SARS-CoV-2 Infection Susceptibility of Pregnant Patients at Term Regarding ABO and Rh Blood Groups: A Cohort Study

Background and Objectives: The susceptibility of pregnant patients at term to SARS-CoV-2 infection regarding the ABO and Rh blood group polymorphism was analyzed in this study. Materials and Methods: In this prospective study, 457 patients admitted for delivery at term in our hospital, between 1 April 2020 and 31 December 2020 were studied. There were 46 positive and 411 SARS-CoV-2 negative patients. Their values for RT-PCR, ABO, and Rh blood group analyses, which were determined upon admittance, were studied. Results: A slightly higher percentage of infected pregnant patients at term belonged to the A blood group compared with the percentage belonging to the other blood groups; this was also true for the healthy control group. For the Rh-negative pregnant patients at term, the odds of being infected with SARS-CoV-2 was OR = 1.22 compared with Rh-positive patients where OR = 1. In our study, the highest risk was found among BIII Rh-negative pregnant patients at term (OR = 3). None of the above differences were statistically significant. Conclusions: No significant difference was found between the percentage of ABO or Rh blood groups in SARS-CoV-2 positive patients when compared with SARS-CoV-2 negative patients (p = 0.562).

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Blood Groups of Recipients of COVID-19 Convalescent plasma

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqab191.279 ◽

2021 ◽

Vol 156 (Supplement_1) ◽

pp. S131-S131

Author(s):

J M Petersen ◽

D Jhala

Keyword(s):

Blood Group ◽

Asian American ◽

Medical Center ◽

Blood Groups ◽

Control Population ◽

Control Group ◽

Plasma Therapy ◽

Unrelated Control ◽

Significant Difference ◽

Group B

Abstract Introduction/Objective COVID -19 Convalescent plasma therapy (CCP) is under an FDA Emergency Use Authorization to treat hospitalized patients with COVID-19. However, being ill enough to require hospitalization for COVID-19 is a negative outcome. There is also contradictory literature on whether ABO blood group is associated with worse outcomes with COVID-19 disease. Therefore, we share a regional Veterans Administration Medical Center (VAMC) experience comparing the blood groups of patients intended to receive CCP to a control group of patients positive for SARS-CoV-2. Methods/Case Report A retrospective review of all patients who had CCP ordered in the year 2020 was performed to identify the blood group of these patients, which was compared to a control population of positive patients early in the pandemic (March 17th, 2020 to May 20th, 2020). Results (if a Case Study enter NA) A total of 15 patients had CCP ordered as part of their care with an age range of 56-85 (average 69.7) years of age, entirely male composition, and a racial breakdown of 13 African Americans (86.7%), 1 Caucasian American (6.7%), and 1 Asian American (6.7%). The blood group distribution amongst these 15 patients for CCP was 1 AB+ (6.7%), 5 A+ (33.3%), 4 B+ (26.7%), and 5 O+ (33.3%). The unrelated control population consisted of 81 SARS-CoV-2 positive patients whose blood groups were distributed as 3 group AB (3.7%), 21 group A (25.9%), 15 group B (18.5%), and 42 group O (51.8%). A Chi squared test did not show a statistically significant difference between the two groups in ABO composition. Conclusion The ABO proportions of patients for whom CCP was ordered compared to the control group was not statistically significant. This provides support to the literature arguing that ABO may not be related to worse outcomes such as hospitalization or need for CCP transfusion.

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Relationship of Blood Group Type and SARS-CoV-2 Infection: Experience in A Peripheral Military Hospital

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v39i2.52389 ◽

2021 ◽

Vol 39 (2) ◽

pp. 94-99

Author(s):

Md Soleman Badsha ◽

Md Mizanur Rahman Khan ◽

SM Belal Uddin ◽

Kamrun Nesa

Keyword(s):

