scholarly journals Ketogenic Diet: A Dietary Modification as an Anxiolytic Approach?

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3822
Author(s):  
Adam Włodarczyk ◽  
Wiesław Jerzy Cubała ◽  
Aleksandra Wielewicka
Keyword(s):  
Anxiety Disorders ◽  
Unmet Need ◽  
Nutritional Intervention ◽  
Daily Basis ◽  
Treatment Modalities ◽  
Full Remission ◽  
Low Carbohydrate ◽  
Promising Treatment ◽  
Socioeconomic Burden ◽  
Fat Diets

Anxiety disorders comprise persistent, disabling conditions that are distributed across the globe, and are associated with the high medical and socioeconomic burden of the disease. Within the array of biopsychosocial treatment modalities—including monoaminergic antidepressants, benzodiazepines, and CBT—there is an unmet need for the effective treatment of anxiety disorders resulting in full remission and recovery. Nutritional intervention may be hypothesized as a promising treatment strategy; in particular, it facilitates relapse prevention. Low-carbohydrate high-fat diets (LCHF) may provide a rewarding outcome for some anxiety disorders; more research is needed before this regimen can be recommended to patients on a daily basis, but the evidence mentioned in this paper should encourage researchers and clinicians to consider LCHF as a piece of advice somewhere between psychotherapy and pharmacology, or as an add-on to those two.

scholarly journals Nanomaterial-Enabled Sensors and Therapeutic Platforms for Reactive Organophosphates

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 224
Author(s):  
Seok Ki Choi
Keyword(s):  
Unmet Need ◽  
Detection Methods ◽  
Treatment Modalities ◽  
Primary Interest ◽  
Biochemical Basis ◽  
Considerable Potential ◽  
Agricultural Pesticides ◽  
Design Concepts ◽  
Spectrophotometric Methods ◽  
The Status

Unintended exposure to harmful reactive organophosphates (OP), which comprise a group of nerve agents and agricultural pesticides, continues to pose a serious threat to human health and ecosystems due to their toxicity and prolonged stability. This underscores an unmet need for developing technologies that will allow sensitive OP detection, rapid decontamination and effective treatment of OP intoxication. Here, this article aims to review the status and prospect of emerging nanotechnologies and multifunctional nanomaterials that have shown considerable potential in advancing detection methods and treatment modalities. It begins with a brief introduction to OP types and their biochemical basis of toxicity followed by nanomaterial applications in two topical areas of primary interest. One topic relates to nanomaterial-based sensors which are applicable for OP detection and quantitative analysis by electrochemical, fluorescent, luminescent and spectrophotometric methods. The other topic is directed on nanotherapeutic platforms developed as OP remedies, which comprise nanocarriers for antidote drug delivery and nanoscavengers for OP inactivation and decontamination. In summary, this article addresses OP-responsive nanomaterials, their design concepts and growing impact on advancing our capability in the development of OP sensors, decontaminants and therapies.

scholarly journals Patient Experiences of Postinfectious Olfactory Dysfunction

ORL ◽  
2021 ◽  
pp. 1-5
Author(s):  
Carl M Philpott ◽  
James Boardman ◽  
Duncan Boak
Keyword(s):  
Online Survey ◽  
Unmet Need ◽  
Olfactory Dysfunction ◽  
Treatment Modalities ◽  
Medical Practitioners ◽  
Clinical Trials Unit ◽  
New Treatment ◽  
The Uk ◽  
Patients Experience ◽  
Age Range

<b><i>Introduction:</i></b> To highlight the importance of the need for new treatment modalities, this study aimed to characterise the experience of patients with postinfectious olfactory dysfunction (PIOD) in terms of the treatment they received. <b><i>Methods:</i></b> An online survey was hosted by the Norwich Clinical Trials Unit on the secure REDCap server. Members of the charity Fifth Sense (the UK charity that represents and supports people affected by smell and taste disorders) were invited to participate. <b><i>Results:</i></b> There were 149 respondents, of whom 127 had identified themselves as having (or had) PIOD. The age range of respondents to the survey was 28–85 years, with a mean of 58 ± 12 years, with the duration of their disorder &#x3c;5 years in 63% of cases. Respondents reported experiencing variable treatment with oral and/or intranasal steroids given typically (28%), often with no benefit, but with 50% receiving no treatment whatsoever; only 3% reported undertaking olfactory training. Over two-thirds of patients experience parosmia and, up to 5 years from the onset of the problem, were still actively seeking a solution. <b><i>Conclusion:</i></b> There appears to be a need to encourage greater use of guidelines for olfactory disorders amongst medical practitioners and also to develop more effective treatments for patients with PIOD, where there is clearly an unmet need.

