scholarly journals Differential Effects of Post-Weaning Diet and Maternal Obesity on Mouse Liver and Brain Metabolomes

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1572
Author(s):  
Sofiane Safi-Stibler ◽  
Etienne A. Thévenot ◽  
Luc Jouneau ◽  
Mélanie Jouin ◽  
Alexandre Seyer ◽  
...  
Keyword(s):  
Weight Loss ◽  
Energy Homeostasis ◽  
Maternal Obesity ◽  
Maternal Diet ◽  
Weight Changes ◽  
Maternal Weight ◽  
Long Term Effect ◽  
The Impact

Nutritional changes during developmental windows are of particular concern in offspring metabolic disease. Questions are emerging concerning the role of maternal weight changes before conception, particularly for weight loss, in the development of diet-related disorders. Understanding the physiological pathways affected by the maternal trajectories in the offspring is therefore essential, but a broad overview is still lacking. We recently reported both metabolic and behavioral negative outcomes in offspring born to obese or weight-loss mothers and fed a control of high-fat diet, suggesting long-term modeling of metabolic pathways needing to be further characterized. Using non-targeted LC–HRMS, we investigated the impact of maternal and post-weaning metabolic status on the adult male offspring’s metabolome in three tissues involved in energy homeostasis: liver, hypothalamus and olfactory bulb. We showed that post-weaning diet interfered with the abundance of several metabolites, including 1,5-anhydroglucitol, saccharopine and β-hydroxybutyrate, differential in the three tissues. Moreover, maternal diet had a unique impact on the abundance of two metabolites in the liver. Particularly, anserine abundance, lowered by maternal obesity, was normalized by a preconceptional weight loss, whatever the post-weaning diet. This study is the first to identify a programming long-term effect of maternal preconception obesity on the offspring metabolome.

scholarly journals Maternal High-Fat–High-Carbohydrate Diet-Induced Obesity Is Associated with Increased Appetite in Peripubertal Male but Not Female C57Bl/6J Mice

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2919 ◽  
Author(s):  
Debra Kulhanek ◽  
Rachel Weigel ◽  
Megan E. Paulsen
Keyword(s):  
Energy Homeostasis ◽  
Maternal Obesity ◽  
Maternal Nutrition ◽  
Maternal Diet ◽  
Critical Role ◽  
Caloric Intake ◽  
Maternal Weight ◽  
High Fat ◽  
High Carbohydrate ◽  
Nutritional Influences

Diet-induced maternal obesity might play a critical role in altering hypothalamic development, predisposing the offspring to obesity and metabolic disease later in life. The objective of this study was to describe both phenotypic and molecular sex differences in peripubertal offspring energy homeostasis, using a mouse model of maternal obesity induced by a high-fat–high-carbohydrate (HFHC) diet. We report that males, not females, exposed to a maternal HFHC diet had increased energy intake. Males exposed to a maternal HFHC diet had a 15% increased meal size and a 46% increased frequency, compared to the control (CON) males, without a change in energy expenditure. CON and HFHC offspring did not differ in body weight, composition, or plasma metabolic profile. HFHC diet caused decreased hypothalamic glucocorticoid expression, which was further decreased in males compared to females. Maternal weight, maternal caloric intake, and male offspring meal frequency were inversely correlated with offspring hypothalamic insulin receptor (IR) expression. There was a significant interaction between maternal-diet exposure and sex in hypothalamic IR. Based on our preclinical data, we suggest that interventions focusing on normalizing maternal nutrition might be considered to attenuate nutritional influences on obesity programming and curb the continuing rise in obesity rates.

Covid-19 In Man: A Very Dangerous Affair.

