scholarly journals Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of Crotalaria cleomifolia Used in Popular Beverages in Madagascar

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3464
Author(s):  
Anjaramampionona Henintsoa Duvale Solofomalala ◽  
Clara Fredeline Rajemiarimoelisoa ◽  
Randriamampianina Lovarintsoa Judicael ◽  
Hanitra Ranjana Randrianarivo ◽  
Danielle Aurore Doll Rakoto ◽  
...  

Seeds of Crotalaria cleomifolia (Fabaceae) are consumed in Madagascar in preparation of popular beverages. The investigation of extracts from the seeds of this species revealed the presence of high amounts of alkaloids from which two pyrrolizidine-derived alkaloids were isolated. One of them was fully characterized by spectroscopic and spectrometric methods, which was found to be usaramine. Owing to the high toxicity of these alkaloids, issuing a strong warning among populations consuming the seeds of Crotalaria cleomifolia must be considered.

2020 ◽  
pp. 22-30
Author(s):  
SERGEY N. DEVYANIN ◽  
◽  
VLADIMIR A. MARKOV ◽  
ALEKSANDR G. LEVSHIN ◽  
TAMARA P. KOBOZEVA ◽  
...  

The paper presents the results of long-term research on the oil productivity and chemical composition of soybean oil of the Northern ecotype varieties in the Central Non-Black Earth Region. The authors consider its possible use for biodiesel production. Experiments on growing soybeans were carried out on the experimental fi eld of Russian State Agrarian University –Moscow Timiryazev Agricultural Academy (2008-2019) on recognized ultra-early ripening varieties of the Northern ecotype Mageva, Svetlaya, Okskaya (ripeness group 000). Tests were set and the research results were analyzed using standard approved methods. It has been shown that in conditions of high latitudes (57°N), limited thermal resources of the Non-Chernozem zone of Russia (the sum of active temperatures of the growing season not exceeding 2000°С), the yield and productivity of soybeans depend on the variety and moisture supply. Over the years, the average yield of soybeans amounted to 1.94 … 2.62 t/ha, oil productivity – 388 … 544 kg/ha, oil content – 19…20%, the content of oleic and linoleic fatty acids in oil – 60%, and their output from seeds harvested – 300 kg/ha. It has been established that as soybean oil and diesel fuel have similar properties,they can be mixed by conventional methods in any proportions and form stable blends that can be stored for a long time. Experimental studies on the use of soybean oil for biodiesel production were carried out on a D-245 diesel engine (4 ChN11/12.5). The concentrations of toxic components (CO, CHx, and NOx) in the diesel exhaust gases were determined using the SAE-7532 gas analyzer. The smoke content of the exhaust gases was measured with an MK-3 Hartridge opacimeter. It has been experimentally established that the transfer of a diesel engine from diesel fuel to a blend of 80% diesel fuel and 20% lubrication oil leads to a change in the integral emissions per test cycle: nitrogen oxides in 0.81 times, carbon monoxide in 0.89 times and unburned hydrocarbons in 0.91 times, i.e. when biodiesel as used as a motor fuel in a serial diesel engine, emissions of all gaseous toxic components are reduced. The study has confi rmed the expediency of using soybeans of the Northern ecotype for biofuel production.


2013 ◽  
Vol 12 (3) ◽  
pp. 239-247

The removal of heavy metals from wastewaters is a matter of paramount importance due to the fact that their high toxicity causes major environmental pollution problems. One of the most efficient, applicable and low cost methods for the removal of toxic metals from aqueous solutions is that of their adsorption on an inorganic adsorbent. In order to achieve high efficiency, it is important to understand the influence of the solution parameters on the extent of the adsorption, as well as the kinetics of the adsorption. In the present work, the adsorption of Cu(II) species onto TiO2 surface was studied. It was found that the adsorption is a rapid process and it is not affected by the value of ionic strength. In addition, it was found that by increasing the pH, the adsorbed amount of Cu2+ ions and the value of the adsorption constant increase, whereas the value of the lateral interaction energy decreases.


2017 ◽  
Vol 68 (1) ◽  
pp. 175-179
Author(s):  
Oana Roxana Chivu ◽  
Augustin Semenescu ◽  
Claudiu Babis ◽  
Catalin Amza ◽  
Gabriel Iacobescu ◽  
...  

