scholarly journals Gold Catalyzed Multicomponent Reactions beyond A3 Coupling

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2255 ◽  
Author(s):  
Renso Visbal ◽  
Sara Graus ◽  
Raquel P. Herrera ◽  
M. Concepción Gimeno
Keyword(s):  
Organic Synthesis ◽  
Multicomponent Reactions ◽  
Molecular Diversity ◽  
Biologically Active ◽  
Active Compounds ◽  
The Past ◽  
New Methods ◽  
Complex Architectures ◽  
Interesting Approach ◽  
A3 Coupling

The preparation of complex architectures has inspired the search for new methods and new processes in organic synthesis. Multicomponent reactions have become an interesting approach to achieve such molecular diversity and complexity. This review intends to illustrate important gold-catalyzed examples for the past ten years leading to interesting skeletons involved in biologically active compounds.

scholarly journals One pot synthesis of 3, 4-dihydropyrimidine-2(1H)-thiones using orange peel powder under ultrasonic irradiation

2020 ◽  
Vol 9 (1) ◽  
pp. 919-923
Keyword(s):  
Reaction Time ◽  
Ultrasonic Irradiation ◽  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Orange Peel ◽  
Biologically Active ◽  
High Yield ◽  
Atom Economy ◽  
One Pot ◽  
The Past

Biginelli, an important multicomponent reaction provides an avenue for the synthesis of different biologically active heterocyclic compounds. During the past decade, one pot multicomponent reactions have attracted the attention of organic and medicinal chemists due to high atom economy, time and enery saving convergent nature. The present manuscript reports a simple one pot three component synthesis of 3, 4-dihydroprimidin-2(1H)-thiones from various diversely substituted aldehydes, ethyl acetoacetate and thiourea using a orange peel powder as a natural catalyst on ultrasonic irradiation in aqueous medium as the solvent. The advantages of this reaction are less reaction time, high yield, easy availability of the catalyst and green nature.

Organic Synthesis

2017 ◽  
Author(s):  
Douglass F. Taber ◽  
Tristan Lambert
Keyword(s):  
Organic Synthesis ◽  
State Of The Art ◽  
Research Area ◽  
Organic Transformations ◽  
The Past ◽  
Catalytic Asymmetric Synthesis ◽  
New Methods ◽  
Recent Developments ◽  
Enantioselective Epoxidation ◽  
To Come

Organic synthesis is a vibrant and rapidly evolving field; chemists can now cyclize alkenes directly onto enones. Like the first five books in this series, Organic Synthesis: State of the Art 2013-2015 will lead readers quickly to the most important recent developments in a research area. This series offers chemists a way to stay abreast of what's new and exciting in organic synthesis. The cumulative reaction/transformation index of 2013-2015 outlines all significant new organic transformations over the past twelve years. Future volumes will continue to come out every two years. The 2013-2015 volume features the best new methods in subspecialties such as C-O, C-N and C-C ring construction, catalytic asymmetric synthesis, selective C-H functionalization, and enantioselective epoxidation. This text consolidates two years of Douglass Taber's popular weekly online column, "Organic Chemistry Highlights" as featured on the organic-chemistry.org website and also features cumulative indices of all six volumes in this series, going back twelve years.

Lawsone in organic synthesis

RSC Advances ◽  
2015 ◽  
Vol 5 (83) ◽  
pp. 67909-67943 ◽  
Author(s):  
Alessandro K. Jordão ◽  
Maria D. Vargas ◽  
Angelo C. Pinto ◽  
Fernando de C. da Silva ◽  
Vitor F. Ferreira
Keyword(s):  
Organic Synthesis ◽  
Biologically Active Compounds ◽  
Starting Material ◽  
Biologically Active ◽  
Active Compounds

Lawsone has been used as the starting material for the synthesis of a variety of biologically active compounds and materials.