Effects of Low-Carbohydrate and Low-Fat Diets

2015 ◽  
Vol 162 (5) ◽  
pp. 392
Author(s):  
Murray Skeaff ◽  
Jim Mann ◽  
Lisa Te Morenga ◽  
Rachael McLean
Keyword(s):  
Low Fat ◽  
Low Carbohydrate ◽  
Fat Diets

Effects of Low-Carbohydrate and Low-Fat Diets

2015 ◽  
Vol 162 (5) ◽  
pp. 391
Author(s):  
Alberto Donzelli ◽  
Alessandra Lafranconi
Keyword(s):  
Low Fat ◽  
Low Carbohydrate ◽  
Fat Diets

A Systematic Review of Low-Carbohydrate High-Fat Diets: Does the Research Evidence Support Practice?

2018 ◽  
Vol 118 (10) ◽  
pp. A126
Author(s):  
L. Ross ◽  
J. Musial ◽  
R. Hay ◽  
A. Cawte ◽  
D. McDermid ◽  
...  
Keyword(s):  
Systematic Review ◽  
Research Evidence ◽  
High Fat ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

Role of takrasevan in agnimandya - a review.

2019 ◽  
Vol 7 (4) ◽  
Author(s):  
Poonam Bharat Mandhare ◽  
Deepa R. Kale
Keyword(s):  
Eating Habits ◽  
Well Being ◽  
Daily Basis ◽  
Treatment Modalities ◽  
Human Beings ◽  
Diet And Exercise ◽  
Life Threatening ◽  
Almost All ◽  
Modern Era

Background: Our health and overall well-being mainly depends on our eating habits, physical activities, sleep patterns etc. Human beings, in order to adjust themselves in the modern era, have been compiled to become fast and mechanical. Due to this they can’t give proper attention to diet and exercise. Due to this Aaharpachan Kriya gets affected leading to Agnimandya (low or decreased digestive power). According to Ayurveda Agnimandya is responsible for almost all diseases. Objectives: Objective is to study importance of Takrasevan in Agnimandya.  Material and methods: Ayurvedic / modern texts and literature, research paper. Discussion: Grahani, Atisar, Arsh etc. are the commonest diseases seen in today’s life.  These diseases are not life threatening but can cause great distress to patient.  Ayurveda gave an amount of treatment modalities; one of them is Takrasevan i. e. consumption of buttermilk. Takra having ushna virya, kashaya rasa, madhur vipak and ruksha guna properties which pacifies Vata, Pitta, Kapha and potentiate the Agni and digests as well as absorbs the food articles and treats the disease in generous way. Conclusion: By this study it can be conclude that Takra (Buttermilk) can use on daily basis as dietary product. As it contains Probiotics which facilitates proper digestion and absorption process, it maintains proper metabolism to keep person free from diseases.   

An Understanding of Low-Carbohydrate, High-Fat Diets and Cancer

2006 ◽  
Vol 2 (3) ◽  
pp. 136-140
Author(s):  
Vasundara Venkateswaran ◽  
Ahmed Q. Haddad ◽  
Laurence H. Klotz ◽  
Rob Nam ◽  
Neil E. Fleshner
Keyword(s):  
High Fat ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Disease burden and cost of hidradenitis suppurativa: a retrospective examination of US administrative claims data

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e030579 ◽  
Author(s):  
Jessica Marvel ◽  
Anna Vlahiotis ◽  
Amy Sainski-Nguyen ◽  
Tina Willson ◽  
Alexandra Kimball
Keyword(s):  
Hidradenitis Suppurativa ◽  
Claims Data ◽  
Healthcare Resource ◽  
Unmet Need ◽  
Treatment Modalities ◽  
Resource Utilisation ◽  
Administrative Claims ◽  
Healthcare Resource Utilisation ◽  
Comorbidity Burden ◽  
Medicare Patients

