scholarly journals Polymer-Based Nanosystems—A Versatile Delivery Approach

Materials ◽  
2021 ◽  
Vol 14 (22) ◽  
pp. 6812
Author(s):  
Adelina-Gabriela Niculescu ◽  
Alexandru Mihai Grumezescu
Keyword(s):  
Vaccine Development ◽  
Polymeric Nanoparticles ◽  
Drug Clearance ◽  
Synthetic Polymer ◽  
Polymer Nanoparticles ◽  
Polymer Nanostructures ◽  
Immunomodulatory Properties ◽  
Delivery Approach ◽  
Review Current ◽  
Encapsulation Ability

Polymer-based nanoparticles of tailored size, morphology, and surface properties have attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting the payload from degradation and maintaining sustained and controlled release of the drug, polymeric nanoparticles can reduce drug clearance, increase their cargo’s stability and solubility, prolong its half-life, and ensure optimal concentration at the target site. The inherent immunomodulatory properties of specific polymer nanoparticles, coupled with their drug encapsulation ability, have raised particular interest in vaccine delivery. This paper aims to review current and emerging drug delivery applications of both branched and linear, natural, and synthetic polymer nanostructures, focusing on their role in vaccine development.

scholarly journals Nanovaccines against Animal Pathogens: The Latest Findings

Vaccines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 988
Author(s):  
Carmen Teresa Celis-Giraldo ◽  
Julio López-Abán ◽  
Antonio Muro ◽  
Manuel Alfonso Patarroyo ◽  
Raúl Manzano-Román
Keyword(s):  
Vaccine Development ◽  
Polymeric Nanoparticles ◽  
Cost Effective ◽  
Antigen Delivery ◽  
Emerging Pathogens ◽  
Persistent Infections ◽  
Self Assembling ◽  
Animal Pathogens ◽  
Novel Delivery Systems ◽  
Encapsulation Ability

Nowadays, safe and efficacious vaccines represent powerful and cost-effective tools for global health and economic growth. In the veterinary field, these are undoubtedly key tools for improving productivity and fighting zoonoses. However, cases of persistent infections, rapidly evolving pathogens having high variability or emerging/re-emerging pathogens for which no effective vaccines have been developed point out the continuing need for new vaccine alternatives to control outbreaks. Most licensed vaccines have been successfully used for many years now; however, they have intrinsic limitations, such as variable efficacy, adverse effects, and some shortcomings. More effective adjuvants and novel delivery systems may foster real vaccine effectiveness and timely implementation. Emerging vaccine technologies involving nanoparticles such as self-assembling proteins, virus-like particles, liposomes, virosomes, and polymeric nanoparticles offer novel, safe, and high-potential approaches to address many vaccine development-related challenges. Nanotechnology is accelerating the evolution of vaccines because nanomaterials having encapsulation ability and very advantageous properties due to their size and surface area serve as effective vehicles for antigen delivery and immunostimulatory agents. This review discusses the requirements for an effective, broad-coverage-elicited immune response, the main nanoplatforms for producing it, and the latest nanovaccine applications for fighting animal pathogens.

scholarly journals Recent Advances in Nanovaccines Using Biomimetic Immunomodulatory Materials

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 534 ◽  
Author(s):  
Vijayan ◽  
Mohapatra ◽  
Uthaman ◽  
Park
Keyword(s):  
Immune Responses ◽  
Targeted Delivery ◽  
Vaccine Development ◽  
Polymeric Nanoparticles ◽  
Vital Role ◽  
Effective Control ◽  
Therapeutic Vaccines ◽  
Hiv Therapy ◽  
Recent Advances ◽  
Wide Range

The development of vaccines plays a vital role in the effective control of several fatal diseases. However, effective prophylactic and therapeutic vaccines have yet to be developed for completely curing deadly diseases, such as cancer, malaria, HIV, and serious microbial infections. Thus, suitable vaccine candidates need to be designed to elicit appropriate immune responses. Nanotechnology has been found to play a unique role in the design of vaccines, providing them with enhanced specificity and potency. Nano-scaled materials, such as virus-like particles, liposomes, polymeric nanoparticles (NPs), and protein NPs, have received considerable attention over the past decade as potential carriers for the delivery of vaccine antigens and adjuvants, due to their beneficial advantages, like improved antigen stability, targeted delivery, and long-time release, for which antigens/adjuvants are either encapsulated within, or decorated on, the NP surface. Flexibility in the design of nanomedicine allows for the programming of immune responses, thereby addressing the many challenges encountered in vaccine development. Biomimetic NPs have emerged as innovative natural mimicking biosystems that can be used for a wide range of biomedical applications. In this review, we discuss the recent advances in biomimetic nanovaccines, and their use in anti-bacterial therapy, anti-HIV therapy, anti-malarial therapy, anti-melittin therapy, and anti-tumor immunity.

