scholarly journals Histological and Histomorphometric Comparison of Innovative Dental Implants Laser Obtained: Animal Pilot Study

Materials ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 1830
Author(s):  
Mastrangelo Filiberto ◽  
Botticelli Daniele ◽  
Bengazi Franco ◽  
Scarano Antonio ◽  
Piattelli Adriano ◽  
...  
Keyword(s):  
Pilot Study ◽  
Surface Characteristics ◽  
Objective Evaluation ◽  
Poor Quality ◽  
Histomorphometric Analysis ◽  
Implant Surface ◽  
Bone Response ◽  
Bone To Implant Contact ◽  
Titanium Surfaces

Objective: Evaluation of the in vivo bone response of two innovative titanium surfaces ytterbium laser active fiber obtained (L1-L2) compared to a sandblasted and acid etched (SBAE) during early phase of osseointegration. Material and Methods: Three implant groups with the same macroscopic features were obtained (L1-L2-SBAE) to promote specific surface characteristics. Scanning electron microscopy, profilometric evaluation, X-ray spectrometry, and diffraction analysis were performed. For each group, six implants were placed in the tibiae of three Peli Buey sheep, and histologic, histomorphometric analysis, bone to implant contact (BIC), and the Dynamic Osseointegration index (DOI) were performed. Results: During the early phases of osseointegration, the histological and histomorphometric results showed significant differences between L1-L2-SBAE implants. At 15 and 30 days, histological analysis detected a newly bone formation around all specimens with an higher vital bone in L2 compared to L1 and SBAE both in cortical and in poor-quality marrow bone. At same time, histomorphometric analysis showed significantly higher BIC values in L2 (42.1 ± 2.6 and 82.4 ± 2.2) compared to L1 (5.2 ± 3.1 and 56.2 ± 1.3) and SBAE (23.3 ± 3.9 and 77.3 ± 0.4). DOI medium value showed a higher rate in L2 (2.83) compared to SBAE (2.60) and L1 (1.91). Conclusions: With the limitations of this pilot study, it is possible to assess that the titanium surface characteristics, and not the technologies used to obtain the modification, played a crucial role during the osseointegration process. Histological, histomorphometric, BIC, and DOI evaluation showed a significantly higher rate in L2 specimens compared to others, confirming that the implant surface could increase the bone response in cortical or marrow poor quality bone during the initial phases of osseointegration.

A Histomophometric Analysis of Bone Healing around Zirconia Implant

2007 ◽  
Vol 342-343 ◽  
pp. 593-596
Author(s):  
Jeong Taek Lee ◽  
Seong Joo Heo ◽  
Jai Young Koak ◽  
Seong Kyun Kim ◽  
Su Young Lee ◽  
...  
Keyword(s):  
Surface Characteristics ◽  
Titanium Implants ◽  
Histomorphometric Analysis ◽  
Group 4 ◽  
Bone Response ◽  
Bone To Implant Contact ◽  
Group 3 ◽  
Group 2 ◽  
Group 1 ◽  
Zirconia Implant

Zirconia was introduced into the dentistry as a metal-replacement material because of its outstanding mechanical properties like high flexural strength and fracture toughness. The purpose of this study was to evaluate bone response and examine the surface characteristics of zirconiabased implant. Screw shaped c.p. titanium implants(group 1), HA-based composite implants(group 2), HA/FA coated ZrO2 implants(group 3) and FA coated ZrO2 implants(group 4) were installed in rabbit tibias. After 4 and 12 weeks of healing period, the histomorphometric analysis was performed with an Olympus BX microscope connected to a computer. The percentage of bone-to-implant contact in the 3 best consecutive threads and the percentage of bone inside the same threads were calculated. the present study demonstrated the excellent bone response of ZrO2-based implants fabricated by various methods to combine the advantages of ZrO2, HA, and FA.

The Influence of Storage in Saline or Irradiation by Ultraviolet on Implant Hydrophilicity and Osseointegration:   An Experimental Study in Rabbits

2021 ◽  
Author(s):  
Yuhao Zhu ◽  
Antian Xu ◽  
Chuan Zhou ◽  
Yefeng Wu ◽  
Guofen Lin ◽  
...  
Keyword(s):  
Uv Irradiation ◽  
Cancellous Bone ◽  
Surface Characterization ◽  
Early Stage ◽  
Healing Time ◽  
Titanium Implants ◽  
Histomorphometric Analysis ◽  
Implant Surface ◽  
Bone Response