Blood Group ◽

Statistical Significance ◽

Blood Groups ◽

Military Hospital ◽

Control Group ◽

P Value ◽

Percentage Distribution ◽

Blood Group A ◽

Significant Difference ◽

Group A

Introduction: Clinical studies have shown that advanced age and chronic diseases increase the risk of infection. Different studies have found blood groups are also a determining factor of severity. However, in Bangladesh it is yet to have any clinical pattern in this respect. The aim of this study is to find out whether there exists a relationship between the blood groups of the patients and risk of SARS-CoV-2 infection. Methods: The study is a retrospective cohort study. It included all hospitalized RT-PCR confirmed COVID-19 patients in Combined Military Hospital (CMH) Barishal. We included both genders and people who are older than 14 years of age. The study was conducted during the period between 4th June and 3rd August, 2020. In this period total 556 individuals reported and tested for SARS-CoV-2 where COVID +ve patients are served as patient group and COVID –ve patients are served as the controls. Results: Our sample consists of 185 patients; we found a percentage distribution of 34.6%, 39.5%, 5.4%, and 20.54% for blood groups A, B, AB and O, respectively. Blood group A was statistically significantly more frequent among those infected with COVID-19 compared to controls (34.6% vs. 21.83%, p-value 0.045 (<0.05); OR: 1.894).On the other hand, the frequency of blood group O was significantly lower in the COVID-19 patients, compared to the control group (20.54% vs 32.88%, p-value0.049 (<0.05); OR: 0.528). Although there was a higher percentage distribution of the B blood group among COVID-19 patients as compared to the control groups, this difference did not reach statistical significance. Also, there was no significant difference in the risk of COVID-19 in blood group AB with a distribution of 6.2% in control group, and5.4% in COVID-19 patients. Conclusion: The results of the present study suggest that the blood group A might have a role in increased susceptibility to the COVID-19 infection and the blood group O might be somewhat protective. J Bangladesh Coll Phys Surg 2021; 39(2): 94-99

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ABO-RH blood group and risk of covid-19 in a moroccan population

10.1101/2020.12.02.20242180 ◽

2020 ◽

Author(s):

Mourad Belaouni ◽

Elhoucine Malki ◽

Rabii El Bahraouy ◽

Bouchra El Maliki ◽

Mohammed Er-Rami ◽

...

Keyword(s):

Blood Group ◽

Comparison Group ◽

Blood Groups ◽

Military Hospital ◽

Control Group ◽

Rt Pcr ◽

Cross Sectional ◽

Moroccan Population ◽

Blood Group A ◽

Group A

AbstractIntroductionGiven the rapid spread, significant morbidity and mortality associated with COVID-19, there has been scientific interest in obtaining data detailing the factors influencing the risk of COVID-19 infection. The aim of this study was to reveal a possible association between the ABO-RH system and the risk of COVID-19 in the Moroccan population.Materials and methodsThis is an analytical cross-sectional study. It was carried out on 1094 patients for the diagnosis of Covid-19 by Rt-PCR at the Moulay Ismaïl military hospital in the province of Meknes. All Rt-PCR negative individuals were used as a comparison group.ResultsAmong the 1094 individuals who were diagnosed, RT-PCR for detection of SARS-CoV-2 was positive for 242 individuals. Comparison of the proportions of blood groups of the two groups showed that the proportion of blood group A in patients with COVID-19 was significantly higher than in people in the comparison group (P = 0.007), while the proportion of blood group O in patients with COVID-19 was significantly lower than in people in the control group (P = 0.017). Comparison of the Rh blood groups of the two groups did not find a significant association (P = 0.608).ConclusionAs demonstrated by several previous studies, we concluded that blood group A was associated with a higher risk of acquiring COVID-19. Equally, the O blood group was associated with a lower risk of infection.

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The Relation between the Blood Groups, Rhesus Factor, and Breast Cancer in the Holy Karbala Governorate

10.32792/utq/utjsci/vol7/2/8 ◽

2020 ◽

pp. 31-33

Keyword(s):

Breast Cancer ◽

Blood Group ◽

Type A ◽

Blood Groups ◽

Abo Blood Groups ◽

Group Type ◽

Rhesus Factor ◽

Significant Difference ◽

Healthy Control ◽

Blood Group Type

The distribution ABO blood groups among patients with breast cancer were as follow: blood group type O (40.8%), blood group type A (25.0%), B (23.7%), and AB (10.4%), for the donor’s healthy control, ABO blood groups percentages were as follow: type O (39.9%) type A (28.1%), type B (22.0%), and type AB (9.9%). There is no significant association between blood types ABO and the breast cancer. (P > 0.05) Rh factor has a significant difference between patients with breast cancer and healthy control (P=0.002). There were significant differences in age categories among patients with breast cancer and controls. (p= 0.000) .