2021 ◽  
Vol 21 ◽  
Author(s):  
Giuseppe Lisco ◽  
Vito A. Giagulli ◽  
Giovanni De Pergola ◽  
Anna De Tullio ◽  
Edoardo Guastamacchia ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Metabolic Diseases ◽  
Systemic Disease ◽  
Public Health Issue ◽  
Immune System Dysfunction ◽  
Data Support ◽  
Systemic Spread ◽  
The Impact

Background: The novel pandemic of Coronavirus disease 2019 (COVID-19) has becoming a public health issue since March 2020 considering that more than 30 million people were found to be infected worldwide. Particularly, recent evidences suggested that men may be considered as at higher risk of poor prognosis or death once the infection occurred and concerns surfaced in regard of the risk of a possible testicular injury due to SARS-CoV-2 infection. Results: Several data support the existence of a bivalent role of testosterone (T) in driving poor prognosis in patients with COVID-19. On one hand, this is attributable to the fact that T may facilitate SARS-CoV-2 entry in human cells by means of an enhanced expression of transmembrane serine-protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2). At the same time, younger man with normal testicular function compared to women of similar age are prone to develop a blunted immune response against SARS-CoV-2, being exposed to less viral clearance and more viral shedding and systemic spread of the disease. Conversely, low levels of serum T observed in hypogonadal men predispose them to a greater background systemic inflammation, cardiovascular and metabolic diseases, and immune system dysfunction, hence driving harmful consequences once SARS-CoV-2 infection occurred. Finally, SARS-CoV-2, as a systemic disease, may also affect testicles with possible concerns for current and future testicular efficiency. Preliminary data suggested that SARS-CoV-2 genome is not normally found in gonads and gametes, therefore sex transmission could be excluded as a possible way to spread the COVID-19. Conclusion: Most data support a role of T as a bivalent risk factor for poor prognosis (high/normal in younger; lower in elderly) in COVID-19. However, the impact of medical treatment aimed to modify T homeostasis for improving the prognosis of affected patients is unknown in this clinical setting. In addition, testicular damage may be a harmful consequence of the infection even in case it occurred asymptomatically but no long-term evidences are currently available to confirm and quantify this phenomenon. Different authors excluded the presence of SARS-CoV-2 in sperm and oocytes, thus limiting worries about both a potential sexual and gamete-to-embryos transmission of COVID-19. Despite these evidence, long-term and well-designed studies are needed to clarify these issues.

scholarly journals Pre-motor versus motor cerebral cortex neuromodulation for chronic neuropathic pain

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Igor Lavrov ◽  
Timur Latypov ◽  
Elvira Mukhametova ◽  
Brian Lundstrom ◽  
Paola Sandroni ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Cerebral Cortex ◽  
Motor Cortex ◽  
Initial Assessment ◽  
Motor Cortex Stimulation ◽  
Chronic Neuropathic Pain ◽  
Long Term Effect ◽  
Stimulation Of

AbstractElectrical stimulation of the cerebral cortex (ESCC) has been used to treat intractable neuropathic pain for nearly two decades, however, no standardized approach for this technique has been developed. In order to optimize targeting and validate the effect of ESCC before placing the permanent grid, we introduced initial assessment with trial stimulation, using a temporary grid of subdural electrodes. In this retrospective study we evaluate the role of electrode location on cerebral cortex in control of neuropathic pain and the role of trial stimulation in target-optimization for ESCC. Location of the temporary grid electrodes and location of permanent electrodes were evaluated in correlation with the long-term efficacy of ESCC. The results of this study demonstrate that the long-term effect of subdural pre-motor cortex stimulation is at least the same or higher compare to effect of subdural motor or combined pre-motor and motor cortex stimulation. These results also demonstrate that the initial trial stimulation helps to optimize permanent electrode positions in relation to the optimal functional target that is critical in cases when brain shift is expected. Proposed methodology and novel results open a new direction for development of neuromodulation techniques to control chronic neuropathic pain.

scholarly journals Long-term changes in the plant ecology of an African savanna landscape and the implications for ecosystem theory and conservation management

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
David Western ◽  
Victor N. Mose ◽  
David Maitumo ◽  
Caroline Mburu
Keyword(s):  
Human Impact ◽  
National Parks ◽  
Conservation Management ◽  
Plant Ecology ◽  
Ecological Resilience ◽  
Pasture Production ◽  
Ecosystem Theory ◽  
The Impact

