scholarly journals A Review on the Protective Effects of Honey against Metabolic Syndrome

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1009 ◽  
Author(s):  
Nur Ramli ◽  
Kok-Yong Chin ◽  
Khairul Zarkasi ◽  
Fairus Ahmad
Keyword(s):  
Metabolic Syndrome ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Therapeutic Agents ◽  
Protective Effects ◽  
Excessive Weight Gain ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Excessive Weight ◽  
Sugar Levels

Metabolic syndrome (MetS) is a cluster of diseases comprising of obesity, diabetes mellitus, dyslipidemia, and hypertension. There are numerous pre-clinical as well as human studies reporting the protective effects of honey against MetS. Honey is a nutritional food low in glycemic index. Honey intake reduces blood sugar levels and prevents excessive weight gain. It also improves lipid metabolism by reducing total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and increasing high-density lipoprotein (HDL), which leads to decreased risk of atherogenesis. In addition, honey enhances insulin sensitivity that further stabilizes blood glucose levels and protects the pancreas from overstimulation brought on by insulin resistance. Furthermore, antioxidative properties of honey help in reducing oxidative stress, which is one of the central mechanisms in MetS. Lastly, honey protects the vasculature from endothelial dysfunction and remodelling. Therefore, there is a strong potential for honey supplementation to be integrated into the management of MetS, both as preventive as well as adjunct therapeutic agents.

scholarly journals ASSOCIATION BETWEEN BLOOD LIPID PROFILE AND BLOOD GLUCOSE LEVELS IN MEN WITH CORONARY HEART DISEASE, METABOLIC SYNDROME, AND TYPE 2 DIABETES MELLITUS

2013 ◽  
Vol 12 (5) ◽  
pp. 29-33
Author(s):  
S. A. Matveeva
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Lipoprotein Cholesterol ◽  
Blood Lipid Profile ◽  
Glucose Levels ◽  
Blood Glucose Levels

Aim.To study the associations between blood lipid profile and blood glucose levels in men with coronary heart disease (CHD), stable effort angina (SEA), metabolic syndrome (MS), and Type 2 diabetes mellitus (DM-2).Material and methods.The study included 82 men (mean age 50,5±0,9 years) with CHD, Functional Class I–III SEA, MS, and DM-2. The following lipid profile parameters were assessed: total cholesterol (TCH), triglycerides (TG), low-density lipoprotein cholesterol (LDL–CH), very low-density lipoprotein cholesterol (VLDL–CH), high-density lipoprotein cholesterol (HDL–CH), atherogenic index (AI), and triglyceride index (TGI), together with fasting blood glucose.Results.There were positive (direct) associations between higher levels (>90th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, HDL–CH, AI, TGI) and blood glucose, as well as between lower levels (≤10th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, AI, TGI) and blood glucose. At the same time, there were negative (inverse) associations between lower lipid levels (≤10th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and higher glucose levels (>90th percentile), as well as between higher lipid levels (>90th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and lower glucose levels (≤10th percentile).Conclusion.Dyslipidemia and hyperglycemia demonstrate synergetic proatherogenic effects in patients with CHD, SEA, MS, and DM-2, as suggested by significant heterogeneous (direct and inverse) associations between lipid profile parameters and fasting blood glucose. The results obtained provide an opportunity for the assessment of risk levels, prognosis, and need for pharmacological prevention and treatment in patients with combined cardiovascular pathology. 

scholarly journals Hypoglycemic potential of Trixis angustifolia aqueous extract in alloxan-induced diabetic mice

2019 ◽  
Vol 14 (2) ◽  
pp. 74-79 ◽  
Author(s):  
Anuar Salazar-Gómez ◽  
María Elena Vargas-Díaz ◽  
Leticia Garduño-Siciliano
Keyword(s):  
Aqueous Extract ◽  
Reducing Sugars ◽  
Low Density Lipoprotein ◽  
Folk Medicine ◽  
Density Lipoprotein ◽  
Diabetic Mice ◽  
Glucose Levels ◽  
Hypoglycemic Agent ◽  
Aerial Parts ◽  
Blood Glucose Levels

The aim of the present study was to evaluate the hypoglycemic potential of Trixis angustifolia in alloxan-induced diabetic mice. An intragastric adminis-tration of the aqueous extract (50, 100 and 200 mg/kg) prepared from the aerial parts of T. angustifolia was evaluated. The treatment with the extract at 100 mg/kg produced a significant lowered (30.5%) of the blood glucose levels in diabetic mice after 15 days of daily oral administration. In addition, the extract induced a significant decrease in serum total cholesterol, low density lipoprotein whereas increased the high-density lipoprotein level. Additionally, the presence of alkaloids, cumarins, saponins, flavonoids and reducing sugars were identified in the extract. These findings provide a basis explain-ing the traditional folk medicine use of this plant as a hypoglycemic agent by the Mexican people.

