scholarly journals Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review

Micromachines ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 768
Author(s):  
Roozbeh Abedini-Nassab ◽  
Mahrad Pouryosef Miandoab ◽  
Merivan Şaşmaz
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetic Particles ◽  
Magnetic Measurement ◽  
Cross Flow ◽  
Lab On A Chip ◽  
Magnetic Thin Films ◽  
Portable Devices ◽  
Microfluidic Chips ◽  
Essential Information ◽  
Wide Range

Magnetic nanoparticles have attracted significant attention in various disciplines, including engineering and medicine. Microfluidic chips and lab-on-a-chip devices, with precise control over small volumes of fluids and tiny particles, are appropriate tools for the synthesis, manipulation, and evaluation of nanoparticles. Moreover, the controllability and automation offered by the microfluidic chips in combination with the unique capabilities of the magnetic nanoparticles and their ability to be remotely controlled and detected, have recently provided tremendous advances in biotechnology. In particular, microfluidic chips with magnetic nanoparticles serve as sensitive, high throughput, and portable devices for contactless detecting and manipulating DNAs, RNAs, living cells, and viruses. In this work, we review recent fundamental advances in the field with a focus on biomedical applications. First, we study novel microfluidic-based methods in synthesizing magnetic nanoparticles as well as microparticles encapsulating them. We review both continues-flow and droplet-based microreactors, including the ones based on the cross-flow, co-flow, and flow-focusing methods. Then, we investigate the microfluidic-based methods for manipulating tiny magnetic particles. These manipulation techniques include the ones based on external magnets, embedded micro-coils, and magnetic thin films. Finally, we review techniques invented for the detection and magnetic measurement of magnetic nanoparticles and magnetically labeled bioparticles. We include the advances in anisotropic magnetoresistive, giant magnetoresistive, tunneling magnetoresistive, and magnetorelaxometry sensors. Overall, this review covers a wide range of the field uniquely and provides essential information for designing “lab-on-a-chip” systems for synthesizing magnetic nanoparticles, labeling bioparticles with them, and sorting and detecting them on a single chip.

scholarly journals Structure and rheology of soft hybrid systems of magnetic nanoparticles in liquid-crystalline matrices: results from particle-resolved computer simulations

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Nima H. Siboni ◽  
Gaurav P. Shrivastav ◽  
Stavros D. Peroukidis ◽  
Sabine H. L. Klapp
Keyword(s):  
Magnetic Nanoparticles ◽  
Liquid Crystalline ◽  
Magnetic Particles ◽  
Cluster Formation ◽  
Soft Materials ◽  
Equilibrium Dynamics ◽  
Planar Shear ◽  
Highly Nonlinear ◽  
Wide Range ◽  
The Impact

Abstract Hybrid mixtures composed of magnetic nanoparticles (MNP) in liquid crystalline (LC) matrices are a fascinating class of soft materials with intriguing physical properties and a wide range of potential applications, e.g., as stimuli-responsive and adaptive materials. Already in the absence of an external stimulus, these systems can display various types of orientationally disordered and ordered phases, which are enriched by self-assembled structures formed by the MNPs. In the presence of external fields, one typically observes highly nonlinear macroscopic behavior. However, an understanding of the structure and dynamics of such systems on the particle level has, so far, remained elusive. In the present paper we review recent computer simulation studies targeting the structure, equilibrium dynamics and rheology of LC-MNP systems, in which the particle sizes of the two components are comparable. As a numerically tractable model system we consider mixtures of soft spherical or elongated particles with a permanent magnetic dipole moment and ellipsoidal non-magnetic particles interacting via a Gay-Berne potential. We address, first, equilibrium aspects such as structural organization and self-assembly (cluster formation) of the MNPs in dependence of the orientational state of the matrix, the role of the size ratio, the impact of an external magnetic field, and the translational and orientational diffusion of the two components. Second, we discuss the non-equilibrium dynamics of LC-MNP mixtures under planar shear flow, considering both, spherical and non-spherical MNPs. Our results contribute to a detailed understanding of these intriguing hybrid materials, and they may serve as a guide for future experiments.

scholarly journals Recent trends in smartphone-based detection for biomedical applications: a review