Rainfall is a major component of the environment and the main source of the air purification becouse of many pollutants increases who have the most varied sources: various human activities including industry and agriculture, and some household duties. Air purification by means of precipitation is achieved by numerous highly complex mechanisms. The final products of degradation of the pollutant in the air, which are generally harmless, can be reacted with each other in the presence of water, giving rise to the final compounds with a high toxicity. Thus, exhaust, mobile sources of noxious almost identical to those specific activities in the industrial processing of oil, contain lead which is the ideal catalyst for converting SO2 to sulfuric acid in the presence of rainwater, with all the disadvantages that they create. This paper will present an experimental research oabout how rainfall water quality is influenced by the activity of the industrial processing of oil, in a chemical plant in Constanta County.


2018 ◽  
Vol 69 (9) ◽  
pp. 2416-2419
Author(s):  
Mihai Branzei ◽  
Mihai Ovidiu Cojocaru ◽  
Leontin Nicolae Druga ◽  
Florica Tudose ◽  
Roxana Trusca

Experimental research aimed to find a solution for replacing components with high toxicity (or generating such components as a result of reactions occurring in the environment at processing temperatures) from the environments used for ferritic nitrocarburising process (FNCP) with non-hazardous components, but extremely active during the process. In the temperature range in which this type of processing is applied (lower than the eutectoid transformation temperature in the Fe-N phase diagram), the most commonly used media are liquid or gaseous; liquid ones contain toxic components (sodium or potassium cyanates/cyanides), and gaseous ones require complex equipments. Packing is extremely rarely used, but in this case pack-mix contain toxic components (15 � 20 wt.% sodium or potassium ferrocyanide). Urea also called carbamide (CO (NH2)2) is the active component in the pack-mixing proposed to be used for FNCP. Carbamide is used in low temperature cyanidation thermochemical heat treatment (liquid FNC), together with sodium or potassium carbonates, resulting in very toxic reaction products (sodium or potassium cyanates). Compared to cyanidation, in the version proposed in the paper, the carbamide does not react with carbonates because they are not found in the composition of the environment but decomposes in the presence or absence of oxygen (by a disproportionation reaction) with the formation of some gas molecules interesting for the process. It has been concluded that the use of carbamide together with two other components, activated charcoal (having a triple role - dispersing, storage, surface saturation) and respectively ammonium chloride as surface reaction activator, is an effective solution for achieving the desired goals by applying this type of thermochemical processing to a wide range of products made of quality steels up to alloy miscellaneous steels.


2021 ◽  
Vol 7 (2) ◽  
pp. 106
Author(s):  
Erika Seki Kioshima ◽  
Patrícia de Souza Bonfim de Mendonça ◽  
Marcus de Melo Teixeira ◽  
Isis Regina Grenier Capoci ◽  
André Amaral ◽  
...  

Paracoccidioidomycosis (PCM) is a notable fungal infection restricted to Latin America. Since the first description of the disease by Lutz up to the present day, Brazilian researchers have contributed to the understanding of the life cycle of this pathogen and provided the possibility of new targets for antifungal therapy based on the structural and functional genomics of Paracoccidioides. In this context, in silico approaches have selected molecules that act on specific targets, such as the thioredoxin system, with promising antifungal activity against Paracoccidioides. Some of these are already in advanced development stages. In addition, the application of nanostructured systems has addressed issues related to the high toxicity of conventional PCM therapy. Thus, the contribution of molecular biology and biotechnology to the advances achieved is unquestionable. However, it is still necessary to transcend the boundaries of synthetic chemistry, pharmaco-technics, and pharmacodynamics, aiming to turn promising molecules into newly available drugs for the treatment of fungal diseases.


2011 ◽  
Vol 92 (7) ◽  
pp. 1519-1525 ◽  
Author(s):  
Rakshit K Devappa ◽  
Harinder PS Makkar ◽  
Klaus Becker

2014 ◽  
Vol 466-467 ◽  
pp. 232-241 ◽  
Author(s):  
Fabianne Ribeiro ◽  
Julián Alberto Gallego-Urrea ◽  
Kerstin Jurkschat ◽  
Alison Crossley ◽  
Martin Hassellöv ◽  
...  

RSC Advances ◽  
2017 ◽  
Vol 7 (70) ◽  
pp. 44226-44233 ◽  
Author(s):  
Ji Wang ◽  
Ming-Fang He ◽  
Dalu Zhang ◽  
Ziyu Ren ◽  
Tian-shun Song ◽  
...  

Tetracycline (TC) is the second most commonly used antibiotic despite its high toxicity and persistence.


2017 ◽  
Vol 25 (11) ◽  
pp. 10383-10391 ◽  
Author(s):  
Giovanni Benelli ◽  
Marimuthu Govindarajan ◽  
Mohamad S. AlSalhi ◽  
Sandhanasamy Devanesan ◽  
Filippo Maggi

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