scholarly journals Sulfur(VI) Fluoride Exchange (SuFEx)-Mediated Synthesis of the Chitosan-PEG Conjugate and Its Supramolecular Hydrogels for Protein Delivery

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 318
Author(s):  
Kyoung-Je Jang ◽  
Woong-Sup Lee ◽  
Sangbae Park ◽  
Jinsub Han ◽  
Jae Eun Kim ◽  
...  
Keyword(s):  
Protein Delivery ◽  
Drug Carriers ◽  
Pluronic F127 ◽  
Chitosan Derivative ◽  
Supramolecular Hydrogel ◽  
Mild Conditions ◽  
Sulfur Fluoride ◽  
Low Cytotoxicity ◽  
Chitosan Hydrogels

Supramolecular hydrogels are considered promising drug carriers in the tissue engineering field due to their versatile nature. Chitosan hydrogels without chemical cross-linkers have low cytotoxicity and good delivery capacity; however, they have lower mechanical properties for injectable hydrogel usage. In this study, we developed novel chitosan derivatives via click chemistry for fabricating supramolecular hydrogels with higher mechanical strength under mild conditions. The chitosan derivative was successfully synthesized by a sulfur fluoride exchange reaction, and the synthesized chitosan-mPEG/Pluronic-F127 (CS-mPEG/F127) interacted with α-cyclodextrin (α-CD) to form a supramolecular hydrogel via a host-guest reaction. The gelation dynamics, hydrogel properties, and bovine serum albumin (BSA) release could be modulated by the concentration ratio of chitosan-mPEG and F127. This supramolecular hydrogel is a promising protein releasing carrier candidate for long term regeneration therapy.

Near-infrared persistent luminescence hollow mesoporous nanospheres for drug delivery and in vivo renewable imaging

2016 ◽  
Vol 4 (48) ◽  
pp. 7845-7851 ◽  
Author(s):  
Junpeng Shi ◽  
Meng Sun ◽  
Xia Sun ◽  
Hongwu Zhang
Keyword(s):  
Drug Delivery ◽  
Near Infrared ◽  
High Sensitivity ◽  
Drug Carriers ◽  
Template Method ◽  
Persistent Luminescence ◽  
Deep Tissue ◽  
Large Capacity

Near-infrared persistent luminescence hollow mesoporous nanospheres have been synthesized via a template method. These nanospheres can be used as large capacity drug carriers and realize super long-term and high sensitivity tracking of drug delivery in deep tissue.

Biocompatibility Evaluation of Hollow Pollen Grains/Fe3 O4 Nanoparticles Composites as Potential Medical Devices

2021 ◽  
Author(s):  
Solmaz Zakhireh ◽  
Yadollah Omidi ◽  
Younes Beygi-Khosrowshahi ◽  
Ayoub Aghanejad ◽  
Jaleh Barar ◽  
...  
Keyword(s):  
Morphological Analysis ◽  
Pollen Grains ◽  
Building Blocks ◽  
Drug Carriers ◽  
Sem Analysis ◽  
Narrow Region ◽  
In Vitro Biocompatibility ◽  
Apoptosis Related Gene

Recently, pollen grains (PGs) have been introduced as drug carriers and scaffolding building blocks. This study aimed to assess the in-vitro biocompatibility of Pistacia vera L. hollow PGs/Fe3O4 nanoparticles (HPGs/Fe3O4NPs) composites using human adipose-derived mesenchymal stem cells (hAD-MSCs). In this regard, iron oxide nanoparticles (Fe3O4NPs) were assembled on the surface of HPGs at different concentrations. The biocompatibility of the prepared composites was assessed through MTT assay, apoptosis-related gene expression and field emission scanning electron microscopy (FE-SEM) analysis. Compared to the bare HPGs, the HPGs/Fe3O4NPs exhibited a biphasic impact on hAD-MSCs. The composite containing 1% Fe3O4NPs demonstrated no cytotoxicity up to 21 days while higher Fe3O4NPs contents and long-term exposure revealed adverse effects on the hAD-MSCs’ growth. The obtained result was verified by the qRT-PCR and morphological analysis carried out through FE-SEM which suggests that a narrow region below 1% Fe3O4NPs may be the optimum choice for medicinal applications of HPGs/Fe3O4NPs microdevices.

