scholarly journals Assessment of Vitamin C and Antioxidant Profiles in Saliva and Serum in Patients with Periodontitis and Ischemic Heart Disease

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2956 ◽  
Author(s):  
Gaetano Isola ◽  
Alessandro Polizzi ◽  
Simone Muraglie ◽  
Rosalia Leonardi ◽  
Antonino Lo Giudice
Keyword(s):  
Heart Disease ◽  
Vitamin C ◽  
Ischemic Heart Disease ◽  
Serum Vitamin ◽  
Multivariate Model ◽  
Ischemic Heart ◽  
Reactive Protein ◽  
Gingival Health ◽  
Hs Crp ◽  
Β Carotene

Vitamin C and antioxidants play a crucial role in endothelial function and may be a link for the known interaction of periodontitis and ischemic heart disease (CAD). This pilot study evaluates the association of gingival health, periodontitis, CAD, or both conditions with salivary and serum vitamin C and antioxidant levels. The clinical and periodontal characteristics, serum, and saliva samples were collected from 36 patients with periodontitis, 35 patients with CAD, 36 patients with periodontitis plus CAD, and 36 healthy controls. Levels of vitamin C, antioxidants, and C-reactive protein (hs-CRP) were assessed with a commercially available kit. The median concentrations of salivary and serum vitamin C and antioxidants (α-tocopherol, β-carotene, lutein, and lycopene) were significantly lower in the CAD group (p < 0.001) and in the periodontitis plus CAD group (p < 0.001) compared to periodontitis patients and controls. In univariate models, periodontitis (p = 0.034), CAD (p < 0.001), and hs-CRP (p < 0.001) were significantly negatively associated with serum vitamin C; whereas, in a multivariate model, only hs-CRP remained a significant predictor of serum vitamin C (p < 0.001). In a multivariate model, the significant predictors of salivary vitamin C levels were triglycerides (p = 0.028) and hs-CRP (p < 0.001). Patients with CAD and periodontitis plus CAD presented lower levels of salivary and serum vitamin C compared to healthy subjects and periodontitis patients. hs-CRP was a significant predictor of decreased salivary and serum vitamin C levels.

scholarly journals COMPARATIVE STUDY OF LEVELS OF SELECTIVE OXIDATIVE STRESS MARKERS (MALONDIALDEHYDE, ZINC, AND ANTIOXIDANT VITAMINS A, E, AND C) IN ISCHEMIC AND NON-ISCHEMIC HEART DISEASE PATIENTS SUFFERING FROM TYPE- 2 DIABETES

2018 ◽  
Vol 11 (8) ◽  
pp. 508
Author(s):  
Abd Elgadir A Altoum ◽  
Ahmed L Osman ◽  
Asaad Ma Babker
Keyword(s):  
Oxidative Stress ◽  
Heart Disease ◽  
Vitamin A ◽  
Ischemic Heart Disease ◽  
Serum Vitamin ◽  
Antioxidant Vitamins ◽  
Ischemic Heart ◽  
Diabetic Patients ◽  
Oxidative Stress Markers ◽  
Stress Markers

Objective: The objective of the current study is to compare the levels of oxidative stress markers malondialdehyde (MDA), zinc, and antioxidant Vitamins (A, E, and C) in ischemic heart disease (IHD) and non-IHD patients with diabetes mellitus.Method: This is cross-sectional study group, conducted in the advanced diagnostic center (Khartoum- Sudan) from the period May 2013 to August 2015. Comprised 100 healthy subjects were, control group with mean (fasting blood sugar) 5.61=m mol/L, the age ranged from 22 to 78 years old, the average of the age was 50.1 years. 300 patients (78 IHD and 222 without) as cases groups, the ages ranged from 30 to 80 years. The age average was 51.2 years, all samples were in a state of fasting for 12 h, and the data were collected using a structured questionnaire and direct interview to collect information. Blood specimens were collected from both groups, and plasma levels of MDA, zinc, and antioxidant Vitamins (A, E, and C) were determined.Results: There was a significant difference between the level of serum Vitamin A, E, and MDA in diabetic patients with IHD and those diabetic without IHD (p<0.05). No significant differences in serum Vitamin C level between both groups (p>0.05).Conclusion: Due to the significant differences in serum Vitamin A, E, Zinc, and MDA between diabetics with IHD and diabetics without IHD, these parameters can be used as prognostic markers for prediction of oxidative stress and antioxidant stress of diabetic patients with IHD complications.

