scholarly journals Chronic Intestinal Pseudo-Obstruction: Is There a Connection with Gut Microbiota?

2021 ◽  
Vol 9 (12) ◽  
pp. 2549
Author(s):  
Giulia Radocchia ◽  
Bruna Neroni ◽  
Massimiliano Marazzato ◽  
Elena Capuzzo ◽  
Simone Zuccari ◽  
...  
Keyword(s):  
Nervous System ◽  
Treatment Strategies ◽  
Endocrine System ◽  
Clinical Syndrome ◽  
Intestinal Lumen ◽  
Significant Challenge ◽  
Severe Impairment ◽  
Intestinal Pseudo Obstruction ◽  
The Relationship

Chronic intestinal pseudo-obstruction (CIPO) is a rare clinical syndrome characterized by severe impairment of gastrointestinal (GI) motility, and its symptoms are suggestive of partial or complete intestinal obstruction in the absence of any lesion restricting the intestinal lumen. Diagnosis and therapy of CIPO patients still represent a significant challenge for clinicians, despite their efforts to improve diagnostic workup and treatment strategies for this disease. The purpose of this review is to better understand what is currently known about the relationship between CIPO patients and intestinal microbiota, with a focus on the role of the enteric nervous system (ENS) and the intestinal endocrine system (IES) in intestinal motility, underling the importance of further studies to deeply understand the causes of gut motility dysfunction in these patients.

Behavioral Endocrinology: Integrating Mind and Body

2020 ◽  
Vol 4 (2) ◽  
pp. 97-110
Author(s):  
Peter T. Ellison
Keyword(s):  
Nervous System ◽  
Steroid Hormones ◽  
Behavioral Ecology ◽  
Endocrine System ◽  
Behavioral Endocrinology ◽  
Paternal Behavior ◽  
Mind And Body ◽  
The Central Nervous System ◽  
Primary Focus

Abstract The nervous system and the endocrine system interact to integrate behavior and physiology. Hormones play an important role in this interaction, particularly steroid hormones. Other molecules, notably oxytocin, can serve both as hormones in the soma and neuromodulators in the central nervous system. Understanding the influence of the endocrine system on human behavior, both individual and social, has been a primary focus of behavioral endocrinology for many decades, though technical and methodological challenges have been formidable. The recent enthusiasm for enzyme-linked immunoassay kits for measuring steroid hormones in saliva has been found to be largely unsound, for example. Despite these difficulties, advances in many areas have been made and new areas, such as the endocrinology of paternal behavior and the role of oxytocin in social interactions, have emerged. Reproductive ecology provides a theoretical framework for integrating the diverse content of human behavioral ecology.

Regulation of TRPV5 and TRPV6 by associated proteins

2006 ◽  
Vol 290 (6) ◽  
pp. F1295-F1302 ◽  
Author(s):  
Stan F. J. van de Graaf ◽  
Joost G. J. Hoenderop ◽  
René J. M. Bindels
Keyword(s):  
Molecular Mechanisms ◽  
Hormonal Control ◽  
Trp Channel ◽  
Intestinal Lumen ◽  
Blood Compartment ◽  
Associated Proteins ◽  
The Relationship ◽  
Insight Into ◽  
Prime Target

The epithelial Ca2+ channels TRPV5 and TRPV6 are the most Ca2+-selective members of the TRP channel superfamily. These channels are the prime target for hormonal control of the active Ca2+ flux from the urine space or intestinal lumen to the blood compartment. Insight into their regulation is, therefore, pivotal in our understanding of the (patho)physiology of Ca2+ homeostasis. The recent elucidation of TRPV5/6-associated proteins has provided new insight into the molecular mechanisms underlying the regulation of these channels. In this review, we describe the various means of TRPV5/6 regulation, the role of channel-associated proteins herein, and the relationship between both processes.

scholarly journals The Osteoporosis/Microbiota Linkage: The Role of miRNA

2020 ◽  
Vol 21 (23) ◽  
pp. 8887 ◽  
Author(s):  
Massimo De Martinis ◽  
Lia Ginaldi ◽  
Alessandro Allegra ◽  
Maria Maddalena Sirufo ◽  
Giovanni Pioggia ◽  
...  
Keyword(s):  
Dynamic Equilibrium ◽  
Treatment Strategies ◽  
Therapeutic Agents ◽  
Osteoporosis Prevention ◽  
Regulate Gene Expression ◽  
Molecular Biotechnology ◽  
Non Coding Rnas ◽  
The Relationship ◽  
Complementary Mechanism