Effect of Curcumin on the Level of Blood Lipid and Blood Glucose in Diabetic Rat Model

2014 ◽  
Vol 1051 ◽  
pp. 419-422
Author(s):  
Ming San Miao ◽  
Lin Guo ◽  
Shuo Tian ◽  
Tan Wang
Keyword(s):  
Blood Glucose ◽  
Rat Model ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Lipoprotein Cholesterol ◽  
Diabetic Rat ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Diabetic Rat Model

Objective: To investigate the effects of curcumin on blood lipid and blood glucose levels and its mechanism in diabetic rat model. Method: After streptozotocin (STZ) induced diabetic rat model, large, medium and small doses of curcumin group were partly given curcumin solution 400,200,100mg·kg-1, administered once a day, continuously 30 days. In 30 th day, determine blood glucose (BG) value, after the last injection , determine the serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels. Results: Compared with the model group rats, each dose of curcumin group rats’ BG, TC, TG and LDL-C levels were significantly decreased, HDL-C levels was increased significantly. Conclusion: Curcumin has a certain impact on blood lipids and blood glucose in diabetic rat model.

scholarly journals Supplementation with Low Doses of a Cod Protein Hydrolysate on Glucose Regulation and Lipid Metabolism in Adults with Metabolic Syndrome: A Randomized, Double-Blind Study

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1991 ◽  
Author(s):  
Caroline Jensen ◽  
Hanna Fjeldheim Dale ◽  
Trygve Hausken ◽  
Jan Gunnar Hatlebakk ◽  
Ingeborg Brønstad ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Composition ◽  
Lipid Profile ◽  
Protein Hydrolysate ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Postprandial Glucose ◽  
Double Blind Study ◽  
Double Blind ◽  
Glucose Levels

The risk of cardiovascular diseases and type 2 diabetes mellitus are increased in subjects with metabolic syndrome (MetS), and hydrolyzed fish protein may have favorable effects on metabolic health. Here, we investigated the effect of 8 weeks supplementation with 4 g of cod protein hydrolysate (CPH) on glucose metabolism, lipid profile and body composition in individuals with MetS in a double-blind, randomized intervention study with a parallel-group design. Subjects received a daily supplement of CPH (n = 15) or placebo (n = 15). Primary outcomes were serum fasting and postprandial glucose levels. Secondary outcomes were fasting and postprandial insulin and glucagon-like peptide 1 (GLP-1), fasting lipid concentrations and body composition. No difference was observed between CPH and placebo for insulin, glucose or GLP-1 after 8 weeks intervention. Fasting triacylglycerol decreased in both the CPH group and placebo group, with no change between groups. Fasting total cholesterol and low-density lipoprotein cholesterol decreased significantly within both groups from baseline to study end, but no difference was observed between the two groups. In conclusion, supplementing with a low dose of CPH in subjects with MetS for 8 weeks had no effect on fasting or postprandial levels of insulin, glucose or GLP-1, lipid profile or body composition.

scholarly journals Bilberry Anthocyanins Ameliorate NAFLD by Improving Dyslipidemia and Gut Microbiome Dysbiosis

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3252
Author(s):  
Hironobu Nakano ◽  
Shusong Wu ◽  
Kozue Sakao ◽  
Taichi Hara ◽  
Jianhua He ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gut Microbiome ◽  
Smooth Muscle Actin ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Thiobarbituric Acid ◽  
Serum Levels ◽  
Protective Effects ◽  
Alcoholic Fatty Liver ◽  
Preventive Effects

