scholarly journals Blood Groups of Recipients of COVID-19 Convalescent plasma

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S131-S131
Author(s):  
J M Petersen ◽  
D Jhala
Keyword(s):  
Blood Group ◽  
Asian American ◽  
Medical Center ◽  
Blood Groups ◽  
Control Population ◽  
Control Group ◽  
Plasma Therapy ◽  
Unrelated Control ◽  
Significant Difference ◽  
Group B

Abstract Introduction/Objective COVID -19 Convalescent plasma therapy (CCP) is under an FDA Emergency Use Authorization to treat hospitalized patients with COVID-19. However, being ill enough to require hospitalization for COVID-19 is a negative outcome. There is also contradictory literature on whether ABO blood group is associated with worse outcomes with COVID-19 disease. Therefore, we share a regional Veterans Administration Medical Center (VAMC) experience comparing the blood groups of patients intended to receive CCP to a control group of patients positive for SARS-CoV-2. Methods/Case Report A retrospective review of all patients who had CCP ordered in the year 2020 was performed to identify the blood group of these patients, which was compared to a control population of positive patients early in the pandemic (March 17th, 2020 to May 20th, 2020). Results (if a Case Study enter NA) A total of 15 patients had CCP ordered as part of their care with an age range of 56-85 (average 69.7) years of age, entirely male composition, and a racial breakdown of 13 African Americans (86.7%), 1 Caucasian American (6.7%), and 1 Asian American (6.7%). The blood group distribution amongst these 15 patients for CCP was 1 AB+ (6.7%), 5 A+ (33.3%), 4 B+ (26.7%), and 5 O+ (33.3%). The unrelated control population consisted of 81 SARS-CoV-2 positive patients whose blood groups were distributed as 3 group AB (3.7%), 21 group A (25.9%), 15 group B (18.5%), and 42 group O (51.8%). A Chi squared test did not show a statistically significant difference between the two groups in ABO composition. Conclusion The ABO proportions of patients for whom CCP was ordered compared to the control group was not statistically significant. This provides support to the literature arguing that ABO may not be related to worse outcomes such as hospitalization or need for CCP transfusion.

scholarly journals Distribution of ABO, Rhesus D and Subgroups of ABO among Blood Donors in Sokoto, North Western Nigeria

2020 ◽  
pp. 6-13
Author(s):  
A. B. Ibrahim ◽  
H. Attahiru ◽  
O. Erhabor ◽  
P. F. Udomah ◽  
A. Yakubu ◽  
...  
Keyword(s):  
Blood Group ◽  
Blood Donors ◽  
Blood Groups ◽  
Blood Group A ◽  
Significant Difference ◽  
Tile Method ◽  
Group A ◽  
The Common ◽  
Group B ◽  
North Western

ABO, Rhesus D and subgroups of ABO are highly immunogenic and are the common cause of antibody production in mismatched blood transfusions, haemolytic transfusion reaction and maternal alloimmunization. The aim of this study was to determine the occurrence of ABO, Rh D and subgroups of ABO among blood donors attending Specialist Hospital Sokoto, Nigeria. ABO, Rhesus D and subgroups of ABO antigen status of 176 blood donors with mean age of 30.44 ± 8.210 years attending Specialist Hospital Sokoto were determined using tile method for ABO and Rh D and conventional tube method for anti- A1, anti- H reagents for ABO subgroups respectively. Among the 176 subjects tested, blood group O+ was the most frequent group with 93 (52.8%), 39 (22.2%) were blood group B+, 37(21.0%) were blood group A+, 5 (2.8%) were blood group AB+, 2 (1.1%) were blood group O-. No data was obtained for A-, B- and AB- blood groups.  Out of 37 A blood groups obtained, 31 (83.8%) had A1 antigens and 6 (16.2%) had A2 antigens. Out of the 5 AB blood groups, all had A1B antigens. The study also shows that there was statistically significant difference between blood group A and ethnic groups (Hausa, Fulani and Yoruba) (p<0.05). Blood group O was found to be the most frequent followed by B, A and AB except among Hausa which revealed a pattern of O> A> B> AB. ABO, subgroups shows majority had A1 followed by A2 and A1B respectively.