Polymer nanoparticles with electrostatically loaded multicargo for combined cancer phototherapy

2015 ◽  
Vol 3 (15) ◽  
pp. 3001-3010 ◽  
Author(s):  
Aurore Fraix ◽  
Ilse Manet ◽  
Marco Ballestri ◽  
Andrea Guerrini ◽  
Paolo Dambruoso ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cell ◽  
Polymeric Nanoparticles ◽  
Polymer Nanoparticles ◽  
Cancer Cell Death

Fluorescent biocompatible polymeric nanoparticles entangling two photoactive chromophores induce amplified cancer cell death due to the simultaneous photogeneration of1O2and NO.

Designing high performance polymer nanocomposites by incorporating robustness-controlled polymeric nanoparticles: insights from molecular dynamics

2022 ◽  
Author(s):  
Guangyi Hou ◽  
Sai Li ◽  
Jun Liu ◽  
Yun-Xuan Weng ◽  
Liqun Zhang
Keyword(s):  
Molecular Dynamics ◽  
Polymer Nanocomposites ◽  
High Performance ◽  
Polymeric Nanoparticles ◽  
Polymer Nanoparticles ◽  
Polymer Matrices ◽  
Interesting Topic ◽  
High Performance Polymer

Introducing polymer nanoparticles into polymer matrices is an interesting topic, and the robustness of polymeric nanoparticles is very crucial for the properties of polymer nanocomposites (PNCs). In this study, by...

Polymer nanoparticles for drug delivery – synthetic vs. biopolymers?

BioResources ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. 2181-2183
Author(s):  
Martin Gericke ◽  
Thomas Heinze
Keyword(s):  
Quality Standards ◽  
Synthetic Polymer ◽  
Molecular Structures ◽  
Polymer Nanoparticles ◽  
Cell Type ◽  
High Quality ◽  
Medical Products ◽  
Physiological Conditions ◽  
Supramolecular Architectures ◽  
Specific Tissue

Nanoparticles have a great prospect for therapeutic applications. They can protect drugs under physiological conditions and act as a matrix for directed delivery of drugs, e.g., to a specific tissue or cell type. Polymer-based nanomaterials are considered as highly effective in this regard. Their properties can be tailored to meet specific demands for given therapeutic purposes. Considering the high-quality standards placed on medical products, the question arises: Which type of polymer material should be employed? One might select synthetic polymer compounds, which are highly diverse in terms of the molecular structures and supramolecular architectures that can be created, or biopolymers such as polysaccharides that are renowned for their native biocompatibility.

Depolymerizable, adaptive supramolecular polymer nanoparticles and networks

2014 ◽  
Vol 5 (12) ◽  
pp. 3788-3794 ◽  
Author(s):  
Joshua A. Kaitz ◽  
Catherine M. Possanza ◽  
Yang Song ◽  
Charles E. Diesendruck ◽  
A. Jolanda H. Spiering ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
Polymer Networks ◽  
Polymer Nanoparticles ◽  
Cross Linking ◽  
Supramolecular Polymer ◽  
Single Chain ◽  
Degradable Polymer

Depolymerizable polymers are appended with supramolecular cross-linking motifs to enable preparation of tunable single-chain polymeric nanoparticles and degradable polymer networks.

Photochromic RAFT reagent helps construct superior photoswitchable fluorescent polymer nanoparticles for rewritable fluorescence patterning and intracellular dual-color imaging

2017 ◽  
Vol 8 (42) ◽  
pp. 6520-6526 ◽  
Author(s):  
Jian Chen ◽  
Weibang Zhong ◽  
Mingju Xue ◽  
Hong Wang ◽  
Maolin Yu ◽  
...  
Keyword(s):  
Chain Transfer ◽  
Polymeric Nanoparticles ◽  
Polymer Nanoparticles ◽  
Color Imaging ◽  
Dual Color ◽  
Fluorescent Polymer

Photoswitchable fluorescent polymeric nanoparticles with photochromic RAFT chain transfer reagent were synthesized for rewritable fluorescence patterning and intracellular dual color imaging.

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