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Spectrum of ABO and Rh blood group in Nepali medical students

Journal of Chitwan Medical College ◽

10.3126/jcmc.v10i2.29676 ◽

2020 ◽

Vol 10 (2) ◽

pp. 63-66

Author(s):

Bishal Joshi ◽

Sanjit Kumar Kar ◽

Laxmi Shrestha ◽

Shankar Yadav

Keyword(s):

Medical Students ◽

Blood Group ◽

Blood Groups ◽

Test Method ◽

The Other ◽

Medical Sciences ◽

The People ◽

The World ◽

Slide Test ◽

Rh Blood Group

Background: ABO and Rh systems are most important types of blood group systems that should be taken into consideration during blood transfusion. Many studies have been done across the globe to determine the distribution of these blood groups among different strata of population. But there are very few studies done in Nepali population. Therefore, in this study we aimed to find out the distribution of blood groups among Nepali medical students and to compare it with the other studies done in Nepal and other countries of the World. Methods: This was a retrospective study, containing the data of ABO and Rh blood groups of medical students recorded over a period of 21 years in Department of Physiology of Universal College of Medical Sciences, Bhairahawa, Nepal. The blood group was determined by open slide test method by using commercially available standard monoclonal antibody. Results: A total of 2031 Nepali medical students were included in the study. Among them 1147 were male and 884 were female. In the present study we found that the most common blood group was O (739, 36.4%) followed by B (624, 30.7%) and A (522, 25.7%) and least common blood group was AB (146, 7.2%). Among all participants 96.8% of the people were Rh positive and 3.2% were Rh negative. Conclusions: This study done in Nepali medical students can provide a new insight for the further study of distribution of blood groups in Nepali population. A study with high sample size, representing every zones of Nepal is the demand of future.

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Association of ABO and Rh Blood Group in Susceptibility, Severity, and Mortality of Coronavirus Disease 2019: A Hospital-Based Study From Delhi, India

Frontiers in Cellular and Infection Microbiology ◽

10.3389/fcimb.2021.767771 ◽

2021 ◽

Vol 11 ◽

Author(s):

Rashmi Rana ◽

Vivek Ranjan ◽

Naveen Kumar

Keyword(s):

Blood Group ◽

Odds Ratio ◽

Recovery Period ◽

Blood Groups ◽

Rt Pcr ◽

Chi Square ◽

Severity Of Disease ◽

Chi Square Test ◽

Group A ◽

Rh Blood Group

BackgroundABO and Rh blood group systems are associated with many diseases including cancerous, infectious, non-infectious, bacterial and viral diseases. Studies have shown association of blood groups A and O with higher and lower odds for coronavirus disease 2019 positivity, respectively.MethodsThis is a single-center, retrospective study conducted at Sir Ganga Ram Hospital, Delhi. We investigated the association of ABO and Rh blood groups with susceptibility to coronavirus disease 2019 infection, severity of disease, recovery period, and mortality of patients. Patients were enrolled from April 8, 2020 to October 4, 2020. A total of 2,586 real-time PCR (RT-PCR)-confirmed coronavirus disease 2019 (COVID-19) patients were recruited. Data was analyzed using chi-square test, odds ratio, and Mann–Whitney test to determine the association of blood groups.ResultsIn the 2,586 COVID-19-infected patients, the frequencies of A, B, O, and AB were 29.93%, 41.80%, 21.19%, and 7.98%, respectively. Of the patients, 98.07% were Rh positive. Blood group A (odds ratio, 1.53; CI, 1.40–1.66; p < 0.001) and B (odds ratio, 1.15; CI, 1.06–1.24; p < 0.001) is observed to be significantly associated with COVID-19 susceptibility, whereas blood group O (odds ratio, 0.65; CI, 0.59–0.71; p < 0.001) and AB (odds ratio, 0.66; CI, 0.59–0.71; p < 0.001) have low risk of COVID-19 infection.ConclusionA, B, and Rh+ are found to be more susceptible to COVID-19 infection, whereas blood groups O, AB, and Rh− are at a lower risk of COVID-19 infection. No association was found between blood groups and susceptibility to severity of disease and mortality.

