scholarly journals Iron Chelation in Local Infection

Molecules ◽  
2021 ◽  
Vol 26 (1) ◽  
pp. 189
Author(s):  
Cassidy Scott ◽  
Gaurav Arora ◽  
Kayle Dickson ◽  
Christian Lehmann
Keyword(s):  
Review Paper ◽  
Iron Chelation ◽  
Essential Element ◽  
Innate Immune ◽  
Iron Regulation ◽  
Oxygen Species ◽  
Iron Availability ◽  
Local Infection ◽  
Physiological Regulation ◽  
Iron Deprivation

Iron is an essential element in multiple biochemical pathways in humans and pathogens. As part of the innate immune response in local infection, iron availability is restricted locally in order to reduce overproduction of reactive oxygen species by the host and to attenuate bacterial growth. This physiological regulation represents the rationale for the therapeutic use of iron chelators to support induced iron deprivation and to treat infections. In this review paper we discuss the importance of iron regulation through examples of local infection and the potential of iron chelation in treating infection.

scholarly journals The Utility of Iron Chelators in the Management of Inflammatory Disorders

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
C. Lehmann ◽  
S. Islam ◽  
S. Jarosch ◽  
J. Zhou ◽  
D. Hoskin ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Iron Chelation ◽  
Iron Regulation ◽  
Human Organism ◽  
Iron Availability ◽  
Pathological Conditions ◽  
Reasonable Approach ◽  
Potential Impact ◽  
Pharmaceutical Agents

Since iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during inflammatory diseases. Under pathological conditions with reduced or increased baseline iron levels different consequences regarding protection or susceptibility to inflammation have to be considered. Given the role of iron in development of inflammatory diseases, pharmaceutical agents targeting this pathway promise to improve the clinical outcome. The objective of this review is to highlight the mechanisms of iron regulation and iron chelation, and to demonstrate the potential impact of this strategy in the management of several acute and chronic inflammatory diseases, including cancer.

scholarly journals Iron Pathways and Iron Chelation Approaches in Viral, Microbial, and Fungal Infections

2020 ◽  
Vol 13 (10) ◽  
pp. 275
Author(s):  
Ravneet Chhabra ◽  
Aishwarya Saha ◽  
Ashkon Chamani ◽  
Nicole Schneider ◽  
Riya Shah ◽  
...  
Keyword(s):  
Iron Uptake ◽  
Fungal Infections ◽  
Iron Acquisition ◽  
Iron Chelation ◽  
Essential Element ◽  
Iron Availability ◽  
Tight Control ◽  
Potential Clinical Benefit ◽  
Bacteria And Fungi ◽  
Spread Of Infection

Iron is an essential element required to support the health of organisms. This element is critical for regulating the activities of cellular enzymes including those involved in cellular metabolism and DNA replication. Mechanisms that underlie the tight control of iron levels are crucial in mediating the interaction between microorganisms and their host and hence, the spread of infection. Microorganisms including viruses, bacteria, and fungi have differing iron acquisition/utilization mechanisms to support their ability to acquire/use iron (e.g., from free iron and heme). These pathways of iron uptake are associated with promoting their growth and virulence and consequently, their pathogenicity. Thus, controlling microorganismal survival by limiting iron availability may prove feasible through the use of agents targeting their iron uptake pathways and/or use of iron chelators as a means to hinder development of infections. This review will serve to assimilate findings regarding iron and the pathogenicity of specific microorganisms, and furthermore, find whether treating infections mediated by such organisms via iron chelation approaches may have potential clinical benefit.

scholarly journals Cyberstalking Victimization Model Using Criminological Theory: A Systematic Literature Review, Taxonomies, Applications, Tools, and Validations