Modern Catalysts in A3- Coupling Reactions

2020 ◽  
Vol 23 (25) ◽  
pp. 2783-2801 ◽  
Author(s):  
Ali Ramazani ◽  
Hamideh Ahankar ◽  
Zahra T. Nafeh ◽  
Sang W. Joo
Keyword(s):  
Transition Metals ◽  
Heterogeneous Catalysts ◽  
Coupling Reaction ◽  
Biologically Active ◽  
Coupling Reactions ◽  
The Past ◽  
Valuable Compounds ◽  
A3 Coupling ◽  
Important Constituent

: Propargylamines are an important constituent of diverse, biologically active and industrially valuable compounds. These useful, convenient and effective compounds can be synthesized via the A3-coupling reactions between an aldehyde, amine, and alkyne in the presence of a catalyst. In the past years, most of the catalysts containing transition metals were applied in these reactions, but today, various heterogeneous catalysts, especially nanocatalysts are used. The purpose of this review was to introduce some modern catalysts for the A3-coupling reaction.

scholarly journals Microwave-assisted Eco-Friendly Synthesis and Antimicrobial Evaluation of Aryl-Triazole-1,3,4-Thiadiazols

2017 ◽  
Vol 1 (3) ◽  
pp. 17-22 ◽  
Author(s):  
Shalini Jaiswal ◽  
Smriti Dwivedi
Keyword(s):  
Microwave Irradiation ◽  
Organic Synthesis ◽  
Research Programme ◽  
Biologically Active Compounds ◽  
Solvent Free ◽  
Biologically Active ◽  
Aromatic Acid ◽  
One Pot ◽  
Active Compounds ◽  
Solvent Free Condition

Due to the growing awareness about environmental pollution and environmental legislation, recent years have witnessed a phenomenal increase in the application of microwave irradiation (MW) in organic synthesis. Heterocyclic compounds are abundant in nature and are of great significance to life because their structural subunits exist in many natural products such as vitamins, hormones, and antibiotics; hence, they have attracted considerable attention in the design of biologically active molecules and advanced organic chemistry. The application of molecular diversity technique to drug discovery is a multidisciplinary effort in organic synthesis. Medicinal chemistry concerns with the discovery, development, interpretation and the identification of mechanism of action of biologically active compounds at the molecular level. Encouraged by above reports and as part of our research programme for development of eco-friendly synthetic protocol for biologically active compounds as well as in pursuing of our work on new solvent-free cyclisation here we report the synthesis of aryl-triazalo -1, 3, 4-thidiazoles. The one-pot reaction of mercapto-s-triazole with aromatic acid using AlCl3 as a catalyst under microwave irradiation (2-3 min) and in solvent-free condition gave aryl-triazalo -1, 3, 4-thidiazoles with improved yield is described here. Keywords: Aryl-triazalo-1, 3, 4-thiadiazoles, Aromatic acid, AlCl3, cyclisation, S. aureus, E. coli, B. subtilis.

scholarly journals Multicomponent Synthesis of 2-(2,4-Diamino-3-cyano-5H-chromeno[2,3-b]pyridin-5-yl)malonic Acids in DMSO

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6839
Author(s):  
Yuliya E. Ryzhkova ◽  
Michail N. Elinson ◽  
Oleg I. Maslov ◽  
Artem N. Fakhrutdinov
Keyword(s):  
Reaction Mechanism ◽  
Organic Synthesis ◽  
Multicomponent Reactions ◽  
Room Temperature ◽  
Low Cost ◽  
2D Nmr ◽  
Biologically Active ◽  
Multicomponent Synthesis ◽  
2D Nmr Spectroscopy ◽  
Low Toxicity

Dimethyl sulfoxide is a widely used solvent in organic synthesis and in the pharmaceutical industry because of its low cost, stability, and low toxicity. Multicomponent reactions are an advanced approach that has become an efficient, economical, and eco-friendly substitute for the conventional sequential multi-step synthesis of various biologically active compounds. This approach was adopted for the synthesis of previously unknown 2-(2,4-diamino-3-cyano-5H-chromeno[2,3-b]pyridin-5-yl)malonic acids via transformation of salicylaldehydes, malononitrile dimer, and malonic acid. It was shown that the use of DMSO at room temperature makes it possible to synthesize previously unavailable compounds. The investigation of the reaction mechanism using 1H-NMR monitoring made it possible to confirm the proposed mechanism of the transformation. The structure of synthesized 5H-chromeno[2,3-b]pyridines was confirmed by 2D-NMR spectroscopy.

