scholarly journals Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6997
Author(s):  
Xu Zhou ◽  
Linlin Dong ◽  
Langtao Shen
Keyword(s):  
Chelating Agents ◽  
Chelation Therapy ◽  
General Structure ◽  
Basic Structure ◽  
Review Article ◽  
Preclinical Studies ◽  
Structure And Properties ◽  
Future Prospects ◽  
Bifunctional Chelators ◽  
Gallium 68

Hydroxypyridinones (HOPOs) have been used in the chelation therapy of iron and actinide metals. Their application in metal-based radiopharmaceuticals has also been increasing in recent years. This review article focuses on how multidentate HOPOs can be used in targeted radiometal-based diagnostic and therapeutic radiopharmaceuticals. The general structure of radiometal-based targeted radiopharmaceuticals, a brief description of siderophores, the basic structure and properties of bidentate HOPO, some representative HOPO multidentate chelating agents, radiopharmaceuticals based on HOPO multidentate bifunctional chelators for gallium-68, thorium-227 and zirconium-89, as well as the future prospects of HOPO multidentate bifunctional chelators in other metal-based radiopharmaceuticals are described and discussed in turn. The HOPO metal-based radiopharmaceuticals that have shown good prospects in clinical and preclinical studies are gallium-68, thorium-227 and zirconium-89 radiopharmaceuticals. We expect HOPO multidentate bifunctional chelators to be a very promising platform for building novel targeted radiometal-based diagnostic and therapeutic radiopharmaceuticals.

Targeting Natural Products for the Treatment of COVID-19 – An Updated Review

2020 ◽  
Vol 26 (41) ◽  
pp. 5278-5285
Author(s):  
Ramachandra R. Pamuru ◽  
Naveen Ponneri ◽  
Amooru G. Damu ◽  
Ramakrishna Vadde
Keyword(s):  
Natural Products ◽  
Severe Acute Respiratory Syndrome ◽  
Disease Control ◽  
Mechanism Of Action ◽  
Basic Structure ◽  
Review Article ◽  
Preclinical Studies ◽  
The World ◽  
Novel Drug ◽  
Microbial Agents

Background: Coronavirus disease 2019 (COVID-19) is an ongoing, rapidly spreading pandemic caused by Severe Acute Respiratory Syndrome Coronavirus2 (SARS-CoV2). Among all the infected countries around the globe as of now (June 15, 2020), the total confirmed positive cases reported are 7,805,148, with the death of 431,192. At present, no specialized treatments evolved to cure COVID-19. Its treatment is symptomatic. Though huge efforts are being made to produce potential therapies to scuffle COVID-19, no drug has been discovered so far. Objective: Natural products have been playing a significant role in disease control since ancient days. These products serve as templates for designing new anti-microbial agents with a different mechanism of action and also open a door for investigation of effective anti-viral drugs to combat COVID-19. By focusing on this, the authors have narrated the basic structure, infection, and pathogenesis of SARS-CoV2 virus in humans and also reported various natural products or plant-based extracts/bioactive compounds tested against coronaviruses like SARS and MERS, as these viruses are structurally similar to SARS-CoV2 and can be used in designing novel drug against this virus. Conclusions: The natural products having the potential to combat SARS, MERS, and other viruses reviewed in this review article might have anti-viral activities against the SARS-CoV2 virus and can be used directly for further preclinical studies. Therefore, all efforts should be focused on overcoming this serious problem to save many people's lives all over the world.

The Basic Structure of Society as the Primary Subject of Justice

2018 ◽  
Author(s):  
Samuel Freeman
Keyword(s):  
Economic System ◽  
Social Institutions ◽  
Basic Structure ◽  
The Political ◽  
Moral Pluralism ◽  
Future Prospects ◽  
Principles Of Justice ◽  
Distribution Of Income

Rawls says that there are two sources for the primacy assigned to the basic structure: the profound effects of basic social institutions on persons and their future prospects, and the need to maintain background justice. This chapter discusses the main reasons behind Rawls’s position that the basic structure of society is the primary subject of justice, and that the political constitution, property, and the economic system are the first subject to which principles of justice apply. First, the primacy of the basic structure is necessary for the freedom, equality, and independence of moral persons. Second, the basic structure’s priority is a condition of economic reciprocity and the just distribution of income and wealth. Third, the primacy of the basic structure is required by moral pluralism and the plurality of values and reasonable conceptions of the good among free and equal persons.

scholarly journals Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer

2021 ◽  
Vol 9 (1) ◽  
pp. e001341
Author(s):  
Chunxiao Li ◽  
Xiaofei Xu ◽  
Shuhua Wei ◽  
Ping Jiang ◽  
Lixiang Xue ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Tumor Progression ◽  
Cancer Cells ◽  
Poor Prognosis ◽  
Tumor Immunotherapy ◽  
Therapeutic Strategies ◽  
Preclinical Studies ◽  
Future Prospects ◽  
Tumor Associated Macrophages

Macrophages are the most important phagocytes in vivo. However, the tumor microenvironment can affect the function and polarization of macrophages and form tumor-associated macrophages (TAMs). Usually, the abundance of TAMs in tumors is closely associated with poor prognosis. Preclinical studies have identified important pathways regulating the infiltration and polarization of TAMs during tumor progression. Furthermore, potential therapeutic strategies targeting TAMs in tumors have been studied, including inhibition of macrophage recruitment to tumors, functional repolarization of TAMs toward an antitumor phenotype, and other therapeutic strategies that elicit macrophage-mediated extracellular phagocytosis and intracellular destruction of cancer cells. Therefore, with the increasing impact of tumor immunotherapy, new antitumor strategies to target TAMs are now being discussed.