Hundreds of trillions of bacteria are present in the human body in a mutually beneficial symbiotic relationship with the host. A stable dynamic equilibrium exists in healthy individuals between the microbiota, host organism, and environment. Imbalances of the intestinal microbiota contribute to the determinism of various diseases. Recent research suggests that the microbiota is also involved in the regulation of the bone metabolism, and its alteration may induce osteoporosis. Due to modern molecular biotechnology, various mechanisms regulating the relationship between bone and microbiota are emerging. Understanding the role of microbiota imbalances in the development of osteoporosis is essential for the development of potential osteoporosis prevention and treatment strategies through microbiota targeting. A relevant complementary mechanism could be also constituted by the permanent relationships occurring between microbiota and microRNAs (miRNAs). miRNAs are a set of small non-coding RNAs able to regulate gene expression. In this review, we recapitulate the physiological and pathological meanings of the microbiota on osteoporosis onset by governing miRNA production. An improved comprehension of the relations between microbiota and miRNAs could furnish novel markers for the identification and monitoring of osteoporosis, and this appears to be an encouraging method for antagomir-guided tactics as therapeutic agents.

scholarly journals The role of probiotics on the roadmap to a healthy microbiota: a symposium report

2020 ◽  
Vol 1 ◽  
Author(s):  
Stacey Lockyer ◽  
Marisol Aguirre ◽  
Louise Durrant ◽  
Bruno Pot ◽  
Kaori Suzuki
Keyword(s):  
Gut Microbiota ◽  
Endocrine System ◽  
Immune Functions ◽  
Epigenetic Programming ◽  
Microbiome Research ◽  
Probiotic Mechanisms ◽  
The Relationship ◽  
Host Genes

ABSTRACT The ninth International Yakult Symposium was held in Ghent, Belgium in April 2018. Keynote lectures were from Professor Wijmenga on using biobanks to understand the relationship between the gut microbiota and health; and Professor Hill on phage–probiotic interactions. Session one included talks from Professor Plӧsch on epigenetic programming by nutritional and environmental factors; Professor Wilmes on the use of “omics” methodologies in microbiome research and Professor Rescigno on the gut vascular barrier. Session two explored the evidence behind Lactobacillus casei Shirota with Dr Nanno explaining the plasticity in immunomodulation that enables the strain to balance immune functions; Dr Macnaughtan outlining its potential therapeutic use in cirrhosis and Professor Nishida detailing effects in subjects under stress. The third session saw Professor Marchesi describing that both the host genes and the gut microbiota can play a role in cancer; Professor Bergheim highlighting crosstalk between the gut and the liver and Professor Cani describing the relationship between the gut microbiota and the endocrine system. The final session explored probiotic mechanisms, with Professor Lebeer dissecting the challenges in conducting mechanistic studies; Professor Wehkamp describing the mucosal defence system and Professor Van de Wiele detailing methods for modelling the gut microbiota in vitro.

Does peer tutoring in kindergarten exist? Thinking around the tutoring concept.

2019 ◽  
Vol X (4 (29)) ◽  
pp. 63-84
Author(s):  
Aneta Babiuk-Massalska
Keyword(s):  
Nervous System ◽  
Preschool Child ◽  
Social Experiences ◽  
The Other ◽  
Older Children ◽  
Student Relationship ◽  
Definition Of ◽  
The Relationship