Anti-Von Willebrand Factor Antibody Is Responsible for Lower Levels of Plasma vWF in Blood Group O Individuals.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 254-254 ◽  
Author(s):  
Letian Dai ◽  
Shawn Cotton ◽  
Alistair Macartney ◽  
Geoffrey Savidge ◽  
Anwar Alhaq
Keyword(s):  
Blood Group ◽  
Blood Groups ◽  
Bleeding Tendency ◽  
Plasma Samples ◽  
Abo Blood Groups ◽  
Acquired Von Willebrand Syndrome ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Von Willebrand

Abstract Plasma levels of vWF are known to be influenced by ABO blood groups, although the mechanism remains unresolved. Group O individuals have a significantly lower level of plasma vWF than those with group A, B or AB. This relative lower level of plasma vWF may result in a bleeding tendency and a shorter half-life of infused factor VIII in group O individuals. The formation of immune complexes between vWF and autoantibodies has been shown to accelerate vWF clearance from plasma in acquired von Willebrand syndrome. However, so far no evidence has been presented that the presence of autoantibodies against vWF is involved in lowering plasma level of vWF in group O individuals. In the present study, plasma samples were obtained from 199 healthy blood donors of blood group O (50), group A (50), group B (49), and group AB (50). A time-resolved fluorescence immunoassay (TRFIA) was developed to detect anti-vWF IgG in plasma samples. Briefly, 100 μl of diluted plasma was loaded on to duplicated vWF-coated and untreated control wells of a microplate. After incubation and washing, 100 μl of Europium-labeled anti-human IgG conjugate (1:500 dilution) was added to the plate to detect vWF IgG. The time-delayed fluorescence was then measured with a Victor microplate reader (PerkinElmer, Turku, Finland). The fluorescence counts of the control wells were subtracted from those of the vWF-coated wells. The results show that anti-vWF IgG was present in all four blood groups (Table 1). Of these blood groups, group O had the highest anti-vWF IgG level with 9.8 x 105 fluorescence counts, which was 2.7- to 3.5-fold higher than that of group A, B or AB. There was a significant difference in the anti-vWF IgG levels between group O and the rest of group A, B or AB. Quantitative analysis of plasma vWF by ELISA showed that the concentration of plasma vWF of group O was 29 to 35% lower than that of group A, B or AB (Table 1). These results suggest that TRFIA is a sensitive assay for detection of anti-vWF IgG in plasma samples, and the presence of the high level of anti-vWF Ig G in group O individuals may be responsible for lowing plasma vWF by acceleration of vWF clearance. Anti-VWF IgG levels and vWF concentrations in diffeent ABO blood groups Group O (n=50) Group A (n=50) Group B (n=49) Group AB (n=50) Data are presented as a mean ± SD. *P<0.01 compared with group A, B or AB. +P<0.01 compared with group A,B or AB. Anti-vWF IgG (x 105 Fluorescence counts) 9.8 ± 6.9* 2.8 ± 2.8 3.1 ± 3.0 3.6 ± 3.5 Concentration of vWF (% of normal controls) 116 ± 42+ 165 ± 46 165 ± 42 179 ± 49

scholarly journals SARS-CoV-2 Infection Susceptibility of Pregnant Patients at Term Regarding ABO and Rh Blood Groups: A Cohort Study

Medicina ◽  
2021 ◽  
Vol 57 (5) ◽  
pp. 499
Author(s):  
Roxana Covali ◽  
Demetra Socolov ◽  
Ioana Pavaleanu ◽  
Alexandru Carauleanu ◽  
Vasile Lucian Boiculese ◽  
...  
Keyword(s):  
Blood Group ◽  
Blood Groups ◽  
The Other ◽  
Control Group ◽  
Rt Pcr ◽  
Study Materials ◽  
Significant Difference ◽  
Infection Susceptibility ◽  
Healthy Control ◽  
Rh Blood Group

Background and Objectives: The susceptibility of pregnant patients at term to SARS-CoV-2 infection regarding the ABO and Rh blood group polymorphism was analyzed in this study. Materials and Methods: In this prospective study, 457 patients admitted for delivery at term in our hospital, between 1 April 2020 and 31 December 2020 were studied. There were 46 positive and 411 SARS-CoV-2 negative patients. Their values for RT-PCR, ABO, and Rh blood group analyses, which were determined upon admittance, were studied. Results: A slightly higher percentage of infected pregnant patients at term belonged to the A blood group compared with the percentage belonging to the other blood groups; this was also true for the healthy control group. For the Rh-negative pregnant patients at term, the odds of being infected with SARS-CoV-2 was OR = 1.22 compared with Rh-positive patients where OR = 1. In our study, the highest risk was found among BIII Rh-negative pregnant patients at term (OR = 3). None of the above differences were statistically significant. Conclusions: No significant difference was found between the percentage of ABO or Rh blood groups in SARS-CoV-2 positive patients when compared with SARS-CoV-2 negative patients (p = 0.562).

