scholarly journals New Zr-Ti-Nb Alloy for Medical Application: Development, Chemical and Mechanical Properties, and Biocompatibility

Materials ◽  
2020 ◽  
Vol 13 (6) ◽  
pp. 1306 ◽  
Author(s):  
Oleg Mishchenko ◽  
Oleksandr Ovchynnykov ◽  
Oleksii Kapustian ◽  
Maksym Pogorielov
Keyword(s):  
Mechanical Properties ◽  
Cell Culture ◽  
Biomedical Application ◽  
Young Modulus ◽  
Commercial Application ◽  
Mechanical Parameters ◽  
Culture Experiment ◽  
Ti Alloys ◽  
Master Alloys ◽  
Cell Culture Experiment

The concept of mechanical biocompatibilities is considered an important factor for orthopedics and dental implants. The high Young modulus of traditional Ti-based alloys can lead to stress-shielding syndrome and late postoperative complications. The development of new Al- and V-free Ti alloys with a low elastic modulus is a critical task for implantology. Despite the relatively low Young modulus and appropriate biological response of metastable beta-Ti alloys, their production requires complex metallurgical solutions and a high final cost that limit commercial application. The current research aimed to develop a Zr-Ti-Nb system with a low Young modulus suitable for biomedical application, including orthopedics and dental implantology. Two different charges were used for new alloy production with melting in a vacuum-arc furnace VDP-1 under atmospheric control (argon + helium) with a non-consumable tungsten electrode and a water-cooled copper crystallizer. Post-treatment included a forging-rolling process to produce a bar suitable for implant production. SEM with EDX and the mechanical parameters of the new alloy were evaluated, and a cell culture experiment provided a biocompatibility assessment. The chemical composition of the new alloy can be represented as 59.57-19.02-21.41 mass% of Zr-Ti-Nb. The mechanical properties are characterized by an extremely low Young modulus—27,27 GPa for the alloy and 34.85 GPa for the bar. The different master alloys used for Zr-Ti-Nb production did not affect the chemical compound and mechanical parameters so it was possible to use affordable raw materials to decrease the final price of the new product. The cell culture experiment demonstrated a full biocompatibility, indicating that this new alloy can be used for dental and orthopedics implant production.

The role of ER stress for the pathogenesis of SCA3 in primary cell culture experiment

2007 ◽  
Vol 34 (S 2) ◽  
Author(s):  
C Funke ◽  
J Hübener ◽  
H Wolburg ◽  
T Schmidt ◽  
H Toresson ◽  
...  
Keyword(s):  
Cell Culture ◽  
Er Stress ◽  
Primary Cell Culture ◽  
Primary Cell ◽  
Culture Experiment ◽  
Cell Culture Experiment

A METALLURGICAL OVERVIEW OF TI – BASED ALLOY IN BIOMEDICAL APPLICATIONS

2015 ◽  
Vol 76 (7) ◽  
Author(s):  
Nur Hidayatul Nadhirah Elmi Azham Shah ◽  
Mazyan Yahaya ◽  
Maheran Sulaiman ◽  
Muhammad Hussain Ismail
Keyword(s):  
Young’S Modulus ◽  
Biomedical Application ◽  
Young's Modulus ◽  
Stress Shielding ◽  
Young Modulus ◽  
Processing Technique ◽  
Shielding Effect ◽  
Β Phase ◽  
Ti Alloys ◽  
Α Phase

Titanium (Ti)-based alloys are prominently used in biomedical application. This review paper emphasizes on some of the important aspects of the Ti-alloys in terms of metallurgical aspects, manufacturing routes and biocompatibility. Two kinds of structure are reviewed namely dense and porous, both differs in terms of purpose and satisfies different needs. This advancement of materials and equipment helps to improve the quality of life for patients and alleviate their health problems. Metallic materials, mainly Ti-based alloys have been used commercially as bone implant owing to its promising mechanical properties, biocompatibility and bioactivity. The outmost important issue in manufacturing  of  this  alloy  is  the  impurity  contents,  specifically  oxygen  and  carbon  which contribute   to decreasing in material performance of the alloy attributed from the formation of unwanted  oxide compounds such as TiO2 and  TiC. Another issue is the mismatch value of the Young’s modulus between the metallic implant and bone that result in stress shielding effect.  The structure of Ti-based  alloy is  mainly comprised of α-phase, β-phase or a combination of  both that result in variation of Young’s modulus ranging from 45 -110 GPa. Compared to α-phase Ti alloy, the β-phase rich alloys may exhibit lower value of Young modulus through the right processing technique. Therefore, the development of β-phase Ti-alloys has been researched progressively in line with the need of low Young’s modulus that suit for implant applications.

Surface Modification of Magnetite Nanoparticles with Doxorubicin and RGD Peptide and their Biomedical Application

2007 ◽  
Vol 342-343 ◽  
pp. 793-796 ◽  
Author(s):  
K.M. Kamruzzaman Selim ◽  
Mi Jin Park ◽  
Hong Mi Kim ◽  
Inn Kyu Kang
Keyword(s):  
Magnetite Nanoparticles ◽  
Tumor Targeting ◽  
Biomedical Application ◽  
Rgd Peptide ◽  
Intracellular Uptake ◽  
Culture Experiment ◽  
Targeting Delivery ◽  
Surface Modified ◽  
Targeting Effect ◽  
Cell Culture Experiment

In the present study, superparamagnetic maltotrionic acid-coated magnetite nanoparticles (MAM) were surface modified with doxorubicin (DOX) and RGD peptide to improve their intracellular uptake, ability to target tumor cells and antitumer effect. RGD was added to the distal end of MAM aiming to construct an enhanced tumor targeting delivery system. To test its targeting effect, DOX, a widely used anticancer drug, was immobilized on the RGD-modified magnetite nanoparticles. DOX-coated magnetite nanoparticles were also prepared as a control. KB cell culture experiment showed that both DOX-modified nanoparticles and DOX-RGD peptide-modified magnetite nanoparticles (DRMAM) were internalized into the cells. But the uptake amount of DRMAMs was higher than that of DOX-modified nanoparticles. This result indicates that DRMAMs have a great potential to be used as contrast agent and antitumor medicine.