Storage in aqueous solution or ultraviolet (UV) irradiation  can  re t ain or regain the hydrophilicity of titanium implant surface.  In this study, t hree types of commercial titanium implants were used : ZBL (ZDI Bone  L evel ® ), CEL (C-tech Esthetic Line ® ) , and modSLA (Straumann SLActive ® ). ZBL and CEL implants were treated with UV irradiation for 4 h. Surface characterization of the four groups (ZBL, ZBL-UV, CEL-UV, modSLA)  was  evaluated by scanning electron microscopy and contact angle measurements. The  in vivo bone response  was  evaluated by removal torque (RTQ) tests and histomorphometric analysis  at  3, 6 , and 12 weeks post-implantation. A total of 144 implants and 36 rabbits were used for experiments according to a previously established randomization sequence. The  ZBL-UV, CEL-UV , andmodSLA groups were hydrophilic, and nanostructures were observed on  the  modSLA implant surface.ModSLA achieved better  RTQ value than ZBL at 12 weeks ( p <0.05). For histomorphometric analysis, ZBL-UV and CEL-UV implants showed higher bone area values in  the  cancellous bone zone at 6 weeks than  did  modSLA and ZBL  implants  ( p <0.05).In  the  cortical bone zone, all groups showed comparable bone-to-implant contact at all healing time points ( p >0.05).Both storage in saline  and UV irradiation could retain or provoke hydr o philic surfaces and improve osseointegration. Compared to storage in saline, UV irradiation displayed slight advantages in promoting new bone formation in cancellous bone zone at  an  early stage.

Calcium Phosphate-Coated Titanium Implants in the Mandible: Limitations of the in vivo Minipig Model

2020 ◽  
Vol 61 (6) ◽  
pp. 177-187
Author(s):  
Till Kämmerer ◽  
Tony Lesmeister ◽  
Victor Palarie ◽  
Eik Schiegnitz ◽  
Andrea Schröter ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Statistical Difference ◽  
Surface Modifications ◽  
Titanium Implants ◽  
In Vivo Model ◽  
Implant Surface ◽  
Press Fit ◽  
Endosseous Implant ◽  
Bone To Implant Contact

Introduction: We aimed to compare implant osseointegration with calcium phosphate (CaP) surfaces and rough subtractive-treated sandblasted/acid etched surfaces (SA) in an in vivo minipig mandible model. Materials and Methods: A total of 36 cylindrical press-fit implants with two different surfaces (CaP, n = 18; SA, n = 18) were inserted bilaterally into the mandible of 9 adult female minipigs. After 2, 4, and 8 weeks, we analyzed the cortical bone-to-implant contact (cBIC; %) and area coverage of bone-to-implant contact within representative bone chambers (aBIC; %). Results: After 2 weeks, CaP implants showed no significant increase in cBIC and aBIC compared to SA (cBIC: mean 38 ± 5 vs. 16 ± 11%; aBIC: mean 21 ± 1 vs. 6 ± 9%). Two CaP implants failed to achieve osseointegration. After 4 weeks, no statistical difference between CaP and SA was seen for cBIC (mean 54 ± 15 vs. 43 ± 16%) and aBIC (mean 43 ± 28 vs. 32 ± 6). However, we excluded two implants in each group due to failure of osseointegration. After 8 weeks, we observed no significant intergroup differences (cBIC: 18 ± 9 vs. 18 ± 20%; aBIC: 13 ± 8 vs. 16 ± 9%). Again, three CaP implants and two SA implants had to be excluded due to failure of osseointegration. Conclusion: Due to multiple implant losses, we cannot recommend the oral mandibular minipig in vivo model for future endosseous implant research. Considering the higher rate of osseointegration failure, CaP coatings may provide an alternative to common subtractive implant surface modifications in the early phase post-insertion.

Alkali-Modified Titanium Surface Stimulating Formation of Bone-Implant Interface

2007 ◽  
Vol 361-363 ◽  
pp. 749-752
Author(s):  
J. Strnad ◽  
Jan Macháček ◽  
Z. Strnad ◽  
C. Povýšil ◽  
Marie Strnadová
Keyword(s):  
Titanium Implant ◽  
Surface Characteristics ◽  
Healing Time ◽  
Machined Surface ◽  
Implant Surface ◽  
Bone Implant ◽  
Bone Response ◽  
Modified Surface ◽  
The Difference ◽  
Titanium Implant Surface

This study was carried out to assess the bone response to alkali-modified titanium implant surface (Bio surface), using histomorphometric investigation on an animal model. The mean net contribution of the Bio surface to the increase in bone implant contact (BIC) with reference to the turned, machined surface was evaluated at 7.94 % (BIC/week), within the first five weeks of healing. The contribution was expressed as the difference in the osseointegration rates ( BIC/'healing time) between the implants with alkali modified surface (Bio surface) and those with turned, machined surface. The surface characteristics that differed between the implant surfaces, i.e. surface morphology, specific surface area, contact angle, hydroxylation/hydration, may represent factors that influence the rate of osseointegration.