Abstract Background Studies of the African savannas have used national parks to test ecological theories of natural ecosystems, including equilibrium, non-equilibrium, complex adaptive systems, and the role of top-down and bottom-up physical and biotic forces. Most such studies have excluded the impact of pastoralists in shaping grassland ecosystems and, over the last half century, the growing human impact on the world’s rangelands. The mounting human impact calls for selecting indicators and integrated monitoring methods able to track ecosystem changes and the role of natural and human agencies. Our study draws on five decades of monitoring the Amboseli landscape in southern Kenya to document the declining role of natural agencies in shaping plant ecology with rising human impact. Results We show that plant diversity and productivity have declined, biomass turnover has increased in response to a downsizing of mean plant size, and that ecological resilience has declined with the rising probability of extreme shortfalls in pasture production. The signature of rainfall and physical agencies in driving ecosystem properties has decreased sharply with growing human impact. We compare the Amboseli findings to the long-term studies of Kruger and Serengeti national parks to show that the human influence, whether by design or default, is increasingly shaping the ecology of savanna ecosystems. We look at the findings in the larger perspective of human impact on African grasslands and the world rangelands, in general, and discuss the implications for ecosystem theory and conservation policy and management. Conclusions The Amboseli study shows the value of using long-term integrated ecological monitoring to track the spatial and temporal changes in the species composition, structure, and function of rangeland ecosystems and the role of natural and human agencies in the process of change. The study echoes the widespread changes underway across African savannas and world’s rangelands, concluding that some level of ecosystem management is needed to prevent land degradation and the erosion of ecological function, services, and resilience. Despite the weak application of ecological theory to conservation management, a plant trait-based approach is shown to be useful in explaining the macroecological changes underway.

The Role of UBI in Mitigating the Effects of Psychosocial Stressors: A Review and Proposal

2021 ◽  
pp. 003329412110051
Author(s):  
Rashmi Gupta ◽  
Jemima Jacob ◽  
Gaurav Bansal
Keyword(s):  
Role Stress ◽  
Psychosocial Stressors ◽  
Basic Income ◽  
Economic Stability ◽  
The Past ◽  
Individual Outcomes ◽  
Long Term Impact ◽  
The Impact

Psychosocial stressors and social disadvantages contribute to inequalities in opportunities and outcomes. In the current paper, we use an epidemiological perspective and highlight the role stress plays on individuals by reviewing the outcomes of major stressors such as poverty and unemployment. We further analyzed the psychological and physical cost of these stressors and their long-term impact. We examined the role of universal basic income and closely looked at income experiments that were implemented in the past, in terms of their effectiveness in enhancing the community as well as individual outcomes and propose the UBI as a tool for alleviating the impact of these stressors. At a time when a major pandemic (e.g., COVID-19) threatens economic stability and health globally, we believe the UBI is relevant now, more than ever.

scholarly journals Impact of weight loss achieved through a multidisciplinary intervention on appetite in patients with severe obesity

2018 ◽  
Vol 315 (1) ◽  
pp. E91-E98 ◽  
Author(s):  
S. R. Coutinho ◽  
J. F. Rehfeld ◽  
J. J. Holst ◽  
B. Kulseng ◽  
C. Martins
Keyword(s):  
Weight Loss ◽  
Severe Obesity ◽  
Peptide Yy ◽  
Plasma Concentrations ◽  
Cardiovascular Fitness ◽  
Ghrelin Concentration ◽  
Time Points ◽  
Diet And Exercise ◽  
The Impact

The impact of lifestyle-induced weight loss (WL) on appetite in patients with obesity remains controversial. This study aimed to assess the short- and long-term impact of WL achieved by diet and exercise on appetite in patients with obesity. Thirty-five (22 females) adults with severe obesity (body mass index: 42.5 ± 5.0 kg/m2) underwent a 2-yr WL program focusing on diet and exercise. Body weight (BW), cardiovascular fitness (V̇o2max), appetite feelings, and plasma concentrations of insulin, active ghrelin (AG), glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and cholecystokinin (CCK), in the fasting and postprandial states, were measured at baseline (B), week 4 (W4), and 1 and 2 yr (and average values for all fasting and postprandial time points computed). BW was significantly reduced and V̇o2max(ml·kg−1·min−1) increased at all time points compared with B (3.5, 8.1, and 8.4% WL and 7, 11, and 8% increase at W4 and 1 and 2 yr, respectively). Basal hunger and average hunger and desire to eat were significantly increased at 1 and 2 yr. Basal fullness was significantly increased at W4, and average ratings were reduced at 1 yr. Average AG and PYY were significantly increased, and insulin was reduced, at all time points compared with B. Average GLP-1 was reduced at W4, and CCK was increased at 2 yr. After lifestyle-induced WL, patients with severe obesity will, therefore, have to deal with increased hunger in the long term. In conclusion, sustained WL at 2 yr achieved with diet and exercise is associated with increased hunger feelings and ghrelin concentration but also increased postprandial concentrations of satiety hormones.