The article reviews the definitions of the tutoring concept in preschoolers relationships. Can we qualify the relationships of preschool children in learning situations as tutoring? Or maybe a different name would be more suitable for them? Preschoolers are used to learning in a different way than adults and older children. They prefer learning mimicking or playing. They obtain knowldge occasionally an unintentionally. In turn, definitions of tutoring quite precisely contain formulated fortifications that a little child is not able to meet yet. Immaturity of the nervous system limit the level and length of attention span of little child and relatively small, compared to school children and adults number of social experiences can seriously hamper the classification of situations in which children learn from each other as tutoring. While the generally understood master-student relationship, associated with tutoring, is quite often noticeable during childhood collaboration and play in which one child can do more than the other, the more detailed assumptions of tutoring are not as accessible to the observer. For example, it is difficult to talk about the regularity or planned nature of children's relationships. The definition of tutoring also sets specific expectations regarding the teacher's skills, among which are: high interpersonal competences, commitment to the relationship with the mentee, professionalism and responsibility. From a preschool child who would play the role of a teacher, it is difficult to demand fluent speech, not to mention professionalism and regularity. A preschool child, who just start to learn numbers, is often unable to orient himself in time, which makes it difficult or even impossible to plan and systematize his activities. Little child needs adult help in this area.

scholarly journals The Role of the Gastrointestinal System in Neuroinvasion by SARS-CoV-2

2021 ◽  
Vol 15 ◽  
Author(s):  
Jiali Xu ◽  
Zifeng Wu ◽  
Mi Zhang ◽  
Shijiang Liu ◽  
Ling Zhou ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gastrointestinal Tract ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Symptoms ◽  
Treatment Strategies ◽  
Gastrointestinal System ◽  
Neurological Manifestations ◽  
Prevention And Treatment

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is one of the most devastating pandemics in history. SARS-CoV-2 has infected more than 100 million people worldwide, leading to more than 3.5 million deaths. Initially, the clinical symptoms of SARS-CoV-2 infection were thought to be restricted to the respiratory system. However, further studies have revealed that SARS-CoV-2 can also afflict multiple other organs, including the gastrointestinal tract and central nervous system. The number of gastrointestinal and neurological manifestations after SARS-CoV-2 infection has been rapidly increasing. Most importantly, patients infected with SARS-CoV-2 often exhibit comorbid symptoms in the gastrointestinal and neurological systems. This review aims to explore the pathophysiological mechanisms of neuroinvasion by SARS-CoV-2. SARS-CoV-2 may affect the nervous system by invading the gastrointestinal system. We hope that this review can provide novel ideas for the clinical treatment of the neurological symptoms of SARS-CoV-2 infection and references for developing prevention and treatment strategies.

Functional Foods in Hypertension

2017 ◽  
pp. 376-396
Author(s):  
Anil Gupta
Keyword(s):  
Public Health ◽  
Nervous System ◽  
Immune System ◽  
Alimentary Canal ◽  
Functional Foods ◽  
Endocrine System ◽  
Optimal Dose ◽  
The Public ◽  
Anti Oxidant

Functional foods contain bioactive compounds which are endowed with remarkable biologically significant properties. These compounds have corrective and preventive potential for diseases affecting cardiovascular system, endocrine system, nervous system, alimentary canal by virtue of their capability to influence bio-macromolecules in the cells. Clinical evidence augments the anti-oxidant, anti-atherogenic, anti-ageing, cardio-protective and immune system modulatory role of the functional foods. However, additional research is necessitated to uncover concerns regarding optimal dose, duration, pharmaco-therapeutics and adverse effects of active compounds in relation to the public health.

The role of hypoxia in the integrity of the genetic apparatus and the formation of memory in drosophila in the paradigm of conditioned reflex suppression of courtship

2021 ◽  
Vol 20 (4) ◽  
pp. 45-54
Author(s):  
Anna V. Medvedeva ◽  
Elena V. Tokmacheva ◽  
Ekaterina A. Nikitina ◽  
Svetlana Alexandrovna Vasilieva ◽  
Ekaterina S. Zalomaeva ◽  
...  
Keyword(s):  
Nervous System ◽  
Conditioned Reflex ◽  
Nervous Activity ◽  
Hypoxic Exposure ◽  
Experimental Conditions ◽  
Adaptive Capabilities ◽  
Mechanisms Of Adaptation ◽  
The Relationship ◽  
Conditioned Connection

M.E. Lobashev and V.В. Savvateev in 1959 obtained unique data on the expansion of the adaptive capabilities of the organism when training the properties of higher nervous activity by the formation of conditioned food reflexes to stimuli that exhaust the nervous system. Apparently, the formation of a conditioned connection help to overcoming stressful effects, adaptation to restrictive conditions, and changes in the functioning of the nervous system. To test this assumption, the influence of stressful influences hypoxia on learning and memory of Drosophila in the paradigm of conditioned reflex suppression of courtship was studied. The results were obtained on the enhancement of the ability to learn under hypoxic exposure. These experimental conditions did not affect memory formation. The effect of hypoxia on chromosomes through the formation of double-stranded breaks was revealed. The data are discussed in light of the relationship between neuroplasticity processes and mechanisms of adaptation to stressors.