scholarly journals Facile benzene reduction promoted by a synergistically coupled Cu–Co–Ce ternary mixed oxide

2020 ◽  
Vol 11 (22) ◽  
pp. 5766-5771
Author(s):  
Hao Chen ◽  
Wenwen Lin ◽  
Zihao Zhang ◽  
Zhenzhen Yang ◽  
Kecheng Jie ◽  
...  
Keyword(s):  
Mixed Oxide ◽  
Aromatic Rings ◽  
Metal Composites ◽  
Mild Conditions ◽  
Earth Abundant ◽  
Ternary Mixed Oxide

Hydrogenation of aromatic rings promoted by earth-abundant metal composites under mild conditions is an attractive and challenging subject in the long term.

Trehalose Limits BSA Aggregation in Spray-Dried Formulations at High Temperatures: Implications in Preparing Polymer Implants for Long-Term Protein Delivery

2013 ◽  
Vol 102 (8) ◽  
pp. 2655-2666 ◽  
Author(s):  
Karthikan Rajagopal ◽  
Joseph Wood ◽  
Benjamin Tran ◽  
Thomas W. Patapoff ◽  
Thierry Nivaggioli
Keyword(s):  
High Temperatures ◽  
Protein Delivery ◽  
Polymer Implants ◽  
Bsa Aggregation ◽  
Spray Dried

scholarly journals Supramolecular Cyclodextrin-Based Hydrogels for Controlled Gene Delivery

Polymers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 514 ◽  
Author(s):  
Ana Rey-Rico ◽  
Magali Cucchiarini
Keyword(s):  
Gene Delivery ◽  
Delivery Systems ◽  
Controlled Delivery ◽  
Transfer Vectors ◽  
Spatial Presentation ◽  
Temporal And Spatial ◽  
Low Cytotoxicity ◽  
Dna Vectors ◽  
Powerful Strategy

Controlled delivery of gene transfer vectors is a powerful strategy to enhance the temporal and spatial presentation of therapeutic agents in a defined target. Hydrogels are adapted biomaterials for gene delivery capable of acting as a localized depot of genes while maintaining the long term local availability of DNA vectors at a specific location. Supramolecular hydrogels based on cyclodextrins (CDs) have attracted considerable attention as potential biomaterials in a broad range of drug delivery applications. Their unique characteristics of thixotropicity and low cytotoxicity due to their production under mild conditions make them potential candidates to form injectable delivery systems. This work aims to provide an overview of the use of CD-based polypseudorotaxane hydrogels as controlled gene delivery systems for different applications in regenerative medicine.

scholarly journals Silica-supported sulfonic acids as recyclable catalyst for esterification of levulinic acid with stoichiometric amounts of alcohols

2016 ◽  
Vol 12 ◽  
pp. 2173-2180 ◽  
Author(s):  
Raimondo Maggi ◽  
N Raveendran Shiju ◽  
Veronica Santacroce ◽  
Giovanni Maestri ◽  
Franca Bigi ◽  
...  
Keyword(s):  
Sulfonic Acid ◽  
Levulinic Acid ◽  
Active Sites ◽  
Solid Acid ◽  
Value Added ◽  
Acid Catalysts ◽  
Mild Conditions ◽  
Simple Protocol ◽  
Sulfonic Acid Groups

Converting biomass into value-added chemicals holds the key to sustainable long-term carbon resource management. In this context, levulinic acid, which is easily obtained from cellulose, is valuable since it can be transformed into a variety of industrially relevant fine chemicals. Here we present a simple protocol for the selective esterification of levulinic acid using solid acid catalysts. Silica supported sulfonic acid catalysts operate under mild conditions and give good conversion and selectivity with stoichiometric amounts of alcohols. The sulfonic acid groups are tethered to the support using organic tethers. These tethers may help in preventing the deactivation of the active sites in the presence of water.