The Sexual Experience of Married Middle-Aged Women as a Source of Mental Wellbeing: Perceptions, Challenges and Coping Mechanisms

2021 ◽  
Vol 30 (1) ◽  
pp. 181-203
Author(s):  
Tal Braverman-Uriel ◽  
Tal Litvak-Hirsch
Keyword(s):  
Quantitative Research ◽  
Sexual Experience ◽  
Women's Leadership ◽  
Mental Wellbeing ◽  
Structured Interviews ◽  
Significant Development ◽  
And Coping ◽  
The Impact

The impact of sexuality on mental wellbeing in women in long-term relationships has only been partially investigated. Emphasis has been on quantitative research studies that do not capture the breadth of the field. The present study looked at how and to what extent women maintain sexual desire in long-term relationships, and how sexuality affects their mental wellbeing. The study used a qualitative narrative approach and included semi-structured interviews with approximately 20 Israeli women aged 40–55 from similar socioeconomic backgrounds and in longstanding, permanent relationships. The findings indicate significant development over the years in the perception of the role of sexuality and its impact on mental wellbeing. The path to good sexuality can and should follow women’s leadership and initiative. Such women have the desire to make an impact, willingness to make an effort, and even an actual ability to exert influence. The interviewees’ tools, strategies, insights and ways of coping can serve as models for other women seeking better sexuality in a long-term relationship.

scholarly journals Has erosion globally increased? Long-term erosion rates as a function of climate derived from the impact crater inventory

2018 ◽  
Author(s):  
Stefan Hergarten ◽  
Thomas Kenkmann
Keyword(s):  
Time Scale ◽  
Impact Crater ◽  
Regional Effect ◽  
Tropical Zone ◽  
Erosion Rates ◽  
Continental Scale ◽  
River Loads ◽  
The Impact

Abstract. Worldwide erosion rates seem to have increased strongly since the beginning of the Quaternary, but there is still discussion about the role of glaciation as a potential driver and even whether the increase is real at all or an artefact due to losses in the long-term sedimentary record. In this study we derive estimates of average erosion rates on the time scale of some tens of million years from the terrestrial impact crater inventory. This approach is completely independent from all other methods to infer erosion rates such as river loads, preserved sediments, cosmogenic nuclides and thermochronometry. Our approach yields average erosion rates as a function of present-day topography and climate. The results confirm that topography accounts for the main part of the huge variation of erosion on Earth, but also identifies a significant systematic dependence on climate in contrast to several previous studies. We found a fivefold increase in erosional efficacy from the cold regimes to the tropical zone and that temperate and arid climates are very similar in this context. Combining our results to a worldwide mean erosion rate we found that erosion rates on the time scale of some tens of million years are at least as high as present-day rates and suggest that glaciation has a rather regional effect with a limited impact at the continental scale.

The Impact of the Reformation

2019 ◽  
pp. 40-61
Author(s):  
Martin Pugh
Keyword(s):  
Sixteenth Century ◽  
Protestant Reformation ◽  
Elizabeth I ◽  
Long Term Effect ◽  
Queen Elizabeth I ◽  
The Reformation ◽  
The Impact ◽  
European Diplomacy ◽  
Francis I

This chapter focuses on the Protestant Reformation of the sixteenth century. Following Henry VIII's break with Rome in 1531, the English Reformation led Britain into a protracted struggle with the two great Catholic powers, Spain and France, for the next 300 years. The long-term effect was to define Britain as the leading Protestant power; but more immediately, it posed a far greater threat to England than Islam, and effectively destroyed the rationale for crusading activities. In this situation, the Islamic empires actually became a valuable balancing factor in European diplomacy. Henry's readiness to deal with the Muslim powers was far from eccentric during the sixteenth century. Both King Francis I of France and Queen Elizabeth I of England took the policy of collaboration much further.

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