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Susceptibility of blood group ABO and Rh for COVID-19

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20205314 ◽

2020 ◽

Vol 8 (12) ◽

pp. 4405

Author(s):

Sonu Suman

Keyword(s):

Blood Group ◽

Bacterial Infections ◽

Central India ◽

Case Control ◽

Blood Groups ◽

Innate Immune ◽

Rt Pcr ◽

Retrospective Case ◽

The Status ◽

Rh Blood Group

Background: The ABO and Rh blood group systems are part of the innate immune system and it has been shown that individuals with different ABO and Rh blood groups differ in their susceptibility or resistance to viral and bacterial infections and diseases. With the discovery of blood groups and subsequent great advancement in its study, many workers have tried to find out a possible relationship between the incidence of these blood groups and the incidence of various diseases. Aim of the study was determine the association between COVID-19 virus infection and blood groups.Methods: This retrospective Case- control observational study was performed among subjects reported to hospital situated at central India for RT PCR-COVID-19 sampling during the period between March to September 2020. Total subjects enrolled were 1682.Results: The individuals with blood group Rh factor positive are found to be more susceptible in acquiring COVID-19 disease. Likelihood of getting COVID-19 is more with factor Rh positive in comparison to Rh negative counterparts. The association is observed statistically between Rh factor and status of COVID-19.Conclusions: In conclusion our results implicate that blood group are found to be associated with the status of COVID-19 disease. It is observed that the Rh positive individuals are more susceptible when compared to their Rh negative counterparts in acquiring COVID-19 disease.

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Interrelations of Thrombo-Embolic Diseases and Blood-Group Distribution

Thrombosis and Haemostasis ◽

10.1055/s-0038-1654999 ◽

1963 ◽

Vol 09 (02) ◽

pp. 472-474 ◽

Cited By ~ 12

Author(s):

W Dick ◽

W Schneider ◽

K Brockmüller ◽

W Mayer

Keyword(s):

Normal Distribution ◽

Blood Group ◽

Blood Groups ◽

The Other ◽

Other Hand ◽

Group Distribution

SummaryA comparison between the repartition of the blood groups in 461 patients suffering from thromboembolic disorders and the normal distribution has shown a statistically ascertained predominance of the group A1. On the other hand the blood groups 0 and A2 are distinctly less frequent than in the normal distribution.

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Ghrelin and orexin levels in infertile male: evaluation of effects on varicocele pathophysiology, relationship seminal and hormonal parameter

Turkish Journal of Biochemistry ◽

10.1515/tjb-2020-0084 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Üçler Kısa ◽

M. Murad Başar ◽

Timuçin Şipal ◽

Özlem Doğan Ceylan

Keyword(s):

The Other ◽

Control Group ◽

Infertile Male ◽

Seminal Parameters ◽

Other Hand ◽

Healthy Control ◽

Regulatory Effects ◽

Serum Ghrelin ◽

Infertile Patients ◽

Group 1

AbstractObjectiveThe aim of the present study was to investigate serum ghrelin and orexin levels in patients with varicocele and compare these levels with idiopathic infertile male and healthy control cases.MethodsThis study enrolled 24 men with varicocele, 24 males having idiopathic infertility, and 21 fertile men as the control group. Hormonal analyses, ghrelin and orexin levels were measured samples. Semen was analyzed after 3 and 5 days of sexual abstinence.ResultsSerum ghrelin levels were statistically different among the three groups (p=0.015), and it was due to a statistically lower level in group-1 than the level in the control cases (p=0.012). On the other hand, serum orexin levels were lower than healthy subjects in infertile groups with/without varicocele, but there was no difference (p=0.685) among three groups. Serum ghrelin level showed a negative and significant correlation only with sperm motility (r=−0.646, p=0.022), there was no correlation with other parameters. On the other hand, serum orexin levels did not show a significant correlation with seminal parameters.ConclusionBoth new investigated peptides ghrelin and orexin have regulatory effects on testicular function. However, ghrelin has a more obvious and complex effect on spermatogenesis. Impaired seminal parameters, especially motility was associated with increased serum ghrelin levels in infertile patients, especially with varicocele.