Ring Closing Metathesis Approach for the Construction of Carbazoles and Indole-Fused Ring Systems

2021 ◽  
Author(s):  
Tirtha Mandal ◽  
Jyotirmayee Dash
Keyword(s):  
Organic Synthesis ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Ring Closing Metathesis ◽  
Active Compounds ◽  
Widespread Occurrence ◽  
Ring Systems ◽  
Fused Ring

The synthesis and functionalization of carbazole ring systems have received considerable attention in organic synthesis due to their widespread occurrence in biologically active compounds . One of the classical methods...

The Use of Cinnamic Acid and Cinnamaldehyde, as Bio-Based Molecules, in Organic Synthesis and Preparation of Biologically Active Compounds

2020 ◽  
Vol 17 ◽  
Author(s):  
Anna S. Zalivatskaya ◽  
Dmitriy N. Zakusilo ◽  
Aleksander V. Vasilyev
Keyword(s):  
Biological Activity ◽  
Double Bond ◽  
Carbonyl Group ◽  
Organic Compounds ◽  
Organic Synthesis ◽  
Cinnamic Acid ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Platform Chemicals

: Cinnamic acid and cinnamaldehyde may be obtained from renewable plant bio-mass, Cinnamon plants, therefore these compounds should be considered as bio-based platform chemicals for synthesis of novel substances. This review describes recent achievements in organic synthesis based on transformations of cinnamaldehyde, cinnamic acid and its derivatives, focusing, mainly, on the preparation of biologically active compounds. Reactions of these cinnamic derivatives may proceed both onto carbon-carbon double bond and carbonyl group that allows obtaining a wide variety of organic compounds having high synthetic importance and different practically valuable properties, including biological activity.

scholarly journals Structure-Based Design of Biologically Active Compounds

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3115
Author(s):  
Sandra Gemma
Keyword(s):  
Drug Targets ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
New Drugs ◽  
Structural Knowledge ◽  
Active Compounds ◽  
The Past ◽  
Tremendous Progress

The past decades have witnessed tremendous progress in the detailed structural knowledge of proteins as potential or validated drug targets and the discovery of new drugs based on this wealth of knowledge progressed in parallel [...]

scholarly journals Furochinoline alkaloids in plants from Rutaceae family – a review

2016 ◽  
Vol 29 (1) ◽  
pp. 33-38 ◽  
Author(s):  
Aldona Adamska-Szewczyk ◽  
Kazimierz Glowniak ◽  
Tomasz Baj
Keyword(s):  
Natural Products ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
The Past ◽  
Pharmacological Studies ◽  
Other Substances ◽  
Hiv And Cancer ◽  
Active Natural ◽  
Methods Of Isolation

Abstract Over the past five years, phytochemical and pharmacological studies have been conducted on material extracted from members of the Rutaceae family. In such work, new furochinoline-structured alkaloids were isolated from Ruta sp. and Dictamnus sp. Beyond the aforementioned, other substances with promising activity were isolated from the less-known species of Zanthoxylum, Evodia, Lonchocarpus, Myrthopsis and Teclea. Currently used forms of extraction, as well as methods of isolation and detection, allow the obtaining of pure, biologically active compounds. Many of these have antifungal, anti-bacterial and anti-plasmodial properties. Others are still being researched as potential drugs, which, in future, may be used in treating those afflicted with HIV and cancer. This article is designed to give the readers a thorough review of the active natural products from the Rutaceae family.

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