Association between Unhealthy Dietary Habits and Proteinuria Onset in a Japanese General Population: A Retrospective Cohort Study

The relationship between dietary habits and development of chronic kidney disease (CKD) is unclear. This retrospective cohort study was conducted to examine the association between unhealthy dietary habits and proteinuria onset, a key prognostic factor of CKD, among a Japanese general population aged ≥40 years. The risks of proteinuria onset were estimated based on the status of baseline unhealthy dietary habits (quick eating, late dinner, late evening snack, and skipping breakfast) compared with the status without these habits. A total of 26,764 subjects were included, with a mean follow-up period of 3.4 years. The most frequent unhealthy dietary habit was quick eating (29%), followed by late dinner (19%), late evening snack (16%), and skipping breakfast (9%). During the follow-up period, 10.6% of participants developed proteinuria. Late dinner and skipping breakfast showed an increased adjusted risk of proteinuria onset (hazard ratio (HR) 1.12, 95% confidence interval (CI) 1.02 to 1.22, and HR 1.15, 95% CI 1.01 to 1.31, respectively). Unhealthy dietary habits were not associated with changes in body mass index or waist-to-height ratio during the follow-up period. Our results suggest that late dinner and skipping breakfast are associated with higher risks for proteinuria onset.

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Association Between Unhealthy Dietary Habits and Proteinuria Onset in a Japanese General Population: A Retrospective Cohort Study

10.21203/rs.3.rs-33533/v1 ◽

2020 ◽

Author(s):

Toshiaki Tokumaru ◽

Tadashi Toyama ◽

Akinori Hara ◽

Kiyoki Kitagawa ◽

Yuta Yamamura ◽

...

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Dietary Habits ◽

Dietary Habit ◽

The Status ◽

Japanese General Population ◽

Late Evening ◽

Skipping Breakfast

Abstract Background The relationship between dietary habits and development of chronic kidney disease (CKD) is uncertain. This retrospective cohort study was conducted to examine the association between unhealthy dietary habits and proteinuria onset, a key prognostic factor of CKD. Methods We conducted a retrospective cohort study among individuals in a Japanese general population aged ≥ 40 years who underwent annual medical checkups from 1998 to 2014 in Kanazawa City, Japan. The risks of proteinuria onset were estimated based on the status of baseline unhealthy dietary habits (quick eating, late dinner, late evening snack, and skipping breakfast) compared with the status without these habits. We calculated the incidence rates per 1000 person-years based on the presence or absence of each unhealthy dietary habit. Multivariable Cox proportional hazards models were used to estimate the risks of proteinuria onset based on baseline unhealthy dietary habits. Changes in body mass index (BMI) and waist-to-height ratio (WHtR), which were possible intermediate factors in unhealthy dietary habits and proteinuria onset, were estimated using a linear mixed-effects model with random intercept and random slope. Results A total of 26,764 subjects were included, with a mean follow-up period of 3.4 years. The most frequent unhealthy dietary habits were quick eating (29%), followed by late dinner (19%), late evening snack (16%), and skipping breakfast (9%). During the follow-up period, 10.6% of the participants developed proteinuria, with an incidence rate of 32.7 per 1000 person-years. Late dinner or skipping breakfast had an increased adjusted risk of proteinuria onset (hazard ratio [HR] 1.12, 95% confidence interval [CI] 1.02 to 1.22, and HR 1.15, 95% CI 1.01 to 1.31, respectively). Each unhealthy dietary habit was not associated with changes in BMI or WHtR. Conclusion Our results suggest that late dinner and skipping breakfast were associated with higher risks for proteinuria onset. Unhealthy dietary habits were not associated with changes in BMI or WHtR during the follow-up period.

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Faculty Opinions recommendation of Evaluation of the economic burden of kidney stone disease in the UK: a retrospective cohort study with a mean follow-up of 19 years.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737186277.793570254 ◽

2020 ◽

Author(s):

Walter Strohmaier

Keyword(s):

Cohort Study ◽

Economic Burden ◽

Retrospective Cohort Study ◽

Kidney Stone ◽

Retrospective Cohort ◽

Stone Disease ◽

Kidney Stone Disease ◽

The Uk

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Status and Determinants of Treatment Outcomes Among New Tuberculosis Patients in South Korea: A Retrospective Cohort Study

Asia Pacific Journal of Public Health ◽

10.1177/10105395211000529 ◽

2021 ◽

pp. 101053952110005

Author(s):

Hyunjin Son ◽

Jeongha Mok ◽

Miyoung Lee ◽

Wonseo Park ◽

Seungjin Kim ◽

...

Keyword(s):

Cohort Study ◽

South Korea ◽

Success Rate ◽

Treatment Outcomes ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Health Care Facilities ◽

Tuberculosis Patients ◽

Lost To Follow Up

This is a retrospective cohort study using notification data in South Korea. We evaluated the nationwide status, regional differences, and the determinants of treatment outcomes among tuberculosis patients. Treatment success rate improved from 77.0% in 2012 to 86.0% in 2015. The lost to follow-up rate was higher among older people, males, and foreign nationals. Health care facilities designated for the Public-Private Mix (PPM) project showed higher success rate and lower rate of lost to follow-up. Moreover, municipalities with low regional deprivation index had higher PPM project coverage. Since there is a large regional difference in the coverage of the PPM project, an additional community-based support program should be implemented, especially for tuberculosis patients residing in region with low PPM project coverage.

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Pioglitazone use and Parkinson’s disease: a retrospective cohort study in Taiwan

BMJ Open ◽

10.1136/bmjopen-2018-023302 ◽

2018 ◽

Vol 8 (8) ◽

pp. e023302 ◽

Cited By ~ 10

Author(s):

Hsiu-Feng Wu ◽

Li-Ting Kao ◽

Jui-Hu Shih ◽

Hui-Han Kao ◽

Yu-Ching Chou ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Asian Population ◽

Secondary Outcome ◽

Study Cohort ◽

Patients With Diabetes

ObjectivesMany researchers have expected pioglitazone to serve as an effective neuroprotective agent against Parkinson’s disease (PD). Therefore, we conducted this cohort study to investigate the association between pioglitazone use and PD by using a large Asian population-based dataset in Taiwan.DesignRetrospective cohort study.SettingTaiwan.Participants7906 patients with diabetes who had received pioglitazone were defined as the study cohort, and 7906 matched patients with diabetes who had not received pioglitazone were defined as the comparison cohort.Primary and secondary outcome measuresWe tracked each patient individually over a 5-year follow-up period to identify those diagnosed as having PD during this period. We performed Cox proportional hazard regression analyses to evaluate the HRs for PD between the study and comparison cohorts.ResultsThe findings indicated that among the sampled patients, PD occurred in 257 (1.63%): 119 (1.51%) pioglitazone users and 138 (1.75%) non-users. The adjusted HR for PD within the follow-up period was 0.90 (95% CI: 0.68 to 1.18) in the patients who had received pioglitazone compared with the matched patients who had not received pioglitazone. Moreover, this study revealed that pioglitazone use was not associated with PD incidence in men (HR: 1.06, 95% CI: 0.71 to 1.59) or women (HR: 0.84, 95% CI: 0.61 to 1.15).ConclusionsThis study did not find the relationship between pioglitazone use and PD incidence, regardless of sex, among an Asian population of patients with diabetes.

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