centre ◽

Benign Tumors ◽

Oral And Maxillofacial Surgery ◽

Age Group ◽

Paediatric Age

INTRODUCTION: With a probability of 50% malignancy, salivary gland tumors are not too commonly noticed in children and adolescents. Most of these have idiopathic etiology but a few pre-disposing factors have been reported in literature. We hereby report eighteen cases of paediatric salivary gland tumors in a study conducted from September 2013 to August 2018 at department of Oral and maxillofacial surgery at Tatyasaheb Kore Dental college and Research Centre, Kohlapur, Maharashtra, India..AIM & OBJECTIVES: This study aimed to inspect the distribution, clinical and histopathological features of salivary gland tumours in children and adolescents.MATERIAL AND METHODS: A total of 18 cases of salivary gland tumors encountered in paediatric age group were studied and explored for age, gender, site proneness and for histopathological nature.RESULTS: Female gender had a predominance over males. Parotid tumors were more common (77.78%) as compared to tumors of submandibular glands. Six cases were diagnosed with benign tumors (pleomorphic adenoma) and rest had malignant tumors (mucoepidermoid in nature). Majority of the cases did not report undergoing any prior treatment.CONCLUSION Present study revealed that salivary gland tumors in paediatric age group are quite rare with female gender being more prone. With majority of cases being mucoepidermoid in nature, parotid gland is most commonly affected.

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Salivary gland tumors in a Brazilian population: a retrospective study of 124 cases

Revista do Hospital das Clínicas ◽

10.1590/s0041-87812002000600005 ◽

2002 ◽

Vol 57 (6) ◽

pp. 271-276 ◽

Cited By ~ 50

Author(s):

Pablo Agustin Vargas ◽

Renê Gerhard ◽

Vergílius J. F. Araújo Filho ◽

Inês Vieira de Castro

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Malignant Tumors ◽

Epidemiological Studies ◽

Salivary Gland Tumors ◽

Benign Tumors ◽

Carcinoma Ex Pleomorphic Adenoma ◽

Minor Salivary Glands ◽

Adenoid Cystic ◽

Malignant Salivary Gland Tumors

Salivary gland tumors constitute a highly heterogeneous histopathologic group. There are few epidemiological studies of large series of benign and malignant salivary gland tumors in Brazil. MATERIAL AND METHODS: Hospital records of 124 patients with salivary gland tumors diagnosed from January 1993 to December 1999 were reviewed. The patients were analyzed according to gender, age, size, location, and histopathology of the tumor. RESULTS AND CONCLUSIONS: Patients with benign and malignant tumors presented with a mean age of 47.7 and 48.8 years, respectively. The frequency of benign tumors was 80% (n = 99) and malignant tumors 20% (n = 25). Tumors were localized in the parotid gland 71% (n = 88), in the submandibular gland 24% (n = 30), and in the minor salivary glands 5% (n = 6). The most common benign tumors were pleomorphic adenoma in 84% (n = 84) and Warthin's tumor in 13% (n = 13). Among malignant tumors, mucoepidermoid carcinoma was the most common in 52% (n = 13), adenoid cystic carcinoma occurred in 20% (n = 5), and carcinoma ex pleomorphic adenoma was detected in 12% (n = 3).

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