2021 ◽  
Vol 413 (9) ◽  
pp. 2389-2406 ◽  
Author(s):  
Soumyabrata Banik ◽  
Sindhoora Kaniyala Melanthota ◽  
Arbaaz ◽  
Joel Markus Vaz ◽  
Vishak Madhwaraj Kadambalithaya ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Histopathological Examination ◽  
Dark Field ◽  
Portable Devices ◽  
Food Technology ◽  
Wide Range ◽  
Technological Interventions ◽  
Recent Trends ◽  
Increasing Demand

AbstractSmartphone-based imaging devices (SIDs) have shown to be versatile and have a wide range of biomedical applications. With the increasing demand for high-quality medical services, technological interventions such as portable devices that can be used in remote and resource-less conditions and have an impact on quantity and quality of care. Additionally, smartphone-based devices have shown their application in the field of teleimaging, food technology, education, etc. Depending on the application and imaging capability required, the optical arrangement of the SID varies which enables them to be used in multiple setups like bright-field, fluorescence, dark-field, and multiple arrays with certain changes in their optics and illumination. This comprehensive review discusses the numerous applications and development of SIDs towards histopathological examination, detection of bacteria and viruses, food technology, and routine diagnosis. Smartphone-based devices are complemented with deep learning methods to further increase the efficiency of the devices.

A Novel Magnetophoretic-Based Device for Magnetometry and Separation of Single Magnetic Particles and Magnetized Cells

Lab on a Chip ◽  
2022 ◽  
Author(s):  
Roozbeh Abedini-Nassab ◽  
Xianting Ding ◽  
Haiyang Xie
Keyword(s):  
Magnetic Particles ◽  
Lab On A Chip ◽  
Magnetic Microparticles

The use of magnetic micro- and nanoparticles in medicine and biology is expanding. One important example is the transport of magnetic microparticles and magnetized cells in lab-on-a-chip systems. The magnetic...

scholarly journals Sound propagation in a lined nozzle with shear and bias flows

2018 ◽  
Vol 18 (1) ◽  
pp. 3-48
Author(s):  
LMBC Campos ◽  
C Legendre
Keyword(s):  
Boundary Layer ◽  
Mach Number ◽  
Boundary Layers ◽  
Lower Boundary ◽  
Cross Flow ◽  
Core Flow ◽  
The Core ◽  
Wide Range ◽  
Bias Flow ◽  
Number Formula

In this study, the propagation of waves in a two-dimensional parallel-sided nozzle is considered allowing for the combination of: (a) distinct impedances of the upper and lower walls; (b) upper and lower boundary layers with different thicknesses with linear shear velocity profiles matched to a uniform core flow; and (c) a uniform cross-flow as a bias flow out of one and into the other porous acoustic liner. The model involves an “acoustic triple deck” consisting of third-order non-sinusoidal non-plane acoustic-shear waves in the upper and lower boundary layers coupled to convected plane sinusoidal acoustic waves in the uniform core flow. The acoustic modes are determined from a dispersion relation corresponding to the vanishing of an 8 × 8 matrix determinant, and the waveforms are combinations of two acoustic and two sets of three acoustic-shear waves. The eigenvalues are calculated and the waveforms are plotted for a wide range of values of the four parameters of the problem, namely: (i/ii) the core and bias flow Mach numbers; (iii) the impedances at the two walls; and (iv) the thicknesses of the two boundary layers relative to each other and the core flow. It is shown that all three main physical phenomena considered in this model can have a significant effect on the wave field: (c) a bias or cross-flow even with small Mach number [Formula: see text] relative to the mean flow Mach number [Formula: see text] can modify the waveforms; (b) the possibly dissimilar impedances of the lined walls can absorb (or amplify) waves more or less depending on the reactance and inductance; (a) the exchange of the wave energy with the shear flow is also important, since for the same stream velocity, a thin boundary layer has higher vorticity, and lower vorticity corresponds to a thicker boundary layer. The combination of all these three effects (a–c) leads to a large set of different waveforms in the duct that are plotted for a wide range of the parameters (i–iv) of the problem.