scholarly journals Relationship of Blood Group Type and SARS-CoV-2 Infection: Experience in A Peripheral Military Hospital

2021 ◽  
Vol 39 (2) ◽  
pp. 94-99
Author(s):  
Md Soleman Badsha ◽  
Md Mizanur Rahman Khan ◽  
SM Belal Uddin ◽  
Kamrun Nesa
Keyword(s):  
Blood Group ◽  
Statistical Significance ◽  
Blood Groups ◽  
Military Hospital ◽  
Control Group ◽  
P Value ◽  
Percentage Distribution ◽  
Blood Group A ◽  
Significant Difference ◽  
Group A

Introduction: Clinical studies have shown that advanced age and chronic diseases increase the risk of infection. Different studies have found blood groups are also a determining factor of severity. However, in Bangladesh it is yet to have any clinical pattern in this respect. The aim of this study is to find out whether there exists a relationship between the blood groups of the patients and risk of SARS-CoV-2 infection. Methods: The study is a retrospective cohort study. It included all hospitalized RT-PCR confirmed COVID-19 patients in Combined Military Hospital (CMH) Barishal. We included both genders and people who are older than 14 years of age. The study was conducted during the period between 4th June and 3rd August, 2020. In this period total 556 individuals reported and tested for SARS-CoV-2 where COVID +ve patients are served as patient group and COVID –ve patients are served as the controls. Results: Our sample consists of 185 patients; we found a percentage distribution of 34.6%, 39.5%, 5.4%, and 20.54% for blood groups A, B, AB and O, respectively. Blood group A was statistically significantly more frequent among those infected with COVID-19 compared to controls (34.6% vs. 21.83%, p-value 0.045 (<0.05); OR: 1.894).On the other hand, the frequency of blood group O was significantly lower in the COVID-19 patients, compared to the control group (20.54% vs 32.88%, p-value0.049 (<0.05); OR: 0.528). Although there was a higher percentage distribution of the B blood group among COVID-19 patients as compared to the control groups, this difference did not reach statistical significance. Also, there was no significant difference in the risk of COVID-19 in blood group AB with a distribution of 6.2% in control group, and5.4% in COVID-19 patients. Conclusion: The results of the present study suggest that the blood group A might have a role in increased susceptibility to the COVID-19 infection and the blood group O might be somewhat protective. J Bangladesh Coll Phys Surg 2021; 39(2): 94-99

scholarly journals Association between blood group and susceptibility to malaria and its effects on platelets, TLC, and Hb

2016 ◽  
Vol 10 (10) ◽  
pp. 1124-1128
Author(s):  
Hira Burhan ◽  
Askari Syed Hasan ◽  
Syed Mansur-ul-Haque ◽  
Ghazanfar Zaidi ◽  
Taha Shaikh ◽  
...  
Keyword(s):  
Blood Group ◽  
Blood Groups ◽  
World Health ◽  
Total Leukocyte Count ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Health Organization ◽  
And Control ◽  
Control Study

Introduction: According to the World Health Organization, the estimated number of malaria cases in Pakistan is about 1.5 million. Hematological variables like platelets, total leukocyte count (TLC), and hemoglobin (Hb) need to be evaluated to diagnose malaria in suspects. This study aimed to investigate the association between blood group and susceptibility to malaria and effects on platelets, TLC, and Hb. Methodology: This was a case-control study with a sample size of 446, of which 224 were malarial cases and 222 were controls. A designated questionnaire was developed to know age, gender, malarial strain, Hb, TLC, platelets, and blood group. Results: Of 224 malarial cases, 213 were P. vivax, and 11 were P. falciparum. There were 58 patients with blood group A, 72 with group B, 69 were O and 23 were AB. There was no significant difference in the blood group of controls compared to malarial patients (p > 0.05). Mean Hb level was 11.5mg/dL in malaria patients and 12.5mg/dL in controls. There was significant difference (p<0.01) in the mean platelet count in malarial (11,7000/μL) and control (24,5000/μL) patients. All blood groups showed similar falls in Hb and platelet levels, showing no significant difference among blood groups (p = 0.79 and p = 0.52, respectively). TLC was not significant between malarial and control groups (p = 0.072). Males were two times susceptible to malaria. Conclusions: There was no significant association between the type of blood group and susceptibility to malaria or developing anemia or thrombocytopenia.

scholarly journals Haemorrhagic stroke in Saudi adult male population and the ABO blood group distribution: a comparative analysis