scholarly journals Intraosseous Temperature Change during Installation of Dental Implants with Two Different Surfaces and Different Drilling Protocols: An In Vivo Study in Sheep

2019 ◽  
Vol 8 (8) ◽  
pp. 1198 ◽  
Author(s):  
Michele Stocchero ◽  
Yohei Jinno ◽  
Marco Toia ◽  
Marianne Ahmad ◽  
Evaggelia Papia ◽  
...  
Keyword(s):  
Temperature Increase ◽  
Element Model ◽  
Multiple Regression Model ◽  
Metatarsal Bone ◽  
Area Fraction ◽  
Bone Area ◽  
Implant Surface ◽  
Bone Necrosis ◽  
Bone To Implant Contact

Background: The intraosseous temperature during implant installation has never been evaluated in an in vivo controlled setup. The aims were to investigate the influence of a drilling protocol and implant surface on the intraosseous temperature during implant installation, to evaluate the influence of temperature increase on osseointegration and to calculate the heat distribution in cortical bone. Methods: Forty Brånemark implants were installed into the metatarsal bone of Finnish Dorset crossbred sheep according to two different drilling protocols (undersized/non-undersized) and two surfaces (moderately rough/turned). The intraosseous temperature was recorded, and Finite Element Model (FEM) was generated to understand the thermal behavior. Non-decalcified histology was carried out after five weeks of healing. The following osseointegration parameters were calculated: Bone-to-implant contact (BIC), Bone Area Fraction Occupancy (BAFO), and Bone Area Fraction Occupancy up to 1.5 mm (BA1.5). A multiple regression model was used to identify the influencing variables on the histomorphometric parameters. Results: The temperature was affected by the drilling protocol, while no influence was demonstrated by the implant surface. BIC was positively influenced by the undersized drilling protocol and rough surface, BAFO was negatively influenced by the temperature rise, and BA1.5 was negatively influenced by the undersized drilling protocol. FEM showed that the temperature at the implant interface might exceed the limit for bone necrosis. Conclusion: The intraosseous temperature is greatly increased by an undersized drilling protocol but not from the implant surface. The temperature increase negatively affects the bone healing in the proximity of the implant. The undersized drilling protocol for Brånemark implant systems increases the amount of bone at the interface, but it negatively impacts the bone far from the implant.

Evaluation of Peri-Implant Bone Response in Implants Retrieved for Fracture After More Than 20 Years of Loading: A Case Series

2015 ◽  
Vol 41 (4) ◽  
pp. 414-418 ◽  
Author(s):  
Carlo Mangano ◽  
Adriano Piattelli ◽  
Carmen Mortellaro ◽  
Francesco Mangano ◽  
Vittoria Perrotti ◽  
...  
Keyword(s):  
Close Contact ◽  
Case Series ◽  
Compact Bone ◽  
Implant Surface ◽  
Bone Response ◽  
Histological Data ◽  
Maturation Stages ◽  
Bone To Implant Contact ◽  
The University

Analysis of human retrieved dental implants is a useful tool in the evaluation of implant success and failure. More human histological data are needed from samples of long-term implant service. The aim of the present case series was a histological and histomorphometrical evaluation of the peri-implant bone responses in implants retrieved for fracture after more than 20 years loading. The archives of the Implant Retrieval Center of the Department of Medical, Oral and Biotechnological Sciences of the University of Chieti-Pescara, Italy were searched. A total of 5 implants, retrieved after a loading period of more than 20 years, were found: 2 had been retrieved after 20 years, 1 after 22 years, 1 after 25 years, and 1 after 27 years. All these implants were histologically processed. Compact, mature bone in close contact with the implant surface was observed in all specimens, with no gaps or connective tissue at the interface. Bone in different maturation stages was found around some implants. Primarily newly formed bone was observed in proximity of the implant surface, while mature compact bone with many remodeling areas and cement lines were detected in areas distant from the implant. Many primary and secondary osteons were present. Bone to implant contact percentage varied from 37.2% to 76%. In conclusion, histology and histomorphometry showed that even after many years of function, all implants presented more than adequate bone to implant contact and they appeared to be very well integrated in the peri-implant bone.

scholarly journals The Effect of Hydroxyapatite Nanocrystals on Osseointegration of Titanium Implants: AnIn VivoRabbit Study