Electrokinetic Focusing and Dispensing of Particles and Cells on Microfluidic Chips

2005 ◽  
Author(s):  
Xiangchun Xuan ◽  
Edmond W. K. Young ◽  
Dongqing Li
Keyword(s):  
Red Blood Cells ◽  
Analytical Model ◽  
Blood Cells ◽  
Lab On A Chip ◽  
Microfluidic Chips ◽  
Whole Process ◽  
Sample Stream ◽  
Custom Made ◽  
Electrical Pulses

This work investigated the electrokinetic focusing and dispensing of polystyrene particles and red blood cells on microfluidic chips. Particles or cells were first electrokinetically focused using the merging of focusing streams on the sample stream, and subsequently separated as a result of the focusing. These particles or cells were then selectively dispensed from the focused sample stream using precise application of electrical pulses. The whole process of focusing, separation and dispensing of particles was visualized by a custom-made microscopy system. In particular, the width of the focused fluorescein stream and the accelerated electrophoretic motion of particles and cells were measured in a cross-channel and compared with a proposed analytical model. The electrokinetic manipulation of particles and cells demonstrated in this work can be used for developing integrated lab-on-a-chip devices for studies of cells.

Manipulation of Clinical Materials Using AC Electrokinetics

2010 ◽  
Author(s):  
Mandy L. Y. Sin ◽  
Pak Kin Wong
Keyword(s):  
Experimental Data ◽  
Sample Preparation ◽  
Theoretical Prediction ◽  
Fluid Motion ◽  
Lab On A Chip ◽  
Clinical Samples ◽  
Electrochemical Reactions ◽  
Ac Electrokinetics ◽  
Wide Range ◽  
Electrothermal Flow

AC electrokinetics is a promising approach for sample preparation and reaction enhancement in lab-on-a-chip devices. However, relative little has been done on the electrokinetic manipulation of physiological fluids and buffers with similar properties, such as conductivity. Herein, electrokinetic manipulation of fluids with a wide range of conductivities has been studied as a function of voltage and frequency. AC electrothermal flow is determined to dominate the fluid motion when the applied frequency of the AC potential is above 100 kHz. Interestingly, experimental data deviate from theoretical prediction for fluids with high conductivities (> 1 Sm−1). The deviation can be understood by voltage modulated electrochemical reactions and should be accounted for when manipulating clinical materials with high conductivities. The study will provide useful in sights in designing lab-on-a-chip devices for manipulating clinical samples in the future.

Vibration Excitation Forces in a Normal Triangular Tube Bundle Subjected to Two-Phase Cross Flow

2011 ◽  
Author(s):  
E. S. Perrot ◽  
N. W. Mureithi ◽  
M. J. Pettigrew ◽  
G. Ricciardi
Keyword(s):  
Tube Bundle ◽  
Cross Flow ◽  
Random Excitation ◽  
Two Phase ◽  
Constant Frequency ◽  
Fluid Forces ◽  
Drag Forces ◽  
Wide Range ◽  
Drag And Lift ◽  
Lift And Drag

This paper presents test results of vibration forces in a normal triangular tube bundle subjected to air-water cross-flow. The dynamic lift and drag forces were measured with strain gage instrumented cylinders. The array has a pitch-to-diameter ratio of 1.5, and the tube diameter is 38 mm. A wide range of void fraction and fluid velocities were tested. The experiments revealed significant forces in both the drag and lift directions. Constant frequency and quasi-periodic fluid forces were found in addition to random excitation. These forces were analyzed and characterized to understand their origins. The forces were found to be dependent on the position of the cylinder within the bundle. The results are compared with those obtained with flexible cylinders in the same tube bundle and to those for a rotated triangular tube bundle. These comparisons reveal the influence of quasi-periodic forces on tube motions.

scholarly journals Masking Orchestration: Multi-Task Pretraining for Multi-Role Dialogue Representation Learning

2020 ◽  
Vol 34 (05) ◽  
pp. 9217-9224
Author(s):  
Tianyi Wang ◽  
Yating Zhang ◽  
Xiaozhong Liu ◽  
Changlong Sun ◽  
Qiong Zhang
Keyword(s):  
Knowledge Integration ◽  
Question Answering ◽  
Representation Learning ◽  
Essential Information ◽  
External Knowledge ◽  
Learning Tasks ◽  
Wide Range ◽  
Specific Learning

Multi-role dialogue understanding comprises a wide range of diverse tasks such as question answering, act classification, dialogue summarization etc. While dialogue corpora are abundantly available, labeled data, for specific learning tasks, can be highly scarce and expensive. In this work, we investigate dialogue context representation learning with various types unsupervised pretraining tasks where the training objectives are given naturally according to the nature of the utterance and the structure of the multi-role conversation. Meanwhile, in order to locate essential information for dialogue summarization/extraction, the pretraining process enables external knowledge integration. The proposed fine-tuned pretraining mechanism is comprehensively evaluated via three different dialogue datasets along with a number of downstream dialogue-mining tasks. Result shows that the proposed pretraining mechanism significantly contributes to all the downstream tasks without discrimination to different encoders.