Electronics ◽  
2021 ◽  
Vol 10 (14) ◽  
pp. 1670
Author(s):  
Waheeb Abu-Ulbeh ◽  
Maryam Altalhi ◽  
Laith Abualigah ◽  
Abdulwahab Ali Almazroi ◽  
Putra Sumari ◽  
...  
Keyword(s):  
Data Analysis ◽  
Structural Equation ◽  
Large Scale ◽  
Review Paper ◽  
Essential Element ◽  
Routine Activities ◽  
Criminological Theory ◽  
Equation Modeling ◽  
Future Research ◽  
Proposed Model

Cyberstalking is a growing anti-social problem being transformed on a large scale and in various forms. Cyberstalking detection has become increasingly popular in recent years and has technically been investigated by many researchers. However, cyberstalking victimization, an essential part of cyberstalking, has empirically received less attention from the paper community. This paper attempts to address this gap and develop a model to understand and estimate the prevalence of cyberstalking victimization. The model of this paper is produced using routine activities and lifestyle exposure theories and includes eight hypotheses. The data of this paper is collected from the 757 respondents in Jordanian universities. This review paper utilizes a quantitative approach and uses structural equation modeling for data analysis. The results revealed a modest prevalence range is more dependent on the cyberstalking type. The results also indicated that proximity to motivated offenders, suitable targets, and digital guardians significantly influences cyberstalking victimization. The outcome from moderation hypothesis testing demonstrated that age and residence have a significant effect on cyberstalking victimization. The proposed model is an essential element for assessing cyberstalking victimization among societies, which provides a valuable understanding of the prevalence of cyberstalking victimization. This can assist the researchers and practitioners for future research in the context of cyberstalking victimization.

scholarly journals The Responses of Bioactive Betanin Pigment and Its Derivatives from a Red Beetroot (Beta vulgaris L.) Betalain-Rich Extract to Hypochlorous Acid

2021 ◽  
Vol 22 (3) ◽  
pp. 1155
Author(s):  
Karolina Starzak ◽  
Katarzyna Sutor ◽  
Tomasz Świergosz ◽  
Boris Nemzer ◽  
Zbigniew Pietrzkowski ◽  
...  
Keyword(s):  
Beta Vulgaris ◽  
Hypochlorous Acid ◽  
Innate Immune ◽  
Inflammatory Factors ◽  
Oxygen Species ◽  
Plant Pigments ◽  
Important Food ◽  
Inflammatory Conditions ◽  
Ph Range

Neutrophils produce hypochlorous acid (HOCl) as well as other reactive oxygen species as part of a natural innate immune response in the human body; however, excessive levels of HOCl can ultimately be detrimental to health. Recent reports suggest that betacyanin plant pigments can act as potent scavengers of inflammatory factors and are notably effective against HOCl. Comparison of the in vitro anti-hypochlorite activities of a novel betalain-rich red beetroot (Beta vulgaris L.) extract with its pure betalainic pigments revealed that the extract had the highest anti-hypochlorite activity, far exceeding the activity of all of the betalainic derivatives and selected reference antioxidants. This suggests that it may be an important food-based candidate for management of inflammatory conditions induced by excessive HOCl production. Among all pigments studied, betanidin exhibited the highest activity across the pH range.

scholarly journals Effects of spaceflight on innate immune function and antioxidant gene expression

2009 ◽  
Vol 106 (6) ◽  
pp. 1935-1942 ◽  
Author(s):  
Farnaz P. Baqai ◽  
Daila S. Gridley ◽  
James M. Slater ◽  
Xian Luo-Owen ◽  
Louis S. Stodieck ◽  
...  
Keyword(s):  
Space Shuttle ◽  
Ex Vivo ◽  
Innate Immune ◽  
Oxygen Species ◽  
Bacterial Product ◽  
Th1 Response ◽  
Antioxidant Gene ◽  
Tnf Α ◽  
Antioxidant Gene Expression ◽  
Cell Mitogen