L-Dopa metabolism in genetically hypertensive mice: effect of pargyline

1987 ◽  
Vol 65 (12) ◽  
pp. 2390-2395 ◽  
Author(s):  
Nguyen T. Buu ◽  
Johanne Duhaime ◽  
Karoly Racz ◽  
Otto Kuchel ◽  
Gunther Schlager
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Monoamine Oxidase ◽  
Hydroxylase Activity ◽  
Sympathetic Nervous ◽  
The Relationship ◽  
The Brain ◽  
Genetically Hypertensive

This study on the role of the sympathetic nervous system in the development of hypertension involves the measurement of dopamine and norepinephrine accumulation in various tissues of the hypertensive and random-bred normotensive strains of mice at basal levels, and following a pargyline–L-dopa treatment. Under such a treatment, designed to suppress the homeostatic action of monoamine oxidase and to better expose the relationship between dopamine and norepinephrine, the brain and heart of the hypertensive mice accumulated more dopamine than the normotensive mice. There was a significantly lower norepinephrine accumulation in the heart of the hypertensive mice in spite of comparable dopamine-β-hydroxylase activity in this tissue between the two strains of mice. Under the pargyline–L-dopa treatment, the brain and heart of the older mice in both hypertensive and normotensive strains accumulated significantly (p < 0.05) more dopamine than those of their younger counterparts, while their norepinephrine accumulation remained unchanged. The results demonstrated different patterns of response of dopamine and norepinephrine in the development of hypertension.

scholarly journals Caste-specific gut symbionts contribute to the different adult longevity in the honeybee

2020 ◽  
Author(s):  
Hongfang Wang ◽  
Baohua Xu
Keyword(s):  
Nervous System ◽  
Immune Regulation ◽  
Agricultural Production ◽  
Endocrine System ◽  
Adult Longevity ◽  
Biological Models ◽  
Gut Symbionts ◽  
Queen Bees ◽  
Honeybee Health ◽  
The Relationship

Abstract Background Honeybees are important pollinators, and their health is important to agricultural production and ecosystem. Queen-bees contain same genome as worker-bees, but live longer and healthier than worker-bees; thus, queen and worker pairs are natural biological models for studying longevity. Concerns are increasing regarding the relationship between gut microbes and honeybee health. We compared the hindgut microflora of queen and worker (Apis mellifera carpatica) by sequencing the bacterial 16S DNA, then salvaging the caste-specific microbes using LEfSe analysis and predicting the microbial functions using Tax4Fun, hoping to find potential gut symbionts associated with longevity. Results The hindgut microflora of queens differed from those of worker. Queens had higher abundances of Commensalibacter, Lactobacillus and Bifidobacterium than workers. The dominant microflora in the worker hindguts were Gilliamella (29.37%), Lactobacillus (15.28%), Commensalibacter (13.65%), Snodgrassella (11.56%), Bifidobacterium (6.07%) and Frischella (3.51%). The dominant microflora in the queen hindguts were Commensalibacter (44.89%), Lactobacillus (38.42%), Bifidobacterium (6.74%), Gilliamella (2.44%) and Bombella (2.41%). Queen-specific microbes was Bombella genus, and worker-specific microbes included Snodgrassella alvi, Frischella perrara and Gilliamella apicola. Queen and worker hindgut microbes exhibited diverse functions in lipid metabolism, neurodegenerative diseases, endocrine system, nervous system and immune system; those functions were linked to honeybee fitness and longevity. The queen-specific symbiont, Bombella, was predicted to be involved in host endocrine and immune regulation, which may contribute to queens living longer and healthier than worker bees. Conclusion The supernal Acetobacteraceae (especially Commensalibacter and Bombella), Lactobacillus and Bifidobacterium in the queen-hindgut help the queen bees live longer and healthier than the worker bees. This study may help determine the mechanisms of queen longevity and enable further understanding the positive roles of gut symbionts in honeybee fitness.

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