scholarly journals Incorporation of Manganese Complexes within Hybrid Resol-Silica and Carbon-Silica Nanoparticles

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 774
Author(s):  
François-Xavier Turquet ◽  
Montserrat Corbella ◽  
Clémentine Fellah ◽  
Gilles Montagnac ◽  
Bruno Reynard ◽  
...  

The incorporation of a luminescent probe into a nano-vector is one of the approaches used to design chemosensors and nanocargos for drug delivery and theranostics. The location of the nano-vector can be followed using fluorescence spectroscopy together with the change of environment that affects the fluorescence properties. The ligand 9-anthracene carboxylate is proposed in this study as a luminescent probe to locate two types of manganese complexes inside three series of porous nanoparticles of different composition: resol-silica, carbon-silica and pure silica. The manganese complexes are a tetranuclear MnIII cluster [MnIII4(μ-O)2(μ-AntCO2)6(bpy)2(ClO4)2] with a butterfly core, and a MnII dinuclear complex [{MnII(bpy)(AntCO2)}2(μ-AntCO2)2(μ-OH2)]. The magnetic measurements indicate that both complexes are present as dinuclear entities when incorporated inside the particles. Both the Mn complexes and the nanoparticles are luminescent. However, when the metal complexes are introduced into the nanoparticles, the luminescent properties of both are altered. The study of the fluorescence of the nanoparticles’ suspensions and of the supernatants shows that MnII compounds seem to be more retained inside the particles than MnIII compounds. The resol-silica nanoparticles with MnII complexes inside is the material that presents the lowest complex leaching in ethanol.

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.


Talanta ◽  
2021 ◽  
Vol 231 ◽  
pp. 122402
Author(s):  
Rongrong Jin ◽  
Jiaxi Wang ◽  
Mingxia Gao ◽  
Xiangmin Zhang

2018 ◽  
Vol 6 (39) ◽  
pp. 6269-6277 ◽  
Author(s):  
Yaya Cheng ◽  
Xiangyu Jiao ◽  
Liang Zhao ◽  
Yang Liu ◽  
Fang Wang ◽  
...  

Inspired by aquaporins in nature, herein, a biomimetic free-blocking on-demand drug delivery system is proposed, which is constructed by controlling the wettability of the inner surface of nanochannels on mesoporous silica nanoparticles (MSNs).


Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3321
Author(s):  
Etienne J. Slapak ◽  
Lily Kong ◽  
Mouad el Mandili ◽  
Rienk Nieuwland ◽  
Alexander Kros ◽  
...  

Pancreatic ductal adenocarcinoma (PDAC) has the worst survival rate of all cancers. This poor prognosis results from the lack of efficient systemic treatment regimens, demanding high-dose chemotherapy that causes severe side effects. To overcome dose-dependent toxicities, we explored the efficacy of targeted drug delivery using a protease-dependent drug-release system. To this end, we developed a PDAC-specific drug delivery system based on mesoporous silica nanoparticles (MSN) functionalized with an avidin–biotin gatekeeper system containing a protease linker that is specifically cleaved by tumor cells. Bioinformatic analysis identified ADAM9 as a PDAC-enriched protease, and PDAC cell-derived conditioned medium efficiently cleaved protease linkers containing ADAM9 substrates. Cleavage was PDAC specific as conditioned medium from leukocytes was unable to cleave the ADAM9 substrate. Protease linker-functionalized MSNs were efficiently capped with avidin, and cap removal was confirmed to occur in the presence of PDAC cell-derived ADAM9. Subsequent treatment of PDAC cells in vitro with paclitaxel-loaded MSNs indeed showed high cytotoxicity, whereas no cell death was observed in white blood cell-derived cell lines, confirming efficacy of the nanoparticle-mediated drug delivery system. Taken together, this research introduces a novel ADAM9-responsive, protease-dependent, drug delivery system for PDAC as a promising tool to reduce the cytotoxicity of systemic chemotherapy.


2012 ◽  
Vol 2012 ◽  
pp. 1-20 ◽  
Author(s):  
María Vallet-Regí

Mesoporous silica nanoparticles are receiving growing attention by the scientific biomedical community. Among the different types of inorganic nanomaterials, mesoporous silica nanoparticles have emerged as promising multifunctional platforms for nanomedicine. Since their introduction in the drug delivery landscape in 2001, mesoporous materials for drug delivery are receiving growing scientific interest for their potential applications in the biotechnology and nanomedicine fields. The ceramic matrix efficiently protects entrapped guest molecules against enzymatic degradation or denaturation induced by pH and temperature as no swelling or porosity changes take place as a response to variations in the surrounding medium. It is possible to load huge amounts of cargo into the mesopore voids and capping the pore entrances with different nanogates. The application of a stimulus provokes the nanocap removal and triggers the departure of the cargo. This strategy permits the design of stimuli-responsive drug delivery nanodevices.


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