Spaceflight conditions have a significant impact on a number of physiological functions due to psychological stress, radiation, and reduced gravity. To explore the effect of the flight environment on immunity, C57BL/6NTac mice were flown on a 13-day space shuttle mission (STS-118). In response to flight, animals had a reduction in liver, spleen, and thymus masses compared with ground (GRD) controls ( P < 0.005). Splenic lymphocyte, monocyte/macrophage, and granulocyte counts were significantly reduced in the flight (FLT) mice ( P < 0.05). Although spontaneous blastogenesis of splenocytes in FLT mice was increased, response to lipopolysaccharide (LPS), a B-cell mitogen derived from Escherichia coli, was decreased compared with GRD mice ( P < 0.05). Secretion of IL-6 and IL-10, but not TNF-α, by LPS-stimulated splenocytes was increased in FLT mice ( P < 0.05). Finally, many of the genes responsible for scavenging reactive oxygen species were upregulated after flight. These data indicate that exposure to the spaceflight environment can increase anti-inflammatory mechanisms and change the ex vivo response to LPS, a bacterial product associated with septic shock and a prominent Th1 response.

scholarly journals Enhanced Oxidative Stress and Physiological Damage inDaphnia magnaby Copper in the Presence of Nano-TiO2

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
W. H. Fan ◽  
M. M. Cui ◽  
Z. W. Shi ◽  
C. Tan ◽  
X. P. Yang
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species Generation ◽  
Aquatic Organisms ◽  
Potential Hazard ◽  
Oxygen Species ◽  
Nano Tio2 ◽  
Physiological Regulation ◽  
Toxic Injury ◽  
Transfer Channel ◽  
Atpase Inhibition

This study examines the potential hazard of an individual nanomaterial on the Cu biotoxicity to aquatic organisms.Daphnia magnain the absence or presence of nano-TiO2was exposed to Cu. Maintaining nano-TiO2at a safe concentration cannot eliminate its potential hazard. The biomarkers superoxide dismutase, catalase, and Na+/K+-ATPase inD. magnawere measured. Cu in the presence of nano-TiO2induced higher levels of oxidative stress and physiological damage because of the sorption of Cu. Nano-TiO2also caused Na+/K+-ATPase inhibition possibly by impeding the Na+/K+transfer channel. The correlations among the biomarkers, mortality, and accumulation further showed that the overloading reactive oxygen species generation caused by nano-TiO2contributed to deeper oxidative stress and physiological regulation, thereby causing greater toxic injury.

Iron influences the expression of colonization factor CS6 of enterotoxigenic Escherichia coli

Microbiology ◽  
2021 ◽  
Vol 167 (9) ◽  
Author(s):  
Debjyoti Bhakat ◽  
Indranil Mondal ◽  
Asish Kumar Mukhopadhyay ◽  
Nabendu Sekhar Chatterjee
Keyword(s):  
Escherichia Coli ◽  
Promoter Activity ◽  
Iron Concentration ◽  
Iron Chelation ◽  
Enterotoxigenic Escherichia Coli ◽  
Watery Diarrhoea ◽  
Rna Expression ◽  
Iron Availability ◽  
Iron Salt ◽  
Ht 29