Gradient Rare-Earths Bioceramic Composite Coating Fabricated by Wide-Band Laser Cladding and its Bioactivity

2009 ◽  
Vol 610-613 ◽  
pp. 1224-1226 ◽  
Author(s):  
Qi Bin Liu ◽  
Ling Wu ◽  
Bang Cheng Yang
Keyword(s):  
Cell Culture ◽  
Alkaline Phosphatase ◽  
Composite Coating ◽  
Laser Cladding ◽  
Rare Earths ◽  
Wide Band ◽  
Culture Experiment ◽  
Tc4 Alloy ◽  
Cell Culture Experiment

A gradient bioceramic composite coating was prepared by wide-band laser cladding technique on TC4 alloy surface. The influence of rare earths oxide CeO2 on microstructure of bioceramic coating was studied. The experimental results indicated that CeO2 plays an important role in inducing HA + β-TCP formation. There is almost no HA+β-TCP in bioceramic coating without CeO2. When CeO2 content is higher than 0.2 wt.%, the amount of HA+β-TCP catalyzed by CeO2 gradually increases. The amount of HA+β-TCP becomes largest when CeO2 content is up to 0.4wt%. However, when CeO2 content ranges from 0.6 wt.% to 0.8 wt.%, the amount of synthesizing HA+β-TCP conversely goes down. Through cell culture experiment in vitro, the effect of bioceramic coating with different CeO2 contents on the expression of characteristic protein is investigated. The results show that the largest amount of expression of hydroxyproline(Hyp) at 2d and alkaline phosphatase(ALP) at 6d on coating is complied with 0.4wt.% CeO2, The result indicates that bioactivity of bioceramic coating is dependent on the amount of HA + β-TCP catalyzed by different CeO2 contents.

Cellulose Nanofibrils-based Hydrogels for Biomedical Applications: Progresses and Challenges

2020 ◽  
Vol 27 (28) ◽  
pp. 4622-4646 ◽  
Author(s):  
Huayu Liu ◽  
Kun Liu ◽  
Xiao Han ◽  
Hongxiang Xie ◽  
Chuanling Si ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Metal Ion ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Cellulose Nanofibrils ◽  
Wound Dressings ◽  
Preparation Methods ◽  
Tissue Scaffold ◽  
Surface Areas ◽  
Mechanical Methods

Background: Cellulose Nanofibrils (CNFs) are natural nanomaterials with nanometer dimensions. Compared with ordinary cellulose, CNFs own good mechanical properties, large specific surface areas, high Young's modulus, strong hydrophilicity and other distinguishing characteristics, which make them widely used in many fields. This review aims to introduce the preparation of CNFs-based hydrogels and their recent biomedical application advances. Methods: By searching the recent literatures, we have summarized the preparation methods of CNFs, including mechanical methods and chemical mechanical methods, and also introduced the fabrication methods of CNFs-based hydrogels, including CNFs cross-linked with metal ion and with polymers. In addition, we have summarized the biomedical applications of CNFs-based hydrogels, including scaffold materials and wound dressings. Results: CNFs-based hydrogels are new types of materials that are non-toxic and display a certain mechanical strength. In the tissue scaffold application, they can provide a micro-environment for the damaged tissue to repair and regenerate it. In wound dressing applications, it can fit the wound surface and protect the wound from the external environment, thereby effectively promoting the healing of skin tissue. Conclusion: By summarizing the preparation and application of CNFs-based hydrogels, we have analyzed and forecasted their development trends. At present, the research of CNFs-based hydrogels is still in the laboratory stage. It needs further exploration to be applied in practice. The development of medical hydrogels with high mechanical properties and biocompatibility still poses significant challenges.

The influence of gadolinium on Al–Ti–C master alloy and its refining effect on AZ31 magnesium alloy

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Wenxue Fan ◽  
Hai Hao
Keyword(s):  
Mechanical Properties ◽  
Magnesium Alloy ◽  
Grain Refinement ◽  
Magnesium Alloys ◽  
Master Alloy ◽  
Cast Alloy ◽  
Az31 Magnesium Alloy ◽  
Synthesis Mechanism ◽  
Refining Effect ◽  
Master Alloys

Abstract Grain refinement has a significant influence on the improvement of mechanical properties of magnesium alloys. In this study, a series of Al–Ti–C-xGd (x = 0, 1, 2, 3) master alloys as grain refiners were prepared by self-propagating high-temperature synthesis. The synthesis mechanism of the Al–Ti–C-xGd master alloy was analyzed. The effects of Al–Ti–C-xGd master alloys on the grain refinement and mechanical properties of AZ31 (Mg-3Al-1Zn-0.4Mn) magnesium alloys were investigated. The results show that the microstructure of the Al–Ti–C-xGd alloy contains α-Al, TiAl3, TiC and the core–shell structure TiAl3/Ti2Al20Gd. The refining effect of the prepared Al–Ti–C–Gd master alloy is obviously better than that of Al–Ti–C master alloy. The grain size of AZ31 magnesium alloy was reduced from 323 μm to 72 μm when adding 1 wt.% Al–Ti–C-2Gd master alloy. In the same condition, the ultimate tensile strength and elongation of as-cast alloy were increased from 130 MPa, 7.9% to 207 MPa, 16.6% respectively.

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