Long-Term Stability of Optical Properties of Colloidal CdSe Nanocrystals in Polymer Matrices

2019 ◽  
Vol 18 (03n04) ◽  
pp. 1940052
Author(s):  
Yu. M. Azhniuk ◽  
V. V. Lopushansky ◽  
A. V. Gomonnai ◽  
B. V. Lopushanska ◽  
A. E. Raevskaya ◽  
...  
Keyword(s):  
Optical Properties ◽  
Optical Absorption ◽  
Polyvinyl Alcohol ◽  
Aqueous Solutions ◽  
Polymer Matrices ◽  
Cdse Nanocrystals ◽  
Term Stability ◽  
Long Term Stability ◽  
Mild Conditions

Properties of CdSe nanocrystals (NCs) fabricated in aqueous solutions at relatively mild conditions in the presence of gelatine and stabilized in polymer (gelatine, gelatine + polyvinylpyrrolidone, polyvinyl alcohol) matrices are characterized by Raman, optical absorption and photoluminescence spectroscopies. The effect of heating of the reaction mixture on the average NC size is discussed.

scholarly journals Non-cytotoxic hydroxyl-functionalized exfoliated boron nitride nanoflakes impair the immunological function of insect haemocytes in vivo

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Elżbieta Czarniewska ◽  
Lucyna Mrówczyńska ◽  
Magdalena Jędrzejczak-Silicka ◽  
Patryk Nowicki ◽  
Martyna Trukawka ◽  
...  
Keyword(s):  
Boron Nitride ◽  
Water Solubility ◽  
Hexagonal Boron Nitride ◽  
Hydroxyl Groups ◽  
Latex Beads ◽  
Insect Haemocytes ◽  
Low Cytotoxicity

Abstract To induce the water solubility of hexagonal boron nitride (h-BN), we exfoliated and functionalized bulk h-BN with hydroxyl groups (h-BN-OH-n). Short-term studies showed that h-BN-OH-n induced low cytotoxicity in different models: insect haemocytes (in vivo), human erythrocytes and mouse fibroblasts (in vitro). We also demonstrated that Alexa Fluor 647-h-BN-OH-n administered topically to the insects passed through the cuticle barrier and was phagocytosed by haemocytes. Nanoflakes did not affect the haemocyte cell membrane and did not interfere with the phagocytosis of latex beads. Long-term immunoassays showed that h-BN-OH-n, despite not inducing haemocytotoxicity, impaired nodulation, the most important cellular immune response in insects. The haemocytes exposed to h-BN-OH-n and then to bacteria differed in morphology and adhesiveness from the haemocytes exposed only to bacteria and exhibited the same morphology and adhesiveness as the control haemocytes. The h-BN-OH-n-induced decrease in nodulation can therefore result from the reduced ability of haemocytes to recognize bacteria, migrate to them or form microaggregates around them, which can lead to dysfunction of the immune system during pathogen infection. Long-term in vivo studies with animal models are still necessary to unambiguously confirm that h-BN is biocompatible and useful for application as a platform for drug delivery or for bioimaging.

Antibacterial PEG-Chitosan Hydrogels for Controlled Antibiotic/Protein Delivery

2019 ◽  
Vol 2 (12) ◽  
pp. 5313-5322 ◽  
Author(s):  
Peeyush Kumar Sharma ◽  
Moumita Halder ◽  
Udit Srivastava ◽  
Yashveer Singh
Keyword(s):  
Protein Delivery ◽  
Chitosan Hydrogels
Sign in / Sign up

Export Citation Format

Share Document