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Corneal Biomechanical Parameters and Central Corneal Thickness in Glaucoma Patients, Glaucoma Suspects, and a Healthy Population

Journal of Clinical Medicine ◽

10.3390/jcm10122637 ◽

2021 ◽

Vol 10 (12) ◽

pp. 2637

Author(s):

Mª. Ángeles del Buey-Sayas ◽

Elena Lanchares-Sancho ◽

Pilar Campins-Falcó ◽

María Dolores Pinazo-Durán ◽

Cristina Peris-Martínez

Keyword(s):

Central Corneal Thickness ◽

Corneal Thickness ◽

Mean Difference ◽

The Other ◽

Control Group ◽

Healthy Population ◽

Diagnostic Categories ◽

Significant Difference ◽

Biomechanical Parameters ◽

The Mean

Purpose: To evaluate and compare corneal hysteresis (CH), corneal resistance factor (CRF), and central corneal thickness (CCT), measurements were taken between a healthy population (controls), patients diagnosed with glaucoma (DG), and glaucoma suspect patients due to ocular hypertension (OHT), family history of glaucoma (FHG), or glaucoma-like optic discs (GLD). Additionally, Goldmann-correlated intraocular pressure (IOPg) and corneal-compensated IOP (IOPcc) were compared between the different groups of patients. Methods: In this prospective analytical-observational study, a total of 1065 patients (one eye of each) were recruited to undergo Ocular Response Analyzer (ORA) testing, ultrasound pachymetry, and clinical examination. Corneal biomechanical parameters (CH, CRF), CCT, IOPg, and IOPcc were measured in the control group (n = 574) and the other groups: DG (n = 147), FHG (n = 78), GLD (n = 90), and OHT (n = 176). We performed a variance analysis (ANOVA) for all the dependent variables according to the different diagnostic categories with multiple comparisons to identify the differences between the diagnostic categories, deeming p < 0.05 as statistically significant. Results: The mean CH in the DG group (9.69 mmHg) was significantly lower compared to controls (10.75 mmHg; mean difference 1.05, p < 0.001), FHG (10.70 mmHg; mean difference 1.00, p < 0.05), GLD (10.63 mmHg; mean difference 0.93, p < 0.05) and OHT (10.54 mmHg; mean difference 0.84, p < 0.05). No glaucoma suspects (FHG, GLD, OHT groups) presented significant differences between themselves and the control group (p = 1.00). No statistically significant differences were found in the mean CRF between DG (11.18 mmHg) and the control group (10.75 mmHg; mean difference 0.42, p = 0.40). The FHG and OHT groups showed significantly higher mean CRF values (12.32 and 12.41 mmHg, respectively) than the DG group (11.18 mmHg), with mean differences of 1.13 (p < 0.05) and 1.22 (p < 0.001), respectively. No statistically significant differences were found in CCT in the analysis between DG (562 μ) and the other groups (control = 556 μ, FHG = 576 μ, GLD = 569 μ, OHT = 570 μ). The means of IOPg and IOPcc values were higher in the DG patient and suspect groups than in the control group, with statistically significant differences in all groups (p < 0.001). Conclusion: This study presents corneal biomechanical values (CH, CRF), CCT, IOPg, and IOPcc for diagnosed glaucoma patients, three suspected glaucoma groups, and a healthy population, using the ORA. Mean CH values were markedly lower in the DG group (diagnosed with glaucoma damage) compared to the other groups. No significant difference was found in CCT between the DG and control groups. Unexpectedly, CRF showed higher values in all groups than in the control group, but the difference was only statistically significant in the suspect groups (FHG, GLD, and OHT), not in the DG group.

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