2020 ◽  
Vol 7 (4) ◽  
pp. 1287
Author(s):  
Mohammad P. Farshori ◽  
Yasir G. Alrashdan ◽  
Mohammed S. Alshammari
Keyword(s):  
Blood Group ◽  
Adult Male ◽  
Diabetes Type 2 ◽  
Fold Increase ◽  
Haemorrhagic Stroke ◽  
Blood Groups ◽  
Control Group ◽  
Stroke Patients ◽  
Male Population ◽  
Group B

Background: Globally stroke is leading cause of death and disability. According to WHO every year 15 million people get stroke and one third of these subjects die and about 5 million become permanently disabled. In SA smoking, diabetes, and hypertension are highly prevalent and since these factors are among ten major risk factors for stroke it puts Saudi population at higher risk of stroke. In current study we studied prevalence of hemorrhagic (HS) stroke and analyzed if there is any correlation between incidences of HS and ABO blood groups in Saudi population.Methods: Blood groups and other relevant data were collected for 2304 stroke patients registered at King Khaled hospital between 1/1/2008 to 1/6/2018. Statistical analysis was performed using Z calculator.Results: We saw 5.4-fold increase in prevalence of diabetes type 2 and 8.7 fold increase in prevalence of hypertension among HS patients as compared to control subjects. Prevalence of smoking was higher in both control and HS patients. 21.7% of stroke patients were HS patients. Distribution of A blood group was significantly higher in male HS patients. AB blood group showed statistically significant reduction in HS patients as compared to control group. Results were statistically significant at (p˂0.01). However, blood group B and O showed no significant differences between two groups.Conclusions: Results of our studies show a correlation between ABO and the incidences of hemorrhagic stroke in Saudi adult male population. Larger studies are needed to confirm these results.

scholarly journals Is There a Relation between ABO Blood Groups and Clinical Outcome in Patients with Pemphigoid? A Case-Control Study

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Sedigheh Bakhtiari ◽  
Parviz Toosi ◽  
Somayyeh Azimi ◽  
Nafiseh Esmaili ◽  
Ali Montazami ◽  
...  
Keyword(s):  
Blood Group ◽  
Case Control Study ◽  
Case Control ◽  
Blood Groups ◽  
Control Group ◽  
Abo Blood Groups ◽  
Chi Square ◽  
Chi Square Test ◽  
Group B ◽  
Control Study

Background.Relationship between blood groups and dermatologic diseases remains controversial and was not yet fully elucidated nor explained clearly. The aim of this study was to examine if any relation exists between different types of pemphigoid diseases and ABO blood group.Methods.In this case-control study, 159 pemphigoid patients and 152 healthy matched-controls were evaluated. All blood group (including Rh status) data for the study was obtained from the hospital medical records. Statistical comparisons were completed with chi-square test and logistic regression.Results.Blood group “O” was found in 32.9% of patients and 38.2% of control group. Blood group “A” was found among 30.8% of patients and 34.2% of control group, while group “B” was reported in 27.4% of cases and 21.1% of controls and “AB” was identified among 8.9% of patients and 6.6% of control group. 84.9% of patients were Rh positive, while in the control group 86.2% of patients were Rh positive. No significant differences were found regarding ABO blood groups (P=0.46) or Rh (P=0.76) between pemphigoid patients and control group. Also, older females had the higher risk of developing bullous pemphigoid.Conclusion.We found no relationship between ABO blood groups and pemphigoid disease.

scholarly journals Association of ABO and Rh blood group systems with blood pressure in a population sample from Peshawar, NWFP, Pakistan

2016 ◽  
Vol 12 (1) ◽  
Author(s):  
Shamim Alam ◽  
Salma Alam ◽  
Rashid Mahmood ◽  
Ihteshamul Haq ◽  
Saima Alam
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Blood Group ◽  
Population Sample ◽  
Age Groups ◽  
Blood Groups ◽  
Normal Limits ◽  
Significant Difference ◽  
Group A ◽  
Group B

Background: Abundant literature is available on the association of blood groups to various diseases. It was thus hypothesized that similar linkage may also exist between blood groups and Hypertension, which prompted me to work on this project. Material and Methods: This study was carried out from June 2001 to September 2003 on 1304 subjects out of which 756 were male and 548 were females. Age ranged from 18-65 years. The blood groups and blood pressure were determined in PMRC Research Center KMC Peshawar, by using standard methods. Results: Out of 1304 subjects distribution of blood groups was such that blood group B (30.1%)> O (29.7%) >A (28.5%)>AB (10.1%). No significant difference in systolic and diastolic blood pressure was found among the all groups. However significant differences existed between the two sexes within blood group B & O for systolic BP and A & O groups for diastolic BP. Significant differences in systolic BP were found between A+ve and O+ve phenotypes only. A-ve males had lower systol ic BP than O-ve males. Substantially more conspicuous Rh factor associated differences became evident among the ABO phenotypes. Nearly similar trends were evident for systolic and diastolic blood pressure as age of both genders of the A, B and AB phenotypes advanced. Statistically significant (P<0.05) increase above the age of 16-20 years group was noticed at least as far as the 41-50 years age groups. Especially highly significant increase in systolic and diastolic Blood pressure in Group A (both males and females) and in Group B and AB (females only) was noticed. Conclusion: It is advisable that the males having blood group O-ve and females having AB-ve should be aware of their blood pressure and maintain it with in the normal limits especially by changing their lifestyle