ObjectivesHidradenitis suppurativa (HS) causes substantial morbidity and quality-of-life impairment. We examined demographic/clinical characteristics of patients with HS and treatment patterns, prevalence and healthcare resource utilisation/expenditures related to HS in the real-world.DesignRetrospective claims data of MarketScan Commercial, Medicare Supplemental and Medicaid databases (2009–2014).SettingUSA.ParticipantsPatients aged ≥12 years with ≥3 non-diagnostic outpatient or inpatient claims with an HS diagnosis code and ≥12 months continuous enrolment with medical and pharmacy benefits before (preindex) and after (postindex) the earliest diagnosis of HS (index) were included.ResultsThere were 11 325 Commercial/Medicare patients (mean age 37.4 years) and 5164 Medicaid patients (mean age 28.3 years). HS was more common in Medicaid than Commercial/Medicare patients (0.301% and 0.098%, respectively, in 2014). Cellulitis and psychiatric disorders were the most common comorbidities and oral antibiotics and narcotics were the most frequently prescribed drugs preindex, with ≥10% increase postindex in both populations. HS-related inpatient costs decreased while outpatient costs increased from preindex to postindex. Medicaid patients had several risk factors that may be associated with poor outcomes (eg, high rates of prescription pain medication use, comorbidities, drug discontinuation/interruption/holiday, emergency department (ED) visits and hospitalisation).ConclusionsCommercial/Medicare and Medicaid HS beneficiaries experience high comorbidity burden but use different treatment modalities to manage HS. Results suggest a substantial unmet need exists among this patient population, with Medicaid patients experiencing a particularly high burden of disease and expensive healthcare resource utilisation.

scholarly journals Very low-carbohydrate high-fat diets are superior to low-fat diets in improving cardiovascular markers: meta-analysis of large, long-term randomised controlled trials

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Teuta Gjuladin-Hellon ◽  
Ian Davies ◽  
Jackie Fealey ◽  
Alexander Montasem ◽  
Katie Lane
Keyword(s):  
Total Cholesterol ◽  
Randomised Controlled Trials ◽  
Fasting Glucose ◽  
Meta Analysis ◽  
High Fat ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Randomised Controlled ◽  
Fat Diets

AbstractOur recent study (1) showed that the amount of dietary carbohydrates in obesity interventions has differential effects on cardiovascular risk markers (CVM) and effects magnitude depends on intervention duration. Very-low carbohydrate high-fat diets (VLCD) were superior in ameliorating lipid markers compared to high-carbohydrate low-fat diets (LFD).We updated our systematic review and meta-analysis to include long-term effects of VLCD (< 50 g /day) on weight, glucose, total cholesterol, insulin and blood pressure (BP) among overweight/obese adults in comparison to LFD.Medline, PubMed, Cochrane Central, and CINAHLPlus were searched to identify large (n > 100) randomised controlled trials (RCT) with duration ≥ 6 months. Risk of bias, a random effects model and subgroup analyses based on duration of follow-up were performed using Review Manager. Results were reported according to PRISMA.Four open label RCT (n = 723; 362 VLCD; 361 LFD) with some form of behavioral intervention and duration 6–24 months were identified. VLCD showed more favorable effects on diastolic BP at 6 months (-1.96; 95%CI, -2.99 to 00.93; P = 0.0002) and 24 months (-2.69; 95%CI, -4.87 to -0.51; P = 0.001), near significant level at 12 months (-1.79; 95%CI, -3.56 to 0.04; P = 0.05) and an overall total favourable effect (-1.98; 95%CI, -2.73 to -1.22). The decrease in systolic BP was greater among VLCD for the whole period and the overall total effect reached the level of significance (-1.76; 95%CI, -3.56 to 0.04; P = 0.05). VLCD showed beneficial effect on total cholesterol level at 6 and 12 months (-0.01 mmol/L; 95%CI, -0.01 to –0.00; P = 0.002 and -0.01 mmol/L; 95%CI, -0.01 to –0.00; P = 0.005, respectively). The mean changes in weight, and fasting glucose and insulin levels revealed non-significant differences between both diets at any measured time, although these parameters decreased within both groups compared to baseline.VLCD led to significant total weighted mean decrease of diastolic BP and near significant decrease of systolic BP independent of changes in body weight, fasting glucose or insulin levels. The present data on decreased levels of diastolic BP and total cholesterol, combined with our recently published results on increased HDL-cholesterol, decreased triglycerides and no significant effect on LDL-cholesterol (1) provide evidence that VLCD are superior to LFD in improving traditional CVM in longer term.

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