scholarly journals Clinical Application of Novel Therapies for Coronary Angiogenesis: Overview, Challenges, and Prospects

2021 ◽  
Vol 22 (7) ◽  
pp. 3722
Author(s):  
Mohamed Sabra ◽  
Catherine Karbasiafshar ◽  
Ahmed Aboulgheit ◽  
Sidharth Raj ◽  
M. Ruhul Abid ◽  
...  
Keyword(s):  
Vascular System ◽  
Therapeutic Angiogenesis ◽  
Clinical Findings ◽  
Preclinical Studies ◽  
Novel Therapies ◽  
Future Prospects ◽  
Surgical Interventions ◽  
Therapeutic Modalities ◽  
Advanced Stages ◽  
Coronary Angiogenesis

Cardiovascular diseases continue to be the leading cause of death worldwide, with ischemic heart disease as the most significant contributor. Pharmacological and surgical interventions have improved clinical outcomes, but are unable to ameliorate advanced stages of end-heart failure. Successful preclinical studies of new therapeutic modalities aimed at revascularization have shown short lasting to no effects in the clinical practice. This lack of success may be attributed to current challenges in patient selection, endpoint measurements, comorbidities, and delivery systems. Although challenges remain, the field of therapeutic angiogenesis is evolving, as novel strategies and bioengineering approaches emerge to optimize delivery and efficacy. Here, we describe the structure, vascularization, and regulation of the vascular system with particular attention to the endothelium. We proceed to discuss preclinical and clinical findings and present challenges and future prospects in the field.

scholarly journals Review article: gene therapy, recent developments and future prospects in gastrointestinal oncology

2010 ◽  
Vol 32 (8) ◽  
pp. 953-968 ◽  
Author(s):  
Y. Touchefeu ◽  
K. J. Harrington ◽  
J. P. Galmiche ◽  
G. Vassaux
Keyword(s):  
Gene Therapy ◽  
Review Article ◽  
Future Prospects ◽  
Recent Developments

Glycosyl-Curcuminoids as Potential New Chelating Agents in Iron Overload Chelation Therapy

2004 ◽  
Vol 2004 (3) ◽  
pp. 646-652 ◽  
Author(s):  
Beatrice Arezzini ◽  
Marco Ferrali ◽  
Erika Ferrari ◽  
Romano Grandi ◽  
Stefano Monti ◽  
...  
Keyword(s):  
Iron Overload ◽  
Chelating Agents ◽  
Chelation Therapy

scholarly journals Synthesis and Evaluation of New Bifunctional Chelators with Phosphonic Acid Arms for Gallium-68 Based PET Imaging in Melanoma

2018 ◽  
Vol 29 (10) ◽  
pp. 3483-3494 ◽  
Author(s):  
Yongkang Gai ◽  
Lingyi Sun ◽  
Xiaoli Lan ◽  
Dexing Zeng ◽  
Guangya Xiang ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Phosphonic Acid ◽  
Bifunctional Chelators ◽  
Gallium 68

scholarly journals Current Biomedical Use of Copper Chelation Therapy

2020 ◽  
Vol 21 (3) ◽  
pp. 1069 ◽  
Author(s):  
Silvia Baldari ◽  
Giuliana Di Rocco ◽  
Gabriele Toietta
Keyword(s):  
Clinical Trials ◽  
Idiopathic Pulmonary Fibrosis ◽  
Genetic Disease ◽  
Copper Concentration ◽  
Chelating Agents ◽  
Chelation Therapy ◽  
Biological Processes ◽  
Copper Chelation ◽  
Excess Copper ◽  
Parkinson’S Diseases

Copper is an essential microelement that plays an important role in a wide variety of biological processes. Copper concentration has to be finely regulated, as any imbalance in its homeostasis can induce abnormalities. In particular, excess copper plays an important role in the etiopathogenesis of the genetic disease Wilson’s syndrome, in neurological and neurodegenerative pathologies such as Alzheimer’s and Parkinson’s diseases, in idiopathic pulmonary fibrosis, in diabetes, and in several forms of cancer. Copper chelating agents are among the most promising tools to keep copper concentration at physiological levels. In this review, we focus on the most relevant compounds experimentally and clinically evaluated for their ability to counteract copper homeostasis deregulation. In particular, we provide a general overview of the main disorders characterized by a pathological increase in copper levels, summarizing the principal copper chelating therapies adopted in clinical trials.

The Structure and Properties Research for Sealing Capsule

2014 ◽  
Vol 1065-1069 ◽  
pp. 1296-1299
Author(s):  
Yong Huan Luo ◽  
Zheng Lin Feng ◽  
Jun Liu ◽  
Hong Feng Guo
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Hong Kong ◽  
Working Conditions ◽  
Basic Structure ◽  
Structure And Properties ◽  
Correlation Model ◽  
Element Analysis ◽  
The Finite Element Analysis ◽  
Pile Cap

This paper, A research for the sealing capsule which used in the construction of the underwater cap of Hong Kong-Zhuhai-Macao Bridge. Through the introduction of precast pile cap construction, combined with the sealing of the capsule works, and the basic structure of the sealing of the capsule with installation design. We establish correlation model, combined with the actual working conditions, the application of the finite element analysis of the sealing capsules water sealing characteristics simulation. It shows that the sealing capsule can well meet the actual needs of the Hong Kong-Zhuhai-Macao Bridge underwater cap construction.

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