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Karin Breding ◽  
Ryo Jimbo ◽  
Mariko Hayashi ◽  
Ying Xue ◽  
Kamal Mustafa ◽  
...  
Keyword(s):  
Surface Chemistry ◽  
Calcium Phosphates ◽  
Surface Characteristics ◽  
Healing Time ◽  
Titanium Implants ◽  
Pcr Analysis ◽  
Rt Pcr ◽  
Implant Surface ◽  
Hydroxyapatite Nanocrystals

Osseointegration is dependent on implant surface characteristics, including surface chemistry and topography. The presence of nanosized calcium phosphates on the implant surface is interesting to investigate since they affect both the nanotopography and surface chemistry, forming a bone mineral resembling surface. In this work, the osseointegration of titanium implants with and without the presence of hydroxyapatite (HA) nanocrystals has been evaluatedin vivo. The integration was examined using removal torque measurements and real-time polymerase chain reaction (RT-PCR) analysis. The study was performed using two healing time points, 3 and 12 weeks. The results showed that the torque needed to remove the implants was insignificant between the non- and HA-coated implants, both at weeks 3 and 12. The RT-PCR, however, showed significant differences for osteoblast, osteoclast, and proinflammation markers when HA nanocrystals were present.

scholarly journals Defining surfaces : Implant topography – a review (Preprint)

2018 ◽  
Author(s):  
Preeti Satheesh Kumar ◽  
Vyoma Venkatesh Grandhi ◽  
Vrinda Gupta
Keyword(s):  
Surface Roughness ◽  
Surface Topography ◽  
Dental Implants ◽  
Sol Gel ◽  
Implant Surface ◽  
Research Publications ◽  
Bone To Implant Contact ◽  
Titanium Dental Implants

BACKGROUND . A variety of claims are made regarding the effects of surface topography on implant osseointegration. The development of implant surfaces topography has been empirical, requiring numerous in vitro and in vivo tests. Most of these tests were not standardized, using different surfaces, cell populations or animal models. The exact role of surface chemistry and topography on the early events of the osseointegration of dental implants remain poorly understood. OBJECTIVE This review considers the major claims made concerning the effects of titanium implant surface topography on osseointegration. The osseointegration rate of titanium dental implants is related to their composition and surface roughness. The different methods used for increasing surface roughness or applying osteoconductive coatings to titanium dental implants are reviewed. Important findings of consensus are highlighted, and existing controversies are revealed. METHODS This review considers many of the research publications listed in MEDLINE and presented in biomedical research publications and textbooks. Surface treatments, such as titanium plasma-spraying, grit-blasting acid-etching,alkaline etching, anodization,polymer demixing ,sol gel conversion and their corresponding surface morphologies and properties are described. RESULTS Many in vitro evaluations are not predictive of or correlated with in vivo outcomes. In some culture models, increased surface topography positively affects pro-osteogenic cellular activities. Many studies reveal increase in bone-to-implant contact,with increased surface topography modifications on implant surfaces. CONCLUSIONS Increased implant surface topography improves the bone-to-implant contact and the mechanical properties of the enhanced interface.

Implant Surface Roughness and Bone Healing: a Systematic Review

2006 ◽  
Vol 85 (6) ◽  
pp. 496-500 ◽  
Author(s):  
M.M. Shalabi ◽  
A. Gortemaker ◽  
M.A. Van’t Hof ◽  
J.A. Jansen ◽  
N.H.J. Creugers
Keyword(s):  
Systematic Review ◽  
Surface Roughness ◽  
Bone Healing ◽  
Animal Studies ◽  
Implant Fixation ◽  
Implant Surface ◽  
Bone Response ◽  
Bone To Implant Contact ◽  
Almost All ◽  
Relationship Of

A systematic review was performed on studies investigating the effects of implant surface roughness on bone response and implant fixation. We searched the literature using MEDLINE from 1953 to 2003. Inclusion criteria were: (1) abstracts of animal studies investigating implant surface roughness and bone healing; (2) observations of three-month bone healing, surface topography measurements, and biomechanical tests; (3) provision of data on surface roughness, bone-to-implant contact, and biomechanical test values. The literature search revealed 5966 abstracts. There were 470, 23, and 14 articles included in the first, second, and third selection steps, respectively. Almost all papers showed an enhanced bone-to-implant contact with increasing surface roughness. Six comparisons were significantly positive for the relationship of bone-to-implant contact and surface roughness. Also, a significant relation was found between push-out strength and surface roughness. Unfortunately, the eventually selected studies were too heterogeneous for inference of data. Nevertheless, the statistical analysis on the available data provided supportive evidence for a positive relationship between bone-to-implant contact and surface roughness.

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