Non-alcoholic fatty liver disease (NAFLD) is a manifestation of metabolic syndrome closely linked to dyslipidemia and gut microbiome dysbiosis. Bilberry anthocyanins (BA) have been reported to have preventive effects against metabolic syndrome. This study aimed to investigate the protective effects and mechanisms of BA in a Western diet (WD)-induced mouse model. The results revealed that supplementation with BA attenuated the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein cholesterol (LDL-c), fat content in liver, 2-thiobarbituric acid reactive substances (TBARS) and α-smooth muscle actin (α-SMA) caused by WD. Furthermore, gut microbiota characterized by 16S rRNA sequencing revealed that BA reduced remarkably the ratio of Firmicutes/Bacteroidetes (F/B) and modified gut microbiome. In particular, BA increased the relative abundance of g_Akkermansia and g_Parabacteroides. Taken together, our data demonstrated that BA might ameliorate WD-induced NAFLD by attenuating dyslipidemia and gut microbiome dysbiosis.

scholarly journals Oxoprolinic short peptides – potential pharmacological means of hypolidemic and antitrombotic actions

2017 ◽  
Vol 63 (6) ◽  
pp. 546-552 ◽  
Author(s):  
N.F. Myasoedov ◽  
L.A. Lyapina ◽  
L.A. Andreeva ◽  
T.Yu. Obergan ◽  
M.E. Grigoryeva ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Regulatory Peptides ◽  
The Body ◽  
Lipid Lowering ◽  
Pharmacological Agents ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Antithrombotic Effects ◽  
The Relationship

One of the most urgent and important tasks of modern biological and medical research is the search and research of pharmacological agents that combine lipid-lowering and antithrombotic effects in the organism. The unique effects of the regulatory peptides of the oxoproline series (5-oхo-Pro-His-Pro-NH2, 5-oxo-Pro-Trp-Pro and 5-oxo-Pro-Arg-Pro or 5-oхo-Pro-His-Pro-NH2, Pyr-Trp-Pro and Pyr-Arg-Pro) have been found in rats with hypercholesterolemia (metabolic syndrome). Multiple intranasal of these peptides to animals with developed hypercholesterolemia increased anticoagulant, fibrinolytic and antiplatelet potential of the blood and simultaneously lowered increased concentrations of total cholesterol, low-density lipoprotein cholesterol and triglycerides. In addition, they contributed to the normalization of blood glucose levels. A week after the last admistration of these peptides, the hypocholesterolemic, normoglycemic and anticoagulant effects persisted. The relationship between the structure of peptides of the oxoproline series and their functional properties is discussed. A conclusion is made about the prospects of further studies of oxoproline peptides as drugs that combine antithrombotic effects with the improvement of fat metabolism in the body.

scholarly journals ANTIHYPERGLYCEMIC, ANTIOXIDANT, AND ANTIHYPERLIPIDEMIC ACTIVITIES OF EXTRACT FROM COCCINIA GRANDIS (L.) VOIGT. LEAVES BY METHANOL ON ALLOXAN INDUCED HYPERGLYCEMIC MICE

2018 ◽  
Vol 16 (2) ◽  
pp. 311-318
Author(s):  
Dai Thi Xuan Trang ◽  
Vo Chi Linh ◽  
Nguyen Thi Ai Lan
Keyword(s):  
Body Weight ◽  
Antioxidant Activities ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Glucose Levels ◽  
Coccinia Grandis ◽  
Blood Glucose Levels ◽  
Alloxan Monohydrate ◽  
Antioxidant Effects

The aim of this study was to investigate antihyperglycemic, antihyperlipidemic and antioxidant activities of the extract of Coccinia grandis leaves (CGL) by methanol in alloxan induced diabetic mice. Hyperglycemic was induced in mice by administration of alloxan monohydrate (135 mg/kg, ip.). CGL was orally given to the normal mice (100 and 1000 mg/kg body weight) to determine the toxicity of CGL. Hyperglycemic mice were treated with the extract of CGL (100 mg/kg body weight/ twice a day). Glucophage, diabetic commercially available drug, was used as a possitive control with dose of 108 mg/kg body weight/twice a day. Mice were administered with both glucophage and CGL extract orally during 21 days. On the 21st day of the experiment, mice blood, liver and brain samples were collected to test biochemical parameters and antioxidant levels. CGL did not show toxicity and death up to dose 1000 mg/kg in mice. Administration of CGL 100 mg/kg significantly (p<0.05) reduced blood glucose levels in alloxan induced hyperglycemic mice. Besides, several serum lipid values including total cholecterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) reduced while high density lipoprotein cholesterol (HDL-C) increased. Malondialdehyde (MDA) in a group of untreated hyperglycemic mice was statistically higher than that of nomal mice. The MDA levels of livers and brains in the CGL treated hyperglycemic mice were lower than that of hyperglycemic control. The effects of hypoglycemic, antihyperlipidemic and antioxidant of CGL were higher than that of glucophage. The total polyphenols and flavonoids contents of the leaf extract were 607,41 + 14,44 mg gallic acid or quercetin equivalents/g and 111,72 + 1,94 mg equivalents/g, respectively. In conclusion, the antihyperglycemic, antihyperlipidemic and antioxidant effects of the CGL suggest a potential therapeutictreatment for hyperglycemic conditions.