scholarly journals Transcriptome-wide Identification and Characterization of microRNAs and Their Targets in a Highly Adaptable Conifer Platycladus orientalis

2022 ◽  
Vol 147 (1) ◽  
pp. 7-17
Author(s):  
Ying Yang ◽  
Xian-Ge Hu ◽  
Bingsong Zheng ◽  
Yue Li ◽  
Tongli Wang ◽  
...  
Keyword(s):  
Stress Tolerance ◽  
Leucine Zipper ◽  
Class Iii ◽  
Conifer Species ◽  
Essential Information ◽  
Sequencing Platform ◽  
Platycladus Orientalis ◽  
Wide Range ◽  
Identification And Characterization

MicroRNAs (miRNAs) are short noncoding RNAs (20–25 nucleotides) that regulate gene expression posttranscriptionally. However, identification and characterization of miRNAs remain limited for conifer species. In this study, we applied transcriptome-wide miRNAs sequencing to a conifer species Platycladus orientalis, which is highly adaptable to a wide range of environmental adversities, including drought, barren soil, and mild salinity. A total of 17,181,542 raw reads were obtained from the Illumina sequencing platform; 31 conserved and 91 novel miRNAs were identified, and their unique characteristics were further analyzed. Ten randomly selected miRNAs were validated by quantificational real-time polymerase chain reaction. Through miRNA target predictions based on psRNATarget, 2331 unique mRNAs were predicted to be targets of P. orientalis miRNAs that involved in 187 metabolic pathways in KEGG database. These targets included not only important transcription factors (e.g., class III homeodomain leucine zipper targeted by por-miR166d) but also indispensable nontranscriptional factor proteins (i.e., por-miR482a-3p regulated nucleotide-binding site leucine-rich repeat protein). Interestingly, six miRNAs (por-miR16, -miR44, -miR60-5p, -miR69–3p, -miR166b-5p, and -miR395c) were found in adaptation-related pathways (e.g., drought), indicating their possible involved in this species’ stress-tolerance characteristics. The present study provided essential information for understanding the regulatory role of miRNAs in P. orientalis and sheds light on their possible use in tree improvement for stress tolerance.

Drag Coefficient and Two-Phase Friction Multiplier on Tube Bundles Subjected to Two-Phase Cross-Flow

2012 ◽  
Vol 135 (1) ◽  
Author(s):  
W. G. Sim ◽  
Njuki W. Mureithi
Keyword(s):  
Drag Coefficient ◽  
Void Fraction ◽  
Euler Number ◽  
Tube Bundle ◽  
Cross Flow ◽  
Water Mixture ◽  
Duct Flow ◽  
Two Phase ◽  
Mass Fluxes ◽  
Wide Range

An approximate analytical model, to predict the drag coefficient on a cylinder and the two-phase Euler number for upward two-phase cross-flow through horizontal bundles, has been developed. To verify the model, two sets of experiments were performed with an air–water mixture for a range of pitch mass fluxes and void fractions. The experiments were undertaken using a rotated triangular (RT) array of cylinders having a pitch-to-diameter ratio of 1.5 and cylinder diameter 38 mm. The void fraction model proposed by Feenstra et al. was used to estimate the void fraction of the flow within the tube bundle. An important variable for drag coefficient estimation is the two-phase friction multiplier. A new drag coefficient model has been developed, based on the single-phase flow Euler number formulation proposed by Zukauskas et al. and the two-phase friction multiplier in duct flow formulated by various researchers. The present model is developed considering the Euler number formulation by Zukauskas et al. as well as existing two-phase friction multiplier models. It is found that Marchaterre's model for two-phase friction multiplier is applicable to air–water mixtures. The analytical results agree reasonably well with experimental drag coefficients and Euler numbers in air–water mixtures for a sufficiently wide range of pitch mass fluxes and qualities. This model will allow researchers to provide analytical estimates of the drag coefficient, which is related to two-phase damping.

Sign in / Sign up

Export Citation Format

Share Document