scholarly journals ASSOCIATION OF BLOOD GROUPS OF THE AB0 SYSTEM WITH HEPATITIS C VIRUS INFECTION

2020 ◽  
Vol 8 (2) ◽  
pp. 153-160
Author(s):  
D. А. Krotyuk ◽  
N. P. Luhovykh ◽  
S. V. Bilokon ◽  
S. L. Miros ◽  
A. L. Sechnyak
Keyword(s):  
Hepatitis C ◽  
Blood Group ◽  
Positive Association ◽  
Risk Groups ◽  
Blood Groups ◽  
Control Group ◽  
Hepatitis C Infection ◽  
Serological Studies ◽  
Different Populations ◽  
Group B

Hepatitis C is a viral liver disease caused by HCV. Worldwide, 71 million people suffer from chronic hepatitis C infection. There is a discussion in the literature sources about the association of blood groups of the AB0 system with viral hepatitis; however, the data obtained in different populations of high rank is controversial. The aim of the study was to investigate possible associations of blood groups of the AB0 system with hepatitis C in the Odessa region. The case-control study was conducted in 2017–2019 at the blood transfusion station of SE «Odessa Railway». The control group consisted of 18 963 healthy individuals, the experimental group consisted of 520 people from the donors examined, in which blood antibodies to HCV were detected. Determination of blood groups was performed according to the standard method, serological studies – ELISA on ELISA analyzer III. The analysis using the χ2 criterion showed that the frequencies of blood groups in the control and experimental groups differed significantly (p ≤ 0.005). To determine the effects of each blood group, relative risk frequencies for each blood group were calculated. People with the AB blood group had the lowest risk of infection (OR = 0.60), with a slightly weaker negative association observed among people with blood group 0 (OR = 0.86). Individuals with blood groups A and B had a positive association; the rate of infection of persons with blood group B was the highest (OR = 1.23). The findings complement a diverse picture of such associations in different populations. The variation in associations in different populations may be due to both statistical causes and genetic diversity of human and HCV populations, as well as the interaction between human immunity-related genetic systems. The existence of associations between the AB0 system and susceptibility/immunity to hepatitis C may be an additional indicator of the assessment of risk groups, which is functional for certain populations in certain sanitary and epidemiological conditions.

Comparative Study to Evaluate the Surface Detail Reproduction of Dental Stone after Immersion in Various Different Disinfectant Solutions, Under Stereomicroscope 10 X Magnification –An In-Vitro Study

2017 ◽  
Vol 9 (3) ◽  
Author(s):  
Rathika Rai ◽  
M. A. Easwaran ◽  
K. T. Dhivya
Keyword(s):  
Sodium Hypochlorite ◽  
In Vitro Study ◽  
Control Group ◽  
Immersion Method ◽  
Significant Difference ◽  
Surface Irregularities ◽  
Disinfectant Solution ◽  
Surface Detail ◽  
Group B

Aim: To evaluate the surface detail reproduction of dental stone this is immersed in different disinfectant solution and studied under stereomicroscope. Methodology: Total number of 30 specimens of dental stone (Type III) were made with measurements of 1.5cm diameter and 1cm height .This samples are divided in to 3 groups group A,B,C. were A is immersed in Distilled water which was taken as control group ;B is immersed in 2% Glutaraldehyde and C is immersed in 5%sodium hypochlorite. Each specimen were immersed in the disinfectant solution for 15 minutes and dried under room temperature for 24 hrs. After 24 hrs each specimens are studied under stereomicroscope for surface details. Result: The results showed no significant difference in the surface irregularities and porosities for a group 1 and group 2 except group 3 which showed significant increase in the porosities, surface irregularities and erosions after disinfection with 5% NaHOCl by immersion method. Conclusion: The surface detail reproduction capacity of die stone was adversely affected when 5% Sodium hypochlorite was used as disinfectant solution when compare d to control group and 2% Glutaraldehyde

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