scholarly journals Antibodies against phosphorylcholine in hospitalized versus non-hospitalized obese subjects

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Amra Jujić ◽  
J. Korduner ◽  
H. Holm ◽  
G. Engström ◽  
E. Bachus ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Smoking Status ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Glucose Levels ◽  
History Of ◽  
Obese Subjects ◽  
Anti Inflammatory

AbstractObesity associates with reduced life expectancy, type 2 diabetes, hypertension and cardiovascular disease, and is characterized by chronic inflammation. Phosphorylcholine (PC) is an epitope on oxidized low-density lipoprotein, dead cells and some microorganisms. Antibodies against PC (anti-PC) have anti-inflammatory properties. Here, we explored the role of anti-PC in hospitalized versus non-hospitalized obese. One-hundred-and-twenty-eight obese (BMI ≥ 30 kg/m2) individuals (59.8 (± 5.5) years, 53.9% women) from the Malmö Diet and Cancer Cardiovascular Cohort were examined and IgM, IgG1 and IgG2 anti-PC were analyzed by ELISA. Individuals with at least one recorded history of hospitalization prior to study baseline were considered hospitalized obese (HO). Associations between IgM, IgG1 and IgG2 anti-PC and HO (n = 32)/non-hospitalized obese (NHO) (n = 96), but also with metabolic syndrome and diabetes were analysed using logistic regressions. Both IgM and IgG1 anti-PC were inversely associated with HO, also after controlling for age and sex. When further adjusted for waist circumference, systolic blood pressure, glucose levels and smoking status, only IgG1 anti-PC remained significantly associated with HO. In multivariate models, each 1 standard deviation of increment in anti-PC IgG1 levels was inversely associated with prevalence of HO (odds ratio 0.57; CI 95% 0.33–0.98; p = 0.044). IgG2 anti-PC did not show any associations with HO. Low levels of IgM and IgG1 anti-PC are associated with higher risk of being a HO individual independent of sex and age, IgG1 anti-PC also independently of diabetes and metabolic syndrome. The anti-inflammatory properties of these antibodies may be related to inflammation in obesity and its complications.

Antidiabetic and antihyperlipidemic potential of ethanol extract of Salacia lehmbachii stem bark in alloxan-induced diabetic rats

2018 ◽  
Vol 30 (2) ◽  
pp. 239-244
Author(s):  
Godwin C. Akuodor ◽  
Linus K. Eban ◽  
Gloria Ahunna Ajoku ◽  
Ndubuisi N. Nwobodo ◽  
Joseph L. Akpan ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Stem Bark ◽  
Diabetic Rats ◽  
Bark Extract ◽  
Low Density ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Treatment Of Diabetes ◽  
Stem Bark Extract

Abstract Background Salacial lehmbachii stem bark is used traditionally for the treatment of diabetes mellitus and its associated complications. Treatment of diabetes is necessary to reduce these complications. Methods In this study, the antidiabetic and antihyperlipidemic potential of S. lehmbachii ethanol stem bark extract was evaluated in alloxan-induced diabetic rats at a dose of 100 mg/kg, 200 mg/kg, and 400 mg/kg p.o. daily for 21 days. Blood glucose levels, serum total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), and very low density lipoprotein (VLDL) were assessed in the animals. Results Treatment of alloxan-induced diabetic rats with S. lehmbachii stem bark extract showed significant (p<0.01) reduction in blood glucose levels when compared with diabetic control. The elevated levels of serum cholesterol, triglycerides, LDL, and VLDL were significantly (p<0.01) reduced by S. lehmbachii stem bark extract, while the level of HDL significantly (p<0.01) increased. Conclusions The results obtained suggest that S. lehmbachii stem bark extract has the potential to treat diabetes condition and hyperlipidemic disorders.

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