Enterotoxigenic Escherichia coli (ETEC) is a major pathogen of acute watery diarrhoea. The pathogenicity of ETEC is linked to adherence to the small intestine by colonization factors (CFs) and secretion of heat-labile enterotoxin (LT) and/or heat-stable enterotoxin (ST). CS6 is one of the most common CFs in our region and worldwide. Iron availability functions as an environmental cue for enteropathogenic bacteria, signalling arrival within the human host. Therefore, iron could modify the expression of CS6 in the intestine. The objective of this study was to determine the effect of iron availability on CS6 expression in ETEC. This would help in understanding the importance of iron during ETEC pathogenesis. ETEC strain harbouring CS6 was cultured under increasing concentrations of iron salt to assess the effect on CS6 RNA expression by quantitative RT-PCR, protein expression by ELISA, promoter activity by β-galactosidase activity, and epithelial adhesion on HT-29 cells. RNA expression of CS6 was maximum in presence of 0.2 mM iron (II) salt. The expression increased by 50-fold, which also reduced under iron-chelation conditions and an increased iron concentration of 0.4 mM or more. The surface expression of CS6 also increased by 60-fold in presence of 0.2 mM iron. The upregulation of CS6 promoter activity by 25-fold under this experimental condition was in accordance with the induction of CS6 RNA and protein. This increased CS6 expression was independent of ETEC strains. Bacterial adhesion to HT-29 epithelial cells was also enhanced by five-fold in the presence of 0.2 mM iron salt. These findings suggest that CS6 expression is dependent on iron concentration. However, with further increases in iron concentration beyond 0.2 mM CS6 expression is decreased, suggesting that there might be a strong regulatory mechanism for CS6 expression under different iron concentrations.

scholarly journals Drosophila hemocytes recognize lymph gland tumors of mxc mutants and activate the Toll pathway in reactive oxygen species-dependent manner

2021 ◽  
Author(s):  
Suzuko Kinoshita ◽  
Kazuki Takarada ◽  
Yoshihiro H. Inoue
Keyword(s):  
Reactive Oxygen Species ◽  
Fat Body ◽  
Ectopic Expression ◽  
Reactive Oxygen ◽  
Underlying Mechanism ◽  
Innate Immune ◽  
Dependent Manner ◽  
Oxygen Species ◽  
Matrix Metalloproteinase 1 ◽  
Membrane Components

Mechanisms of cancer cell recognition and elimination by the innate immune system remains unclear. Circulating hemocytes are associated with the hematopoietic tumors in Drosophila mxcmbn1 mutant larvae. The innate immune signalling pathways are activated in the fat body to suppress the tumor growth by inducing antimicrobial peptides (AMP). Here, we investigated the regulatory mechanism underlying the activation in the mutant. Reactive oxygen species accumulated in the hemocytes due to induction of dual oxidase and its activator. The hemocytes were also localized on the fat body. These were essential for transmitting the information on tumors toward the fat body to induce AMP expression. Regarding to the tumor recognition, we found that matrix metalloproteinase 1 (MMP1) and MMP2 were highly expressed in the tumors. Ectopic expression of MMP2 was associated with AMP induction in the mutants. Furthermore, the basement membrane components in the tumors were reduced and ultimately lost. The hemocytes may recognize the disassembly in the tumors. Our findings highlight the underlying mechanism via which macrophage-like hemocytes recognize tumor cells and relay the information toward the fat body to induce AMPs. and contribute to uncover the immune system's roles against cancer.

Subversion of host cell signalling by the protozoan parasiteLeishmania

Parasitology ◽  
2005 ◽  
Vol 130 (S1) ◽  
pp. S27-S35 ◽  
Author(s):  
D. J. GREGORY ◽  
M. OLIVIER
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Cell Signalling ◽  
Protein Tyrosine Phosphatases ◽  
Innate Immune ◽  
Signalling Pathways ◽  
Oxygen Species ◽  
Obligate Intracellular ◽  
Intracellular Parasites ◽  
Intracellular Ca

The protozoaLeishmaniaspp. are obligate intracellular parasites that inhabit the macrophages of their host. Since macrophages are specialized for the identification and destruction of invading pathogens, both directly and by triggering an innate immune response,Leishmaniahave evolved a number of mechanisms for suppressing some critical macrophage activities. In this review, we discuss how various species ofLeishmaniadistort the host macrophage's own signalling pathways to repress the expression of various cytokines and microbicidal molecules (nitric oxide and reactive oxygen species), and antigen presentation. In particular, we describe how MAP Kinase and JAK/STAT cascades are repressed, and intracellular Ca2+and the activities of protein tyrosine phosphatases, in particular SHP-1, are elevated.

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