GENETICALLY ELLEVATED C-REACTIVE PROTEIN AND ISCHEMIC HEART DISEASE: THREE MENDELIAN RANDOMIZATION STUDIES

2008 ◽  
Vol 9 (1) ◽  
pp. 81
Author(s):  
J. Zacho ◽  
A. Tybjaerg-Hansen ◽  
J. SkovJensen ◽  
P. Grande ◽  
B.G. Nordestgaard
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Mendelian Randomization ◽  
Ischemic Heart ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals C-Reactive Protein, Fibrin D-Dimer, and Incident Ischemic Heart Disease in the Speedwell Study

2001 ◽  
Vol 21 (4) ◽  
pp. 603-610 ◽  
Author(s):  
Gordon D. O. Lowe ◽  
John W. G. Yarnell ◽  
Ann Rumley ◽  
David Bainton ◽  
Peter M. Sweetnam
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
D Dimer

scholarly journals Elaboration of New Medical Technology for Predicting the Risk of Ischemic Heart Disease in the Workers of the Coal Industry

2019 ◽  
Vol 4 (3) ◽  
pp. 52-57 ◽  
Author(s):  
N. I. Panev ◽  
S. N. Filimonov ◽  
O. Yu. Korotenko ◽  
R. N. Panev ◽  
N. Ya. Paneva
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Genetic Markers ◽  
Medical Technology ◽  
Density Lipoprotein ◽  
Morphological Type ◽  
Coal Industry ◽  
Ischemic Heart ◽  
C Reactive Protein ◽  
Reactive Protein

Background. Ischemic heart disease is the leading cause of death in the majority of developed countries, including Russia. It determines the importance of elaboration of individual risk prediction of ischemic heart disease for primary prevention.Aim: to develop a strategy for predicting the ischemic heart disease in coal industry workers.Materials and methods. Ischemic heart disease incidence and its risk factors were studied in 196 coalmine workers (sinkers, stope miners). Rose Questionnaire, daily ECG monitoring and bicycle ergometry were used to detect angina. The indices of lipid metabolism, hemostatic system, the level of homocysteine, uric acid, C-reactive protein, constitutional-morphological type by Rees – Eysenck, genetic markers of blood groups of AB0, P and MN systems were studied.When elaborating the prognostic system, we used the Bayes method. A prognostic coefficient was calculated for each factor. Prediction of ischemic heart disease was carried out according to the sum of prognostic coefficients.Results. Ischemic heart disease was detected in 18 (9.2 %) miners. According to the above mentioned indices, a medical technology was elaborated to predict the ischemic heart disease, based on the determination of the most significant risk markers: age, work experience in harmful working conditions, type A behavior, arterial hypertension, fasting hyperglycemia, metabolic syndrome, hypercholesterolemia, decrease in the level of high density lipoprotein cholesterol, increase in the value of low density lipoprotein cholesterol, hypertriglyceridemia, hyperhomocysteinemia, hyperfibrinogenemia, increase in the level of soluble fibrin monomer complexes and C-reactive protein, abdominal obesity, hypersthenic constitutional-morphological type by Rees – Eysenck, genetic markers of blood groups of AB0, P and MN systems.Conclusion. Based on the most significant markers, a personalized strategy for ischemic heart disease prediction in miners was elaborated, which allowed timely undertaking therapeutic and preventive measures.

scholarly journals Serum LOX-1, ADMA and hs-CRP as Biomarkers of Ischemic Heart Disease in Chronic kidney Disease Patients

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
youssf Nassar ◽  
Ahmed Harfoosh ◽  
Ahmed Abd El Aziz ◽  
Asmaa Saleh ◽  
noura Mostafa
Keyword(s):  
Chronic Kidney Disease ◽  
Heart Disease ◽  
Kidney Disease ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Hs Crp
Sign in / Sign up

Export Citation Format

Share Document